RU2008905C1 - Method for treatment of patients suffered from obesity at neutroendocrine form of hypothalamic syndrome - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: short-time medicinal starvation is carried out, 3-5 days being starvation itself, 3 days being recovery period. 0.02% solution of sodium hydrochloride is injected intravenously by drops (its quantity being 200-400 ml) after starvation course. The process is carried out 3 times in 1-2 days. Thus stable decreasing in weight together with normalization of lipid and hydrocarbon exchanges are attained. EFFECT: decreases treatment time, increases efficiency of the method. 4 tbl

Description

 The invention relates to medicine, namely to endocrinology, and can be used to treat patients with obesity.

 Known methods for treating obesity include a range of effects, the most permanent of which is the diet. However, the use of a diet (both low-calorie, reduced, and dosed starvation) does not allow to achieve persistent weight loss, to normalize the state of lipid, carbohydrate metabolism even during long courses of treatment.

 Methods are also known, including the use of medications, however, these methods for hypothalamic obesity are not effective enough due to side effects or contraindications: thyroid hormones can be used only with a proven decrease in thyroid function, anorexigenic drugs have an exciting effect on the central nervous system, increase blood pressure, addictive.

 In addition, a treatment method is known, including the use of hyperbaric oxygenation, however, the use of this method is limited by the damaging effect of hyperbaric oxygen on biological membranes.

 Closest to the proposed is a method of treating patients with dosed starvation in cerebral form of obesity, which consists in conducting two courses of fasting from 10 to 14 days each with two recovery periods of the same duration. However, despite the effectiveness, treatment according to the prototype has several disadvantages: a long duration of treatment in a hospital, insufficient stability of weight loss, a long period of fasting (10-14 days), which in some patients was accompanied by fluctuations in blood pressure, autonomic crises, general weakness, headaches, disturbing manifestations.

 The aim of the invention is to reduce the time and increase the efficiency of treatment of patients due to a stable decrease in body weight, improve carbohydrate, lipid metabolism and the state of cell membranes.

 This goal is achieved by the fact that the patient is given short-term therapeutic fasting, including 3 to 5 days of hunger and 3 days of recovery. After a fasting course, a 0.02% sodium hypochlorite solution is administered intravenously in drops of 200 to 400 ml after 1 to 2 days 3 times.

 Comparative analysis with the prototype showed that the proposed technical solution differs from the known one in that, after a fasting course, an additional 0.02% sodium hypochlorite solution is injected intravenously in a dose of 200-400 ml every 1 to 2 days 3 times, and fasting includes 3 - 5 days of hunger and 3 days of recovery. Thus, the claimed method meets the criteria of the invention of "novelty."

 Analysis of the special and patent literature showed that in the literature there are no methods for treating obesity, including the introduction of intravenous sodium hypochlorite.

 A method for the treatment of obesity with the neuro-endocrine form of the hypothalamic syndrome is proposed. In the pathogenesis of this form of obesity, skull injuries, infectious diseases, intracranial hypertension, stressful effects play an important role, which determines the variety of clinical manifestations (in addition to obesity, this group of patients has neurological disorders, arterial hypertension, disorders of carbohydrate, lipid metabolism, ovarian dysfunction, trophic disorders on the skin). The most difficult for this group of patients is the treatment of obesity.

 Sodium hypochlorite obtained by electrolysis of a 0.9% sodium chloride solution is an active oxidizing agent of certain toxins and ballast substances and is used as a detoxifying agent.

 The proposed method of treatment allows to obtain a stable effect of weight loss with the normalization of lipid and carbohydrate metabolism and the state of the membranes. Thus, the proposed solution meets the criterion of "inventive step".

 The method is as follows. Before starting the course of treatment, the patients are examined: in addition to general clinical methods, the blood glucose is determined under the conditions of a glucose tolerance test, glucose in the urine (glucosuric profile), coagulation system parameters, blood pH, lipid metabolism parameters are examined. In the process of treatment, the dynamics of the studied parameters, body weight, hemodynamic parameters are evaluated, the formative function of red blood cells in peripheral blood is studied using electron scanning microscopy.

 The examined patients with the neuro-endocrine form of the hypothalamic syndrome undergo complex treatment, including exercise therapy (constantly), at the first stage, dosed fasting (3–5 days of hunger and 3 days of the recovery period), after a fasting course, sodium hypochlorite solution 0.02 is administered intravenously. % 200 - 400 ml after 1 - 2 days 3 times. A solution of sodium hypochlorite is obtained by electrolysis of a 0.9% sodium chloride solution on an EDC-3 electrochemical detoxification apparatus. Oxidation of physiological saline is carried out according to the "Instructions for indirect electrochemical detoxification of the body using the EDO-3 apparatus" at a current of 3 A for 5 min (hypochlorite concentration of 200 mg / l). The solution is prepared immediately before administration. After each injection of the solution, blood glucose and other indicators are monitored.

 PRI me R 1. Patient T., 36 years old, was admitted to endocrine. Dep. City Clinical Hospital N 10, Irkutsk, January 15, 1991. Diagnosis: hypothalamic syndrome, neuro-endocrine form (obesity, II stage, hypertension, trophic disorders on the skin, polycystic ovary). The patient considers himself since 1979, when after childbirth she began to progressively gain weight, headaches, hypertension, menstrual irregularities, and hirsutism appeared.

 Upon admission to the ward, the patient was disturbed by headaches, overweight, thirst, swelling, excessive body hair, menstrual irregularity.

