RU2007137044A - HEMOPOESITIMULATING AND HEPATOPROTECTIVE ACTION MEDICINES - Google Patents

HEMOPOESITIMULATING AND HEPATOPROTECTIVE ACTION MEDICINES Download PDF

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Publication number
RU2007137044A
RU2007137044A RU2007137044/15A RU2007137044A RU2007137044A RU 2007137044 A RU2007137044 A RU 2007137044A RU 2007137044/15 A RU2007137044/15 A RU 2007137044/15A RU 2007137044 A RU2007137044 A RU 2007137044A RU 2007137044 A RU2007137044 A RU 2007137044A
Authority
RU
Russia
Prior art keywords
radiation
soluble polymer
water
granulocyte colony
polymer carrier
Prior art date
Application number
RU2007137044/15A
Other languages
Russian (ru)
Inventor
Андрей Владимирович Артамонов (RU)
Андрей Владимирович Артамонов
Петр Иванович Родионов (RU)
Петр Иванович Родионов
Евгений Данилович Гольдберг (RU)
Евгений Данилович Гольдберг
Александр Михайлович Дыгай (RU)
Александр Михайлович Дыгай
Андрей Александрович Бекарев (RU)
Андрей Александрович Бекарев
Петр Петрович Родионов (RU)
Петр Петрович Родионов
Алексей Вячеславович Степанов (RU)
Алексей Вячеславович Степанов
Евгений Иванович Верещагин (RU)
Евгений Иванович Верещагин
Вадим Вадимович Жданов (RU)
Вадим Вадимович Жданов
Глеб Николаевич Зюзьков (RU)
Глеб Николаевич Зюзьков
Original Assignee
Общество С Ограниченной Ответственностью "Концерн О3" (Ru)
Общество С Ограниченной Ответственностью "Концерн О3"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество С Ограниченной Ответственностью "Концерн О3" (Ru), Общество С Ограниченной Ответственностью "Концерн О3" filed Critical Общество С Ограниченной Ответственностью "Концерн О3" (Ru)
Priority to RU2007137044/15A priority Critical patent/RU2007137044A/en
Priority to PCT/RU2008/000252 priority patent/WO2009045123A1/en
Publication of RU2007137044A publication Critical patent/RU2007137044A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. Лекарственное средство, обладающее гемопоэзстимулирующим и гепатопротекторным действием, включающее гранулоцитарный колониестимулирующий фактор, отличающееся тем, что содержит терапевтически эффективное количество гранулоцитарного колониестимулирующего фактора, иммобилизованного на водорастворимом полимерном носителе под действием ионизирующего излучения. ! 2. Лекарственное средство по п.1, отличающееся тем, что содержит в качестве водорастворимого полимерного носителя полиэтиленгликоль или гидроксиэтилкрахмал молекулярной массы от 400 до 4000 Да. ! 3. Лекарственное средство по п.1 или 2, отличающееся тем, что в качестве ионизирующего излучения используют электронное излучение, гамма-излучение, рентгеновское излучение, лазерное излучение или ультрафиолетовое излучение.1. A drug having hematopoietic stimulating and hepatoprotective effects, including granulocyte colony stimulating factor, characterized in that it contains a therapeutically effective amount of granulocyte colony stimulating factor immobilized on a water-soluble polymer carrier under the action of ionizing radiation. ! 2. The drug according to claim 1, characterized in that it contains as a water-soluble polymer carrier polyethylene glycol or hydroxyethyl starch of molecular weight from 400 to 4000 Da. ! 3. The drug according to claim 1 or 2, characterized in that as the ionizing radiation using electronic radiation, gamma radiation, x-ray radiation, laser radiation or ultraviolet radiation.

Claims (3)

1. Лекарственное средство, обладающее гемопоэзстимулирующим и гепатопротекторным действием, включающее гранулоцитарный колониестимулирующий фактор, отличающееся тем, что содержит терапевтически эффективное количество гранулоцитарного колониестимулирующего фактора, иммобилизованного на водорастворимом полимерном носителе под действием ионизирующего излучения.1. A drug with hematopoietic stimulating and hepatoprotective effects, including granulocyte colony stimulating factor, characterized in that it contains a therapeutically effective amount of granulocyte colony stimulating factor immobilized on a water-soluble polymer carrier under the action of ionizing radiation. 2. Лекарственное средство по п.1, отличающееся тем, что содержит в качестве водорастворимого полимерного носителя полиэтиленгликоль или гидроксиэтилкрахмал молекулярной массы от 400 до 4000 Да.2. The drug according to claim 1, characterized in that it contains as a water-soluble polymer carrier polyethylene glycol or hydroxyethyl starch of molecular weight from 400 to 4000 Da. 3. Лекарственное средство по п.1 или 2, отличающееся тем, что в качестве ионизирующего излучения используют электронное излучение, гамма-излучение, рентгеновское излучение, лазерное излучение или ультрафиолетовое излучение.3. The drug according to claim 1 or 2, characterized in that as the ionizing radiation using electronic radiation, gamma radiation, x-ray radiation, laser radiation or ultraviolet radiation.
RU2007137044/15A 2007-10-05 2007-10-05 HEMOPOESITIMULATING AND HEPATOPROTECTIVE ACTION MEDICINES RU2007137044A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2007137044/15A RU2007137044A (en) 2007-10-05 2007-10-05 HEMOPOESITIMULATING AND HEPATOPROTECTIVE ACTION MEDICINES
PCT/RU2008/000252 WO2009045123A1 (en) 2007-10-05 2008-04-22 Medicinal agent exhibiting hemopoiesis-stimulating and hepatoprotective actions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2007137044/15A RU2007137044A (en) 2007-10-05 2007-10-05 HEMOPOESITIMULATING AND HEPATOPROTECTIVE ACTION MEDICINES

Publications (1)

Publication Number Publication Date
RU2007137044A true RU2007137044A (en) 2009-04-10

Family

ID=40526424

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007137044/15A RU2007137044A (en) 2007-10-05 2007-10-05 HEMOPOESITIMULATING AND HEPATOPROTECTIVE ACTION MEDICINES

Country Status (2)

Country Link
RU (1) RU2007137044A (en)
WO (1) WO2009045123A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298410A (en) * 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
RU2213557C2 (en) * 2001-12-26 2003-10-10 Закрытое акционерное общество "Аксис" Pharmaceutical composition eliciting thrombolytic, anti-inflammatory and cytoprotective properties
EP1492506B2 (en) * 2002-04-05 2016-06-29 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
RU2243784C2 (en) * 2003-02-25 2005-01-10 Козлов Владимир Александрович Method for treatment of patients with chronic hepatitis
KR100507796B1 (en) * 2003-04-03 2005-08-17 한미약품 주식회사 Peg-biologically active polypeptide homodimer conjugate having enhanced half life in blood and process for the preparation thereof

Also Published As

Publication number Publication date
WO2009045123A1 (en) 2009-04-09

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Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20090811