RU2008100493A - SILVER N- (6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINSULPHONE) -N'-ISONICOTINOYLHYDRASIDE SALT, MANIFESTING IMMUNOTROPIC RESISTANCE MEDICINE ON ITS BASIS - Google Patents

SILVER N- (6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINSULPHONE) -N'-ISONICOTINOYLHYDRASIDE SALT, MANIFESTING IMMUNOTROPIC RESISTANCE MEDICINE ON ITS BASIS Download PDF

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RU2008100493A
RU2008100493A RU2008100493/04A RU2008100493A RU2008100493A RU 2008100493 A RU2008100493 A RU 2008100493A RU 2008100493/04 A RU2008100493/04 A RU 2008100493/04A RU 2008100493 A RU2008100493 A RU 2008100493A RU 2008100493 A RU2008100493 A RU 2008100493A
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cristaphone
silver salt
silver
immunotropic
mixture
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RU2008100493/04A
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RU2368609C1 (en
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Лев Давидович Раснецов (RU)
Лев Давидович Раснецов
Яков Юделевич Шварцман (RU)
Яков Юделевич Шварцман
Ольга Константиновна Яшнова (RU)
Ольга Константиновна Яшнова
Нина Борисовна Мельникова (RU)
Нина Борисовна Мельникова
Юлия Викторовна Чудецкая (RU)
Юлия Викторовна Чудецкая
Александр Александрович Волков (RU)
Александр Александрович Волков
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Лев Давидович Раснецов (RU)
Лев Давидович Раснецов
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Priority to PCT/RU2008/000809 priority patent/WO2009091291A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

1. Серебряная соль N-(6-метил-2,4-диоксо-1,2,3,4-тетрагидро-5Н-пиримидинсульфон)-N'-изоникотиноилгидразида (кристафона), полученная путем его взаимодействия с нитратом серебра при диспергировании их смеси в молярном соотношении от 50:50 мол.% до 20:80 мол.% в воде, с последующей промывкой, фильтрацией и высушиванием, проявляющая иммунотропную, противомикробную, противогрибковую (противомикотическую) активность. ! 2. Серебряная соль кристафона по п.1, отличающаяся тем, что она представляет собой соединение формулы I ! ! или соединение формулы II ! , ! или смесь соединений I и II. ! 3. Способ получения серебряной соли кристафона по п.1 или 2, заключающийся в том, что в водную суспензию кристафона, интенсивно перемешанную до однородного состояния, добавляют нитрат серебра при мольном соотношении кристафона к нитрату серебра от 1:1 до 1:4, затем без доступа света реакционную смесь перемешивают до получения объемного гомогенного осадка, полученный осадок фильтруют, многократно промывают бидистиллированной водой и высушивают при температуре 50-80°С. ! 4. Способ по п.3, отличающийся тем, что для приготовления водной суспензии используют кристафон в мелко дисперсном состоянии. ! 5. Лекарственное средство, обладающее иммунотропной, противомикробной, противогрибковой активностью, содержащее активное вещество, отличающееся тем, что в качестве активного вещества оно содержит серебряную соль кристафона по любому из пп.1, 2 либо смесь кристафона и его серебряной соли в соотношении от 1:1 до 4:1. ! 6. Средство по п.5, отличающееся тем, что оно выполнено в форме таблеток, капсул, мазей, суппозиториев.1. The silver salt of N- (6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulfone) -N'-isonicotinoyl hydrazide (cristaphone), obtained by its interaction with silver nitrate when dispersing them mixtures in a molar ratio of from 50:50 mol.% to 20:80 mol.% in water, followed by washing, filtering and drying, showing immunotropic, antimicrobial, antifungal (antimycotic) activity. ! 2. The silver salt of Christophone according to claim 1, characterized in that it is a compound of formula I! ! or a compound of formula II! ! or a mixture of compounds I and II. ! 3. The method for producing the silver salt of cristaphone according to claim 1 or 2, which consists in adding silver nitrate at a molar ratio of cristaphone to silver nitrate from 1: 1 to 1: 4 to an aqueous suspension of cristaphone, intensively mixed to a homogeneous state, then without access to light, the reaction mixture is stirred until a homogeneous bulk precipitate is obtained, the resulting precipitate is filtered, washed repeatedly with bidistilled water and dried at a temperature of 50-80 ° C. ! 4. The method according to claim 3, characterized in that for the preparation of an aqueous suspension using cristaphone in a finely dispersed state. ! 5. A medicinal product having immunotropic, antimicrobial, antifungal activity, containing an active substance, characterized in that as an active substance it contains a silver salt of cristaphone according to any one of claims 1, 2, or a mixture of cristaphone and its silver salt in a ratio of 1: 1 to 4: 1. ! 6. The tool according to claim 5, characterized in that it is made in the form of tablets, capsules, ointments, suppositories.

