RU2007137190A - SOME SUBSTITUTED AMIDES, METHOD FOR PRODUCING AND METHOD OF APPLICATION - Google Patents

Abstract

1. At least one chemical entity comprising a pharmacophore selected from radicals of formula 1:! ! and its pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs and mixtures thereof, where! * represents the point of attachment; ! R3 is selected from optionally substituted piperidinyl, tert-butyl and isopropyl; ! X is selected from CH and N; and! R1 and R2 are independently selected from hydrogen, lower alkyl and halogen, provided that at least one of R1 and R2 is not hydrogen. ! 2. At least one chemical entity according to claim 1, wherein X is CH. ! 3. At least one chemical object according to claim 1, where X represents N.! 4. At least one chemical entity, including a pharmacophore selected from radicals of formula 1A:! ! and its pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs and mixtures thereof, where! * represents the point of attachment; ! R40 is selected from hydrogen, hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, and heteroaryl; and! R1 and R2 are independently selected from hydrogen, lower alkyl and halogen, provided that at least one of R1 and R2 is not hydrogen. ! 5. At least one chemical entity according to any one of claims 1 to 4, wherein R1 and R2 are independently selected from hydrogen, methyl, and fluoro. ! 6. At least one chemical entity according to claim 5, wherein R1 is selected from methyl and fluorine, and R2 is hydrogen. ! 7. At least one chemical entity according to claim 5, wherein R2 is selected from methyl and fluorine, and R1 is hydrogen. ! 8. At least one chemical entity according to claim 5, wherein R1 and R2 are independently selected from methyl and fluoro. ! 9. At least one chemical object, one at a time

Claims (115)

1. At least one chemical entity comprising a pharmacophore selected from radicals of formula 1:

and its pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs and mixtures thereof, where * represents the point of attachment; R _{3 is} selected from optionally substituted piperidinyl, tert-butyl and isopropyl; X is selected from CH and N; and R ₁ and R _{2 are} independently selected from hydrogen, lower alkyl and halogen, provided that at least one of R ₁ and R _{2 is} not hydrogen. 2. At least one chemical entity according to claim 1, wherein X is CH. 3. At least one chemical object according to claim 1, where X represents N. 4. At least one chemical entity comprising a pharmacophore selected from radicals of formula 1A:

and its pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs and mixtures thereof, where * represents the point of attachment; R _{40 is} selected from hydrogen, hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, and heteroaryl; and R ₁ and R _{2 are} independently selected from hydrogen, lower alkyl and halogen, provided that at least one of R ₁ and R _{2 is} not hydrogen. 5. At least one chemical entity according to any one of claims _{1 to 4} , wherein R ₁ and R _{2 are} independently selected from hydrogen, methyl, and fluoro. 6. At least one chemical object according to claim 5, where R ₁ selected from methyl and fluorine, and R ₂ represents hydrogen. 7. At least one chemical object according to claim 5, where R ₂ selected from methyl and fluorine, and R ₁ represents hydrogen. 8. At least one chemical entity according to claim 5, wherein R ₁ and R _{2 are} independently selected from methyl and fluoro. 9. At least one chemical entity according to one of claims 1 or 4, wherein R _{40 is} selected from hydrogen and lower alkyl. 10. At least one chemical entity selected from compounds of formula 2:

and its pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs and mixtures thereof, where R is selected from optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; M is selected from a covalent bond and —CH═CH—; Q is selected from

,

,

,

and

; where R ₁₀ and R _{11 are} independently selected from hydrogen, C ₁ -C ₆ alkyl, and C ₁ -C ₆ haloalkyl; and R ₁₂ , R ₁₃ , R ₁₄ and R _{15 are} each independently selected from hydrogen C ₁ -C ₆ alkyl, C ₁ -C ₆ halogenated, phenyl substituted phenyl selected from mono-, di- and trisubstituted phenyl, where the substituents are independently selected from hydroxy, nitro, cyano, amino, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, (C ₁ -C ₆ alkyloxy ) C ₁ -C ₆ alkoxy, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkoxy, mono (C ₁ -C ₆ alkyl) amino, di (C ₁ -C ₆ alkyl) amino and amino (C ₁ - C ₆ alkyl) heteroaryl and substituted heteroaryl selected from mono-, di- and trisubstituted heteroaryl, where the substituents are independently selected from hydroxy, nitro, cyano, amino, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, (C ₁ -C ₆ alkyloxy ) C ₁ -C ₆ alkoxy, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkoxy, mono (C ₁ -C ₆ alkyl) amino, di (C ₁ -C ₆ alkyl) amino and amino (C ₁ - C ₆ alkyl); and Z is selected from optionally substituted phenylene and optionally substituted pyridylidene; W represents an optionally substituted heteroaryl group other than an imidazo [1,2-A] pyrazine group; and D is a hydrogen bond donor other than hydrogen, provided that the compound of formula 2 is not (4- {6 - [(4-chlorobenzyl) methylamino] pyrazin-2-yl} phenyl) piperidin-1-ylmethanone. 11. At least one chemical object according to claim 10, where Z is selected from ortho-phenylene, meta-phenylene, para-phenylene, ortho-pyridylidene, meta-pyridylidene and para-pyridylidene, each of which is optionally substituted with a group selected from optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy. 12. At least one chemical entity according to claim 11, wherein Z is selected from meta-phenylene and meta-phenylene substituted with a group selected from optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy. 13. At least one chemical entity according to claim 12, wherein Z is selected from meta-phenylene and meta-phenylene substituted with a group selected from lower alkyl and halogen. 14. At least one chemical entity according to claim 13, wherein Z is selected from meta-phenylene and meta-phenylene substituted with a group selected from methyl and halogen. 15. At least one chemical entity according to any one of claims 10-14, wherein M is a covalent bond. 16. At least one chemical entity according to any one of claims 10-14, wherein M is —CH = CH—. 17. At least one chemical object according to claim 10, where the compound of formula 2 is selected from compounds of formula 3:

where R ₃ selected from optionally substituted piperidinyl, tert-butyl and isopropyl; X is selected from CH and N; R ₁ and R _{2 are} independently selected from hydrogen, lower alkyl and halogen, provided that at least one of R ₁ and R _{2 is} not hydrogen. 18. At least one chemical entity according to claim 17, wherein X is CH. 19. At least one chemical entity according to claim 17, wherein X is N. 20. At least one chemical entity according to any one of claims 17-19, wherein R ₁ and R _{2 are} independently selected from hydrogen, methyl, and fluoro. 21. At least one chemical entity according to claim 20, wherein R _{1 is} selected from methyl and fluoro and R ₂ is hydrogen. 22. At least one chemical entity according to claim 20, wherein R ₁ and R _{2 are} independently selected from methyl and fluoro. 23. At least one chemical entity of claim 10, wherein W is an optionally substituted heteroaryl group, which further includes a hydrogen bond acceptor. 24. At least one chemical object according to claim 10, where

selected from

and

each of which is optionally substituted with one or two groups selected from hydroxy, cyano, halogen, optionally substituted lower alkyl and optionally substituted lower alkoxy, and where R _{16 is} selected from hydrogen, cyano, optionally substituted cycloalkyl and optionally substituted lower alkyl; R ₁₇ , R ₁₈ , R ₁₉ , R ₂₁ , R ₂₂ and R _{23 are} independently selected from hydrogen and optionally substituted lower alkyl; and R _{20 is} selected from hydrogen, hydroxy, cyano, halogen, optionally substituted lower alkyl, and optionally substituted lower alkoxy. 25. At least one chemical entity according to paragraph 24, where R ₁₇ , R ₁₈ , R ₁₉ , R ₂₁ and R _{22 are} independently selected from hydrogen and lower alkyl. 26. At least one chemical object according to paragraph 24 or 25, where R ₂₀ represents hydrogen. 27. At least one chemical object according to claim 10, where

includes

where Y is selected from N and CR ₂₁ ; and R ₁₆ , R ₂₁ and R _{22 are} independently selected from hydrogen and optionally substituted lower alkyl; 28. At least one chemical entity of claim 10, wherein D is —NHR ₉ , wherein R _{9 is} selected from optionally substituted aryl and optionally substituted heteroaryl. 29. At least one chemical object according to claim 10, where D is —N (H) -B-L-G, where In selected from optionally substituted phenylene, optionally substituted pyridylidene, optionally substituted 2-oxo-1,2-dihydropyridinyl,

and

where * indicates the point of joining the -LG group and intermittent

shows the point of attachment to the amino group; X _{1 is} selected from N and CR ₃₁ ; X _{2 is} selected from N and CR ₃₁ ; and X _{3 is} selected from N and CR ₃₁ ; and where not more than one of X ₁ , X ₂ and X ₃ represents N, R _{30 is} selected from hydrogen, hydroxy, piano, halogen, optionally substituted lower alkyl, and optionally substituted lower alkoxy; R _{31 is} selected from hydrogen, hydroxy, cyano, halogen, optionally substituted lower alkyl, and optionally substituted lower alkoxy; L is selected from optionally substituted C ₀ -C ₄ alkylene, -O-optionally substituted C ₀ -C ₄ alkylene, - (C ₀ -C ₄ alkylene) (SO) -, - (C ₀ -C ₄ alkylene) (SO ₂ ) - and - (C ₀ -C ₄ alkylene) (C = O) -; and G is selected from hydrogen, halogen, hydroxy, alkoxy, nitro, optionally substituted alkyl, optionally substituted amino, optionally substituted carbamimidoyl, optionally substituted heterocycloalkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl. 30. At least one chemical object according to clause 29, comprising a compound of formula 4:

