RU2003119138A - THREE-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL PRODUCT CONTAINING THEM AS AN ACTIVE INGREDIENT - Google Patents

Claims (23)

1. The compound of formula (I):

where each of X and Y independently from each other represents carbon or nitrogen, and both are not simultaneously nitrogen; W represents carbon or nitrogen; U and Z each independently of each other represents CR ² , NR ¹³ , nitrogen, oxygen, sulfur, C = O or C = S; R ² represents (i) hydrogen, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) halogen, (vi) CF ₃ , (vii) cyano, (viii) nitro, (ix) NR ⁹ R ¹⁰ where each of the substituents R ⁹ and R ¹⁰ independently from each other represents: (i) hydrogen, (ii) C1-4 alkyl, (iii) a C3-10 mono- or bi-carbocyclic ring, (iv) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, or (v) C1-4 alkyl substituted with a C3-10 mono- or bi-carbocyclic ring or a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, (x) OR ¹¹ , where R ¹¹ represents: (i) hydrogen, (ii) C1-4 alkyl, (iii) a C5-6 carbocyclic ring, (iv) a 5- or 6-membered heterocyclic ring containing 1 to 2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, or (v) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, (xi) SH, (xii) S (O) _n R ¹² , where n is 0, 1 or 2, R ¹² represents: (i) C1-4 alkyl, (ii) a C5-6 carbocyclic ring, (iii) a 5- or 6-membered heterocyclic ring containing 1 to 2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, or (iv) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, (xiii) COR ¹¹ , (xiv) COOR ¹¹ , (xv) CONR ⁹ R ¹⁰ , (xvi) a C3-10 mono- or bi-carbocyclic ring, (xvii) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, or (xviii) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , C3-10-mono- or bi-carbocyclic ring and 3-10-membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 atoms oxygen and / or 1-2 sulfur atoms, R ¹³ represents (i) hydrogen, (ii) C1-4 alkyl, (iii) C2-4 alkenyl, (iv) C2-4 alkynyl, (v) C3-10 mono- or bi-carbocyclic ring, (vi) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, or (vii) C1-4 alkyl substituted with a C3-10 mono- or bi-carbocyclic ring or a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms,