 Height 164 cm, weight 103 kg 500 g, multiple whitish striae on the skin, swelling on the legs, blood pressure 150/100, 180/100 mm RT. Art. Pulse 98 in 1 min, the borders of the heart expanded to the left, auscultation of heart sounds are muffled, the emphasis of the II tone on the aorta, the boundaries of the lungs are within normal limits, vesicular breathing. ECG: signs of left ventricular hyperfunction. With electroencephalography, there are signs of a distinct dysfunction of the mesodiencephalic structures. In the study of lipid metabolism (see table. 1) revealed hypercholesterolemia, hyperlipidemia. Glycemia within normal limits, aglycosuria. In the study of peripheral blood, the number of normocytes was reduced to 52%, pathological forms of red blood cells were found.

 The patient was treated, including exercise therapy, fasting, (5 days, 3 days of the recovery period), after which a solution of sodium hypochlorite 0.02% - 400.0 iv / drop was administered, 3 times a day. The total duration of treatment was 13 days.

 As a result of the treatment, the weight decreased by 10.5 kg, blood pressure returned to normal, and the amount of excreted fluid increased from 1200/800 to 1400/1800 ml per day. In the study of peripheral blood, the number of normocytes increased from 52 to 85%. During dynamic observation after 3 months, the patient continued to lose weight (another 1 kg), the regular menstrual cycle was restored without additional measures. The dynamics of lipid metabolism in patient T. during treatment by the proposed method is reflected in the table. 1.

 PRI me R 2. Patient K., 31 years old, was admitted to endocrine. Dep. State Clinical Hospital No. 10 of Irkutsk on February 25, 1991. Diagnosis: hypothalamic syndrome, neuro-endocrine form (obesity, striae, polycystic ovary). The patient considers herself since 1985, when she suddenly gained weight after a spontaneous miscarriage. In 1987, after a pathological birth (cesarean treatment, the child died), she again gained weight. Menstrual irregularities, excessive hair growth for several years.

 Upon admission, she complained of headaches, overweight, excessive body hair, increased fatigue, irritability, and menstrual irregularities.

 Height 165 cm, weight 90 kg, multiple stretch marks on the skin. Hirsutism. HELL 120/80, 120/80, mm RT. Art. With electroencephalography, there are signs of hypothalamic dysfunction. In the study of lipid metabolism (see table. 2) revealed hyperlipidemia, hypercholesterolemia. Glycemia within normal limits, aglycosuria. In the study of peripheral blood, the number of normocytes is reduced to 71%, pathological forms of red blood cells are found.

 The patient was treated, including exercise therapy, fasting (4 days and 3 days of the recovery period) and the introduction of a 0.02% solution of sodium hypochlorite in / in a drop of 200 ml every other day 3 times. The total duration of treatment was 12 days.

 As a result of the treatment, the weight decreased by 9 kg, the amount of excreted fluid increased from 1500/1500 to 1500/1700 ml per day. In the study of peripheral blood counts, the number of normocytes increased from 71% to 81%. During dynamic observation after 3 months, the lost weight did not recover. The dynamics of lipid metabolism in patient K. during treatment by the proposed method is reflected in the table. 2.

 6 patients with the neuro-endocrine form of the hypothalamic syndrome were treated with the proposed method. The most constant clinical manifestations in this group of patients were as follows: obesity II - III degree, hypertension, neuro-vegetative disorders, trophic changes on the skin, menstrual irregularities. To conduct a comparative assessment of the proposed method with the prototype 10 patients were treated only with dosed fasting. In both groups, treatment was carried out under the control of lipid and carbohydrate metabolism, weight dynamics was assessed, etc.

 As can be seen from the data presented in table. 2, as a result of the treatment according to the proposed method, patients lost 11 ± 2 kg of weight in 11-15 days, which is more effective than treatment by fasting only. In addition, during dynamic observation after 3 months, patients who received treatment according to the proposed method not only did not restore the original weight, but also continued to reduce it by an average of 4 ± 1.2 kg. In the group using the proposed method, in contrast to treatment only with hunger, there is a decrease in the concentration of total lipids in the blood plasma, free cholesterol, the content of esterified cholesterol and the esterification coefficient increase. As a result of treatment only with hunger, the level of lipids in the blood increases, which creates the conditions for quick weight recovery after treatment.

 When studying the processes of free radical oxidation of lipids in patients treated with the proposed method, the plasma content of the final product of free radical oxidation of lipids - malondialdehyde - increased to a lesser extent than when treated only with hunger, at the same time activation of the enzymatic link of the antioxidant system was noted (peroxidase) and the improvement of the formative function of red blood cells according to electron microscopy (see table. 4).

 Thus, the proposed method is more effective in treating obesity in patients with a neuro-endocrine form of the hypothalamic syndrome than the method adopted as a prototype, since it has a positive effect on lipid metabolism, reduces the possibility of implementing risk factors for atherosclerosis, normalizes the morphological picture of peripheral blood and provides stable reduction in body weight while reducing treatment time. (56) T.G. Voznesenskaya and other Soviet medicine, N 1, 1990, p. 88 - 91.

Claims (1)

 METHOD FOR TREATING PATIENTS WITH OBESITY WITH A NEUROENDOKRIN FORM OF THE HYPOTHALAMIC SYNDROME, including therapeutic fasting, characterized in that after a fasting course, an additional 0.02% sodium hypochlorite solution is administered intravenously drop by drop, 200 to 400 ml every 1 to 2 days 3 times, and therapeutic includes 3 to 5 days of hunger and 3 days of recovery.

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