31. At least one chemical object according to clause 29, comprising a compound of formula 5:

32. At least one chemical entity according to claim 30, comprising a compound of formula 6:

where R ₄ selected from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy. 33. At least one chemical object according to p. 31, comprising a compound of formula 7:

where R ₄ selected from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy. 34. At least one chemical entity according to any one of claims 29 to 33, wherein B is selected from ortho-phenylene, meta-phenylene, para-phenylene, ortho-pyridylidene, meta-pyridylidene, para-pyridylidene,

and

35. At least one chemical entity according to claim 34, wherein B is selected from para-phenylene and meta-phenylene. 36. At least one chemical entity according to claim 35, wherein B is meta-phenylene. 37. At least one chemical object according to claim 34, wherein B is selected from

and

38. At least one chemical entity of claim 10, wherein R ₁₂ , R ₁₃ , R _14, and R _{15 are} each independently selected from hydrogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, and phenyl. 39. At least one chemical entity according to claim 38, wherein R _{13 is} selected from hydrogen and C ₁ -C ₆ alkyl. 40. At least one chemical object according to claim 10, where R is selected from phenyl, substituted phenyl selected from mono-, di- and trisubstituted phenyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfanyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or several halogen atoms, lower alkyl, substituted hydroxy, lower alkyl, substituted lower alkoxy, optionally substituted piperidinyl and heteroaryl, pyridyl substituted pyridyl selected from mono-, di- and trisubstituted pyridyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, pyrimidinyl, substituted pyrimidinyl selected from mono-, di- and trisubstituted pyridyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, pyrazinyl substituted pyrazinyl selected from mono-, di- and trisubstituted pyridyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, pyridazinyl, substituted pyridazinyl selected from mono-, di- and trisubstituted pyridyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, oxazol-2-yl, substituted oxazol-2-yl selected from mono-, di- and trisubstituted oxazol-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, 2H-pyrazol-3-yl, substituted 2H-pyrazol-3-yl selected from mono-, di- and trisubstituted 2H-pyrazol-3-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, [1,2,3] thiadiazol-4-yl, substituted [1,2,3] thiadiazol-4-yl selected from mono-, di- and trisubstituted [1,2,3] thiadiazol-4-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, isoxazol-5-yl, substituted isoxazol-5-yl selected from mono-, di- and trisubstituted isoxazol-5-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl, substituted 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl selected from mono-, di- and trisubstituted 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, 4,5,6,7-tetrahydrobenzofuran-2-yl, substituted 4,5,6,7-tetrahydrobenzofuran-2-yl selected from mono-, di- and trisubstituted 4,5,6,7-tetrahydrobenzofuran-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, 4,5,6,7-tetrahydro-1H-indol-2-yl, substituted 4,5,6,7-tetrahydro-1H-indol-2-yl selected from mono-, di- and trisubstituted 4,5,6,7-tetrahydro-1H-indol-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, and where the nitrogen atom of the amino group of the indole ring is optionally substituted by an optionally substituted lower alkyl group, 1H-indol-2-yl, substituted 1H-indol-2-yl selected from mono-, di- and trisubstituted 1H-indol-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, and where the nitrogen atom of the amino group of the indole ring is optionally substituted by an optionally substituted lower alkyl group, benzofuran-2-yl, substituted benzofuran-2-yl selected from mono-, di- and trisubstituted benzofuran-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, benzo [b] thiophen-2-yl and substituted benzo [b] thiophen-2-yl selected from mono-, di- and trisubstituted benzo [b] thiophen-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl. 41. At least one chemical entity according to claim 40, wherein R is selected from phenyl, substituted phenyl selected from mono-, di- and trisubstituted phenyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, pyridyl substituted pyridyl selected from mono-, di- and trisubstituted pyridyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, oxazol-2-yl, substituted oxazol-2-yl selected from mono-, di- and trisubstituted oxazol-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, 2H-pyrazol-3-yl, substituted 2H-pyrazol-3-yl selected from mono-, di- and trisubstituted 2H-pyrazol-3-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl, substituted 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl selected from mono-, di- and trisubstituted 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, [1,2,3] thiadiazol-4-yl, substituted [1,2,3] thiadiazol-4-yl selected from mono-, di- and trisubstituted [1,2,3] thiadiazol-4-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl, isoxazol-5-yl and substituted isoxazol-5-yl selected from mono-, di- and trisubstituted isoxazol-5-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl. 42. At least one chemical entity according to paragraph 41, wherein R is selected from 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl and substituted 4,5,6,7-tetrahydrobenzo [b] thiophene 2-yl selected from mono-, di- and trisubstituted 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy and heteroaryl. 43. At least one chemical entity according to claim 42, wherein R is selected from 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl and substituted 4,5,6,7-tetrahydrobenzo [b] thiophene 2-yl selected from mono-, di- and trisubstituted 4,5,6,7-tetrahydrobenzo [b] thiophen-2-yl, where the substituent is lower alkyl. 44. At least one chemical entity according to claim 43, wherein R is substituted phenyl selected from mono-, di- and trisubstituted phenyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfanyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or more halogen atoms, lower alkyl, substituted by hydroxy, lower alkyl, substituted by lower alkoxy, optionally substituted piperidinyl and goethe oarila. 45. At least one chemical entity according to claim 44, wherein R is substituted phenyl selected from mono-, di- and trisubstituted phenyl, where the substituents are independently selected from hydroxy, lower alkyl, sulfonyl, halogen, lower alkoxy, optionally substituted piperidinyl and heteroaryl. 46. At least one chemical entity according to claim 45, wherein R is 4-lower alkyl phenyl. 47. At least one chemical entity according to claim 46, wherein R is 4-tert-butylphenyl. 48. At least one chemical entity according to claim 46, wherein R is 4-iso-propylphenyl. 49. At least one chemical entity according to claim 45, wherein R is phenyl substituted with optionally substituted piperidinyl. 50. At least one chemical entity according to claim 32, comprising a compound of formula 8:

and where X is selected from N and CH; U is selected from N and CR ₄₁ ; R _{41 is} selected from hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, hydroxy, nitro, cyano, sulfhydryl, sulfanyl, sulfinyl, sulfonyl, carboxy, aminocarbonyl and optionally substituted amino; and R _{5 is} selected from hydrogen, hydroxy, lower alkyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or more halogen atoms, lower alkyl, substituted hydroxy, optionally substituted heterocycloalkyl and optionally substituted heteroaryl. 51. At least one chemical entity according to claim 33, comprising a compound of formula 9:

and where X is selected from N and CH; U is selected from N and CR ₄₁ ; R _{41 is} selected from hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, hydroxy, nitro, cyano, sulfhydryl, sulfanyl, sulfinyl, sulfonyl, carboxy, aminocarbonyl and optionally substituted amino; R _{5 is} selected from hydrogen, halogen, hydroxy, lower alkyl, sulfanyl, sulfonyl, optionally substituted amino, lower alkoxy, cycloalkyl, optionally substituted heterocycloalkyl, lower alkyl, substituted hydroxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted one or more halogen atoms, lower alkyl, substituted hydroxy, and optionally substituted heteroaryl. 52. At least one chemical entity according to any one of claims 29-51, wherein L is selected from optionally substituted C ₀ -C ₄ alkylene, -O-optionally substituted C ₀ -C ₄ alkylene, - (C ₀ -C ₄ alkylene) (SO ₂ ) - and - (C ₀ -C ₄ alkylene) (C = O) -. 53. At least one chemical object according to paragraph 52, where L is selected from a covalent bond, - (C = O) -, -CH ₂ -, -CH ₂ (C = O) -, -SO ₂ - and -CH (CH ₃ ) (C = O) -. 54. At least one chemical entity according to claim 53, wherein L is selected from - (C = O) -, —CH ₂ -, —CH ₂ (C = O) -, —SO ₂ -, and —CH (CH ₃ ) (C = O) -. 55. At least one chemical entity according to claim 50, comprising a compound of formula 10:

Where f is selected from 0, 1 and 2. 56. At least one chemical entity according to claim 55, comprising a compound of formula 11:

