RU2008150378A

RU2008150378A - METHOD FOR TREATING CHRONIC RHINOSINUSITIS

Info

Publication number: RU2008150378A
Application number: RU2008150378/15A
Authority: RU
Inventors: Юрий Константинович Янов (RU); Юрий Константинович Янов; Галина Порфирьевна Захарова (RU); Галина Порфирьевна Захарова
Priority date: 2008-12-15
Filing date: 2008-12-15
Publication date: 2010-09-10
Also published as: RU2410028C2

Abstract

1. Способ лечения хронического риносинусита, включающий определение нарушений мукоцилиарного транспорта (МЦТ) путем измерения параметров движения ресничек мерцательного эпителия, по меньшей мере, скорости мукоцилиарного транспорта, при этом скорость движения кончика реснички получают на основании математического моделирования с последующими расчетами по формуле ! ! где Vс - скорость кончика реснички [мкм·с-1]; ! K1, К2, α вычислены в качестве средних величин, характерных для каждого из рассматриваемых состояний организма человека: здоровые, больные острой или хронической формами синусита по разработанной модели движения ресничек; K1 - кривизна рабочей длины реснички, константа равна 1/38 мкм-1; К2 - кривизна реснички от рабочей длины до кончика [мкм-1]; α - угол наклона реснички относительно вертикального положения [град]; ! π=3.1417 - константа; ! L, Тр и Те - параметры, измеряемые индивидуально у каждого больного; L - длина реснички [мкм]; Тр - время от начала движения до максимального распрямления кончика реснички [с]; Те - время эффективного удара [с], ! и учитывая, что значение Vc=9,6-11,3 мм/мин соответствует нормальному функционированию МЦТ, для больных хроническим риносинуситом, сопровождающимся нарушением МЦТ, назначают комплексное консервативное лечение, включающее: общепринятую терапию (антибиотикотерапию, противоотечную и десенсибилизирующую терапию), а также назаначение препаратов, обладающих мукоактивным (секретолитическим, секретомоторным и секретокинетическим) действием, отличающийся тем, что назначают препарат, после воздействия которого в течение суток на слизистую оболочку полости носа больного исследован 1. A method for the treatment of chronic rhinosinusitis, including the determination of mucociliary transport disorders (MCT) by measuring the cilia of the ciliated epithelium, at least the speed of the mucociliary transport, and the speed of the cilia tip is obtained based on mathematical modeling with subsequent calculations by the formula! ! where Vc is the speed of the cilia tip [μm · s-1]; ! K1, K2, α are calculated as average values characteristic of each of the considered conditions of the human body: healthy, sick with acute or chronic sinusitis according to the developed model of cilia movement; K1 is the curvature of the working length of the cilia, the constant is 1/38 μm-1; K2 - curvature of the cilia from the working length to the tip [μm-1]; α is the angle of inclination of the cilia relative to the vertical position [deg]; ! π = 3.1417 is a constant; ! L, Tr and Te - parameters measured individually for each patient; L is the length of the cilia [μm]; Tr - time from the start of movement to the maximum straightening of the tip of the cilia [s]; Those are the time of effective strike [s],! and given that the value Vc = 9.6-11.3 mm / min corresponds to the normal functioning of the ICT, for patients with chronic rhinosinusitis accompanied by a violation of the ICT, a complex conservative treatment is prescribed, including: conventional therapy (antibiotic therapy, decongestant and desensitizing therapy), and also the appointment of drugs with mucoactive (secretolytic, secretomotor and secretokinetic) action, characterized in that the drug is prescribed, after exposure to which during the day on the mucous membrane the nasal cavity of the patient is investigated

Claims

1. A method for the treatment of chronic rhinosinusitis, including the determination of mucociliary transport disorders (MCT) by measuring the cilia of the ciliated epithelium, at least the speed of the mucociliary transport, and the speed of the cilia tip is obtained based on mathematical modeling with subsequent calculations by the formula

where V _{with the} speed of the tip of the cilia [μm · s ^-1 ];

K ₁ , K ₂ , α are calculated as average values characteristic of each of the considered conditions of the human body: healthy, sick with acute or chronic sinusitis according to the developed model of cilia movement; K ₁ - the curvature of the working length of the cilia, the constant is 1/38 μm ^-1 ; To ₂ - the curvature of the cilia from the working length to the tip [μm ^-1 ]; α is the angle of inclination of the cilia relative to the vertical position [deg];

π = 3.1417 is a constant;

L, T _p and T _e - parameters measured individually for each patient; L is the length of the cilia [μm]; T _p - time from the start of movement to the maximum straightening of the tip of the cilia [s]; T _e - time effective strike [s],

and taking into account that the value of V _c = 9.6-11.3 mm / min corresponds to the normal functioning of the MCT, for patients with chronic rhinosinusitis accompanied by a violation of the MCT, a complex conservative treatment is prescribed, including: conventional therapy (antibiotic therapy, decongestant and desensitizing therapy), and also the appointment of drugs with mucoactive (secretolytic, secretomotor and secretokinetic) action, characterized in that the drug is prescribed, after exposure to which during the day on the mucous membrane In the patient’s nasal cavity, the ICT study revealed a large positive dynamics, the speed of the cilia tip (V _c ).

2. A method of treating chronic rhinosinusitis according to claim 1, characterized in that one of the drugs is prescribed: rinofluimucil or sinupred 15 drops three times a day in each half of the nose for 30 days.