RU2013130124A - METHOD FOR PRODUCING 2-EXO- [3 '- (6'-CHLOROPYRIDYL)] - 7-AZABICYCLO [2.2.1] -HEPTANE - Google Patents

METHOD FOR PRODUCING 2-EXO- [3 '- (6'-CHLOROPYRIDYL)] - 7-AZABICYCLO [2.2.1] -HEPTANE Download PDF

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RU2013130124A
RU2013130124A RU2013130124/04A RU2013130124A RU2013130124A RU 2013130124 A RU2013130124 A RU 2013130124A RU 2013130124/04 A RU2013130124/04 A RU 2013130124/04A RU 2013130124 A RU2013130124 A RU 2013130124A RU 2013130124 A RU2013130124 A RU 2013130124A
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chloropyridyl
azabicyclo
heptane
exo
producing
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RU2013130124/04A
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Russian (ru)
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RU2537390C1 (en
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Павел Васильевич Казаков
Олег Иванович Лукашов
Наталья Сергеевна Мирзабекова
Михаил Иванович Власов
Фидель Михайлович Семченко
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Федеральное государственное унитарное предприятие "Государственный завод медицинских препаратов"
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1. Способ получения 2-экзо-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана изомеризацией эндо-изомера 2-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана в присутствии сильных оснований, отличающийся тем, что реакцию проводят в растворе полярного апротонного растворителя.2. Способ по п.1, отличающийся тем, что в качестве полярного апротонного растворителя используют диметилсульфоксид, N,N-диметилформамид, ацетонитрил, N-метилпирролидон.3. Способ по п.1, отличающийся тем, что в качестве сильного основания используют разветвленный алкоголят щелочного металла, где алкильный радикал - C3-C5, а щелочной металл - натрий или калий в количестве 5-25% мол.%.4. Способ по п.1, отличающийся тем, что реакцию изомеризации проводят при комнатной температуре.1. The method of producing 2-exo [3 '- (6'-chloropyridyl)] - 7-azabicyclo [2.2.1] heptane by isomerization of the endo-isomer 2- [3' - (6'-chloropyridyl)] - 7- azabicyclo [2.2.1] heptane in the presence of strong bases, characterized in that the reaction is carried out in a solution of a polar aprotic solvent. 2. The method according to claim 1, characterized in that dimethyl sulfoxide, N, N-dimethylformamide, acetonitrile, N-methylpyrrolidone are used as the polar aprotic solvent. The method according to claim 1, characterized in that a branched alkali metal alcoholate is used as a strong base, where the alkyl radical is C3-C5, and the alkali metal is sodium or potassium in an amount of 5-25 mol%. The method according to claim 1, characterized in that the isomerization reaction is carried out at room temperature.

Claims (4)

1. Способ получения 2-экзо-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана изомеризацией эндо-изомера 2-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана в присутствии сильных оснований, отличающийся тем, что реакцию проводят в растворе полярного апротонного растворителя.1. The method of producing 2-exo [3 '- (6'-chloropyridyl)] - 7-azabicyclo [2.2.1] heptane by isomerization of the endo-isomer 2- [3' - (6'-chloropyridyl)] - 7- azabicyclo [2.2.1] heptane in the presence of strong bases, characterized in that the reaction is carried out in a solution of a polar aprotic solvent. 2. Способ по п.1, отличающийся тем, что в качестве полярного апротонного растворителя используют диметилсульфоксид, N,N-диметилформамид, ацетонитрил, N-метилпирролидон.2. The method according to claim 1, characterized in that dimethyl sulfoxide, N, N-dimethylformamide, acetonitrile, N-methylpyrrolidone are used as the polar aprotic solvent. 3. Способ по п.1, отличающийся тем, что в качестве сильного основания используют разветвленный алкоголят щелочного металла, где алкильный радикал - C3-C5, а щелочной металл - натрий или калий в количестве 5-25% мол.%.3. The method according to claim 1, characterized in that a branched alkali metal alcoholate is used as the strong base, where the alkyl radical is C3-C5 and the alkali metal is sodium or potassium in an amount of 5-25 mol%. 4. Способ по п.1, отличающийся тем, что реакцию изомеризации проводят при комнатной температуре. 4. The method according to claim 1, characterized in that the isomerization reaction is carried out at room temperature.
RU2013130124/04A 2013-07-02 2013-07-02 Method of producing 2-exo-[3'-(6'-chloropyridyl)]-7-azabicyclo[2,2,1]-heptane RU2537390C1 (en)

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RU2013130124/04A RU2537390C1 (en) 2013-07-02 2013-07-02 Method of producing 2-exo-[3'-(6'-chloropyridyl)]-7-azabicyclo[2,2,1]-heptane

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FR2912404B1 (en) * 2007-02-09 2009-04-10 Sanofi Aventis Sa AZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.

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Effective date: 20150703