RU2008101827A - PHARMACEUTICAL COMPOSITION FOR INHIBITING PROTEINKINASE - Google Patents

Abstract

1. A pharmaceutical composition for inhibiting protein kinase, comprising an amount of a compound of general formula (I) inhibiting selective kinase:! ! where:! R1 represents aryl or heteroaryl, each of which is optionally substituted with one or more groups selected from alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, cyano, halogen, hydroxy, heteroaryl, heterocycloalkyl, nitro, R4, -C (= O) -R , -C (= O) -OR5, -C (= O) -NYlY2, -NY1Y2, -N (R6) -C (= O) -R7, -N (R6) -C (= O) -NY3Y4, -N (R6) -C (= O) -OR7, -N (R6) -SO2-R7, -N (R6) -SO2-NY3Y4, -SO2-NY1Y2 and -Z2R; ! R2 is hydrogen, acyl, cyano, halogen, lower alkenyl, -Z2R4, -SO2NY3Y4, -NY1Y2 or lower alkyl, optionally substituted with a substituent selected from aryl, cyano, heteroaryl, heterocycloalkyl, hydroxy, -Z2R4, -C (= O) -NY1Y2, -C (= O) -R, -CO2R8, -NY3Y4, -N (R6) -C (= O) -R, -N (R6) -C (= O) -NY1Y2, -N (R6 ) -C (= O) -OR7, -N (R6) -SO2-R7, -N (R6) -SO2-NY3Y4, -SO2NY1Y2 and one or more halogen atoms; ! R3 is hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, -Z2R4, -C (= O) -OR5 or -C (= O) -NY3Y4; ! R4 is alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each of which is optionally substituted with a substituent selected from aryl, cycloalkyl, cyano, halogen, heteroaryl, heterocycloalkyl, —CHO (or a 5-, 6-cyclic a-member thereof) ), -C (= O) -NY1Y2, -C (= O) -OR5, -NY1Y2, -N (R6) -C (= O) -R7, -N (R6) -C (= O) -NY3Y4 , -N (R6) -SO2-R7, -N (R6) -SO2-NY3Y4, -Z3R7 and one or more groups selected from hydroxy, alkoxy and carboxy; ! R5 represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; ! R6 is hydrogen or lower alkyl; ! R7 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; ! R8 represents hydrogen or lower alkyl; !

Claims (100)

1. A pharmaceutical composition for inhibiting protein kinase, comprising an amount of a compound of general formula (I) inhibiting selective kinase:

Where: R ¹ represents aryl or heteroaryl, each of which is optionally substituted with one or more groups selected from alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, cyano, halogen, hydroxy, heteroaryl, heterocycloalkyl, nitro, R ⁴ , -C (= O) -R, -C (= O) -OR ⁵ , -C (= O) -NY ^l Y ² , -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N ( R ⁶ ) —C (= O) —NY ³ Y ⁴ , —N (R ⁶ ) —C (= O) —OR ⁷ , —N (R ⁶ ) —SO ₂ —R ⁷ , —N (R ⁶ ) -SO ₂ -NY ³ Y ⁴ , -SO ₂ -NY ¹ Y ² and -Z ² R; R ² represents hydrogen, acyl, cyano, halogen, lower alkenyl, —Z ² R ⁴ , —SO ₂ NY ³ Y ⁴ , —NY ¹ Y ^2, or lower alkyl optionally substituted with a substituent selected from aryl, cyano, heteroaryl, heterocycloalkyl , hydroxy, -Z ² R ⁴ , -C (= O) -NY ¹ Y ² , -C (= O) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) -R, -N (R ⁶ ) -C (= O) -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -OR ⁷ , -N (R ⁶ ) -SO ₂ —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —SO ₂ NY ¹ Y ^2, and one or more halogen atoms; R ³ represents hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, —Z ² R ⁴ , —C (= O) —OR ⁵ or —C (= O) —NY ³ Y ⁴ ; R ⁴ represents alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each of which is optionally substituted with a substituent selected from aryl, cycloalkyl, cyano, halogen, heteroaryl, heterocycloalkyl, —CHO (or a 5-, 6- or 7-membered derivative thereof acetal), -C (= O) -NY ¹ Y ² , -C (= O) -OR ⁵ , -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N ( R ⁶ ) —C (= O) —NY ³ Y ⁴ , —N (R ⁶ ) —SO ₂ —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —Z ³ R ^7, and one or more groups selected from hydroxy, alkoxy and carboxy; R ⁵ represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; R ⁶ represents hydrogen or lower alkyl; R ⁷ represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R ⁸ represents hydrogen or lower alkyl; R represents aryl or heteroaryl; alkenyl; or alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each of which is optionally substituted with a substituent selected from aryl, cycloalkyl, cyano, halogen, heteroaryl, heterocycloalkyl, -CHO (or a derivative of 5-, 6- or 7-acyl) , -C (= O) -NY ¹ Y ² , -C (= O) -OR ⁵ , -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N (R ⁶ ) -C (= O) -NY ³ Y ⁴ , -N (R ⁶ ) -SO ₂ -R ⁷ , -N (R ⁶ ) -SO ₂ -NY ³ Y ⁴ , -Z ³ R ⁷ and one or more groups selected from hydroxy, alkoxy and carboxy; X ¹ represents N or CH; Y ³ and Y ⁴ independently represent hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or the group —NY ³ Y ⁴ may form a cyclic amine; Z ² represents O or S (O) _n ; Z ³ represents O, S (O) _n , NR ⁶ ; n is zero or an integer of 1 or 2; or an N-oxide, ester prodrug, bioisosteres of an acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisosteres of an acid of such a salt or solvate; together with one or more pharmaceutically acceptable carriers or excipients, where “Bioisostere acid” means a compound in which the carboxyl group is replaced by a group selected from —C (= O) —NHOH, —C (= O) —CH ₂ OH, —C (= O) CH ₂ SH, —C (= O) -NH-CN, sulfo, phosphono, alkylsulfonylcarbamoyl, tetrazolyl, arylsulfonylcarbamoyl, heteroarylsulfonylcarbamoyl, N-methoxycarbamoyl, 3-hydroxy-3-cyclobuten-1,2-dione, 3,5-dioxo-1,2,4-oxazi or heterocyclic phenols, such as 3-hydroxyisoxazolyl and 3-hydroxy-1-methylpyrazolyl; “Alkenyl” means an aliphatic hydrocarbon group containing a carbon-carbon double bond, which may be unbranched or branched, containing from about 2 to about 15 carbon atoms in the chain; “Aryl” as a group, or part of a group, means: (i) an optionally substituted monocyclic or polycyclic aromatic carbocyclic moiety from about 6 to about 14 carbon atoms, such as phenyl or naphthyl; or (ii) an optionally substituted partially saturated polycyclic aromatic carbocyclic moiety in which the aryl and cycloalkyl or cycloalkenyl group are fused together to form a cyclic structure, the aryl groups can be substituted with one or more substituents, which include acyl, acylamino, alkoxy, alkoxycarbonyl, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, alkylthio, aroyl, aroylamino, aryl, arylalkyloxy, arylalkyloxycarbonyl, arylalkylthio, aryloxy, aryloxycarbonyl, arylsulfinyl, arylsulfonyl, arylthio, carboxy (or acid bioisostere), cyano, halo, heteroaroyl, heteroaryl, heteroarylalkyloxy, geteroaroilamino, heteroaryloxy, hydroxy, nitro, trifluoromethyl, -NY ³ Y ^4, -CONY ³ Y ^4, -SO ₂ NY ³ Y ⁴ , —NY ³ —C (= O) alkyl, —NY ³ SO ₂ alkyl, or alkyl optionally substituted with aryl, heteroaryl, hydroxy, or —NY ³ Y ⁴ ; “Cycloalkyl” means a saturated monocyclic or bicyclic ring system containing from about 3 to about 10 carbon atoms, optionally substituted by oxo; “Heteroaryl” as a group, or part of a group, means: (i) an aromatic monocyclic or polycyclic organic moiety containing from 5 to 10 members in a ring in which one or more members of the ring represents (represent) an element (s) other than carbon ; (ii) an optionally substituted, partially saturated polycyclic heterocarbocyclic moiety in which the heteroaryl and cycloalkyl or cycloalkenyl groups are fused to each other to form a cyclic structure; the heteroaryl group has optional substituents which include one or more “aryl group substituents” as described above; and “Heterocycloalkyl” means: (i) a cycloalkyl group containing from about 3 to 7 members in the ring, which contains one or more heteroatoms or heteroatom-containing groups selected from O, S and NY ⁷ , and may optionally be substituted by oxo; (ii) a partially saturated polycyclic heterocarbocyclic moiety in which the aryl (or heteroaryl) ring is each optionally substituted with one or more “aryl group substituents” and the heterocycloalkyl group is fused together to form a cyclic structure. 2. The compound of formula (I)