57. At least one chemical entity according to paragraph 51, comprising a compound of formula 12:

Where f is selected from 0, 1 and 2. 58. At least one chemical entity according to claim 57, comprising a compound of formula 13:

59. At least one chemical entity according to any one of claims 54-58, wherein the group GC (O) - (CH ₂ ) _{f is} attached at the 3-position of the ring. 60. At least one chemical entity according to any one of claims 54-58, wherein the group GC (O) - (CH ₂ ) _{f is} attached at the 4-position of the ring. 61. At least one chemical object according to clause 29, where G is selected from hydrogen hydroxy —NR ₇ R ₈ where R ₇ and R _{8 are} independently selected from hydrogen, optionally substituted acyl and optionally substituted (C ₁ -C ₆ ) alkyl; or where R ₇ and R _8, together with the nitrogen atom to which they are attached, form an optionally substituted 5-7 membered nitrogen-containing heterocycloalkyl, which optionally further includes one or two additional heteroatoms selected from N, O and S; optionally substituted 5,6-dihydro-8H-imidazo [1,2-a] pyrazin-7-yl, lower alkoxy, and 1H-tetrazol-5-yl. 62. At least one chemical entity according to claim 61, wherein G is selected from hydrogen hydroxy N-methylethanolamine, optionally substituted morpholin-4-yl, optionally substituted piperazin-1-yl; and optionally substituted homopiperazin-1-yl. 63. At least one chemical entity according to claim 62, wherein G is selected from hydrogen morpholin-4-yl, 4-acylpiperazin-1-yl, 4-lower alkylpiperazin-1-yl, 3-oxopiperazin-1-yl, homopiperazin-1-yl and 4-lower alkyl-homopiperazin-1-yl. 64. At least one chemical entity according to claim 55, comprising a compound of formula 14:

where R ₇ and R _{8 are} independently selected from hydrogen and optionally substituted (C ₁ -C ₆ ) alkyl; or R ₇ and R _8, together with the nitrogen atom to which they are bonded, form an optionally substituted 5-7 membered nitrogen-containing heterocycloalkyl, which optionally also includes one or two additional heteroatoms selected from N, O and S. 65. At least one chemical entity according to claim 57, comprising a compound of formula 15:

where R ₇ and R _{8 are} independently selected from hydrogen and optionally substituted (C ₁ -C ₆ ) alkyl; or R ₇ and R _8, together with the nitrogen atom to which they are bonded, form an optionally substituted 5-7 membered nitrogen-containing heterocycloalkyl, which optionally also includes one or two additional heteroatoms selected from N, O and S. 66. At least one chemical entity according to claim 64 or 65, wherein R ₇ and R _8, together with the nitrogen atom to which they are bonded, form a 5-7 membered nitrogen-containing heterocycloalkyl selected from optionally substituted morpholin-4-yl and optionally substituted piperazin-1-yl. 67. At least one chemical entity according to claim 66, wherein R ₇ and R _8, together with the nitrogen atom to which they are bonded, form a 5-7 membered nitrogen-containing heterocycloalkyl selected from morpholin-4-yl, 4-acylpiperazin- 1-yl and 4-lower alkylpiperazin-1-yl. 68. At least one chemical object according to clause 29, comprising a compound of formula 16:

where X is selected from N and CH; R _{5 is} selected from hydrogen, hydroxy, lower alkyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or more halogen atoms, lower alkyl, substituted hydroxy, optionally substituted heterocycloalkyl and optionally substituted heteroaryl; R _{4 is} selected from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy; R _{16 is} selected from hydrogen, cyano, optionally substituted cycloalkyl and optionally substituted lower alkyl; and R _{22 is} selected from hydrogen and optionally substituted lower alkyl. 69. At least one chemical object according to clause 29, comprising a compound of formula 17:

where X is selected from N and CH; R _{5 is} selected from hydrogen, hydroxy, lower alkyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or more halogen atoms, lower alkyl, substituted hydroxy, optionally substituted heterocycloalkyl and optionally substituted heteroaryl; R _{4 is} selected from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy; R _{16 is} selected from hydrogen, cyano, optionally substituted cycloalkyl and optionally substituted lower alkyl; and R _{22 is} selected from hydrogen and optionally substituted lower alkyl. 70. At least one chemical object according to clause 29, comprising a compound of formula 18:

where X is selected from N and CH; R _{5 is} selected from hydrogen, hydroxy, lower alkyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or more halogen atoms, lower alkyl, substituted hydroxy, optionally substituted heterocycloalkyl and optionally substituted heteroaryl; R _{4 is} selected from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy; R _{16 is} selected from hydrogen, cyano, optionally substituted cycloalkyl and optionally substituted lower alkyl and R _{22 is} selected from hydrogen and optionally substituted lower alkyl. 71. At least one chemical object according to clause 29, comprising a compound of formula 19:

