RU2012105674A - PHARMACEUTICAL COMPOSITION OF ISONIAZID - Google Patents
PHARMACEUTICAL COMPOSITION OF ISONIAZID Download PDFInfo
- Publication number
- RU2012105674A RU2012105674A RU2012105674/15A RU2012105674A RU2012105674A RU 2012105674 A RU2012105674 A RU 2012105674A RU 2012105674/15 A RU2012105674/15 A RU 2012105674/15A RU 2012105674 A RU2012105674 A RU 2012105674A RU 2012105674 A RU2012105674 A RU 2012105674A
- Authority
- RU
- Russia
- Prior art keywords
- isoniazid
- rifampicin
- pharmaceutical composition
- phthalate
- sustained release
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
1. Твердая пероральная фармацевтическая композиция, содержащая рифампицин, пиперин и изониазид, где соотношение рифампицина и изониазида находится в диапазоне от 0,3 до 0,9, причем биодоступность рифампицина повышена в присутствии изониазида.2. Твердая пероральная фармацевтическая композиция по п.1, где изониазид находится в форме с замедленным высвобождением.3. Композиция по п.1, где изониазид находится в форме таблетки.4. Композиция по п.3, где изониазид находится в форме таблетки с энтеросолюбильным покрытием.5. Композиция по п.2, где замедленного высвобождения изониазида достигают посредством использования полимеров на основе фталата типа целлюлозы ацетата фталата, гидроксипропилметилцеллюлозы фталата, поливинилацетата фталата и полимеров метакриловой кислоты.1. Solid oral pharmaceutical composition containing rifampicin, piperine and isoniazid, where the ratio of rifampicin and isoniazid is in the range from 0.3 to 0.9, and the bioavailability of rifampicin is increased in the presence of isoniazid. 3. The solid oral pharmaceutical composition of claim 1, wherein the isoniazid is in sustained release form. Composition according to claim 1, wherein the isoniazid is in the form of a tablet. The composition of claim 3, wherein the isoniazid is in the form of an enteric-coated tablet. The composition of claim 2, wherein the sustained release of isoniazid is achieved by using phthalate-based polymers such as cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, and methacrylic acid polymers.
Claims (5)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1765/MUM/2009 | 2009-07-31 | ||
IN1765MU2009 | 2009-07-31 | ||
IN1991/MUM/2009 | 2009-09-01 | ||
IN1991MU2009 | 2009-09-01 | ||
PCT/IB2010/001871 WO2011012987A1 (en) | 2009-07-31 | 2010-07-29 | Pharmaceutical composition of isoniazid |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2012105674A true RU2012105674A (en) | 2013-09-10 |
Family
ID=43528828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2012105674/15A RU2012105674A (en) | 2009-07-31 | 2010-07-29 | PHARMACEUTICAL COMPOSITION OF ISONIAZID |
Country Status (4)
Country | Link |
---|---|
AP (1) | AP2012006119A0 (en) |
RU (1) | RU2012105674A (en) |
WO (1) | WO2011012987A1 (en) |
ZA (1) | ZA201200659B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017501117A (en) | 2013-07-26 | 2017-01-12 | サノフイ | Antitubercular composition comprising rifampicin, isoniazid, ethambutol and pyrazinamide and method for producing the same |
MX2016001155A (en) | 2013-07-26 | 2016-04-29 | Sanofi Sa | Anti-tuberculosis stable pharmaceutical composition in a form of a dispersible tablet comprising granules of isoniazid and granules of rifapentine and its process of preparation. |
EP3773731A1 (en) | 2018-04-05 | 2021-02-17 | Cipla Limited | Pharmaceutical formulations |
CN112438951A (en) * | 2019-08-28 | 2021-03-05 | 重庆华邦制药有限公司 | Method for preparing isoniazid preparation and preparation thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0650728B1 (en) * | 1993-10-29 | 2002-02-27 | Council of Scientific and Industrial Research | Pharmaceutical compositions containing piperine and an antituberculosis or antileprosydrug |
AU778389C (en) * | 2000-08-09 | 2006-12-14 | Panacea Biotec Limited | Novel pharmaceutical compositions of anti-tubercular drugs and process for their preparation |
-
2010
- 2010-07-29 WO PCT/IB2010/001871 patent/WO2011012987A1/en active Application Filing
- 2010-07-29 RU RU2012105674/15A patent/RU2012105674A/en unknown
- 2010-07-29 AP AP2012006119A patent/AP2012006119A0/en unknown
-
2012
- 2012-01-26 ZA ZA2012/00659A patent/ZA201200659B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201200659B (en) | 2012-10-31 |
WO2011012987A1 (en) | 2011-02-03 |
AP2012006119A0 (en) | 2012-02-29 |
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