Where: R ¹ represents aryl or heteroaryl, each of which is optionally substituted with one or more groups selected from alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, cyano, halogen, hydroxy, heteroaryl, heterocycloalkyl, nitro, R ⁴ , -C (= O) -R, -C (= O) -OR ⁵ , -C (= O) -NY ^l Y ² , -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N ( R ⁶⁾ -C (= O) -NY ³ Y ^4, -N (R ⁶⁾ -C (= O) -OR ^7, -N (R ⁶⁾ SO ₂ -R ^7, -N (R ⁶⁾ SO ₂ -NY ³ Y ⁴ , -SO ₂ -NY ¹ Y ² and -Z ² R; R ² represents hydrogen, acyl, cyano, halogen, lower alkenyl, —Z ² R ⁴ , —SO ₂ NY ³ Y ⁴ , —NY ³ Y ^2, or lower alkyl optionally substituted with a substituent selected from aryl, cyano, heteroaryl, heterocycloalkyl , hydroxy, -Z ² R ⁴ , -CC-O-NY ¹ Y ² , -C (= 0) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) -R, -N (R ⁶ ) -C (= O) NY ¹ Y ² , -N (R ⁶ ) -C (= O) -OR ⁷ , -N (R ⁶ ) -SO ₂ -R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —SO ₂ NY ¹ Y ^2, and one or more halogen atoms; R ³ represents hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, —Z ² R ⁴ , —C (= O) —OR ⁵ or —C (= O) —NY ³ Y ⁴ ; R ⁴ represents alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each of which is optionally substituted with a substituent selected from aryl, cycloalkyl, cyano, halogen, heteroaryl, heterocycloalkyl, —CHO (or a 5-, 6- or 7-membered derivative thereof acetal), -C (= O) -NY ¹ Y ² , -C (= O) -OR ⁵ , -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N ( R ⁶ ) —C (= O) —NY ³ Y ⁴ , —N (R ⁶ ) —SO ₂ —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —Z ³ R ⁷ and one or more groups selected from hydroxy, alkoxy, and carboxy; R ⁵ represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; R ⁶ represents hydrogen or lower alkyl; R ⁷ represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R ⁸ represents hydrogen or lower alkyl; R represents aryl or heteroaryl; alkenyl; or alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each of which is optionally substituted with a substituent selected from aryl, cycloalkyl, cyano, halogen, heteroaryl, heterocycloalkyl, -CHO (or a derivative of 5-, 6- or 7-acyl) , -C (= O) -NY ¹ Y ² , -C (= O) -OR ⁵ , -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N (R ⁶ ) -C (= O) -NY ³ Y ⁴ , -N (R ⁶ ) -SO ₂ -R ⁷ , -N (R ⁶ ) -SO ₂ -NY ³ Y ⁴ , -Z ³ R ⁷ and one or more groups selected from hydroxy, alkoxy and carboxy; X ¹ represents N or CH; Y ³ and Y ⁴ independently represent hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or the group —NY ³ Y ⁴ may form a cyclic amine; Z ² represents O or S (O) _n ; Z ³ represents O, S (O) _n , NR ⁶ ; n is zero or an integer of 1 or 2; or an N-oxide, prodrug, bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, prodrug or bioisostere of an acid of such a salt or solvate, wherein “Bioisostere acid” means a compound in which the carboxyl group is replaced by a group selected from —C (= O) —NHOH, —C (= O) —CH ₂ OH, —C (= O) CH ₂ SH, —C (= O) -NH-CN, sulfo, phosphono, alkylsulfonylcarbamoyl, tetrazolyl, arylsulfonylcarbamoyl, heteroarylsulfonylcarbamoyl, N-methoxycarbamoyl, 3-hydroxy-3-cyclobuten-1,2-dione, 3,5-dioxo-1,2,4-oxazi or heterocyclic phenols, such as 3-hydroxyisoxazolyl and 3-hydroxy-1-methylpyrazolyl; “Alkenyl” means an aliphatic hydrocarbon group containing a carbon-carbon double bond, which may be unbranched or branched, containing from about 2 to about 15 carbon atoms in the chain; “Aryl” as a group, or part of a group, means: (i) an optionally substituted monocyclic or polycyclic aromatic carbocyclic moiety from about 6 to about 14 carbon atoms, such as phenyl or naphthyl; or (ii) an optionally substituted partially saturated polycyclic aromatic carbocyclic moiety in which the aryl and cycloalkyl or cycloalkenyl group are fused together to form a cyclic structure, the aryl groups can be substituted with one or more substituents, which include acyl, acylamino, alkoxy, alkoxycarbonyl, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, alkylthio, aroyl, aroylamino, aryl, arylalkyloxy, arylalkyloxycarbonyl, arylalkylthio, aryloxy, aryloxycarbonyl, arylsulfinyl , arylsulfonyl, arylthio, carboxy (or bioisostere acid), cyano, halogen, heteroaroyl, heteroaryl, heteroarylalkyloxy, heteroaryloamino, heteroaryloxy, hydroxy, nitro, trifluoromethyl, -NY ³ Y ⁴ , -CONY ³ Y ⁴ , -SO ₂ NY ^{3 3} Y ⁴ , -SO ₂ NY ^{3 3} Y ⁴ , -SO ₂ NY ^{3 3} Y ⁴ , -SO ₂ NY ^{3 3} Y ⁴ , -SO ₂ NY ^{3 3 4} , —NY ³ —C (= O) alkyl, —NY ³ SO ₂ alkyl, or alkyl optionally substituted with aryl, heteroaryl, hydroxy, or —NY ³ Y ⁴ ; “Cycloalkyl” means a saturated monocyclic or bicyclic ring system containing from about 3 to about 10 carbon atoms, optionally substituted by oxo; “Heteroaryl” as a group, or part of a group, means: (i) an aromatic monocyclic or polycyclic organic moiety containing from 5 to 10 members in a ring in which one or more members of the ring represents (represent) an element (s) other than carbon ; (ii) an optionally substituted, partially saturated polycyclic heterocarbocyclic moiety in which the heteroaryl and cycloalkyl or cycloalkenyl groups are fused to each other to form a cyclic structure; the heteroaryl group has optional substituents which include one or more “aryl group substituents” as described above; and “Heterocycloalkyl” means: (i) a cycloalkyl group containing from about 3 to 7 members in the ring, which contains one or more heteroatoms or heteroatom-containing groups selected from O, S and NY ⁷ , and may optionally be substituted by oxo; (ii) a partially saturated polycyclic heterocarbocyclic moiety in which the aryl (or heteroaryl) ring is each optionally substituted with one or more “aryl group substituents” and the heterocycloalkyl group is fused together to form a cyclic structure; provided that such a connection is different from 2-phenyl-lH-pyrrolo [2,3-b] pyridine, 2- (4-bromophenyl) -3-methyl-lH-pyrrolo [2,3-b] pyridine, 4- (3-methyl-lH-pyrrolo [2,3-b] pyridin-2-yl) benzoic acid methyl ester, 2- (4-chlorophenyl) -1H-pyrrolo [2,3-b] pyridine, 2- (4-methoxyphenyl) -1H-pyrrolo [2,3-b] pyridine, 5-methyl-2-phenyl-1H-pyrrolo [2,3-b] pyridine, 4-methyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine, 2-pyridin-3-yl-lH-pyrrolo [2,3-b] pyridine, 4- (3-methyl-1H-pyrrolo [2,3-blpyridin-2-yl) benzoic acid, 2- (4-methoxyphenyl) -3-methyl-lH-pyrrolo [2,3-b] pyridine, 2- (4-methylphenyl) -3-methyl-1H-pyrrolo [2,3-b] pyridine, 4- (3-methyl-1H-pyrrolo {2,3-b] pyridin-2-yl) benzoic acid isopropyl ester, 2-phenyl-3-methyl-lH-pyrrolo [2,3-b] pyridine, 5-bromo-2-phenyl-3-methyl-lH-pyrrolo [2,3-b] pyridine, 6-chloro-2-phenyl-1H-pyrrolo [2,3-b] pyridine, 6-chloro-4-methyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine, 4-methyl-2-phenyl-lH-pyrrolo [2,3-b] pyridin-3-ylcarboxaldehyde, 2-phenyl-lH-pyrrolo [2,3-b] pyridin-3-yl-acetonitrile, 2-phenyl-3-prop-l-enyl-lH-pyrrolo [2,3-b] pyridine, 4-methyl-2-phenyl-1H-pyrrolo [2,3-b] pyridin-3-ylcarboxaldehyde, dimethyl (2-phenyl-1H-pyrrolo [2,3-b] pyridin-3-ylmethyl) amine, 2,2'-diphenyl-1H, 1'H- [3,3 '] bi [pyrrolo (2,3-b] pyridinyl], 2- (2-phenyl-1H-pyrrolo [2,3-b] pyridin-3-yl) acetamide, 3-allyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine, (2-phenyl-lH-pyrrolo [2,3-b] pyridin-3-yl) acetonitrile, 2-phenyl-lH-pyrrolo [2,3-b] pyridin-3-carbaldehyde, 3-morpholin-4-ylmethyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine, N- [2- (2-phenyl-1H-pyrrolo [2,3-b] pyridin-3-yl) ethyl] acetamide, 6-phenyl-5H-pyrrolo [2,3-b] pyrazine, 6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine, 6- (4-chlorophenyl) -5H-pyrrolo [2,3-b] pyrazine, 6- (2-chlorophenyl) -5H-pyrrolo [2,3-b] pyrazine, 3-methyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine, 2-methyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine and 7-methyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine. 3. The compound of claim 2, wherein R ¹ is optionally substituted heteroaryl. 4. The compound according to claim 3, where R ¹ is optionally substituted azaheteroaryl. 5. The compound according to claim 4, where R ¹ represents optionally substituted indolyl, optionally substituted pyridyl, optionally substituted pyrrolyl, optionally substituted pyrazolyl, optionally substituted quinolinyl, optionally substituted isoquinolinyl, optionally substituted imidazolyl, optionally substituted indazolyl, optionally substituted indolisinyl, tetrahydroindolisinyl or optionally substituted indazolinyl. 6. The compound of claim 5, wherein R ¹ is optionally substituted indolyl, optionally substituted indolisinyl, or optionally substituted pyrrolyl. 7. The compound of claim 6, wherein R ¹ is optionally substituted indol-3-yl, indolysin-1-yl, optionally substituted pyrrol-3-yl, optionally substituted indol-2-yl, or optionally substituted pyrrol-2-yl. 8. The compound according to any one of claims 3, 4, 5, 6 or 7, where the substituents, which are optionally substituted by heteroaryl groups R ¹ , represent one or more groups selected from alkylenedioxy, alkenyl, alkenyloxy, aryl, cyano, halogen, hydroxy , heteroaryl, heterocycloalkyl, R ⁴ , —C (= O) —R, —C (= O) —OR ⁵ , —C (= O) —NY ^l Y ² , —NY ^l Y ^2, and —OR. 9. The compound of claim 2, wherein R ¹ is optionally substituted aryl. 10. The compound of claim 9, wherein R ¹ is optionally substituted phenyl. 11. The compound of claim 10, where R ¹ represents 4-substituted phenyl. 12. The compound of claim 11, wherein R ¹ is 4-tert-butylphenyl. 13. The compound according to claim 9 or 10, where the substituents, which optionally substituted heteroaryl groups R ¹ represent one or more groups selected from alkylenedioxy, halogen, heteroaryl, hydroxy, R ⁴ , -NY ¹ Y ² and -OR. 14. The compound according to any one of paragraphs.2, 3, 4, 5, 6, 7, 9, 10, 11 or 12, where R ² represents acyl. 15. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11 or 12, where R ² represents halogen. 16. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11, or 12, where R ² is lower alkyl optionally substituted with cyano, halogen, hydroxy, heteroaryl, -C (= O ) -NY ¹ Y ² , tetrazolyl, -C (= O) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) -R, -N (R ⁶ ) -C (= O) -NY ¹ Y ² , -N (R ⁶ ) -SO ₂ -R ⁷ or -N (R ⁶ ) -SO ₂ -NY ³ Y ⁴ . 17. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11 or 12, where R ² represents lower alkenyl. 18. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11, or 12, where R ³ is —C (═O) —OR ⁵ . 19. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11, or 12, where R ³ is —C (═O) —OH. 20. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11, or 12, where R ³ represents lower alkyl. 21. The compound according to any one of claims 2, 3, 4, 5, 6, 7, 9, 10, 11, or 12, where R ³ is methyl. 22. The compound according to claim 2 of formula (la):