where X is selected from N and CH; R _{5 is} selected from hydrogen, hydroxy, lower alkyl, sulfonyl, optionally substituted amino, lower alkoxy, lower alkyl, substituted by one or more halogen atoms, lower alkoxy, substituted by one or more halogen atoms, lower alkyl, substituted hydroxy, optionally substituted heterocycloalkyl and optionally substituted heteroaryl; R _{4 is} selected from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halogen and hydroxy; R _{16 is} selected from hydrogen, cyano, optionally substituted cycloalkyl and optionally substituted lower alkyl; and R _{22 is} selected from hydrogen and optionally substituted lower alkyl. 72. At least one chemical entity according to any one of claims 68-71, wherein L is a covalent bond and G is hydrogen. 73. At least one chemical entity according to claim 55, where f is 0. 74. At least one chemical object according to item 50, where U represents CR ₄₁ . 75. At least one chemical entity according to claim 50, wherein R _{5 is} selected from hydrogen, optionally substituted piperidinyl and lower alkyl. 76. At least one chemical entity according to claim 75, wherein R _{5 is} selected from hydrogen, optionally substituted piperidinyl, isopropyl and tert-butyl. 77. At least one chemical entity according to claim 75, wherein R ₅ is tert-butyl. 78. At least one chemical entity according to claim 30, wherein R _{22 is} selected from hydrogen and methyl. 79. At least one chemical entity according to claim 78, wherein R ₂₂ is hydrogen. 80. At least one chemical object according to claim 10, where at least one chemical object has an IC ₅₀ value of 10 μm or less in an in vitro biochemical analysis of Btk activity. 81. At least one chemical object according to claim 80, wherein at least one chemical object has an IC ₅₀ value of 1 μm or less in an in vitro biochemical analysis of Btk activity. 82. At least one chemical object according to Claim 81, wherein at least one chemical object has an IC ₅₀ value of 0.1 μm or less in an in vitro biochemical analysis of Btk activity. 83. At least one chemical entity of claim 10, wherein the at least one chemical entity has an IC _{50 of} 10 μm or less in the assay for inhibiting B cell activity. 84. At least one chemical entity according to Claim 83, wherein the at least one chemical entity has an IC ₅₀ value of 1 μm or less in an assay for inhibiting B cell activity. 85. At least one chemical entity according to Claim 84, wherein the at least one chemical entity has an IC _{50 of} 500 nm or less in the assay for inhibiting B cell activity. 86. At least one chemical object according to claim 10, where at least one chemical object has an IC ₅₀ value of at least 3 times greater than the IC ₅₀ value in an assay for inhibiting T cell proliferation, which indicates at least one chemical entity in the assay for inhibiting B cell proliferation. 87. At least one chemical object according to claim 86, wherein at least one chemical object has an IC ₅₀ value of at least 5 times greater than the IC ₅₀ value in the assay for inhibiting T cell proliferation, which indicates at least one chemical entity in the assay for inhibiting B cell proliferation. 88. At least one chemical object according to Claim 87, wherein at least one chemical object has an IC ₅₀ value of at least 10 times greater than the IC ₅₀ value of the T ₅₀ cell proliferation inhibition assay, which indicates at least one chemical entity in the assay for inhibiting B cell proliferation. 89. At least one chemical entity of claim 10, wherein the at least one chemical entity has an IC ₅₀ value of 10 μm or less in a B-ALL cell survival assay. 90. At least one chemical entity of claim 10, wherein the compound of formula 1 is selected from the following compounds: 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4- (morpholin-4-carbonyl) phenylamino] -6-oxo-1,6-dihydropyridin-3-yl} phenyl )benzamide; 4- {5- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino} benzoic acid; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -6-oxo-1,6-dihydropyridin-3-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4- (N-methylethanolamine-2-carbonyl) phenylamino] -6-oxo-1,6-dihydropyrazin-3-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4 - ([1,4] oxazepan-4-carbonyl) phenylamino] -6-oxo-1,6-dihydropyridine- 3-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {5- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -1-methyl-6-oxo-1,6-dihydropyridin-3-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4- (morpholin-4-carbonyl) phenylamino] -6-oxo-1,6-dihydropyridin-3-yl} phenyl )benzamide; 4- {5- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino} benzoic acid; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -6-oxo-1,6-dihydropyridin-3-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4- (N-methylethanolamine-2-carbonyl) phenylamino] -6-oxo-1,6-dihydropyrazin-3-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {1-methyl-5- [4 - ([1,4] oxazepan-4-carbonyl) phenylamino] -6-oxo-1,6-dihydropyridine- 3-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {5- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -1-methyl-6-oxo-1,6-dihydropyridin-3-yl} -2- methylphenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid ethyl ester; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methyl- [1,4] diazepan-1-carbonyl) phenylamino] -5-oxo-4, 5-dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {4-methyl-6- [4- (2-hydroxyethylmethylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-ethyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-ethyl-6- [4- (N-methylethanolamine-2-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (methylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-fluorophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4,5-dimethyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-fluorobenzoic acid; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (methylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl) -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (2-hydroxyethylmethylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (1H-indazol-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {3- [6- (1H-indazol-5-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {6- [3-fluoro-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (1H-imidazol-2-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-methanesulfonylaminocarbonylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {4-methyl-6- [4- (3-aminopropylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1H-imidazol-2-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (thiomorpholine-4-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-114-thiomorpholine-4-carbonyl) phenylamino] -4,5-dihydropyrazine -2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-sulfamoylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-5-oxo-6- (4-sulfamoylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (1H-tetrazol-5-yl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid ethyl ester; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methyl- [1,4] diazepan-1-carbonyl) phenylamino] -5-oxo-4, 5-dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {4-methyl-6- [4- (2-hydroxyethylmethylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-ethyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-ethyl-6- [4- (N-methylethanolamine-2-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (methylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-fluorophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4,5-dimethyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-fluorobenzoic acid; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (methylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (2-hydroxyethylmethylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (1H-indazol-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {3- [6- (1H-indazol-5-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {6- [3-fluoro-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (1H-imidazol-2-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (5- {6- [4- (1H-imidazol-2-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-methanesulfonylaminocarbonylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {4-methyl-6- [4- (3-aminopropylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1H-imidazol-2-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (thiomorpholine-4-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholine-4-carbonyl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-sulfamoylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-5-oxo-6- (4-sulfamoylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-methyl-5- [4-methyl-5-oxo-6- (4-sulfamoylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (1H-tetrazol-5-yl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) phenyl] -4,5-dimethyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (3- {3,4-dimethyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [3- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (N, N-bis- (2-hydroxyethyl) aminocarbonyl) phenylamino] -5-oxo-4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N, N-bis- (2-hydroxyethyl) aminocarbonyl) phenylamino] -5-oxo-4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1H-tetrazol-5-yl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzenesulfinic acid morpholin-4-yl ester; N- {3- [6- (1H-benzoimidazol-5-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4-morpholin-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (2-cyano-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- {3- [6- (6-hydroxypyridin-3-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (4-ethylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (3-oxopiperazin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N-methyl-N- (cyanomethyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 4-tert-butyl-N- (6- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} pyridin-2-yl )benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (2-methoxyethyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine-2- silt} phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (2-dimethylaminoethyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine-2- silt} phenyl) benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-6- (4-morpholin-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4-oxazol-2-yl-phenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-6- (4-oxazol-2-yl-phenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {3- [6- (4-imidazol-1-yl-phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methyl-phenyl} benzamide; 4-tert-butyl-N- {2-fluoro-3- [6- (4-imidazol-1-yl-phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (N, N-bis- (2-methoxyethyl) aminocarbonyl) phenylamino] -5-oxo-4,5- dihydropyrazin-2-yl} phenyl) benzamide; N- (3- {6- [4- (4-acetylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert -butylbenzamide; N- (3- {6- [4- (4-acetylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) -4-tert -butylbenzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (thiomorpholine-4-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-bromo-N- (2-fluoro-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholine-4-carbonyl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4- (1-hydroxy-1-methylethyl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine -2-yl} phenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-thiomorpholin-4-yl-phenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {3- [6- (4-imidazol-1-ylmethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-bromo-N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4 - ([1,4] oxazepan-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-fluorophenyl] -3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (4-oxopiperidin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (4-hydroxymethylpiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (2-hydroxymethylmorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (N- (2,2-dimethyl- [1,3] dioxolan-4-ylmethyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert-butylthiophen- 2-carboxylic acid; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-6- (4-morpholin-4-yl-phenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (N- (2- (2-hydroxyethoxy) ethyl) aminocarbonyl) phenylamino] -5-oxo-4,5 -dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- {2-fluoro-3- [6- (4-imidazol-1-ylmethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4 - ([1,4] oxazepan-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (N- (2,3-dihydroxypropyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-5-oxo-6- (4-thiomorpholin-4-ylmethylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (4-hydroxymethylpiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (2-hydroxymethylmorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-5-oxo-6- (4-thiomorpholin-4-yl-phenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butylcyclohexanecarboxylic acid (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide ; 4-tert-butyl-N- (3- {4-ethyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2- silt} -2-methylphenyl) benzamide; 4-dimethylamino-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (4-oxo-4H-pyridin-1-yl) phenylamino] -4,5-dihydropyrazine -2-yl} phenyl) benzamide; 4-isopropyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin- 2-yl} phenyl) benzamide; 4- (1-hydroxy-1-methylethyl) -N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino ] -4,5-dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-5-oxo-6- (4-pyrrolidin-1-ylmethylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (2-hydroxymethylmorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-ylmethyl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4-N- (2-methoxyethyl) -N-methylaminocarbonylphenylamino] -5-oxo-4,5-dihydropyrazine-2- silt} phenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) nicotinamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2,4-difluorophenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (4-methoxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N-methyl-N-ethylaminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyrrolidin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl) phenyl )benzamide; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -3-phenylacrylamide; N- (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -3- (3 -fluorophenyl) acrylamide; (2-fluoro-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide benzo [b] thiophene- 2-carboxylic acid; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide benzo [b] thiophene- 2-carboxylic acid; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-bromothiophen-2- carboxylic acid; (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-bromothiophen-2- carboxylic acid; N- (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-methylsulfanylbenzamide; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-methylsulfanylbenzamide; 4-ethylsulfanyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; (2-Fluoro-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzofuran-2-carboxylic acid amide ; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4,5-dibromothiophen- 2-carboxylic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [6- (1-oxo-1λ ^4- thiomorpholin-4-yl) -pyridin-3-ylamino] -4,5-dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2,6-difluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-cyclopropyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- {3- [6- (3-fluoro-4-thiomorpholin-4-yl-phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methyl-phenyl }benzamide; 4-tert-butyl-N- (3- {6- [3-fluoro-4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5- dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; 4-tert-butyl-N- (3- {6- [4- (4-methoxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (4-methanesulfonylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-fluoro-3- {6- [4- (4-methanesulfonylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4-tert-butylcyclohexanecarboxylic acid ; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4-morpholin-4-yl-phenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (ethylmethylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (ethylmethylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (2-morpholin-4-ylpyridin-4-ylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) benzo [b] thiophene-2-carboxylic acid amide; N- (3- {6- [4- (4-acetylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) -4-tert -butylbenzamide; N- (3- {6- [4- (4-acetylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert -butylbenzamide; 4-tert-butyl-N- {3- [6- (4-hydroxymethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-piperidin-1-yl-phenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-pyridin-4-yl-phenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-fluoro-3- [4-methyl-6- (4-methylaminomethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (3-ethyl-1-methylureidomethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- fluorophenyl) benzamide; 4-tert-butyl-N- (3- [6- (3-hydroxymethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (3-hydroxypyrrolidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-pyridin-3-yl-phenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- [2-fluoro-3- (6- {4 - [(methanesulfonylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) phenyl] benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-hydroxypyridin-3-yl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 1- (4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) piperidine-4-carboxylic amide acids; 4-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl ) -N-methylbenzamide; N- (3- {6- [4- (4-acetyl- [1,4] diazepan-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2 methylphenyl) -4-tert-butylbenzamide; 4-tert-butyl-N- (3- {6- [4- (4-methanesulfonyl- [1,4] diazepan-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (2-ethyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 1- (4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) piperidine-3-carbonyl amide acids; 1- (4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) pyrrolidine-2-carbonyl amide acids; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (pyridin-4-ylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-ethyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (1-hydroxypyridin-3-ylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (1-hydroxypyridin-4-ylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (1,4-dioxa-8-azaspiro [4,5] dec-8-yl) phenylamino] -4-methyl-5-oxo-4 5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-carbamimidoylmethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {4-cyclopropyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (3-dimethylaminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (pyridin-4-ylmethyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (pyridin-3-ylmethyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 6-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-hydroxypyridin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- {3- [6- (1-ethyl-2-oxo-1,2-dihydropyridin-4-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2- il] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {4-cyano-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (piperidin-4-yl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin- 2-yl} phenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (3-morpholin-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid amide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (1-ethylpiperidin-4-yl) aminocarbonyl) phenylamino] -5-oxo-4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-hydroxyphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (3-nitrophenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {3- [6- (4-methanesulfonylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; N- {3- [6- (3-aminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (piperidin-4-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- {3- [6- (3-hydroxyphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (2-pyridin-4-yl-ethyl) aminocarbonyl) phenylamino] -5-oxo-4,5- dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (2-methylthiazol-4-yl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (2-morpholin-4-ylethoxy) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) 4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid amide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) 6-methyl-4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid amide; N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) -4-piperidin-1-ylbenzamide; 6-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4-morpholin-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (3-aminophenyl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2- silt} phenyl) benzamide; N- (3- {6- [4- (4-aminopiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert -butylbenzamide; 4-tert-butyl-N- (3- {6- [4- (1-ethylpiperidin-4-yloxy) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; N- {3- [6- (Benzothiazol-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; N- (3- {6- [4- (2-aminopyridin-4-ylmethoxy) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert -butylbenzamide; 4-tert-butyl-N- [3- (6- {4- [4- (2-hydroxyethyl) piperazine-1-carbonyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazine-2- il) -2-methylphenyl] benzamide; 4-tert-butyl-N- {3- [6- (2,3-dihydrobenzo [1,4] dioxin-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4,5,6, 7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4,5,6, 7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (2-morpholin-4-yl-acetyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) 5-tert-butylpyridin-2-carboxylic acid amide; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-piperidine- 1-ylbenzamide; N- (2-fluoro-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-piperidine- 1-ylbenzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyridin-4-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyridin-4-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; 4-tert-butyl-N- [3- (6- {4- [4- (2-hydroxyethyl) piperazin-1-yl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2- il) -2-methylphenyl] benzamide; 6-tert-butyl-N- [3- (6- {4- [4- (2-hydroxyethyl) piperazin-1-yl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2- il) -2-methylphenyl] nicotinamide; N- {3- [6- (3-aminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -6-tert-butyl nicotinamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 3,4,5, 6-tetrahydro-2H- [1,2 '] bipyridinyl-5'-carboxylic acid; N- {3- [6- (2-aminopyridin-4-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N, N-bis- (2-methoxyethyl) aminocarbonyl) phenylamino] -5-oxo-4,5- dihydropyrazin-2-yl} phenyl) benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert-butylpyridin- 2-carboxylic acid; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert-butylpyridin- 2-carboxylic acid; 4-iodine-N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide ; N- {3- [6- (3-benzylaminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (2-morpholin-4-ylethoxy) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (tetrahydropyran-4-yl) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine- 2-yl} phenyl) benzamide; 4-tert-butyl-N- [2-methyl-3- (4-methyl-5-oxo-6- {4 - [(tetrahydropyran-4-ylamino) methyl] phenylamino} -4,5-dihydropyrazin-2- il) phenyl] benzamide; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-pyrrolidin- 1-ylbenzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) tetrahydrofuran-2-carboxylic acid amide; 4-tert-butyl-N- (3- {6- [3- (cyclohexanecarbonylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; N- {3- [6- (3-amino-4-fluorophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5,6-dihydro- 4H-cyclopenta [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [1- (2-morpholin-4-yl-ethyl) -2-oxo-1,2-dihydropyridin-4-ylamino] - 5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide; N- (2-methyl-3- {4-methyl-6- [4- (1-methylpiperidin-4-yloxy) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4- piperidin-1-ylbenzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 6-tert-butyl-N- (3- {6- [4- (4-ethylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) nicotinamide; 6-tert-butyl-N- [3- (6- {4- [4- (2-hydroxyethyl) piperazine-1-carbonyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazine-2- il) -2-methylphenyl] nicotinamide; 4- (6- {3 - [(6-tert-butylpyridin-3-carbonyl) amino] -2-methylphenyl} -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino) benzoic acid; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide benzo [b] thiophene- 5-carboxylic acid; 6-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methyl- [1,4] diazepan-1-carbonyl) phenylamino] -5-oxo-4, 5-dihydropyrazin-2-yl} phenyl) nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [3- (pyridin-3-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [3- (pyridin-3-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4,4-dimethylchroman- 