Claims (6)

1. Серебряная соль N-(6-метил-2,4-диоксо-1,2,3,4-тетрагидро-5Н-пиримидинсульфон)-N'-изоникотиноилгидразида (кристафона), полученная путем его взаимодействия с нитратом серебра при диспергировании их смеси в молярном соотношении от 50:50 мол.% до 20:80 мол.% в воде, с последующей промывкой, фильтрацией и высушиванием, проявляющая иммунотропную, противомикробную, противогрибковую (противомикотическую) активность.1. The silver salt of N- (6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulfone) -N'-isonicotinoyl hydrazide (cristaphone), obtained by its interaction with silver nitrate when dispersing them mixtures in a molar ratio of from 50:50 mol.% to 20:80 mol.% in water, followed by washing, filtering and drying, showing immunotropic, antimicrobial, antifungal (antimycotic) activity. 2. Серебряная соль кристафона по п.1, отличающаяся тем, что она представляет собой соединение формулы I2. The silver salt of Christophone according to claim 1, characterized in that it is a compound of formula I
Figure 00000001
Figure 00000001
 или соединение формулы IIor a compound of formula II
Figure 00000002
,
Figure 00000002
, или смесь соединений I и II.or a mixture of compounds I and II. 3. Способ получения серебряной соли кристафона по п.1 или 2, заключающийся в том, что в водную суспензию кристафона, интенсивно перемешанную до однородного состояния, добавляют нитрат серебра при мольном соотношении кристафона к нитрату серебра от 1:1 до 1:4, затем без доступа света реакционную смесь перемешивают до получения объемного гомогенного осадка, полученный осадок фильтруют, многократно промывают бидистиллированной водой и высушивают при температуре 50-80°С.3. The method of obtaining silver salt of cristaphone according to claim 1 or 2, which consists in the fact that silver nitrate is added to the aqueous suspension of cristaphone, intensively mixed until homogeneous, with a molar ratio of cristaphone to silver nitrate from 1: 1 to 1: 4, then without access to light, the reaction mixture is stirred until a homogeneous bulk precipitate is obtained, the resulting precipitate is filtered, washed repeatedly with bidistilled water and dried at a temperature of 50-80 ° C. 4. Способ по п.3, отличающийся тем, что для приготовления водной суспензии используют кристафон в мелко дисперсном состоянии.4. The method according to claim 3, characterized in that for the preparation of an aqueous suspension using cristaphone in a finely dispersed state. 5. Лекарственное средство, обладающее иммунотропной, противомикробной, противогрибковой активностью, содержащее активное вещество, отличающееся тем, что в качестве активного вещества оно содержит серебряную соль кристафона по любому из пп.1, 2 либо смесь кристафона и его серебряной соли в соотношении от 1:1 до 4:1.5. A medicinal product having immunotropic, antimicrobial, antifungal activity, containing an active substance, characterized in that it contains the silver salt of cristaphone according to any one of claims 1, 2 or a mixture of cristaphone and its silver salt in a ratio of 1: 1 to 4: 1. 6. Средство по п.5, отличающееся тем, что оно выполнено в форме таблеток, капсул, мазей, суппозиториев. 6. The tool according to claim 5, characterized in that it is made in the form of tablets, capsules, ointments, suppositories.
RU2008100493/04A 2008-01-09 2008-01-09 Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt RU2368609C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2008100493/04A RU2368609C1 (en) 2008-01-09 2008-01-09 Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt
PCT/RU2008/000809 WO2009091291A1 (en) 2008-01-09 2008-12-29 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulfone)-isonicotinoyl hydrazide silver salt

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RU2008100493/04A RU2368609C1 (en) 2008-01-09 2008-01-09 Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt

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MD4075C1 (en) * 2009-12-31 2011-07-31 Анатолий ЭФКАРПИДИС Process for obtaining highly dispersed colloidal silver
RU2706357C1 (en) * 2018-05-22 2019-11-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ПГФА) Silver salts of 3,4-diaryl-5-[4-(acetylaminosulphonyl)phenyl]-4,6-dihydropyrrolo[3,4-c]pyrazol-6-ones exhibiting antifungal activity
CN113333772B (en) * 2021-06-18 2023-01-03 南昌大学 Preparation method of gold nanocluster and application of gold nanocluster in 2,4, 6-trinitrophenol detection

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RU2191015C2 (en) * 1999-11-05 2002-10-20 Общество с ограниченной ответственностью "Центр бифункциональных иммуномодуляторов" N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulfone)-n′- isonicotinoyl hydrazide disodium salt eliciting antibacterial and immunotropic activity and medicinal agent based on thereof

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