RU2010149502A - POLYEEPYTOPIC PROTEIN, NUCLEOTIDE SEQUENCE, ENCODING POLYEPEPITOUS PROTEIN, PLASMIDA WITH SEQUENCE, ENCODING POLYEEPITOPE PROTEIN, AND POLYULEDI POLYULEPHILE CLEAN - Google Patents
POLYEEPYTOPIC PROTEIN, NUCLEOTIDE SEQUENCE, ENCODING POLYEPEPITOUS PROTEIN, PLASMIDA WITH SEQUENCE, ENCODING POLYEEPITOPE PROTEIN, AND POLYULEDI POLYULEPHILE CLEAN Download PDFInfo
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- RU2010149502A RU2010149502A RU2010149502/10A RU2010149502A RU2010149502A RU 2010149502 A RU2010149502 A RU 2010149502A RU 2010149502/10 A RU2010149502/10 A RU 2010149502/10A RU 2010149502 A RU2010149502 A RU 2010149502A RU 2010149502 A RU2010149502 A RU 2010149502A
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Abstract
1. Полиэпитопный вакцинный белок, предназначенный для иммунизации против вируса ящура, который включает аминокислотную последовательность В-клеточного эпитопа белка VP4 с 21-й по 40-ю аминокислоту, начиная с N-конца, аминокислотную последовательность В-клеточного эпитопа белка VP1 с 135-й по 160-ю аминокислоту, начиная с N-конца, аминокислотную последовательность В-клеточного эпитопа белка VP1 с 200-й по 213-ю аминокислоту, начиная с N-конца, аминокислотную последовательность Т-клеточного эпитопа белка 2С с 68-й по 76-ю аминокислоту, начиная с N-конца, аминокислотную последовательность Т-клеточного эпитопа белка 3D с 1-й по 115-ю аминокислоту, начиная с N-конца, и аминокислотную последовательность Т-клеточного эпитопа белка 3D с 421-й по 460-ю аминокислоту вируса ящура серотипа О/Тайвань/99. ! 2. Нуклеотидная последовательность, кодирующая полиэпитопный вакцинный белок по п.1. ! 3. Рекомбинантная плазмида, содержащая нуклеотидную полседовательность по п.2, обеспечивающая синтез полиэпитопного вакцинного белка по п.1 в растениях. ! 4. Вакцинный препарат полиэпитопного белка по п.1, вызывающий иммунный ответ против вируса ящура серотипа О/Тайвань/99 и устойчивость к заражению у лабораторных животных. ! 5. Вакцинный препарат по п.4, который дополнительно включает адъювант. 1. A polyepitope vaccine protein intended for immunization against FMD virus, which comprises the amino acid sequence of the B-cell epitope of the VP4 protein from the 21st to the 40th amino acid, starting from the N-terminus, the amino acid sequence of the B-cell epitope of the VP1 protein from 135- the 160th amino acid, starting from the N-terminus, the amino acid sequence of the B-cell epitope of the VP1 protein from the 200th to the 213rd amino acid, starting from the N-terminus, the amino acid sequence of the T-cell epitope of the protein 2C from the 68th to The 76th amino acid, starting at the N-terminus, aminok the acid sequence of the T-cell epitope of the 3D protein from the 1st to the 115th amino acid, starting from the N-terminus, and the amino acid sequence of the T-cell epitope of the 3D protein from the 421st to the 460th amino acid of the FMD virus serotype O / Taiwan / 99 . ! 2. The nucleotide sequence encoding the polyepitope vaccine protein according to claim 1. ! 3. The recombinant plasmid containing the nucleotide half-sequence according to claim 2, providing for the synthesis of the polyepitope vaccine protein of claim 1 in plants. ! 4. The vaccine preparation of the polyepitope protein according to claim 1, causing an immune response against foot and mouth disease virus serotype O / Taiwan / 99 and resistance to infection in laboratory animals. ! 5. The vaccine preparation according to claim 4, which further comprises an adjuvant.
Claims (5)
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RU2010149502/10A RU2467014C2 (en) | 2010-12-06 | 2010-12-06 | Polyepitope protein, nucleotide sequence coding polyepitope protein, plasmid with sequence coding polyepitope protein, and preparation of polyepitope protein for induction of immune response on murrain virus |
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RU2010149502/10A RU2467014C2 (en) | 2010-12-06 | 2010-12-06 | Polyepitope protein, nucleotide sequence coding polyepitope protein, plasmid with sequence coding polyepitope protein, and preparation of polyepitope protein for induction of immune response on murrain virus |
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RU2010149502A true RU2010149502A (en) | 2012-06-20 |
RU2467014C2 RU2467014C2 (en) | 2012-11-20 |
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RU2010149502/10A RU2467014C2 (en) | 2010-12-06 | 2010-12-06 | Polyepitope protein, nucleotide sequence coding polyepitope protein, plasmid with sequence coding polyepitope protein, and preparation of polyepitope protein for induction of immune response on murrain virus |
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Families Citing this family (2)
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KR20150137085A (en) * | 2013-03-26 | 2015-12-08 | 더 피르브라이트 인스티튜트 | Stabilised fmdv capsids |
ES2899230T3 (en) * | 2015-11-23 | 2022-03-10 | Boehringer Ingelheim Animal Health Usa Inc | Fusion proteins of FMDV and E2 and uses thereof |
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DE19638044A1 (en) * | 1996-09-18 | 1998-03-19 | Bayer Ag | Immunogenic peptides from foot-and-mouth disease viruses |
US6774225B2 (en) * | 1999-04-15 | 2004-08-10 | Hong Kong University Of Science & Technology | Antigenized antibody vaccine for foot-and-mouth disease |
WO2006063445A1 (en) * | 2004-12-14 | 2006-06-22 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health | Recombinant foot and mouth disease vaccine |
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