7-carboxylic acid; 6-tert-butyl-N- (3- {6- [4- (2-hydroxymethylmorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) nicotinamide; 6-tert-butyl-N- (2-fluoro-3- {6- [4- (2-hydroxymethylmorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [3- (pyridin-4-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [3- (pyridin-4-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; 6-tert-butyl-N- (3- {6- [4- (2-hydroxymethylmorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) nicotinamide; 6-tert-butyl-N- (2-fluoro-3- {6- [4- (2-hydroxymethylmorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 6-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (4-methyl- [1,4] diazepan-1-carbonyl) phenylamino] -5-oxo-4, 5-dihydropyrazin-2-yl} phenyl) nicotinamide; 6-tert-butyl-N- (3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) nicotinamide; 6-tert-butyl-N- (2-fluoro-3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4-nitrophenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; N- {3- [6- (4-aminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; N- (3- {6- [4- (4-aminopiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -6-tert -butyl nicotinamide; 4- (6- {3 - [(6-tert-butylpyridin-3-carbonyl) amino] -2-fluorophenyl} -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino) benzoic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyridin-3-ylmethoxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyridin-3-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyridin-3-yloxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (piperazin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; 6-tert-butyl-N- [2-fluoro-3- (6- {4- [4- (2-hydroxyethyl) piperazin-1-yl] phenylamino} -4-methyl-5-oxo-4,5- dihydropyrazin-2-yl) phenyl] nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-yl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (4-ethylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (N- (hydroxy) aminocarbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide; N- {3- [6- (3-aminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-piperidin-1-ylbenzamide; 6-tert-butyl-N- [3- (6- {4 - [(2-hydroxyethyl) methylcarbamoyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl ] nicotinamide; 6-tert-butyl-N- (3- {6- [4- (cyanomethylmethylcarbamoyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) nicotinamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (3-oxopiperazin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; N- (3- {6- [4- (4-ethylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-piperidine -1-ylbenzamide; 6-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-yl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 6-tert-butyl-N- (3- {6- [4- (4-ethylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2- methylphenyl) nicotinamide; N- {2-methyl-3- [4-methyl-6- (4-morpholin-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} -4-piperidin-1-ylbenzamide ; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (N- (1-aminoethylidene)) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- {3- [6- (3-cyclopropylaminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (3-piperidin-1-ylmethylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- [3- (6- {3 - [(cyanomethylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide ; 1- (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzyl) piperidine-4-carboxylic amide acids; 4-tert-butyl-N- {3- [6- (3 - {[(2-hydroxyethyl) methylamino] methyl} phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] - 2-methylphenyl} benzamide; 4-tert-butyl-N- [3- (6- {3 - [(2-hydroxyethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl ]benzamide; 4-tert-butyl-N- (3- {6- [3- (4-hydroxypiperidin-1-ylmethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [3- (2-hydroxymethylmorpholin-4-ylmethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; (4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) amidetetrahydrofuran-2-carboxylic acid; (4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) amidetetrahydrofuran-3-carboxylic acid; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 3,4,5, 6-tetrahydro-2H- [1,3 '] bipyridinyl-6'-carboxylic acid; 6-tert-butyl-N- (2-fluoro-3- {4-methyl-5-oxo-6- [4- (piperazin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2 methylphenyl) -4-piperidin-1-ylbenzamide; 6-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-fluorophenyl) nicotinamide; (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 2-tert-butylpyrimidine- 5-carboxylic acid; 6-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (pyridin-3-ylmethoxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl ) nicotinamide; N- (3- {6- [4- (4-aminopiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) -6-tert -butyl nicotinamide; 6-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert-butylpyrazine- 2-carboxylic acid; 6-tert-butyl-N- (2-fluoro-3- {6- [4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-yl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4- piperidin-1-ylbenzamide; N- (3- {6- [4- (4-ethylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-piperidine -1-ylbenzamide; 6-tert-butyl-N- (2-fluoro-3- {4-methyl-6- [4- (4-methylpiperazin-1-yl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) nicotinamide; 6-tert-butyl-N- (3- {6- [4- (4-ethylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- fluorophenyl) nicotinamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (4-oxopiperidin-1-yl) phenylamino] -4,5-dihydropyrazin-2-yl } phenyl) benzamide; N- (3- {6- [4- (3-aminopropylcarbamoyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) -6-tert-butylnicotinamide; N- (3- {6- [4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-piperidine -1-ylbenzamide; 6-tert-butyl-N- (3- {6- [4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) nicotinamide; 4-azepan-1-yl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; (2-fluoro-3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert- butyl pyridine-2-carboxylic acid; N- {3- [5- (3-aminophenylamino) -1-methyl-6-oxo-1,6-dihydropyridin-3-yl] -2-methylphenyl} -4-tert-butylbenzamide; (3- {5- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino} phenyl) amidetetrahydrofuran-2-carboxylic acid; 4-tert-butyl-N- {3- [1,4-dimethyl-5- (4-morpholin-4-ylphenylamino) -6-oxo-1,6-dihydropyridin-3-yl] -2-methylphenyl} benzamide ; 4-tert-butyl-N- (3- {5- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -1-methyl-6-oxo-1,6-dihydropyridine- 3-yl} -2-methylphenyl) benzamide; 6-tert-butyl-N- (3- {6- [4- (carbamoylmethylmethylcarbamoyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) nicotinamide; 6-tert-butyl-N- {3- [6- (4-hydroxycarbamoylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} nicotinamide; (3- {6- [4- (4-ethylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-tert-butylpyridine -2-carboxylic acid; N- (3- {6- [4- (4-aminopiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert -butylbenzamide; 4- {6- [3- (4- (1-piperidinyl) benzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzohydroxamic acid; (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl ) 5-tert-butylpyridin-2-carboxylic acid amide; (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert- butylpyrazine-2-carboxylic acid; (3- {6- [4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-tert-butylpyridine -2-carboxylic acid; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4- (4 methylpiperidin-1-yl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (5-methyl-1H-pyrazol-3-ylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; (3- {6- [4- (2-hydroxymethylmorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-tert-butylpyridine -2-carboxylic acid; N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (3-oxopiperazin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) -4- piperidin-1-ylbenzamide; 4- (1-piperidinyl) -N- (3- {4-methyl-6- [4- (2-hydroxyethylmethylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (1H-pyrazol-3-ylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; N- (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) isonicotinamide; (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl ) 5-tert-butylpyrazine-2-carboxylic acid amide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-fluorophenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) tetrahydrofuran-2-carboxylic acid amide; (3- {6- [4- (carbamoylmethylmethylcarbamoyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-tert-butylpyridin-2-carboxylic acid; (3- {6- [4- (carbamoylmethylmethylcarbamoyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4,5,6,7-tetrahydrobenzo [b ] thiophene-2-carboxylic acid; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4- (3 methylpiperidin-1-yl) benzamide; N- {3- [6- (3-acetylaminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) tetrahydrofuran-3-carboxylic acid amide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) thiazole-4-carboxylic acid amide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) carbamic acid ethyl ester; 4-tert-butyl-N- (3- {6- [3- (2-methoxyacetylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert-butylpyrimidine- 2-carboxylic acid; 4- (isopropylmethylamino) -N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- (2-methyl-3- {6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-ylmethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl} -2-methylphenyl) benzamide; N- [2-methyl-3- (4-methyl-5-oxo-6- {4 - [(tetrahydropyran-4-ylamino) methyl] phenylamino} -4,5-dihydropyrazin-2-yl) phenyl] -4 piperidin-1-ylbenzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-ylmethyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (4-ethylpiperazin-1-ylmethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (4 - {[(2-hydroxyethyl) methylamino] methyl} phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] - 2-methylphenyl} benzamide; N- [3- (6- {4- [4- (2-hydroxyethyl) piperazine-1-carbonyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl ] -4-piperidin-1-ylbenzamide; 1- (4- {4-methyl-6- [2-methyl-3- (4-piperidin-1-ylbenzoylamino) phenyl] -3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) piperidine amide 4-carboxylic acid; (3- {6- [4- (4-aminopiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-tert-butylpyrazine -2-carboxylic acid; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4- (4 methylpiperazin-1-ylmethyl) benzamide; 4-tert-butyl-N- [2-fluoro-3- (4-methyl-6- {3- [2- (4-methylpiperazin-1-yl) acetylamino] phenylamino} -5-oxo-4,5- dihydropyrazin-2-yl) phenyl] benzamide; N- {3- [6- (3-aminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-fluorophenyl} -4-tert-butylbenzamide; N- {3- [6- (3-aminophenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (piperazin-1-carbonyl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) amide 5-tert-butylpyridine- 2-carboxylic acid; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) amide tetrahydrofuran-2-carboxylic acid; [3- (6- {2-methyl-3 - [(4,5,6,7-tetrahydrobenzo [b] thiophen-2-carbonyl) amino] phenyl} -3-oxo-3,4-dihydropyrazine-2- amylamino) phenyl] tetrahydrofuran-2-carboxylic acid amide; (5- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-fluorophenyl) amide tetrahydrofuran-2- carboxylic acid; 3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl ester of acetic acid; N- (2-methyl-3- {6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-piperidin-1-ylbenzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-2-ylmethoxy) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl )benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 6-tert-butylpyridazin- 3-carboxylic acid; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (3-oxo-3,4-dihydro-2H-benzo [1,4] oxazin-6-ylamino ) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-imidazol-1-yl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- (3- {6- [3- (3-methoxypropionylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) furan-2-carboxylic acid amide; 6-tert-butyl-N- (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) nicotinamide; 4-tert-butyl-N- [3- (6- {4- [2- (4-ethylpiperazin-1-yl) ethoxy] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2- il) -2-methylphenyl] benzamide; tetrahydrofuran-3-yl ester (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) carbamic acid ; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) tetrahydrofuran-2-carboxylic acid amide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) tetrahydrofuran-2-carboxylic acid