RU2008117121A - METHOD FOR PRODUCING 1-13C-CAPRYLIC ACID - Google Patents
METHOD FOR PRODUCING 1-13C-CAPRYLIC ACID Download PDFInfo
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- RU2008117121A RU2008117121A RU2008117121/04A RU2008117121A RU2008117121A RU 2008117121 A RU2008117121 A RU 2008117121A RU 2008117121/04 A RU2008117121/04 A RU 2008117121/04A RU 2008117121 A RU2008117121 A RU 2008117121A RU 2008117121 A RU2008117121 A RU 2008117121A
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- triphenylphosphine
- mpa
- solvent
- palladium
- carried out
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Способ получения каприловой кислоты со стабильным изотопом углерода (1-13C) реакцией гидрокарбоксилирования 1-гептена с монооксидом углерода 13СО и водой при температуре 100-170°С и давлении не более 5 МПа, в присутствии растворителя и каталитической системы, включающей комплексное соединение палладия и трифенилфосфин в соотношении, взятом из диапазона от 1:2 до 1:100, отличающийся тем, что в качестве растворителя используют диоксан и/или ароматический углеводород. ! 2. Способ по п.1, отличающийся тем, что процесс проводят при 140-160°С. ! 3. Способ по п.1, отличающийся тем, что процесс проводят под давлением 0,5-1,0 МПа. ! 4. Способ по п.1, отличающийся тем, что соотношение между комплексным соединением палладия и трифенилфосфином берут из диапазона от 1:10 до 1:40. ! 5. Способ по п.1, отличающийся тем, что в реакционную смесь дополнительно вводят соляную кислоту.1. A method of producing caprylic acid with a stable carbon isotope (1-13C) by the reaction of 1-heptene hydrocarboxylation with 13CO carbon monoxide and water at a temperature of 100-170 ° C and a pressure of not more than 5 MPa, in the presence of a solvent and a catalytic system comprising a complex compound palladium and triphenylphosphine in a ratio taken from the range from 1: 2 to 1: 100, characterized in that dioxane and / or aromatic hydrocarbon are used as solvent. ! 2. The method according to claim 1, characterized in that the process is carried out at 140-160 ° C. ! 3. The method according to claim 1, characterized in that the process is carried out under a pressure of 0.5-1.0 MPa. ! 4. The method according to claim 1, characterized in that the ratio between the complex compound of palladium and triphenylphosphine is taken from the range from 1:10 to 1:40. ! 5. The method according to claim 1, characterized in that hydrochloric acid is additionally introduced into the reaction mixture.
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008117121/04A RU2382025C2 (en) | 2008-05-05 | 2008-05-05 | 1-13c-caprylic acid synthesis method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008117121/04A RU2382025C2 (en) | 2008-05-05 | 2008-05-05 | 1-13c-caprylic acid synthesis method |
Publications (2)
Publication Number | Publication Date |
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RU2008117121A true RU2008117121A (en) | 2009-11-10 |
RU2382025C2 RU2382025C2 (en) | 2010-02-20 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2008117121/04A RU2382025C2 (en) | 2008-05-05 | 2008-05-05 | 1-13c-caprylic acid synthesis method |
Country Status (1)
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RU (1) | RU2382025C2 (en) |
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2008
- 2008-05-05 RU RU2008117121/04A patent/RU2382025C2/en not_active IP Right Cessation
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Publication number | Publication date |
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RU2382025C2 (en) | 2010-02-20 |
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MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190506 |