RU2011127776A - Derivatives of 2,6-diisobornylphenol - Google Patents

Derivatives of 2,6-diisobornylphenol Download PDF

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RU2011127776A
RU2011127776A RU2011127776/04A RU2011127776A RU2011127776A RU 2011127776 A RU2011127776 A RU 2011127776A RU 2011127776/04 A RU2011127776/04 A RU 2011127776/04A RU 2011127776 A RU2011127776 A RU 2011127776A RU 2011127776 A RU2011127776 A RU 2011127776A
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group
isobornyl
configuration
moieties
formula
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RU2011127776/04A
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RU2575294C2 (en
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Александр Васильевич Кучин
Ирина Юрьевна Чукичева
Ирина Витальевна Федорова
Евгений Владимирович Буравлев
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Учреждение Российской академии наук Институт химии Коми научного центра Уральского отделения РАН
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

1. Группа соединений представлена формулой (I)где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'5),где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),Rпредставляет собой группу общей формулы II -(CH)NX, где X - алкильный радикал С1-С8 линейный или разветвленный, циклогексил-, морфолин-, пиперидин-, бензил-, сальсолидина, сальсолина, N-бензил-1-фенилэтиламина,n=1-30.2. Группа соединений представлена формулой (I)где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'5),где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),Rпредставляет собой группу общей формулы II -(СН)НХ, где X - алкильный радикал С1-С8 линейный или разветвленный, циклогексил-, морфолин-, пиперидин-, бензил;n=1-30.3. Группа соединений представлена формулой (I)где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'5),где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),Rпредставляет собой группу общей формулы III -(CH)Y где Y - ОН-группа; Hal; SH;n=1-30.4. Группа соединений представлена формулой (I) ОНгде изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'S),где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),R- формильная группа.1. The group of compounds represented by formula (I) where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'5), where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'S, 2'R, 4'R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R is a group of the general formula II - (CH) NX, where X is an alkyl radical C1-C8 linear or branched, cyclohexyl-, morpholine-, piperidine, benzyl, salsolidine, salsoline, N-benzyl-1-phenylethylamine, n = 1-30.2. The group of compounds is represented by formula (I) where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'5), where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'S, 2'R, 4 ' R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R is a group of the general formula II - (CH) HX, where X is an alkyl radical C1-C8 linear or branched, cyclohexyl-, morpholine-, piperidine- benzyl; n = 1-30.3. The group of compounds is represented by formula (I) where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'5), where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'S, 2'R, 4 ' R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R is a group of the general formula III - (CH) Y where Y is an OH group; Hal; SH; n = 1-30.4. The group of compounds is represented by formula (I) where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'S), where the isobornyl moieties have the configuration (1S, 2R, 4R, 1'S, 2'R, 4'R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R is a formyl group.

Claims (4)

1. Группа соединений представлена формулой (I)1. The group of compounds represented by formula (I)
Figure 00000001
Figure 00000001
 где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'5),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'5), где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'S, 2'R, 4'R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R1 представляет собой группу общей формулы II -(CH2)nNX2, где X - алкильный радикал С1-С8 линейный или разветвленный, циклогексил-, морфолин-, пиперидин-, бензил-, сальсолидина, сальсолина, N-бензил-1-фенилэтиламина,R 1 represents a group of the general formula II - (CH 2 ) n NX 2 , where X is the C1-C8 alkyl radical linear or branched, cyclohexyl, morpholine, piperidine, benzyl, salsolidine, salsoline, N-benzyl-1 α-phenylethylamine, n=1-30.n = 1-30. 2. Группа соединений представлена формулой (I)2. The group of compounds represented by formula (I)
Figure 00000002
Figure 00000002
 где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'5),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'5), где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'S, 2'R, 4'R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R1 представляет собой группу общей формулы II -(СН2)nНХ, где X - алкильный радикал С1-С8 линейный или разветвленный, циклогексил-, морфолин-, пиперидин-, бензил;R 1 represents a group of general formula II - (CH 2 ) n HX, where X is an alkyl radical C1-C8 linear or branched, cyclohexyl, morpholine, piperidine, benzyl; n=1-30.n = 1-30. 3. Группа соединений представлена формулой (I)3. The group of compounds represented by formula (I)
Figure 00000003
Figure 00000003
 где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'5), where isobornyl fragments have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'5), где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'S, 2'R, 4'R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R1 представляет собой группу общей формулы III -(CH2)nY где Y - ОН-группа; Hal; SH;R 1 represents a group of the general formula III - (CH 2 ) n Y where Y is an OH group; Hal; SH; n=1-30.n = 1-30. 4. Группа соединений представлена формулой (I) ОН4. The group of compounds represented by formula (I) OH
Figure 00000004
Figure 00000004
 где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'R, 2'S, 4'S),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'R, 2'S, 4'S), где изоборнильные фрагменты имеют конфигурацию (1S, 2R, 4R, 1'S, 2'R, 4'R) и (1R, 2S, 4S 1'R, 2'S, 4'S),where isobornyl fragments have the configuration (1S, 2R, 4R, 1'S, 2'R, 4'R) and (1R, 2S, 4S 1'R, 2'S, 4'S), R1 - формильная группа. R 1 is a formyl group.
RU2011127776/04A 2011-07-06 2011-07-06 2,6-diisobornyl phenol derivatives RU2575294C2 (en)

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RU2011127776/04A RU2575294C2 (en) 2011-07-06 2,6-diisobornyl phenol derivatives
PCT/RU2012/000533 WO2013006098A2 (en) 2011-07-06 2012-06-27 2,6-diisobornylphenol derivatives

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