amide; N- {3- [6- (5-aminopyridin-3-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- {3- [6- (1H-indol-5-ylamino) -5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) pyrrolidine-2-carboxylic acid amide; 4-tert-butyl-N- (3- {6- [3- (2-hydroxyacetylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- [3- (6-cyclopropylamino-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide; 4-tert-butyl-N- [3- (6-hydroxy-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide; 4-tert-butyl-N- (3- {6- [3- (2-ethoxyacetylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; N- {3- [6- (3-amino-4-methylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- (3- {6- [4- (4-hydroxymethylpiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [3- (2-hydroxy-2-methylpropionylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) tetrahydropyran-4-carboxylic acid amide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (4-thiomorpholin-4-ylmethylphenylamino) -4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4- (4-hydroxypiperidin-1-yl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine -2-yl} phenyl) benzamide; N- {3- [6- (3-amino-4-chlorophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4 tert-butylbenzamide; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4- (2 methylpiperidin-1-yl) benzamide; (3- {6- [4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl ) amide 4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- {3- [6- (3-dimethylaminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (piperidin-4-ylmethoxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; 4-tert-butyl-N- [3- (6- {4 - [(2-hydroxyethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl ]benzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) carbamic acid phenyl ester; 4-tert-butyl-N- {3- [6- (4-cyclopropylaminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- [3- (6- {4 - [(carbamoylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide ; 4- (4-methoxymethoxypiperidin-1-yl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine -2-yl} phenyl) benzamide; N- (3- {6- [3- (2-aminoacetylamino) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; (3- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) azetidine-2-carboxylic acid amide; (5- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-methylphenyl) amide tetrahydrofuran-2- carboxylic acid; 4-tert-butyl-N- (3- {6- [4- (4-hydroxy-4-methylpiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } -2-methylphenyl) benzamide; 1-methyl-3- [4- (morpholin-4-carbonyl) phenylamino] -5- (2-phenylbenzooxazol-7-yl) -1H-pyrazin-2-one; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (1-methylpiperidin-2-ylmethoxy) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 5- [2- (4-methoxyphenyl) benzooxazol-7-yl] -1-methyl-3- [4- (morpholin-4-carbonyl) phenylamino] -1H-pyrazin-2-one; 4-tert-butyl-N- {3- [6- (1H-indol-5-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; N- {3- [6- (3-aminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- (3- {6- [4- (1-ethylpiperidin-4-ylmethoxy) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2- methylphenyl) benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (1-pyridin-4-ylmethyl-1H-indol-6-ylamino) -4,5-dihydropyrazin- 2-yl] phenyl} benzamide; 4-furan-2-yl-N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4- (2-methoxy-1,1-dimethylethyl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5 -dihydropyrazin-2-yl} phenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (4-hydroxy-4-methylpiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {6- [4- (4-hydroxy-4-methylpiperidin-1-ylmethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } -2-methylphenyl) benzamide; {3- [6- (3-aminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} amide 6-methyl-4,5,6,7-tetrahydrobenzo [ b] thiophene-2-carboxylic acid; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-hydroxybenzoic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) -3-nitrophenylamino] -5-oxo-4,5-dihydropyrazine-2- silt} phenyl) benzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 5-ethyl-4, 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-azetidin-1-yl-N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-3-methoxy-N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine-2 -yl} phenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-methoxybenzoic acid; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 1,4,4- trimethyl-1,2,3,4-tetrahydroquinoline-7-carboxylic acid; 4- (1-methoxy-1-methylethyl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine -2-yl} phenyl) benzamide; 4- (2,2-dimethylpropionyl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine-2 -yl} phenyl) benzamide; 4-tert-butyl-N- (3- {6- [3-methoxy-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-methoxy-N- (3-methoxypropyl )benzamide; N- {3- [6- (3-acryloylaminophenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- {3- [6- (1H-indol-4-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- [3- (6- {4 - [(2-methoxyethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl ]benzamide; 4-tert-butyl-N- {3- [6- (4-ethylaminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {3- [6- (4-diethylaminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- [3- (6- {4 - [(isopropylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide ; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [4- (2-methylpiperidin-1-ylmethyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- [2-methyl-3- (4-methyl-5-oxo-6- {4- [2- (tetrahydropyran-4-ylamino) ethyl] phenylamino} -4,5-dihydropyrazin- 2-yl) phenyl] benzamide; 5-amino-2- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N-cyclopropylbenzamide; (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl) phenyl) amide 5-amino-benzo [ b] thiophene-2-carboxylic acid; 2-amino-N- {3- [6- (benzothiazol-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-piperidin-1- ilbenzamide; 4-tert-butyl-N- [3- (6- {2 - [(2-hydroxyethyl) methylamino] pyridin-4-ylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl ) -2-methylphenyl] benzamide; 4-tert-butyl-N- (3- {6- [3-methoxy-4- (4-methylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl } -2-methylphenyl) benzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N- (2-hydroxyethyl) -2- methoxy-N-methylbenzamide; 4-tert-butyl-N- (3- {6- [3-methoxy-4- (piperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) benzamide; N- {3- [6- (3-amino-4-morpholin-4-ylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert- butylbenzamide; N- {3- [6- (4-amino-2-piperidin-1-ylmethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert- butylbenzamide; (4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzylamino) acetic acid; 4-tert-butyl-N- [3- (6- {4 - [(cyclopropylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide ; N- {3- [6- (3-amino-4-thiomorpholin-4-yl-phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methyl-phenyl} -4-tert- butylbenzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-5-oxo-6- [4- (piperidin-3-ylmethoxy) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl )benzamide; N- (3- {6- [3-amino-4- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2- yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (piperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4 tert-butylbenzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-5-oxo-6- (1,2,3,4-tetrahydroisoquinolin-6-ylamino) -4,5-dihydropyrazin-2- sludge] phenyl} benzamide; 4-tert-butyl-N- [3- (6- {4- [2- (4-ethylpiperazin-1-yl) ethyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2- il) -2-methylphenyl] benzamide; 4-tert-butyl-N- [3- (6- {4- [2- (2-hydroxyethylamino) ethyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2 methylphenyl] benzamide; 4-tert-butyl-N- {3- [6- (4- {2 - [(2-hydroxyethyl) methylamino] ethyl} phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl ] -2-methylphenyl} benzamide; 4-tert-butyl-N- (3- {6- [4- (2-diethylaminoethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N- (2-hydroxyethyl ) -N-methylbenzamide; 4- [2- (2-methoxyethoxy) -1,1-dimethylethyl] -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo -4,5-dihydropyrazin-2-yl} phenyl) benzamide; 4- (3-methoxymethoxypiperidin-1-yl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazine -2-yl} phenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-hydroxymethyl-3-methoxyphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {3- [6- (1H-indol-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; N- (3- {6- [3-amino-4- (4-methylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (4-ethylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; 2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N- (2-dimethylaminoethyl )benzamide; 4-tert-butyl-N- {2-methyl-3- [6- (4-morpholin-4-yl-3-nitrophenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4-morpholin-4-yl-3-nitrophenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; N- {3- [6- (3-amino-4-morpholin-4-ylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N- (2-diethylaminoethyl )benzamide; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (phenylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- (3- {4-ethyl-6- [4- (2-methylphenylcarbamoyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) benzamide; 4-tert-butyl-N- {3- [6- (4-cyclopropylaminomethyl-3-methoxyphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {3- [6- (4-cyclopropylaminomethyl-3-methoxyphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; 4-tert-butyl-N- {3- [6- (3- {2 - [(2- hydroxyethyl) methylamino] ethyl} phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} benzamide; N- (3- {6- [3-amino-4- (1-osco-1λ ⁴ -thiomorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; 4- (1-methylcyclobutyl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; N- {3- [6- (4 - {[bis- (2-hydroxyethyl) amino] methyl} phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- [3- (6- {3- [2- (2-hydroxyethylamino) ethyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2 methylphenyl] benzamide; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [3- (2-morpholin-4-yl-ethyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl } phenyl) benzamide; 4-tert-butyl-N- [3- (6- {3- [2- (1,1-dioxo-1λ ⁶ -thiomorpholin-4-yl) ethyl] phenylamino} -4-methyl-5-oxo-4 5-dihydropyrazin-2-yl) -2-methylphenyl] benzamide; 4-tert-butyl-N- [3- (6- {3- [2- (4-ethylpiperazin-1-yl) ethyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2- il) -2-methylphenyl] benzamide; N- {3- [6- (3- {2- [bis- (2-hydroxyethyl) amino] ethyl} phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2- methylphenyl} -4-tert-butylbenzamide; 4-tert-butyl-N- {3- [6- (3,4-dihydro-2H-benzo [1,4] oxazin-6-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazine- 2-yl] -2-methylphenyl} benzamide; N- (3- {6- [4- (4-aminomethyl-4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; 2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} benzoic acid; 5- (3-amino-2-methylphenyl) -1-methyl-3- (4-morpholin-4-yl-3-nitrophenylamino) -1H-pyrazin-2-one; {3- [6- (3-amino-4-morpholin-4-ylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} amide 5-tert-butylpyridin- 2-carboxylic acid; {3- [6- (3-amino-4-morpholin-4-ylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} amide 4,5,6, 7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- {3- [6- (3-amino-4-morpholin-4-ylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-piperidin- 1-ylbenzamide; N- (2-methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) -4-methylsulfanylbenzamide; N- {3- [6- (3-amino-4-cyclopropylaminomethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-methyl -4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- (3- {6- [3-amino-4- (thiomorpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4 tert-butylbenzamide; 2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N-pyridin-3- ilbenzamide; N- (5- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4 tert-butylbenzamide; 2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -N- (2-methoxyethyl ) -N-methylbenzamide; (2-Methyl-3- {4-methyl-6- [4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) octahydroisoquinoline-2-carboxylic acid amide ; N- (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -6 tert-butyl nicotinamide; N- {3- [6- (2-aminoindan-5-ylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) -4 tert-butylbenzamide; N- {3- [6- (3-amino-4-methoxyphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (4-ethylpiperazin-1-ylmethyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; 1- (2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) piperidine amide -4-carboxylic acid; N- {3- [6- (3-amino-4-morpholin-4-yl-phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-fluorophenyl} -4-tert- butylbenzamide; N- (3- {6- [3-amino-4- (4-ethylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [4- (4-aminomethyl-4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [4- (l, 1-dioxo-1λ ⁶ -thiomorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2 methylphenyl) -4-pentafluoroethylbenzamide; {2-methyl-3- [4-methyl-6- (4-morpholin-4-ylmethyl-phenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} amide 5-methyl-4,5,6 , 7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) amide 5-methyl -4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- {3- [6- (3-amino-4- [1,4] oxazepan-4-yl-phenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methyl-phenyl} -4-tert-butylbenzamide; (3- {6- [3-amino-4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5 methyl 4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- [3- (6- {3-amino-4- [4- (2-hydroxyethyl) piperazin-1-yl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] -4-tert-butylbenzamide; 4-tert-butyl-N- {3- [6- (3-methoxy-4-morpholin-4-ylmethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl }benzamide; N- (3- {6- [3-amino-4- (4-hydroxy-4-methylpiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} - 2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (2-morpholin-4-yl-ethoxy) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methyl-phenyl) -4-tert-butylbenzamide; (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4,5 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- [3- (6- {3-amino-4 - [(2-methoxyethyl) methylamino] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] - 4-tert-butylbenzamide; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-methylbenzoic acid methyl ester; 4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} -2-methylbenzoic acid; (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-fluorophenyl) amide 4,5 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (3-methyl-4-morpholin-4-yl-phenylamino) -5-oxo-4,5-dihydropyrazin-2-yl] phenyl} benzamide; (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4,5, 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; [2-methyl-3- (4-methyl-5-oxo-6- {4 - [(tetrahydropyran-4-ylamino) methyl] phenylamino} -4,5-dihydropyrazin-2-yl) phenyl] amide 5-methyl -4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4- [1,4] oxazepan-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl ] phenyl} benzamide; {3- [6- (4-hydroxymethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} amide 5-methyl-4,5,6,7-tetrahydrobenzo [ b] thiophene-2-carboxylic acid; [3- (6- {4 - [(carbamoylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] amide 5-methyl-4,5, 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-methyl-4,5 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 1- (2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) -4 hydroxypyridinium; N- [3- (6- {3-amino-4 - [(2-hydroxyethyl) methylamino] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] - 4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-piperidin-1 -ylbenzamide; N- (3- {6- [3-amino-4- (4-methylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; (2-methyl-3- {4-methyl-5-oxo-6- [4- (1-oxo-1λ ^4- thiomorpholin-4-yl) phenylamino] -4,5-dihydropyrazin-2-yl} phenyl) 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid amide; (2-methyl-3- {4-methyl-6- [4- (4-methylpiperazin-1-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} phenyl) amide 4,5, 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; [2-methyl-3- (4-methyl-5-oxo-6- {4 - [(tetrahydropyran-4-ylamino) methyl] phenylamino} -4,5-dihydropyrazin-2-yl) phenyl] amide 5-methyl -4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- {2-methyl-3- [4-methyl-6- (4- [1,4] oxazepan-4-ylmethylphenylamino) -5-oxo-4,5-dihydropyrazin-2-yl ] phenyl} benzamide; {3- [6- (4-hydroxymethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} amide 5-methyl-4,5,6,7-tetrahydrobenzo [ b] thiophene-2-carboxylic acid; [3- (6- {4 - [(carbamoylmethylamino) methyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] amide 5-methyl-4,5, 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (morpholin-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 5-methyl-4,5 6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (4-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 1- (2-amino-4- {6- [3- (4-tert-butylbenzoylamino) -2-methylphenyl] -4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino} phenyl) -4 hydroxypyridinium; N- [3- (6- {3-amino-4 - [(2-hydroxyethyl) methylamino] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] - 4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-piperidin-1 -ylbenzamide; N- (3- {6- [3-amino-4- (4-methylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; (3- {6- [3-amino-4- (4-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- (3- {6- [3-amino-4- (3-hydroxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (3-hydroxypyrrolidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- {3- [6- (3-amino-4-piperidin-1-ylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl} -4-tert- butylbenzamide; 4- (2-hydroxy-1,1-dimethylethyl) -N- (2-methyl-3- {4-methyl-6- [4- (morpholine-4-carbonyl) phenylamino] -5-oxo-4,5 -dihydropyrazin-2-yl} phenyl) benzamide; amide 1- [2-amino-4- (4-methyl-6- {2-methyl-3 - [(4,5,6,7-tetrahydrobenzo [b] thiophen-2-carbonyl) amino] phenyl} -3 -oxo-3,4-dihydropyrazin-2-ylamino) benzoyl] piperidin-4-carboxylic acid; (3- {6- [3-amino-4- (3-hydroxypyrrolidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (4-ethylpiperazin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; (3- {6- [3-amino-4- (3-hydroxypiperidin-1-carbonyl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; N- (3- {6- [3-amino-4- (4-methyl- [1,4] diazepan-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2- yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (2-hydroxymethylmorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (4-hydroxymethylpiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; amide 1- [2-amino-4- (4-methyl-6- {2-methyl-3 - [(4,5,6,7-tetrahydrobenzo [b] thiophen-2-carbonyl) amino] phenyl} -3 -oxo-3,4-dihydropyrazin-2-ylamino) phenyl] piperidine-4-carboxylic acid; (3- {6- [3-amino-4- (2-hydroxymethylmorpholin-4-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) amide 4 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; [3- (6- {3-amino-4 - [(2-hydroxyethyl) methylcarbamoyl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] amide 4, 5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid; 4-tert-butyl-N- (2-methyl-3- {4-methyl-6- [3-nitro-4- (pyridin-3-yloxy) phenylamino] -5-oxo-4,5-dihydropyrazin-2 -yl} phenyl) benzamide; N- [3- (6- {3-amino-4- [4- (2-hydroxyethyl) piperidin-1-yl] phenylamino} -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl) -2-methylphenyl] -4-tert-butylbenzamide; {2-methyl-3- [4-methyl-5-oxo-6- (pyridin-3-ylamino) -4,5-dihydropyrazin-2-yl] phenyl} amide 4,5,6,7-tetrahydrobenzo [b ] thiophene-2-carboxylic acid; 4-tert-butyl-N- {3- [6- (3-fluoro-4-morpholin-4-ylmethylphenylamino) -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl] -2-methylphenyl }benzamide; N- (3- {6- [3-amino-4- (4-methoxypiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (4-cyanopiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; amide 1- [2-amino-4- (4-methyl-6- {2-methyl-3 - [(4,5,6,7-tetrahydrobenzo [b] thiophen-2-carbonyl) amino] phenyl} -3 -oxo-3,4-dihydropyrazin-2-ylamino) phenyl] piperidine-3-carboxylic acid; N- (3- {6- [3-amino-4- (3-hydroxymethylpiperidin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide; N- (3- {6- [3-amino-4- (3-methylpiperazin-1-yl) phenylamino] -4-methyl-5-oxo-4,5-dihydropyrazin-2-yl} -2-methylphenyl) -4-tert-butylbenzamide and {2-methyl-3- [4-methyl-5-oxo-6- (pyridin-4-ylamino) -4,5-dihydropyrazin-2-yl] phenyl} amide 4,5,6,7-tetrahydrobenzo [b] thiophene-2-carboxylic acid. 91. A pharmaceutical composition comprising at least one chemical entity according to any one of claims 10-90 together with at least one pharmaceutically acceptable binder material selected from carriers, adjuvants and excipients. 92. The pharmaceutical composition according p, where the composition is in the form selected from injection liquids, aerosols, creams, gels, tablets, pills, capsules, syrups, ophthalmic solutions and transdermal patches. 93. A packaged pharmaceutical composition comprising the pharmaceutical composition of claim 91 or 92 and instructions for using the composition for treating a patient suffering from a disease associated with inhibition of Btk activity. 94. The packaged pharmaceutical composition of claim 93, wherein the disease associated with inhibition of Btk activity is cancer. 95. The packaged pharmaceutical composition of claim 93, wherein the disease associated with inhibition of Btk activity is selected from allergic disorders, autoimmune diseases, inflammatory diseases, and acute inflammatory reactions. 96. A method of treating a patient with a disease associated with inhibition of Btk activity, comprising administering to the patient an effective amount of at least one chemical entity according to any one of claims 10-90. 97. The method according to p, where the patient is a person. 98. The method according to p, where the patient is selected from cats and dogs. 99. The method according to any one of claims 96-98, wherein the disease associated with inhibition of Btk activity is cancer. 100. The method of claim 99, wherein the disease associated with inhibition of Btk activity is B-cell lymphoma and leukemia. 101. The method according to p, where the effective amount of the specified at least one chemical object is administered by a method selected from intravenous, intramuscular and parenteral. 102. The method according to p, where the effective amount of the specified at least one chemical object is administered orally. 103. A method of treating a patient with a disease selected from cancer, autoimmune diseases, inflammatory diseases, acute inflammatory reactions and allergic disorders, comprising administering to the patient an effective amount of at least one chemical object according to any one of claims 10-90. 104. The method according to p, where the patient is a person. 105. The method according to p, where the patient is selected from cats and dogs. 106. The method according to any one of paragraphs.103-105, where an effective amount of the specified at least one chemical object is administered by a method selected from intravenous, intramuscular and parenteral. 107. The method according to any one of paragraphs 103-105, where an effective amount of the specified at least one chemical object is administered orally. 108. A method of increasing the sensitivity of cancer cells to chemotherapy, comprising administering to a patient undergoing chemotherapy with a chemotherapeutic agent, an amount of at least one chemical object according to any one of claims 10-90, sufficient to increase the sensitivity of cancer cells to a chemotherapeutic agent. 109. A method of reducing medical error and increasing the therapeutic susceptibility of a patient treatable for a disease associated with inhibition of Btk activity, which comprises administering a packaged pharmaceutical preparation according to item 93, where the instructions further include information on contraindications and adverse reactions inherent in the packaged pharmaceutical composition. 110. A method of inhibiting ATP hydrolysis, which comprises contacting cells expressing Btk with at least one chemical object according to any one of claims 10-90 in an amount sufficient to detectably reduce the level of ATP hydrolysis in vitro. 111. The method of claim 110, wherein the cells are mammalian cells. 112. The method of claim 111, wherein the mammal is a human. 113. The method according to p. 111, where the mammal is selected from cats and dogs. 114. A method for determining the presence of Btk in a sample, comprising contacting the sample with at least one chemical object according to any one of paragraphs 10-90 under conditions that allow to determine the activity of Btk, by determining the level of Btk activity in the sample, and, therefore, determining the presence or absence of Btk in the sample. 115. A method of inhibiting B-cell activity, comprising contacting cells expressing Btk with at least one chemical object according to any one of claims 10-90, in an amount sufficient to detectably reduce in vitro B-cell activity.