RU2012129763A - METHOD FOR FORECASTING RISK OF DEVELOPMENT OF BRONCHIAL ASTHMA - Google Patents
METHOD FOR FORECASTING RISK OF DEVELOPMENT OF BRONCHIAL ASTHMA Download PDFInfo
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- RU2012129763A RU2012129763A RU2012129763/15A RU2012129763A RU2012129763A RU 2012129763 A RU2012129763 A RU 2012129763A RU 2012129763/15 A RU2012129763/15 A RU 2012129763/15A RU 2012129763 A RU2012129763 A RU 2012129763A RU 2012129763 A RU2012129763 A RU 2012129763A
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- gsdmb
- b4galt1
- igfbp3
- rs1496499t
- gene
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Abstract
1. Способ прогнозирования риска развития бронхиальной астмы, включающий выделение ДНК из лимфоцитов периферической венозной крови больного, отличающийся тем, что проводят генотипирование полиморфного варианта rs7216389 гена гасдермина В (GSDMB), полиморфного варианта rs12342831 гена бета 1,4-галактозилтрансферазы 1 (B4GALT1) и полиморфного варианта rs1496499 гена белка 3, связывающего инсулиноподобные факторы роста (IGFBP3).2. Способ по п.1, отличающийся тем, что проводят идентификацию одного из сочетаний генотипов по трем полиморфным локусам генов:GSDMB*rs7216389C/T - B4GALT1*rs12342831T/Т - IGFBP3*rs1496499T/G; GSDMB*rs7216389T/T - B4GALT1*rs12342831T/T - IGFBP3*rs1496499T/G; GSDMB*rs7216389T/T - B4GALT1*rs12342831T/T - IGFBP3*rs1496499T/T, и прогнозируют риск развития бронхиальной астмы у индивидов различной этнической принадлежности.3. Способ по п.1, отличающийся тем, что у индивидов русской этнической принадлежности дополнительно проводят генотипирование полиморфного варианта rs1492313 гена муцина 19, идентификацию одного из сочетаний генотипов по четырем полиморфным локусам генов:GSDMB*rs7216389T/T - B4GALT1*rs12342831T/Т - IGFBP3*rs1496499T/G - MUC19*rs1492313A/А;GSDMB*rs7216389T/T - B4GALT1*rs12342831T/T - IGFBP3*rs1496499T/T-MUC19*rs1492313A/A,и прогнозируют риск развития бронхиальной астмы у русских.1. A method for predicting the risk of developing bronchial asthma, including the extraction of DNA from lymphocytes of the patient’s peripheral venous blood, characterized in that the polymorphic variant rs7216389 of the gasdermin B gene (GSDMB), the polymorphic variant rs12342831 of the beta gene of 1,4-galactosyltransferase 1 (B4GALT1) are genotyped polymorphic variant rs1496499 of protein 3 gene that binds insulin-like growth factors (IGFBP3) .2. The method according to claim 1, characterized in that one of the combinations of genotypes is identified by three polymorphic loci of genes: GSDMB * rs7216389C / T - B4GALT1 * rs12342831T / T - IGFBP3 * rs1496499T / G; GSDMB * rs7216389T / T - B4GALT1 * rs12342831T / T - IGFBP3 * rs1496499T / G; GSDMB * rs7216389T / T - B4GALT1 * rs12342831T / T - IGFBP3 * rs1496499T / T, and predict the risk of bronchial asthma in individuals of different ethnicities. 3. The method according to claim 1, characterized in that individuals of Russian ethnicity additionally carry out genotyping of the polymorphic variant rs1492313 of the mucin 19 gene, identify one of the combinations of genotypes by four polymorphic gene loci: GSDMB * rs7216389T / T - B4GALT1 * rs12342831T / T - IGFBP3 * rs1496499T / G - MUC19 * rs1492313A / A; GSDMB * rs7216389T / T - B4GALT1 * rs12342831T / T - IGFBP3 * rs1496499T / T-MUC19 * rs1492313A / A, and predict the risk of bronchial asthma in Russians.
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RU2012129763/15A RU2510508C1 (en) | 2012-07-13 | 2012-07-13 | Method for risk prediction of bronchial asthma |
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RU2012129763/15A RU2510508C1 (en) | 2012-07-13 | 2012-07-13 | Method for risk prediction of bronchial asthma |
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RU2012129763A true RU2012129763A (en) | 2014-01-20 |
RU2510508C1 RU2510508C1 (en) | 2014-03-27 |
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Families Citing this family (1)
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RU2677294C1 (en) * | 2018-09-04 | 2019-01-16 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова" (ФГБНУ "НИИ МТ") | Method for prediction of risk of developing occupational bronchial asthma |
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RU2324937C1 (en) * | 2006-11-27 | 2008-05-20 | Институт биохимии и генетики Уфимского научного центра Российской академии наук (ИБГ УНЦ РАН) | Method of risk prediction of bronchial asthma |
RU2383019C1 (en) * | 2008-12-09 | 2010-02-27 | Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО СибГМУ Росздрава) | Method of predicting risk of bronchial asthma development |
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