Where: R ² represents hydrogen, acyl, cyano, halogen, lower alkenyl, —Z ² R ⁴ , —SO ₂ NY ³ Y ⁴ , —NY ¹ Y ^2, or lower alkyl, optionally substituted with a substituent selected from aryl, cyano, heterocycloalkyl heteroaryl, hydroxy, -Z ² R ⁴ , -C (= O) -NY ¹ Y ² , -C (= O) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C ( = O) —R, —N (R ⁶ ) —C (= O) —NY ¹ Y ² , —N (R ⁶ ) —C (= O) —OR ⁷ , —N (R ⁶ ) —SO ₂ - R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —SO ₂ NY ¹ Y ^2, and one or more halogen atoms; R ³ represents hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, —Z ² R ⁴ , —C (= O) —OR ⁵ or —C (= O) —NY ³ Y ⁴ ; X ¹ represents N or CH; R ⁹ represents hydrogen, alkenyl or R ⁴ ; R ¹⁰ represents alkenyloxy, carboxy (or bioisostere acid), cyano, halogen, hydroxy, heteroaryl, R ⁴ , -C (= O) -R, -C (= O) -NY ¹ Y ² , -OR ⁴ , -N (R ⁶ ) —C (= O) —R ⁷ , -N (R ⁶ ) -SO ₂ -R ⁷ or -NY ¹ Y ² ; p is zero or an integer of 1 or 2; and the remainder

attached at position 2 or 3 of the indole ring; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 23. The compound of claim 22, wherein R ¹⁰ is carboxy (or an acid bioisostere); hydroxy; alkyl substituted carboxy; alkyl substituted with —N (R ⁶ ) —SO ₂ —R ⁷ ; -N (R ⁶ ) -CO-NY ³ Y ⁴ ; heteroaryl; -OR ⁴ where R ⁴ is alkyl; -OR ⁴ where R ⁴ is alkyl or cycloalkylalkyl substituted with one or more hydroxy groups; -OR ⁴ where R ⁴ is alkyl or cycloalkyl substituted with one or more carboxy groups; -OR ⁴ where R ⁴ is cycloalkyl substituted with -C (= O) -NY ¹ Y ² ; —C (═O) —R wherein R is alkyl; —C (= O) —NY ¹ Y ² or —N (R ⁶ ) —C (= O) —R ⁷ . 24. The compound of claim 22, wherein R ¹⁰ is —OCH ₂ CO ₂ H,

