RU2010120536A - Pyridine and pyrazine derivatives useful for the treatment of cellular cellular disorders - Google Patents
Pyridine and pyrazine derivatives useful for the treatment of cellular cellular disorders Download PDFInfo
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- RU2010120536A RU2010120536A RU2010120536/04A RU2010120536A RU2010120536A RU 2010120536 A RU2010120536 A RU 2010120536A RU 2010120536/04 A RU2010120536/04 A RU 2010120536/04A RU 2010120536 A RU2010120536 A RU 2010120536A RU 2010120536 A RU2010120536 A RU 2010120536A
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- alkyl
- piperidin
- amino
- alkoxy
- methyl
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Abstract
1. Соединение формулы I ! , ! в которой W представляет собой СН или N; ! J представляет собой О или S; ! каждый из G1, G2, G3 и G4 выбран из СН и N, при условии, что не более чем два из G1, G2, G3 и G4 представляют собой N; ! кольцо А выбрано из: ! (1) фенила, замещенного R1 и возможно замещенного группами R2 в количестве вплоть до трех; или ! (2) 5- или 6-членного моноциклического гетероарильного кольца с кольцевыми гетероатомами в количестве вплоть до трех, выбранными из кислорода, азота и серы, причем указанное кольцо замещено R1 и возможно замещено группами R2 в количестве вплоть до трех; или ! (3) 8-, 9- или 10-членной бициклической кольцевой системы, возможно содержащей вплоть до трех кольцевых гетероатомов, выбранных из кислорода, азота и серы, и возможно замещенной R1 и возможно замещенной группами R2 в количестве вплоть до трех; ! R1 представляет собой группу формулы: !R4-X1-, ! где X1 представляет собой прямую связь или выбран из О, S, SO, SO2, N(R5), CO, CH(OR5), CON(R5), N(R5)CO, N(R5)CON(R5), SO2N(R5), N(R5)SO2, C(R5)2O, OC(R5)2, C(R5)2S, SC(R5)2, C(R5)2, C(R5)2N(R5) и N(R5)N(R5)2, где каждый R5 независимо выбран из водорода, (1-8С)алкила, гидрокси-(1-6С)алкила, (1-6С)алкокси-(1-6С)алкила, циано-(1-6С)алкила, галогено-(1-6С)алкила, ди-[(1-6С)алкил]амино-(1-6С)алкила, (1-6С)алкиламино-(1-6С)алкила или амино-(1-6С)алкила, и когда X1 представляет собой прямую связь или выбран из CH(OR5), C(R5)2O, C(R5)2S, C(R5)2 или C(R5)2N(R5), где R5 имеет любое из значений, определенных выше, тогда R4 представляет собой гидрокси-(1-6С)алкил, (1-6С)алкокси-(1-6С)алкил, R5-S, R5-S(O), R5-SO2, R5-SO2-O, R5-S-(1-6С)алкил, R5-S(O)-(1-6С)алкил, R5-SO2-(1-6C)aлкил, N,N-ди(R5)сульфамоил, N,N-ди-(R5)cyльфaмoил-(1-6C)aлкил, R5-SO2N(R5), R5-SO2N(R5)-(1-6C)aлкил, R5-CON(R5), R5O-CON(R5), R5-CON(R5)-(1-6C)aлкил, R5O-CON(R5)-(1-6C)aлкил, (R5)2N-SO2N(R5), (R5)2N-SO2N(R5)-(1-6C)aлкил, (R5)2N-CON(R5), (R5)2N-CON(R5)-(1-6С)алкил, R5-CO 1. The compound of formula I! ! in which W represents CH or N; ! J represents O or S; ! each of G1, G2, G3 and G4 is selected from CH and N, provided that no more than two of G1, G2, G3 and G4 are N; ! Ring A is selected from:! (1) phenyl substituted with R1 and optionally substituted with up to three groups of R2; or ! (2) a 5- or 6-membered monocyclic heteroaryl ring with up to three ring heteroatoms selected from oxygen, nitrogen, and sulfur, said ring being substituted with R1 and optionally substituted with up to three R2 groups; or ! (3) an 8-, 9- or 10-membered bicyclic ring system, possibly containing up to three ring heteroatoms selected from oxygen, nitrogen and sulfur, and optionally substituted with R1 and possibly substituted with up to three groups of R2; ! R1 is a group of the formula:! R4-X1-,! where X1 is a direct bond or is selected from O, S, SO, SO2, N (R5), CO, CH (OR5), CON (R5), N (R5) CO, N (R5) CON (R5), SO2N (R5), N (R5) SO2, C (R5) 2O, OC (R5) 2, C (R5) 2S, SC (R5) 2, C (R5) 2, C (R5) 2N (R5) and N (R5) N (R5) 2, where each R5 is independently selected from hydrogen, (1-8C) alkyl, hydroxy- (1-6C) alkyl, (1-6C) alkoxy- (1-6C) alkyl, cyano- ( 1-6C) alkyl, halo- (1-6C) alkyl, di - [(1-6C) alkyl] amino (1-6C) alkyl, (1-6C) alkylamino (1-6C) alkyl or amino (1-6C) alkyl, and when X1 is a direct bond or is selected from CH (OR5), C (R5) 2O, C (R5) 2S, C (R5) 2 or C (R5) 2N (R5), where R5 has any of the meanings defined above, then R4 is hydroxy- (1-6C) alkyl, (1-6C) alkoc and- (1-6C) alkyl, R5-S, R5-S (O), R5-SO2, R5-SO2-O, R5-S- (1-6C) alkyl, R5-S (O) - (1 -6C) alkyl, R5-SO2- (1-6C) alkyl, N, N-di (R5) sulfamoyl, N, N-di- (R5) sylphamoyl- (1-6C) alkyl, R5-SO2N (R5) , R5-SO2N (R5) - (1-6C) alkyl, R5-CON (R5), R5O-CON (R5), R5-CON (R5) - (1-6C) alkyl, R5O-CON (R5) - (1-6C) alkyl, (R5) 2N-SO2N (R5), (R5) 2N-SO2N (R5) - (1-6C) alkyl, (R5) 2N-CON (R5), (R5) 2N-CON (R5) - (1-6C) alkyl, R5-CO
Claims (18)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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EP07301491 | 2007-10-25 | ||
EP07301491.2 | 2007-10-25 | ||
EP07305005 | 2007-12-21 | ||
EP07305005.6 | 2007-12-21 | ||
EP08305180.5 | 2008-05-19 |
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RU2010120536A true RU2010120536A (en) | 2011-11-27 |
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RU2010120536/04A RU2010120536A (en) | 2007-10-25 | 2008-10-22 | Pyridine and pyrazine derivatives useful for the treatment of cellular cellular disorders |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2632885C2 (en) * | 2012-01-31 | 2017-10-11 | Дайити Санкио Компани, Лимитед | Pyridon derivatives |
RU2707953C2 (en) * | 2014-07-07 | 2019-12-02 | Дайити Санкио Компани, Лимитед | Pyridone derivative having tetrahydropyranylmethyl group |
-
2008
- 2008-10-22 RU RU2010120536/04A patent/RU2010120536A/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2632885C2 (en) * | 2012-01-31 | 2017-10-11 | Дайити Санкио Компани, Лимитед | Pyridon derivatives |
RU2707953C2 (en) * | 2014-07-07 | 2019-12-02 | Дайити Санкио Компани, Лимитед | Pyridone derivative having tetrahydropyranylmethyl group |
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