RU2010141922A - (E) -4'-aryl-7'-arylmethylene-4 ', 5', 6 ', 7'-tetrahydro-2'n-spiro [cycloalkane-1,3'-cyclopent [b] pyran] -2' -THE MANIFESTATION OF ANALGETIC ACTIVITY AND METHOD FOR PRODUCING THEM - Google Patents

(E) -4'-aryl-7'-arylmethylene-4 ', 5', 6 ', 7'-tetrahydro-2'n-spiro [cycloalkane-1,3'-cyclopent [b] pyran] -2' -THE MANIFESTATION OF ANALGETIC ACTIVITY AND METHOD FOR PRODUCING THEM Download PDF

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RU2010141922A
RU2010141922A RU2010141922/04A RU2010141922A RU2010141922A RU 2010141922 A RU2010141922 A RU 2010141922A RU 2010141922/04 A RU2010141922/04 A RU 2010141922/04A RU 2010141922 A RU2010141922 A RU 2010141922A RU 2010141922 A RU2010141922 A RU 2010141922A
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arylmethylene
cycloalkane
pyran
spiro
tetrahydro
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RU2010141922/04A
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RU2455300C2 (en
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Николай Федорович Кириллов (RU)
Николай Федорович Кириллов
Рамиз Рагибович Махмудов (RU)
Рамиз Рагибович Махмудов
Александр Геннадьевич Гаврилов (RU)
Александр Геннадьевич Гаврилов
Людмила Геннадьевна Марданова (RU)
Людмила Геннадьевна Марданова
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Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" (RU)
Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет"
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Abstract

1. (Е)-4′-арил-7′-арилметилен-4′,5′,6′,7′-тетрагидро-2′H-спиро[циклоалкан-1,3′-циклопента[b]пиран]-2′-оны общей формулы ! ! n=1, 2, 3; ! проявляющие анальгетическую активность. ! 2. Способ получения (Е)-4′-арил-7′-арилметилен-4′,5′,6′,7′-тетрагидро-2′H-спиро[циклоалкан-1,3′-циклопента[b]пиран]-2′-онов общей формулы ! ! n=1, 2, 3; ! заключающийся в том, что метиловые эфиры 1-бромциклоалканкарбоновых кислот кипятят с цинком и 2,5-бис-арилметиленпентанонами в среде бензол-этилацетат - ГМФТА (10:5:1) в течении 4 ч. 1. (E) -4′-aryl-7′-arylmethylene-4 ′, 5 ′, 6 ′, 7′-tetrahydro-2′H-spiro [cycloalkane-1,3′-cyclopenta [b] pyran] - 2′-ones of the general formula! ! n is 1, 2, 3; ! exhibiting analgesic activity. ! 2. The method of obtaining (E) -4′-aryl-7′-arylmethylene-4 ′, 5 ′, 6 ′, 7′-tetrahydro-2′H-spiro [cycloalkane-1,3′-cyclopenta [b] pyran ] -2′-ones of the general formula! ! n is 1, 2, 3; ! consisting in the fact that methyl esters of 1-bromocycloalkanecarboxylic acid are boiled with zinc and 2,5-bis-arylmethylene pentanones in benzene-ethyl acetate - HMFTA (10: 5: 1) for 4 hours.

Claims (2)

1. (Е)-4′-арил-7′-арилметилен-4′,5′,6′,7′-тетрагидро-2′H-спиро[циклоалкан-1,3′-циклопента[b]пиран]-2′-оны общей формулы1. (E) -4′-aryl-7′-arylmethylene-4 ′, 5 ′, 6 ′, 7′-tetrahydro-2′H-spiro [cycloalkane-1,3′-cyclopenta [b] pyran] - 2′-ones of the general formula
Figure 00000001
Figure 00000001
 n=1, 2, 3;n is 1, 2, 3; проявляющие анальгетическую активность.exhibiting analgesic activity. 2. Способ получения (Е)-4′-арил-7′-арилметилен-4′,5′,6′,7′-тетрагидро-2′H-спиро[циклоалкан-1,3′-циклопента[b]пиран]-2′-онов общей формулы2. The method of obtaining (E) -4′-aryl-7′-arylmethylene-4 ′, 5 ′, 6 ′, 7′-tetrahydro-2′H-spiro [cycloalkane-1,3′-cyclopenta [b] pyran ] -2′-ones of the general formula
Figure 00000002
Figure 00000002
 n=1, 2, 3;n is 1, 2, 3; заключающийся в том, что метиловые эфиры 1-бромциклоалканкарбоновых кислот кипятят с цинком и 2,5-бис-арилметиленпентанонами в среде бензол-этилацетат - ГМФТА (10:5:1) в течении 4 ч. consisting in the fact that methyl esters of 1-bromocycloalkanecarboxylic acid are boiled with zinc and 2,5-bis-arylmethylene pentanones in benzene-ethyl acetate - HMFTA (10: 5: 1) for 4 hours.
RU2010141922/04A 2010-10-14 2010-10-14 (E)-4'-ARYL-7'-ARYLMETHYLENE-4',5',6',7'-TETRAHYDRO-2'H-SPIRO[CYCLOALKANE-1,3'-CYCLOPENTA[b]PYRAN]-2'-ONES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF RU2455300C2 (en)

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RU2010141922/04A RU2455300C2 (en) 2010-10-14 2010-10-14 (E)-4'-ARYL-7'-ARYLMETHYLENE-4',5',6',7'-TETRAHYDRO-2'H-SPIRO[CYCLOALKANE-1,3'-CYCLOPENTA[b]PYRAN]-2'-ONES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF

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RU2010141922/04A RU2455300C2 (en) 2010-10-14 2010-10-14 (E)-4'-ARYL-7'-ARYLMETHYLENE-4',5',6',7'-TETRAHYDRO-2'H-SPIRO[CYCLOALKANE-1,3'-CYCLOPENTA[b]PYRAN]-2'-ONES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF

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RU2713946C1 (en) * 2019-11-13 2020-02-11 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) 4,7-dimethyl-3,4,4a,5,8,8a-hexahydrospiro[chromene-2,1'-cyclohexane]-4,8-diol as an analgesic agent

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