RU2004107012A - METHOD FOR INCREASING ANTITUMOR AND ANTIMETASTIC ACTIVITY OF CYCLOPHOSPHANE IN EXPERIMENT - Google Patents

METHOD FOR INCREASING ANTITUMOR AND ANTIMETASTIC ACTIVITY OF CYCLOPHOSPHANE IN EXPERIMENT Download PDF

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Publication number
RU2004107012A
RU2004107012A RU2004107012/14A RU2004107012A RU2004107012A RU 2004107012 A RU2004107012 A RU 2004107012A RU 2004107012/14 A RU2004107012/14 A RU 2004107012/14A RU 2004107012 A RU2004107012 A RU 2004107012A RU 2004107012 A RU2004107012 A RU 2004107012A
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RU
Russia
Prior art keywords
cyclophosphamide
experiment
antitumor
increasing
activity
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RU2004107012/14A
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Russian (ru)
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RU2270682C2 (en
Inventor
Олег Викторович Кокорев (RU)
Олег Викторович Кокорев
Надежда Викторовна Чердынцева (RU)
Надежда Викторовна Чердынцева
Олес Владимировна Зюзикова (RU)
Олеся Владимировна Зюзикова
Original Assignee
Государственное учреждение Научно-исследовательсковский институт онкологии Сибирского отделени Российской академии медицинских наук (ГУ НИИ онкологии СО РАМН) (RU)
Государственное учреждение Научно-исследовательсковский институт онкологии Сибирского отделения Российской академии медицинских наук (ГУ НИИ онкологии СО РАМН)
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Application filed by Государственное учреждение Научно-исследовательсковский институт онкологии Сибирского отделени Российской академии медицинских наук (ГУ НИИ онкологии СО РАМН) (RU), Государственное учреждение Научно-исследовательсковский институт онкологии Сибирского отделения Российской академии медицинских наук (ГУ НИИ онкологии СО РАМН) filed Critical Государственное учреждение Научно-исследовательсковский институт онкологии Сибирского отделени Российской академии медицинских наук (ГУ НИИ онкологии СО РАМН) (RU)
Priority to RU2004107012/14A priority Critical patent/RU2270682C2/en
Publication of RU2004107012A publication Critical patent/RU2004107012A/en
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Publication of RU2270682C2 publication Critical patent/RU2270682C2/en

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Claims (3)

1. Способ повышения противоопухолевой и антиметастатической активности циклофосфана в эксперименте, заключающийся в перевивки опухоли экспериментальному животному и во внутрибрюшинном введении на 3 и 7 сутки циклофосфана, отличающейся тем, что циклофосфан вводят в дозе 120 мг/кг и дополнительно внутривенно трансплантируют экспериментальному животному стволовые клетки фетальной печени эмбрионов ранних стадий гестаций.1. A method of increasing the antitumor and antimetastatic activity of cyclophosphamide in an experiment, which consists in inoculating a tumor to an experimental animal and intraperitoneally administering cyclophosphamide on days 3 and 7, characterized in that cyclophosphamide is administered at a dose of 120 mg / kg and additionally transplanting fetal stem cells to the experimental animal liver of embryos of early stages of gestation. 2. Способ повышения противоопухолевой и антиметастатической активности циклофосфана в эксперименте по п.1, отличающийся тем, что стволовые клетки фетальной печени трансплантируют в дозе 25×106 клеток на килограмм массы животного внутривенно по 0,05 мл.2. A method of increasing the antitumor and antimetastatic activity of cyclophosphamide in the experiment according to claim 1, characterized in that the stem cells of the fetal liver are transplanted at a dose of 25 × 10 6 cells per kilogram of animal weight intravenously at 0.05 ml. 3. Способ повышения противоопухолевой и антиметастатической активности циклофосфана в эксперименте по п.1 и 2, отличающийся тем, что стволовые клетки фетальной печени трансплантируют через сутки после перевивки опухоли LLC (карцинома легких Льюиса).3. A method of increasing the antitumor and antimetastatic activity of cyclophosphamide in the experiment according to claim 1 and 2, characterized in that the stem cells of the fetal liver are transplanted one day after the inoculation of an LLC tumor (Lewis lung carcinoma).
RU2004107012/14A 2004-03-09 2004-03-09 Method for enhancing of cyclophosphan antitumor and antimetastatic activity in experiment RU2270682C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2004107012/14A RU2270682C2 (en) 2004-03-09 2004-03-09 Method for enhancing of cyclophosphan antitumor and antimetastatic activity in experiment

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Application Number Priority Date Filing Date Title
RU2004107012/14A RU2270682C2 (en) 2004-03-09 2004-03-09 Method for enhancing of cyclophosphan antitumor and antimetastatic activity in experiment

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RU2004107012A true RU2004107012A (en) 2005-09-10
RU2270682C2 RU2270682C2 (en) 2006-02-27

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2488173C1 (en) * 2012-04-26 2013-07-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук Method for creating biological model of moderate growth inhibition of tumour and metastases in lewis lung carcinoma with prolonged cyclophosphanine-induced leukopenia in mice

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Effective date: 20060310