25. The compound of claim 22, wherein R ¹⁰ is carboxy, pyridyl,

or —CONHC (CH ₃ ) ₂ CH ₂ OH, —C (= O) —NH — CH ₂ —C (CH ₃ ) ₂ —OH, or —CONHCH ₂ CH ₂ OCH ₃ . 26. The compound of claim 22, wherein p is 1 and R ^{10 is} attached at position 5 or at position 6 of the indolyl ring. 27. The compound of claim 22, wherein p is 2 and R ^{10 is} attached at position 5 or at position 6 of the indolyl ring. 28. The compound according to item 22, where R ² represents hydrogen; R ³ represents hydrogen; X ¹ represents CH; R ⁹ represents hydrogen, C _1-4 alkyl, C _1-4 alkyl, substituted hydroxy, C _1-4 alkyl, substituted -N (R ⁶ ) C (= O) -R ⁷ , C _1-4 alkyl, substituted - C (= O) -NY ¹ Y ² , or cycloalkylalkyl substituted with hydroxy; R ^l0 represents a carboxy or bioisostere acid; hydroxy; alkyl substituted carboxy; alkyl substituted with —N (R ⁶ ) —SO ₂ —R ⁷ ; alkyl substituted with —N (R ⁶ ) —CO — NY ³ Y ⁴ ; heteroaryl; -OR ⁴ where R ⁴ is alkyl; -OR ⁴ where R ⁴ is alkyl or cycloalkylalkyl substituted with one or more hydroxy groups; —OR ⁴ where R ⁴ is alkyl substituted with one or more alkoxy groups; -OR ⁴ where R ⁴ is alkyl or cycloalkyl substituted with one or more carboxy groups; -OR ⁴ where R ⁴ is cycloalkyl substituted with -C (= O) -NY ¹ Y ² ; —C (═O) —R wherein R is alkyl; -C (= O) -NY ¹ Y ² or -N (R ⁶ ) -C (= O) -R ⁷ ; and where the group R ^{10 is} attached at position 5 or at position 6 of the indolyl ring, if p is 1; and R ¹⁰ groups are attached at positions 5 and 6 of the indolyl ring if p is 2; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 29. The compound according to item 22, where R ² represents hydrogen; R ³ represents hydrogen; X ¹ represents N; R ⁹ represents hydrogen; C _1-4 alkyl; C _1-4 alkyl substituted with hydroxy; C _1-4 alkyl substituted with —N (R ⁶ ) C (= O) —R ⁷ ; C _1-4 alkyl substituted with -C (= O) -NY ¹ Y ² ; cycloalkylalkyl substituted hydroxy; R ^l0 represents a carboxy or bioisostere acid ; hydroxy; alkyl substituted carboxy; alkyl substituted with —N (R ⁶ ) —SO ₂ —R ⁷ ; alkyl substituted with —N (R ⁶ ) —CO — NY ³ Y ⁴ ; heteroaryl; -OR ⁴ where R ⁴ is alkyl; -OR ⁴ where R ⁴ is alkyl or cycloalkylalkyl substituted with one or more hydroxy groups; —OR ⁴ where R ⁴ is alkyl substituted with one or more alkoxy groups; -OR ⁴ where R ⁴ is alkyl or cycloalkyl substituted with one or more carboxy groups; -OR ⁴ where R ⁴ is cycloalkyl substituted with -C (= O) -NY ¹ Y ² ; —C (═O) —R wherein R is alkyl; -C (= O) -NY ¹ Y ² or -N (R ⁶ ) -C (= O) -R ⁷ ; and where the group R ^{10 is} attached at position 5 or at position 6 of the indolyl ring, if p is 1; and groups R ^{10 is} attached at positions 5 and 6 of the indolyl ring, if p is 2; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 30. The compound of claim 28 or 29, wherein R ⁹ is —CH ₃ or —CH ₂ CH ₃ . 31. The compound of claim 28 or 29, wherein R ⁹ is —CH ₂ OH, —CH ₂ CH ₂ OH, or —CH ₂ CH ₂ CH ₂ OH. 32. The compound of claim 28 or 29, wherein R ⁹ is —CH ₂ CH ₂ CH ₂ NHC (= O) CH ₃ . 33. The compound of claim 28 or 29, wherein R ⁹ is

or

. 34. The compound of claim 28 or 29, wherein R ⁹ is

. 35. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents

. 36. A compound according to any one of claims 22 and 28-29, wherein R ¹⁰ represents -CH ₂ CH ₂ CO ₂ H. 37. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents

. 38. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents

. 39. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents,

or pyridyl. 40. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents-OCH ₃ . 41. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ is —OCH ₂ CH ₂ OH, —OCH ₂ CH ₂ CH ₂ OH, —OCH (CH ₃ ) CH ₂ OH,

. 42. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents —OCH (CH ₃ ) CH ₂ OCH ₃ . 43. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents —OCH ₂ CO ₂ H, —OCH (CH ₃ ) CO ₂ H or

. 44. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents

or

. 45. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents —C (═O) —CH ₃ . 46. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents —CONH ₂ , —CONHCH ₃ , —CONHCH (CH ₂ OH) ₂ , —CONHCH ₂ CH ₂ OH, —CONHC (CH ₃ ) ₂ CH ₂ OH, -C (= O) -NH-CH ₂ -C (CH ₃ ) ₂ -OH, -C (= O) -NH-CH ₂ -CH ₂ -CO ₂ H, -CONHCH ₂ CH ₂ OCH ₃ , -CONHCH ₂ CH ₂ CONH ₂ or

. 47. The compound according to any one of paragraphs.22 and 28-29, where R ¹⁰ represents —NHC (= O) CH ₃ . 48. The compound according to claim 2 of formula (Ib)

Where R ² represents hydrogen, acyl, cyano, halogen, lower alkenyl, —Z ² R ⁴ , —SO ₂ NY ₃ Y ₄ , —NY ¹ Y ^2, or lower alkyl optionally substituted with a substituent selected from aryl, cyano, heteroaryl, heterocycloalkyl , hydroxy, -Z ² R ⁴ , -C (= O) -NY ¹ Y ² , -C (= O) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) -R, -N (R ⁶ ) -C (= O) -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -OR ⁷ , -N (R ⁶ ) -SO ₂ —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —SO ₂ NY ¹ Y ^2, and one or more halogen atoms; R ³ represents hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, —Z ² R ⁴ , —C (= O) —OR ⁵ or —C (= O) —NY ³ Y ⁴ ; X ¹ represents N or CH; R ⁹ represents hydrogen, alkenyl or R ⁴ ; R ¹⁰ represents alkenyloxy, carboxy (or bioisostere acid), cyano, halogen, hydroxy, heteroaryl, R ⁴ , -C (= O) -R, -C (= O) -NY ¹ Y ² , -OR ⁴ , -N (R ⁶ ) —C (═O) —R ⁷ , —N (R ⁶ ) —SO ₂ —R ⁷ or —NY ¹ Y ² ; p is zero or an integer of 1 or 2; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 49. The compound of claim 48, wherein p is zero. 50. The compound of claim 48, wherein: R ² represents hydrogen; R ³ represents hydrogen; X ¹ represents CH; R ⁹ represents hydrogen or C _1-4 alkyl; p is zero; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 51. The compound of claim 50, wherein R ⁹ is hydrogen. 52. The compound of claim 48, wherein: R ² represents hydrogen; R ³ represents hydrogen; X ¹ represents N; R ⁹ represents hydrogen or C _1-4 alkyl; and p is zero. 53. The compound according to claim 2 of formula (Ic):

