RU2013130124A - METHOD FOR PRODUCING 2-EXO- [3 '- (6'-CHLOROPYRIDYL)] - 7-AZABICYCLO [2.2.1] -HEPTANE - Google Patents
METHOD FOR PRODUCING 2-EXO- [3 '- (6'-CHLOROPYRIDYL)] - 7-AZABICYCLO [2.2.1] -HEPTANE Download PDFInfo
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- RU2013130124A RU2013130124A RU2013130124/04A RU2013130124A RU2013130124A RU 2013130124 A RU2013130124 A RU 2013130124A RU 2013130124/04 A RU2013130124/04 A RU 2013130124/04A RU 2013130124 A RU2013130124 A RU 2013130124A RU 2013130124 A RU2013130124 A RU 2013130124A
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- chloropyridyl
- azabicyclo
- heptane
- exo
- producing
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1. Способ получения 2-экзо-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана изомеризацией эндо-изомера 2-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана в присутствии сильных оснований, отличающийся тем, что реакцию проводят в растворе полярного апротонного растворителя.2. Способ по п.1, отличающийся тем, что в качестве полярного апротонного растворителя используют диметилсульфоксид, N,N-диметилформамид, ацетонитрил, N-метилпирролидон.3. Способ по п.1, отличающийся тем, что в качестве сильного основания используют разветвленный алкоголят щелочного металла, где алкильный радикал - C3-C5, а щелочной металл - натрий или калий в количестве 5-25% мол.%.4. Способ по п.1, отличающийся тем, что реакцию изомеризации проводят при комнатной температуре.1. The method of producing 2-exo [3 '- (6'-chloropyridyl)] - 7-azabicyclo [2.2.1] heptane by isomerization of the endo-isomer 2- [3' - (6'-chloropyridyl)] - 7- azabicyclo [2.2.1] heptane in the presence of strong bases, characterized in that the reaction is carried out in a solution of a polar aprotic solvent. 2. The method according to claim 1, characterized in that dimethyl sulfoxide, N, N-dimethylformamide, acetonitrile, N-methylpyrrolidone are used as the polar aprotic solvent. The method according to claim 1, characterized in that a branched alkali metal alcoholate is used as a strong base, where the alkyl radical is C3-C5, and the alkali metal is sodium or potassium in an amount of 5-25 mol%. The method according to claim 1, characterized in that the isomerization reaction is carried out at room temperature.
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RU2013130124/04A RU2537390C1 (en) | 2013-07-02 | 2013-07-02 | Method of producing 2-exo-[3'-(6'-chloropyridyl)]-7-azabicyclo[2,2,1]-heptane |
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RU2013130124/04A RU2537390C1 (en) | 2013-07-02 | 2013-07-02 | Method of producing 2-exo-[3'-(6'-chloropyridyl)]-7-azabicyclo[2,2,1]-heptane |
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RU2013130124A true RU2013130124A (en) | 2015-01-10 |
RU2537390C1 RU2537390C1 (en) | 2015-01-10 |
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RU2013130124/04A RU2537390C1 (en) | 2013-07-02 | 2013-07-02 | Method of producing 2-exo-[3'-(6'-chloropyridyl)]-7-azabicyclo[2,2,1]-heptane |
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FR2912404B1 (en) * | 2007-02-09 | 2009-04-10 | Sanofi Aventis Sa | AZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
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