represents a single or double bond,

represents a C4-6 carbocyclic ring or a 4-6 membered heterocyclic ring containing at least one nitrogen, oxygen and sulfur atom, and these rings are unsubstituted or substituted by 1-3 substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen and CF ₃ , R ¹ represents (i) C1-8 alkyl which is unsubstituted or substituted by 1-5 R ¹⁴ substituents; (ii) C2-8 alkenyl, which is unsubstituted or substituted with 1-5 R ¹⁴ substituents; (iii) C2-8-alkynyl, which is unsubstituted or substituted with 1-5 R ¹⁴ substituents; (iv) NR ⁴ R ⁵ where each of the substituents R ⁴ and R ⁵ independently from each other represents (i) hydrogen, (ii) C1-15 alkyl, which is unsubstituted or substituted with 1-5 substituents R ¹⁷ ; (iii) C2-15 alkenyl, which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (iv) C2-15 alkynyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (v) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 R ¹⁸ substituents; (vi) a 3-15 membered mono- or bi-heterocyclic ring, containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (v) OR ⁶ where the substituent R ⁶ represents (i) hydrogen, (ii) C1-10 alkyl, (iii) C2-10 alkenyl, (iv) C2-10 alkynyl, (v) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 R ¹⁸ substituents; (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (vii) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , a C3-10 mono- or bi-carbocyclic ring that is unsubstituted or substituted with 1-5 substituents R ¹⁸ , and a 3-10-membered mono- or bi-heterocyclic a ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (vi) SH, (vii) S (O) _n R ⁷ , where n takes the above values, R ⁷ represents: (i) C1-8 alkyl, (ii) a C3-10 mono- or bi-carbocyclic ring that is unsubstituted or is substituted with 1-5 R ¹⁸ substituents; (iii) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (iv) C1-4 alkyl substituted with a C3-10-mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 substituents R ¹⁸ , or a 3-10-membered mono- or bi-heterocyclic ring containing 1 -4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (viii) COR ⁶ , (ix) COOR ⁶ , (x) CONR ⁴ R ⁵ , (xi) NR ⁸ COR ^6a , where R ^6a represents: (i) hydrogen, (ii) C1-10 alkyl, (iii) C2-10 alkenyl, (iv) C2-10 alkynyl or (v) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ^11a , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ and CONR ⁹ R ¹⁰ , (xii) NR ⁸ COOR ⁶ , where R ⁶ has the above meanings, R ⁸ represents: (i) hydrogen, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) a C3-10 mono- or bi-carbocyclic ring which is unsubstituted or is substituted with 1-5 R ¹⁸ substituents; (vi) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; or (vii) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , a C3-10 mono- or bi-carbocyclic ring that is unsubstituted or substituted with 1-5 substituents R ¹⁸ , and a 3-10-membered mono- or bi-heterocyclic a ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (xiii) NR ⁸ CONR ⁴ R ⁵ , (xiv) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or is substituted with 1-5 R ¹⁵ substituents; or (xv) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁵ substituents, R ^11a represents (i) hydrogen, (ii) C1-4 alkyl or (iii) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, R ¹⁴ represents (a) halogen, (b) CF ₃ , (c) OCF ₃ , (d) cyano, (e) nitro, (f) NR ⁴ R ⁵ , (g) OR ⁶ , (h) = N -OR ⁶ , (j) SH, (k) S (O) _n R ⁷ , (l) COR ⁶ , (m) COOR ⁶ , (n) CONR ⁴ R ⁵ , (o) NR ⁸ COR ⁶ , (p ) NR ⁸ COOR ⁶ , (q) NR ⁸ CONR ⁴ R ⁵ , (r) C3-15-mono- or bi-carbocyclic ring, which is unsubstituted or substituted by 1-5 substituents R ¹⁵ , or (s) 3-15 a membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁵ substituents; R ¹⁵ represents (a) C1-8 alkyl, (b) C2-8 alkenyl, (c) C2-8 alkynyl, (d) C1-4 alkoxy (C1-4) alkyl, (e) halogen, (f) CF ₃ , (g) OCF ₃ , (h) cyano, (j) nitro, (k) NR ⁴ R ⁵ , (l) OR ⁶ , (m) SH, (n) S (O) _n R ⁷ , (o) COR ⁶ , (p) COOR ⁶ , (q) CONR ⁴ R ⁵ , (r) NR ⁸ COR ⁶ , (s) NR ⁸ COOR ⁶ , (t) NR ⁸ CONR ⁴ R ⁵ , (u) a C3-10 mono- or bi-carbocyclic ring which is unsubstituted or substituted by 1-5 R ²⁰ substituents, (v) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 substituents R ²⁰ , or (w) C1-4 alkyl, substituted by 1-2 substituents, selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁴ R ⁵ , OR ⁶ , = N-OR ⁶ , SH, S (O) _n R ⁷ , COR ⁶ , COOR ⁶ , CONR ⁴ R ⁵ , NR ⁸ COR ⁶ , NR ⁸ COOR ⁶ , NR ⁸ CONR ⁴ R ⁵ , C3-10-mono- or bi-carbocyclic ring, which is unsubstituted or substituted by 1-5 substituents R ²⁰ , and 3-10-membered mono- or bi a heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ²⁰ substituents; R ¹⁷ represents (a) halogen, (b) CF ₃ , (c) OCF ₃ , (d) cyano, (e) nitro, (f) NR ⁹ R ¹⁰ , (g) OR ^11a , (h) = N -OR ¹¹ , (j) SH, (k) S (O) _n R ¹² , (l) COR ¹¹ , (m) COOR ¹¹ , (n) CONR ⁹ R ¹⁰ , (o) NR ⁸ COR ¹¹ , (p ) NR ⁸ COOR ¹¹ , (q) NR ⁸ CONR ⁹ R ¹⁰ , (r) C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted by 1-5 substituents R ^18a , or (s) 3-15 a membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ^18a substituents; R ¹⁸ is (a) C1-4 alkyl, (b) C2-4 alkenyl, (c) C2-4 alkynyl, (d) halogen, (e) CF ₃ , (f) OCF ₃ , (g ) cyano, (h) nitro, (j) SH, (k) S (O) _n R ¹² , (l) NR ⁹ R ¹⁰ , (m) OR ¹¹ , (n) COR ¹¹ , (o) COOR ¹¹ , (p) CONR ⁹ R ¹⁰ , (q) a C5-6 carbocyclic ring, (r) a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, or (s ) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, R ^18a represents (a) C1-4 alkyl, (b) C2-4 alkenyl, (c) C2-4 alkynyl, (d) halogen, (e) CF ₃ , (f) OCF ₃ , (g ) cyano, (h) nitro, (j) SH, (k) S (O) _n R ¹² , (l) NR ⁹ R ¹⁰ , (m) OR ^11a , (n) COR ¹¹ , (o) COOR ¹¹ or (p) CONR ⁹ R ¹⁰ , R ¹⁹ represents C1-4 alkyl, C1-4 alkoxy, halogen, CF ₃ , OCF ₃ , cyano, nitro, amino, NH (C1-4 alkyl) or N (C1-4 alkyl) ₂ , R ³ represents (i) a C5-10 mono- or bi-carbocyclic ring substituted with 1-5 substituents R ¹⁶ , or (ii) a 5-10-membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms 1-2 oxygen atoms and / or 1-2 sulfur atoms substituted with 1-5 R ¹⁶ substituents, R ¹⁶ represents (a) C1-8 alkyl, (b) C2-8 alkenyl, (c) C2-8 alkynyl, (d) halogen, (e) CF ₃ , (f) OCF ₃ , (g) cyano, (h) nitro, (j) NR ⁹ R ¹⁰ , (k) OR ¹¹ , (l) SH, (m) S (O) _n R ¹² , except phenylthio, (n) COR ¹¹ , (o) COOR ¹¹ , (p) CONR ⁹ R ¹⁰ , (q) NR ⁸ COR ¹¹ , (r) NR ⁸ COOR ¹¹ , (s) NR ⁸ CONR ⁹ R ¹⁰ , (t) a C3-10 mono- or bi-carbocyclic ring, (u) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, (v) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , NR ⁸ COR ¹¹ , NR ⁸ COOR ¹¹ , NR ⁸ CONR ⁹ R ¹⁰ , C3-10 mono- or bi-carbocyclic ring, and 3-10 membered a mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, provided that, (1) when each of X and W is carbon, each of Y and Z is nitrogen, U is CR ⁴ and R ¹ is OR ^6, then the substituent R ³ is not phenyl substituted with one halogen atom, phenyl substituted by 1 trifluoromethyl, and phenyl substituted by trifluoromethyl and nitro, (2) when each of X, Y and Z is carbon, each of U and W is nitrogen, then R ³ substituent is a C5-10 mono- or bi-carbocyclic a ring substituted with 1-5 substituents R ¹⁶ ; its pharmaceutically acceptable salt or hydrate. 2. The compound according to claim 1, where X is carbon, Y is nitrogen, each of U and Z is carbon or nitrogen, and W is carbon, a pharmaceutically acceptable salt or hydrate thereof. 3. The compound according to claim 2, where each of X, U and W represents carbon, each of Y and Z represents nitrogen, its pharmaceutically acceptable salt or hydrate. 4. The compound according to claim 2, where each of X, Z, U and W represents carbon, Y represents nitrogen, its pharmaceutically acceptable salt or hydrate. 5. The compound according to claim 1, where each of X, Y, Z and U represents carbon, W represents nitrogen, its pharmaceutically acceptable salt or hydrate. 6. The compound according to claim 1, where