Where: R ² represents hydrogen, acyl, cyano, halogen, lower alkenyl, —Z ² R ⁴ , —SO ₂ NY ³ Y ⁴ , —NY ¹ Y ^2, or lower alkyl optionally substituted with a substituent selected from aryl, cyano, heteroaryl, heterocycloalkyl , hydroxy, -Z ² R ⁴ , -C (= O) -NY ¹ Y ² , -C (= O) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) -R, -N (R ⁶ ) -C (= O) -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -OR ⁷ , -N (R ⁶ ) -SO ₂ —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —SO ₂ NY ¹ Y ^2, and one or more halogen atoms; R ³ represents hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, —Z ² R ⁴ , —C (= O) —OR ⁵ or —C (= O) —NY ³ Y ⁴ ; X ¹ represents N or CH; R ⁹ represents hydrogen, alkenyl or R ⁴ ; R ¹⁰ represents alkenyloxy, carboxy (or bioisostere acid), cyano, halogen, hydroxy, heteroaryl, R ⁴ , -C (= O) -R, -C (= O) -NY ¹ Y ² , -OR ⁴ , -N (R ⁶ ) —C (= O) —R ⁷ , -N (R ⁶ ) -SO ₂ -R ⁷ or -NY ¹ Y ² ; p is zero or an integer of 1 or 2; and the remainder

attached at position 2 or 3 of the pyrrole ring, and the group - (R ¹⁰ ) _{p is} attached at position 4 or 5 of the pyrrole ring; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 54. The compound according to any one of claims 2 to 7, 9-12, 22, 48 and 60, where R ² represents hydrogen. 55. The compound according to any one of claims 2 to 7, 9-12, 22, 48 and 60, where R ³ represents hydrogen. 56. The compound of claim 48, wherein R ⁹ is C _1-4 alkyl. 57. The compound of claim 53, wherein R ¹⁰ is aryl. 58. The compound according to paragraph 53, where: R ² represents hydrogen; R ³ represents hydrogen; X ¹ represents CH; R ⁹ represents C _1-4 alkyl; p represents 1; and R ¹⁰ represents aryl. 59. The compound of claim 53, wherein: R ² represents hydrogen; R ³ represents hydrogen; X ¹ represents N; R ⁹ represents C _1-4 alkyl; p is 1; and R ¹⁰ represents aryl. 60. The compound according to any one of paragraphs.48, 52, 53, 58 and 59, where R ⁹ is —CH ₃ . 61. The compound according to any one of paragraphs.48, 52, 53, 58 and 59, where R ¹⁰ represents phenyl. 62. The compound according to claim 2 of formula (Id):

Where R ² represents hydrogen, acyl, cyano, halogen, lower alkenyl, —Z ² R ⁴ , —SO ₂ NY ³ Y ⁴ , —NY ¹ Y ^2, or lower alkyl optionally substituted with a substituent selected from aryl, cyano, heteroaryl, heterocycloalkyl , hydroxy, -Z ² R ⁴ , -C (= O) -NY ¹ Y ² , -C (= O) -R, -CO ₂ R ⁸ , -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) -R, -N (R ⁶ ) -C (= O) -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -OR ⁷ , -N (R ⁶ ) -SO ₂ —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ⁴ , —SO ₂ NY ¹ Y ^2, and one or more halogen atoms; R ³ represents hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, —Z ² R ⁴ , —C (= O) —OR ⁵ or —C (= O) —NY ³ Y ⁴ ; X ¹ represents N or CH; p is zero or an integer of 1 or 2; and R ¹⁰ represents alkenyloxy, carboxy (or bioisostere acid), cyano, halogen, hydroxy, heteroaryl, R ⁴ , -C (= O) -R, -C (= O) -NY ¹ Y ² , -OR ⁴ , -N (R ⁶ ) —C (= O) —R ⁷ , -N (R ⁶ ) -SO ₂ -R ⁷ or -NY ¹ Y ² ; or An N-oxide, ester prodrug or a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide or ester prodrug form of such a salt or solvate. 63. The compound of claim 62, wherein R ⁷ is hydrogen, lower alkyl, lower alkyl substituted with —CONY ¹ Y ² , lower alkyl substituted with carboxy, lower alkyl substituted with tetrazolyl, lower alkyl substituted with hydroxy, or lower alkyl substituted —N (R ⁶ ) —SO ₂ —R ⁷ , —N (R ₆ ) —C (═O) —R or —C (= O) —R. 64. The compound of claim 63, wherein R ² is —CH ₂ CH ₂ C (= O) CH ₃ . 65. The compound according to any one of claims 2 to 7, 9-12 and 63-64, where R ³ represents hydrogen. 66. The compound according to any one of claims 2 to 7, 9-12, 22, 48, 53 and 63-65, where X ¹ represents N. 67. The compound according to any one of paragraphs.53, 63 and 64, where p is 1. 68. The compound according to any one of claims 63-64, wherein R ¹⁰ is alkyl. 69. The compound according to any one of claims 63-64, wherein R ^{10 is} attached at position 4. 70. The compound of claim 62, wherein: R ² is hydrogen, lower alkyl, lower alkyl substituted with —CONY ¹ Y ² , lower alkyl substituted with carboxy, lower alkyl substituted with tetrazolyl, lower alkyl substituted with hydroxy, lower alkyl substituted with —N (R ⁶ ) —SO ₂ - R ⁷ , lower alkyl, substituted with -N (R ⁶ ) -C (= O) -R; R ³ represents hydrogen; X ¹ represents N; P is 1; R ¹⁰ represents alkyl; and R ^{10 is} attached at position 4. 71. The compound of claim 63 or 70, wherein R ² is methyl. 72. The compound of claim 63 or 70, wherein R ² is —CH ₂ CH ₂ CONH ₂ or —CH ₂ CH ₂ CONHCH ₃ . 73. The compound of claims 63 or 70, wherein R ² is —CH ₂ CH ₂ CO ₂ N. 74. The compound of claim 63 or 70, wherein R ² is

. 75. The compound of claim 63 or 70, wherein R ² is —CH ₂ CH ₂ CH ₂ OH or —CH ₂ CH ₂ C (CH ₃ ) ₂ OH. 76. The compound of claim 63 or 70, wherein R ² is —CH ₂ CH ₂ CH ₂ NHSO ₂ CH ₃ . 77. The compound of claim 63 or 70, wherein R ² is —CH ₂ CH ₂ CH ₂ NHC (= O) CH ₃ . 78. The compound according to any one of claims 63-64 and 70, wherein R ¹⁰ is tert-butyl. 79. The use of the compounds of claim 2 for the manufacture of a medicament for the treatment of inflammatory diseases by inhibiting the catalytic activity of Syk. 80. The use of the compounds of claim 2 for the manufacture of a medicament that inhibits the catalytic activity of FAK. 81. The use of the compounds according to claim 2 for the manufacture of a medicament that inhibits the catalytic activity of KDR. 82. The use of the compounds of claim 2 for the manufacture of a medicament that inhibits the catalytic activity of Aurora2. 83. The use of the compounds of claim 2 for the manufacture of a medicament that inhibits the catalytic activity of IGF1R. 84. The use of the compounds of claim 2 for the manufacture of a medicament for the treatment of cancer by inhibiting the catalytic activity of IGF1R. 85. The use of claim 79, wherein the inflammatory diseases are asthma, inflammatory dermatosis, allergic rhinitis, allergic conjunctivitis, or joint inflammation. 86. The use of claim 79, wherein the inflammatory diseases are asthma, psoriasis, herpetiform dermatitis, eczema, necrotizing vasculitis, skin vasculitis, bullous disease, allergic rhinitis, allergic conjunctivitis, arthritis, rheumatoid arthritis, measles arthritis, psoriatic arthritis or osteoarthritis. 87. The compound according to claim 2 of formula (I)