represents a C4-6 carbocyclic ring, a pharmaceutically acceptable salt or hydrate thereof. 7. The compound according to claim 1, where

represents a 4-6 membered heterocyclic ring containing at least one nitrogen, oxygen and sulfur atom, a pharmaceutically acceptable salt or hydrate thereof. 8. The compound according to claim 1, in which the substituent R ¹ represents: (i) C1-8 alkyl which is unsubstituted or substituted by 1-5 R ¹⁴ substituents; (ii) C2-8 alkenyl, which is unsubstituted or substituted with 1-5 R ¹⁴ substituents; (iii) C2-8-alkynyl, which is unsubstituted or substituted with 1-5 R ¹⁴ substituents; (iv) NR ⁴ R ⁵ ; (v) OR ⁶ ; (vi) a C3-15 mono- or bi-carbocyclic ring that is unsubstituted or substituted with 1-5 R ¹⁵ substituents; or (vii) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁵ substituents, where R ¹⁴ and R ^15, are as defined in claim 1, a pharmaceutically acceptable salt or hydrate thereof. 9. The compound of formula (I-i):

where all the symbols have the meanings defined in claim 1, according to claim 1, its pharmaceutically acceptable salt or hydrate. 10. The compound according to claim 9, where

represents a C4-6 carbocyclic ring, a pharmaceutically acceptable salt or hydrate thereof. 11. The compound according to claim 9, where

represents a 4-6 membered heterocyclic ring containing at least one nitrogen, oxygen and sulfur atom, a pharmaceutically acceptable salt or hydrate thereof. 12. The compound according to claim 9, where the substituent R ¹ represents NR ⁴ R ⁵ , and (a) R ⁴ represents (i) hydrogen, (ii) C1-15 alkyl, which is unsubstituted or substituted by 1-5 substituents R ¹⁷ ; (iii) C2-15 alkenyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents, (iv) C2-15 alkenyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (v) a C3-15 mono- or bi-carbocyclic ring that is unsubstituted or is substituted with 1-5 R ¹⁸ substituents; or (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; or (b) R ⁴ is (ii) C1-15 alkyl which is unsubstituted or substituted by 1-5 substituents of R ¹⁷ ; (iii) C2-15 alkenyl, which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (iv) C2-15 alkynyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; or (v-1) a C3-6 mono-carbocyclic ring, and R ⁵ represents (ii) C1-15 alkyl, which is unsubstituted or substituted with 1-5 substituents R ¹⁷ ; (iii) C2-15 alkenyl, which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (iv) C2-15 alkynyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (v) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 R ¹⁸ substituents; or (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents, its pharmaceutically acceptable salt or hydrate. 13. The compound of formula (I-ii):

where all the symbols have the meanings defined in claim 1, according to claim 1, its pharmaceutically acceptable salt or hydrate. 14. The compound according to item 13, where

represents a C4-6 carbocyclic ring, a pharmaceutically acceptable salt or hydrate thereof. 15. The compound according to item 13, where

represents a 4-6 membered heterocyclic ring containing at least one nitrogen, oxygen and sulfur atom, a pharmaceutically acceptable salt or hydrate thereof. 16. The compound according to item 13, where the substituent R ¹ represents NR ⁴ R ⁵ , and (a) R ⁴ represents (i) hydrogen, (ii) C1-15 alkyl, which is unsubstituted or substituted by 1-5 substituents R ¹⁷ ; (iii) C2-15 alkenyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents, (iv) C2-15 alkenyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (v) a C3-15 mono- or bi-carbocyclic ring that is unsubstituted or is substituted with 1-5 R ¹⁸ substituents; or (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; or (b) R ⁴ is (ii) C1-15 alkyl which is unsubstituted or substituted by 1-5 substituents of R ¹⁷ ; (iii) C2-15 alkenyl, which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (iv) C2-15 alkynyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; or (v-1) a C3-6 mono-carbocyclic ring, and R ⁵ represents (ii) C1-15 alkyl, which is unsubstituted or substituted with 1-5 substituents R ¹⁷ ; (iii) C2-15 alkenyl, which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (iv) C2-15 alkynyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (v) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 R ¹⁸ substituents; or (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents, its pharmaceutically acceptable salt or hydrate. 17. The compound according to claim 1, which is selected from the group including: (1) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (2) 8- (N-ethyl-N-n-butylamino) -2-methoxymethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (3) 8- (N-propyl-N- (2-hydroxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (4) 9- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,6,7,8-tetrahydropyrazolo [3,2-b] quinazoline; (5) 8 - [(2S) -1,1-dimethoxybutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (6) 8- (1,3-dimethoxypropan-2-yl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1, 5-a] pyrimidine; (7) 8-bis (2-methoxyethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (8) 8- (3-pentylamino) -2-methyl-3- (2,4-dichlorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (9) 8-diethylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (10) 8- (N-ethyl-N-n-butylamino) -2-methyl-3- (2,4-dichlorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (11) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydropyrrolo [3,4-d] pyrazolo [1,5-a] pyrimidine; (12) 8- (3-pentylamino) -2-methoxymethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (13) 8-cyclopropylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (14) 8- (3-pentylamino) -2-methyl-3- (3,4-dimethoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (15) 8- (3-pentylamino) -2-cyclobutyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (16) 8- (3-pentylamino) -2-ethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (17) 8- (3-pentylamino) -2-isopropyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (18) 8- (2-ethylbutylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (19) 8- (3-pentylamino) -2-methylthiomethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (20) 8- (3-pentylamino) -2-methyl-3- (2,4-dimethylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (21) 8- (3-pentylamino) -2-methyl-3- (2,5-dimethylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (22) 8-cyclobutylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (23) 8- (N-ethyl-N-cyclobutylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (24) 8- (propan-1,3-diol-2-yl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (25) 8- (3-pentylamino) -2- (2-furyl) -3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (26) 8- (3-pentylamino) -2-phenyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (27) 8- (2-dimethylaminoethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (28) 8- (N-methyl-N- (2-dimethylaminoethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (29) 8- (N-ethyl-N- (2-dimethylaminoethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (30) 8- (4-heptylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (31) 8- (2-butylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (32) 8- (N-propyl-N-cyclopropylmethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (33) 8- (3-pentylamino) -3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (34) 8 - [(2R) -1-methoxybutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (35) 8 - [(2S) -1-methoxybutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (36) 8-cyclopentylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (37) 8- (3-pentylamino) -2-methyl-3- (2,4-difluorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (38) 8- (3-pentylamino) -2-trifluoromethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (39) 8- (N-ethyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (40) 8-cyclohexylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (41) 8- (N-propyl-N- (3-pentyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (42) 8- (3-pentylamino) -2-methyl-3- (4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (43) 8- (3-pentylamino) -2-isopropyl-3- (4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (44) 8-tert-butylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (45) 8- (3-pentylamino) -3- (2,4,6-trimethylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (46) 8- (1-cyclobutylethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (47) 8- (3-pentylamino) -2-methyl-3- (2,3-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (48) 8- (3-pentylamino) -2-methyl-3- (2,5-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (49) 8- (N- (2,2,2-trifluoroethyl) -N-cyclopropylmethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d ] pyrazolo [1,5-a] pyrimidine; (50) 8- (2,2,2-trifluoroethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (51) 8- (3-pentylamino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (52) 8- (3-pentylamino) -3- (4,6-dimethyl-2-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (53) 8- (3-pentylamino) -2-methyl-3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (54) 8- (3-pentylamino) -2-methyl-3- (4,6-dimethyl-2-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (55) 8- (3-methylpentan-3-yl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (56) 8- (3-pentylamino) -2-methyl-3- (5-chloro-1,3-dioxaindan-6-yl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (57) 8- (N-ethyl-N-benzylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (58) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-trifluoromethoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (59) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (60) 8- (N-benzyl-N- (2-methoxyethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (61) 8- (3-pentylamino) -2-methyl-3- (2-methoxy-4,5-dimethylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (62) 8-phenylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (63) 8- (2-methylphenyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (64) 