Where: R ¹ represents aryl or heteroaryl, each of which is optionally substituted with one or more groups selected from alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, hydroxy, heteroaryl, heterocycloalkyl, -C (= O) -R, -C (= O) -NY ¹ Y ² , -N (R ⁶ ) -C (= O) -R ⁷ , -N (R ⁶ ) -C (= O) -NY ³ Y ⁴ , -N (R ⁶ ) -C (= O) —OR ⁷ , —N (R ⁶ ) —SO ² —R ⁷ , —N (R ⁶ ) —SO ₂ —NY ³ Y ^4, and —SO ₂ —NY ¹ Y ² ; or An N-oxide, an ester prodrug, a bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 88. The compound of claim 53, wherein R ⁹ is C _1-4 alkyl substituted with alkoxy or C _1-4 alkyl substituted with —NY ¹ Y ² ; and R ¹⁰ represents optionally substituted heteroaryl or optionally substituted aryl. 89. The application of claim 84, wherein the cancer is colorectal cancer, prostate cancer, breast cancer, thyroid cancer, skin cancer, colon cancer, or lung cancer. 90. The compound according to claim 2, which is a 6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-lH-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (3-bromophenyl) -5H-pyrrolo [2,3-b] pyrazine; 7-isopropyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine; 6- (4-bromophenyl) -5H-pyrrolo [2,3-b] pyrazine; 2- (4-bromophenyl) -lH-pyrrolo [2,3-b] pyrazine; 6- (4- [1,3] dioxan-2-ylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (3- [1,3] dioxan-2-yl-phenyl) -5H-pyrrolo [2,3-b] pyrazine; 2- (5H-pyrrolo [2,3-b] pyrazin-6-yl) quinoline; 3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) isoquinoline; 6- [1-methyl-1H-indol-5-yl] -5H-pyrrolo [2,3-b] pyrazine; 6- (5-methoxy-1-methyl-1H-indol-3-yl) -2-methyl-5H-pyrrolo [2,3-b] pyrazine; 3-methyl-6- (1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-benzyl-5-methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-1H-pyrrol-2-yl) -5H-pyrrolo [2,3-b] pyrazine; 6-indolysin-1-yl-5H-pyrrolo [2,3-b] pyrazine; 6- (3-methylindolisin-1-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-2-phenyl-1H-pyrrol-4-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (5,6,7,8-tetrahydroindolisin-1-yl) -5H-pyrrolo [2,3-b] pyrazine; 6-furan-3-yl-5H-pyrrolo [2,3-b] pyrazine; dimethyl [4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] amine; 6- (5-methoxy-1-methyl-1H-indol-3-yl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine; 6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-tert-butylphenyl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine; 6- (3,4-dimethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-aminophenyl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine; 6- [4- (l-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazine; 6- (1H-l-methyl-2- (methylthio) imidazol-5-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-1H-indazol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-4-phenyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- [4- (tert-butyl) phenyl] -7- (prop-1-enyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-methylthiophenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (3-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-1H-pyrazol-4-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-5-phenyl-1H-pyrazol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (pyridin-2-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (pyridin-4-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (3,4-dimethylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-trifluoromethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-aminophenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methylphenyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1,5-dimethyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1,4-dimethyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 2- (1-methyl-4-phenyl-1H-pyrrol-3-yl) -1H-pyrrolo [2,3-b] pyridine; 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propan-1-ol; 3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propan-1-ol; 2- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] ethanol; 6- (1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] ethanol; 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] propylamine; 3- [5-methoxy-3- (5H-pyrrolo (2,3-b] pyrazin-6-yl) indol-1-yl] propylamine; N- {3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] propyl} acetamide; N- [4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] acetamide; 6- [1- (3-morpholin-4-ylpropyl) -1H-indol-3-yl] -5H-pyrrolo [2,3-b] pyrazine; 6- [1- (3-piperidin-1-yl-propyl) -1H-indol-3-yl] -5H-pyrrolo [2,3-b] pyrazine; 6- {l- [3- (pyridin-3-yloxy) propyl] -lH-indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-ol; 6- (2-chloro-5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) benzaldehyde; 4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) benzaldehyde; [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] methanol; [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] methanol; [4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] methanol; 6- (5-methoxy-lH-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] -1-morpholin-4-ylethanone; [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetic acid; l- [l-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] propan-2-ol; [5,6-dimethoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetic acid; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -1-morpholin-4-ylethanone; 1- [l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] cyclobutanecarboxylic amide; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid methylamide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid methylamide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid (2-hydroxyethyl) amide; L-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid (2-morpholin-4-yl-ethyl) amide; (2-carbamoylethyl) amide l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid bis (2-hydroxyethyl) amide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid amide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1,1-bishydroxymethylethyl) amide; (2-hydroxy-1-hydroxymethyl-1-methylethyl) amide 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid; (2,3-dihydroxypropyl) l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid amide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1,1-dimethylethyl) amide; L-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid (2-hydroxy-l-hydroxymethylethyl) amide; (2-carbamoylethyl) l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-6-carboxylic acid amide; L-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-6-carboxylic acid (2-hydroxyethyl) amide; (1H- [1,2,4] triazol-3-yl) amide 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-6-carboxylic acid; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-6-carboxylic acid (2-hydroxy-1-hydroxymethylethyl) amide; L-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1,1-dimethylethyl) amide; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N-methylpropionamide; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N, N-dimethylpropionamide; L-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-methoxyethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-thien-2-yl-ethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-fluoroethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-carboethoxyethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid (hydroxymethyl) carbomethoxymethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-hydroxyethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid methylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid dimethylamide; [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] morpholin-4-ylketone; 4-hydroxy- [l- [l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indol-5-yl] carbonylpiperidine; 3- [l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] carbonylaminopropionic acid methylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indole-5-carboxylic acid 3-hydroxypropylamide; 3- {6- [4- (l-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionic acid methylamide; 3- [6- (4-Methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid methylamide; 3- {6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionamide; 3- {6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionamide; 3- [6- (4-Fluorophenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid methylamide; 2- [5,6-dimethoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -l-morpholin-4-yl-ethanone; [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] acetic acid; 2- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propionic acid; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid; l-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-ol; 1- {1- (cyclobutanecarboxylic acid) -3-1H-pyrrolo [2,3-b] pyridin-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-6-carboxylic acid; 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yl] propionic acid; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid; [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenoxy] acetic acid; 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] propionic acid; 3- [l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] carbonylaminopropionic acid; 3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid; potassium 2- (5-methoxy) -1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine-4-carboxylate; 2- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] ethanol; 2- [l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-l-ol; {1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutyl} methanol; 2- (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) ethanol; 3- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indol-5-yl] carbonylaminopropionic acid; 2- [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenoxy] ethanol; 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] propan-1-ol; 3- {6- {4- (l-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propanol; 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine; 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol; 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1-ol; 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-2-ol; 2- [l-methyl-5- (2H-tetrazol-5-yl) -lH-indol-3-yl] -lH-pyrrolo [2,3-b] pyridine; 2- [1-methyl-5- (2-methyl-2H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 2- [1-methyl-5- (1-methyl-1H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yl] ethanone; 2- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine; (S) -3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-l, 2-diol; (R) -3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol; 2- [5- (2-methoxy-1-methylethoxy) -1-methyl-1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 2- [l-methyl-5- (5-methyl [I, 2,4] oxadiazol-3-yl) -1H-indol-3-yl] -lH-pyrrolo [2,3-b] pyridine; (R) -3- [6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol ; 6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-ol; 2- [5- (pyridin-4-yl) -1-methyl-1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 2- (5-methoxy-l-methyl-1H-indol-2-yl) -1H-pyrrolo [2,3-b] pyridine; 2- (5-methoxy-1-methyl-1H-indol-3-yl) -3-methyl-1H-pyrrolo [2,3-b] pyridine; 2- (1H-pyrrol-2-yl) -1H-pyrrolo [2,3-b] pyridine; 2- (1-methyl-1H-pyrrol-2-yl) -1H-pyrrolo [2,3-b] pyridine; 5-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-6-ol; 2- (6-isopropoxy-5-methoxy-1-methyl-1H-indol-3-yl) -lH-pyrrolo [2,3-b] pyridine; 2- [5,6-dimethoxy-1- (2-morpholin-4-yl-ethyl) -lH-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-ylamine; N- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yl] methanesulfonamide; N- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yl] acetamide; N- {1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-ml] methyl} thien-2-ylsulfonamide; {l- [5- (l-hydroxymethylcyclobutoxy) -3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] cyclobutyl} methanol; {1- [l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yloxy] cyclobutyl} methanol; 5- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] ethyl-2H-tetrazole; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionitrile; 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] propionamide; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid; 3- {6- [4- (l-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionic acid; 3- [6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid; 3- [6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propan-l-ol; [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenoxy] acetic acid ethyl ester; 2-methoxy-5- (5H-pyrrolo [2,3-b] pyridin-6-yl) phenol; 3-fluoro-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine; 3- {6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionic acid; ethyl 3- {6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionate; 6- (4-methylsulfinyl phenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-methylsulfonylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propylamine; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} acetamide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} cyclopropylcarboxylic acid amide; N- (3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} butyramide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} methoxyacetamide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} thien-2-yl-carboxylic acid amide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} -N'-propylurea; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} -N'-carboethoxymethylurea; N- {l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yl] methyl} -N'-tetrahydropyran-2-ylurea; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} -N ', N'-diethylurea; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} methanesulfonamide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} thien-2-ylsulfonamide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} dimethylisoxazol-4-ylsulfonamide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} -l-methylimidazol-4-ylsulfonamide; 3- [6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N-methylpropionamide; 3- [6- (4-morpholin-4-ylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N-methylpropionamide; 6- (4-pyrrolidin-l-ylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4- (furan-2-yl) phenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4- (3,5-dimethylisoxazol-4-yl) phenyl) -5H-pyrrolo [2,3-b] pyrazine; 2- [4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] propan-2-ol; 1- [4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] ethanone; 6- [4- (4- {2-morpholin-4-yl-ethyl} piperazin-1-yl) -phenyl] -5H-pyrrolo [2,3-b] pyrazine; 6- (4-piperazin-1-ylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 2-methyl-4- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] butan-2-ol; [3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -l-methyl-1H-indol-5-yl] methylamine; 2 - {[5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -l- (l-methylpiperazine) -4-yl} ethanone; N-cyclobutyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; N- (3-imidazol-1-ylpropyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 1- (2,5-dihydropyrrol-1-yl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone; N-cyclohexyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N-cyclopentyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N- (3-dimethylaminopropyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 6- {2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetylamino} hexanoic acid methyl ester; 1- [1,4 '] bipiperidinyl-1'-yl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] ethanone; N- (3,3-dimethylbutyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N- (3-ethoxypropyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; 1- (3,3-dimethylpiperidin-l-yl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] ethanone; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (3-oxoisoxazolidin-4-yl) acetamide; 1- [4- (4-chlorophenyl) piperazin-l-yl] -2- (5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] ethanone ; l- (4-hydroxypiperidin-1-yl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] ethanone; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1-thiazolidin-3-ylethanone; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -l- [4- (3-phenylallyl) piperazin-1-yl] ethanone ; N-furan-2-ylmethyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (2-pyridin-4-yl-ethyl) acetamide; N-cyclopropylmethyl-2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N-propylacetamide; N- (1-cyclohexylethyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N-methyl-N-pyridin-3-ylmethylacetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1- (4-methatolylpiperazin-1-yl) ethanone; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N- (2-phenylsulfanylethyl) acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N- (4-morpholin-4-ylphenyl) acetamide; N-cyclopropyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1- (3-methylpiperazin-1-yl) ethanone; N- (4-cyclohexylphenyl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (2-methylcyclohexyl) acetamide; N-cyclohexylmethyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -l-pyrrolidin-l-ylethanone; 4- {2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetyl} piperazin-2-one; 4- {2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetyl} -3,3-dimethylpiperazin-2-one; 4- {2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetyl} -1-methylpiperazin-2-one; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1-thiomorpholin-4-ylethanone; N- (2-hydroxy-2-phenylethyl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 1- (2,6-dimethylmorpholin-4-yl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone; N- (4-diethylaminomethylphenyl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; N- [2- (4-hydroxyphenyl) ethyl] -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (tetrahydrofuran-2-ylmethyl) acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N-pyridin-2-ylmethylacetamide; N- (1,2-dimethylpropyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N- (3-benzyloxypyridin-2-yl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; 2- (5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N-quinolin-3-yl-acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N-quinolin-8-yl-acetamide; N-isoquinolin-5-yl-2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N- (3-methylbutyl) acetamide; N-isoquinolin-1-yl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N-quinolin-2-yl-acetamide; 1- (3,6-dihydro-2H-pyridin-1-yl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N- [3- (4-methylpiperazin-1-yl) propyl] acetamide ; N- (2-cyclohex-1-enylethyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N- [2- (1H-indol-3-yl) ethyl] -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide ; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -l- [4- (tetrahydrofuran-2-carbonyl) piperazin-1-yl ] ethanone; N-adamantan-1-yl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl] indol-1-yl] acetamide; N- (2-dimethylaminoethyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N-methylacetamide; 1- (4-benzo [1,3] dioxol-5-ylmethylpiperazin-l-yl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol- 1-yl] ethanone; 1- [4- (4-chlorobenzyl) piperazin-1-yl] -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone ; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1- [4- (1-phenylethyl) piperazin-1-yl] ethanone ; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1- [4- (2-morpholin-4-yl-ethyl) piperazin-1 -yl] ethanone; 1- [4- (4-methoxyphenyl) piperazin-1-yl] -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone ; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- [3- (2-oxopyrrolidin-l-yl) propyl] acetamide ; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1-piperidin-1-ylethanone; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (2-piperidin-l-yl-ethyl) acetamide; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (2-pyrrolidin-l-yl-ethyl) acetamide; 1- [4- (2-methoxyethyl) piperazin-1-yl] -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone ; 1- [4- (2-dimethylaminoethyl) piperazin-1-yl] -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone ; N-isobutyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; 1- [4- (4-tert-butylbenzyl) piperazin-l-yl] -2- [5-methyloxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl ] ethanone; 2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (l-methyl-3-phenylpropyl) acetamide; N- (4-diethylamino-1-methylbutyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N-benzyl-N- (2-hydroxyethyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; l- {4- [2- (2-hydroxyethoxy) ethyl] piperazin-l-yl} -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indole- 1-yl] ethanone; N- (1-hydroxymethyl-2-methylbutyl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; N-benzyl-2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N-methylacetamide; N- (2-methoxy-1-methylethyl) -2- [5-methoxy ~ 3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; N- (3-hydroxypropyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; N- (3-methoxyphenyl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; 1- (4-benzhydrylpiperazin-l-yl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] ethanone; 1- (4-benzylpiperazin-1-yl) -2- [5-methoxy-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] ethanone; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N- (3-pyrrolidin-1-ylpropyl) acetamide; N- (1-benzylpiperidin-4-yl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetamide; 1- [4- (4-chlorophenyl) -4-hydroxypiperidin-1-yl] -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1- silt] ethanone; 2- {2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] acetylamino} -3-methylpentanoic acid methyl ester; 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (2-methylquinolin-4-yl) acetamide; N- (2-benzylsulfanyl-1-hydroxymethylethyl) -2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] acetamide; [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] acetic acid; 2 - {[2- (lH-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] -l-cyclopropylamino} ethanone; N- (3-ethoxypropyl) -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] acetamide; 1-pyrrolidin-1-yl-2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] ethanone; 1- (3,6-dihydro-2H-pyridin-1-yl) -2- [2- (lH-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] ethanone; l-methyl-4- {2- [2- (lH-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] acetyl} piperazin-2-one; 2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] -N- (tetrahydrofuran-2-ylmethyl) acetamide; 1- (2,6-dimethylmorpholin-4-yl) -2- [2- (lH-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] ethanone; 2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] -1-thiomorpholin-4-ylethanone; 1- (4-hydroxypiperidin-1-yl) -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] ethanone; 1- (3,3-dimethylpiperidin-1-yl) -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] ethanone; 4- {2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] acetyl} piperazin-2-one; N- (1-methylbutyl) -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] acetamide; N-bicyclo [2.2.1] hept-2-yl-2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] acetamide; N- [3- (4-methylpiperazin-l-yl) propyl] -2- [2- (lH-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] acetamide; 1- [4- (3-dimethylaminopropyl) piperazin-1-yl] -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] ethanone; 1- (4-methylpiperazin-1-yl) -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] ethanone; 1- [4- (4-chlorophenyl) -4-hydroxypiperidin-l-yl] -2- [2- (1H-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-1-yl] ethanone; 1- [4- (3-hydroxyphenyl) piperazin-l-yl] -2- [2- (lH-pyrrolo [2,3-b] pyridin-2-yl) pyrrol-l-yl] ethanone; 3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] propionic acid; 3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1-morpholin-4-ylpropan-1-one; 3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N-phenylpropionamide; 3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -l-thiomorpholin-4-ylpropan-l-one; 3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -1- (4-methylpiperazin-1-yl) propan-1-one; 3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] -N- (tetrahydrofuran-2-ylmethyl) propionamide; N- (2-hydroxy-2-phenylethyl) -3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] propionamide; N- (2-hydroxyethyl) -3- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] propionamide; 1- [4- (4-chlorophenyl) -4-hydroxypiperidin-1-yl] -2- [5-methoxy-2- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l- silt] ethanone; or an N-oxide, ester prodrug, bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 91. The compound according to claim 2, which is a 6- (5-methoxy-l-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 6- (1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] propan-l-ol; 3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propan-1-ol; 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] ethanol; 6- (lH-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; N- {3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propyl} acetamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-ol; [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] methanol; 6- (5-methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-l-yl] -l-morpholin-4-ylethanone; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] propan-2-ol; 1- [l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] cyclobutanecarboxylic amide; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid methylamide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid (2-hydroxyethyl) amide; (2-carbamoylethyl) amide 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid amide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1-indole-5-carboxylic acid (2-hydroxy-1,1-dimethylethyl) amide; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid (2-hydroxy-l-hydroxymethylethyl) amide; (2-carbamoylethyl) amide 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-6-carboxylic acid; (1H- [l, 2,4] triazol-3-yl) amide 1-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-6-carboxylic acid; L-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indole-5-carboxylic acid 2-methoxyethylamide; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-hydroxyethylamide; l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indole-5-carboxylic acid methylamide; 2- [l-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propionic acid; l- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutane-1-carboxylic acid; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-ol; 1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-6-carboxylic acid; 3- [l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yl] propionic acid; 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid; 3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid; 2- [l-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] ethanol; 2- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-l-ol; {1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] cyclobutyl} methanol; 2- (5-methoxy-l-methyl-lH-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine; 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol; 3- [l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] propan-l-ol; 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] propan-2-ol; 2- [1-methyl-5- (2H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 2- [1-methyl-5- (2-methyl-2H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yl] ethanone; 2- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine; (R) -3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol; (S) -3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol; 2- [5- (2-methoxy-1-methylethoxy) -1-methyl-1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; 2- [1-methyl-5- (5-methyl [1,2,4] oxadiazol-3-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; (R) -3- [6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propan-1,2-diol ; 6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-ol; N- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yl] acetamide; {l- [5- (1-hydroxymethylcyclobutoxy) -3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-l-yl] cyclobutyl} methanol; {l- [l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indol-5-yloxy] cyclobutyl} methanol; or an N-oxide, ester prodrug, bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 92. The compound according to claim 2, which is a 6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine; 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic amide; 2- [l-methyl-5- (2H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine; {1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indol-5-yloxy] cyclobutyl} methanol; or N-oxide, an ester prodrug, a bioisostere of an acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 93. The compound according to claim 2, which is a 6-indolysin-l-yl-5H-pyrrolo [2,3-b] pyrazine or 6- (3-methylindolisin-1-yl) -5H-pyrrolo [2,3-b] pyrazine; or an N-oxide, ester prodrug, bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 94. The compound according to claim 2, which is a 6- (1-methyl-4-phenyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine or an N-oxide, ester prodrug, bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 95. The compound according to claim 2, which is a 6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine; 6- (4-tert-butylphenyl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N-methylpropionamide; 5- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] ethyl-2H-tetrazole; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionamide; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid; 3- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propan-1-ol; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} acetamide; N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} methanesulfonamide; 2-methyl-4- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] butan-2-ol or 4- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] butan-2-one; or N-oxide, an ester prodrug, a bioisostere of an acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 96. The compound according to claim 2, which is a l-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-6-carboxylic acid; 2- [1-methyl-5- (pyridin-4-yl) -1H-indol-3-yl] -4-1H-pyrrolo [2,3-b] pyridine; N- {l-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-ml] methyl} thien-2-ylsulfonamide; N- {1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yl] methyl} -N'-tetrahydropyran-2-ylurea; or 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) indol-1-yl] -N- (2-methylquinolin-4-yl) acetamide or N-oxide, ester prodrug, bioisostere acid, pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 97. The compound according to claim 2, which is a 6- (l-methyl-1H-pyrrol-2-yl) -5H-pyrrolo [2,3-b] pyrazine; or an N-oxide, ester prodrug, bioisostere acid, a pharmaceutically acceptable salt or solvate of such a compound; or an N-oxide, ester prodrug or bioisostere of an acid of such a salt or solvate. 98. The compound of claim 53, wherein R ⁹ is optionally substituted C _1-4 alkyl. 99. The compound of claim 53, wherein R ¹⁰ is optionally substituted aryl or optionally substituted heteroaryl. 100. The compound of claim 53, wherein R ⁹ is C _1-4 alkyl substituted with alkoxy or C _1-4 alkyl substituted with —NY ¹ Y ² ; and R ¹⁰ is optionally substituted heteroaryl or optionally substituted aryl.