8- (3-methylphenyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (65) 8- (4-methylphenyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (66) 8- (N-phenyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (67) 8- (N-benzyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (68) 8- (N, N-diallylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (69) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-dimethylaminophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (70) 8- (1-phenylpropylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (71) 8- (N- (2-phenylethyl) -N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (72) 8- (N- (3-phenylpropyl) -N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (73) 8- (N- (4-phenylbutyl) -N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (74) 8- (1-phenyl-2-butyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (75) 8- (1-phenyl-2-pentyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (76) 8- (N- (4-methylphenyl) -N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (77) 8- (N- (4-methylphenyl) methyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (78) 8- (N- (3-methylphenyl) -N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (79) 8- (N- (4-methoxyphenyl) methyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (80) 8- (N- (4-chlorophenyl) methyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (81) 8- (N- (2-methylphenyl) -N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (82) 8- (3-pentylamino) -2-methyl-3- (2-dimethylamino-4-methyl-pyridin-5-yl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (83) 8 - ((2S) -1-methoxy-3-phenyl-2-propyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [ d] pyrazolo [1,5-a] pyrimidine; (84) 8- (N- (4-methylthiophenyl) methyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (85) 8- (N, N-dibutylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (86) 8- (N-methyl-N-butylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (87) 8- (N- (4-methylphenyl) methyl-N-butylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (88) 8- (N- (4-methylphenyl) methyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (89) 8- (N-cyclopropyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (90) 8- (N-cyclopropylmethyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (91) 8- (N, N-dipropylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (92) 8- (N- (4-methylphenyl) methyl-N- (2-butynyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (93) 8- (N-propyl-N- (2-butynyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (94) 8- (5-nonylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (95) 8- (N-cyclopentyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (96) 8- (N-cyclopropylmethyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (97) 8- (N- (4-fluorophenyl) methyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (98) 8- (N-cyclobutyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (99) 8- (N-ethyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (100) 8- (N-propyl-N- (4-trifluoromethylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (101) 8- (N-propyl-N- (tetrahydrofuran-2-yl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (102) 8- (N-butyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (103) 8- (N-propyl-N-cyclopropylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (104) 8- (N-cyclobutylmethyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (105) 8- (4-heptylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (106) 8- (N-cyclopropylmethyl-N- (2-butyryl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (107) 8- (N- (2-methoxyethyl) -N- (2-butyryl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [ d] pyrazolo [1,5-a] pyrimidine; (108) 8- (2-butyrylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (109) 8- (N-cyclopropylmethyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (11) 8-dicyclopropylmethylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (110) 8- (N-propyl-N- (4-trifluoromethyloxyphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (111) 8- (N- (2-butyryl) -N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (112) 8- (N-propyl-N- (3-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (113) 8- (N-propyl-N- (2-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (114) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-ethoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (115) 8- (N-methyl-N-hexylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (116) 8- (N-methyl-N- (3-pentyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (117) 8- (N-methyl-N- (4-heptyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (118) 8- (N-cyclobutyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (119) 8- (N-isobutyl-N- (2-dimethylaminoethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (120) 8- (N-propyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (121) 8- (N-cyclopropylmethyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (122) 8- (3-pentylamino) -2-methyl-3- (3-chloro-5-trifluoromethyl-pyridin-2-yl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (123) 8- (N-butyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (124) 8- (N-cyclopropyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (125) 8- (N-propyl-N- (2-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (126) 8- (N-propyl-N- (3-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (127) 8-dicyclopropylmethylamino-2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (128) 8- (N-butyl-N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (129) 8- (N-cyclopropylmethyl-N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (13) 8- (3-pentylamino) -2-methyl-3- (1,3-dioxaindan-5-yl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (130) 8- (N- (2-butynyl) -N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (131) 8- (N-butyl) -N- (2-methoxyethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (132) 8- (N-cyclopropylmethyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (133) 8- (3-pentylamino) -2-methyl-3- (3,5-dichloropyridin-2-yl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (134) 8- (N-butyl-N-ethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (135) 8- (N-cyclopropylmethyl-N- (4-trifluoromethylphenyl) methyl-amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (136) 8- (N-benzyl-N- (2-dimethylaminoethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (137) 8- (N-benzyl-N- (2-dimethylaminoethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (138) 8- (N- (2-butynyl) -N-ethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (139) 8- (N- (2-butynyl) -N-ethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (140) 8- (N, N-dipropylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (141) 8- (N-propyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (142) 8- (N-propyl-N- (3-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (143) 8-dipropylamino-2-methyl-3- (2,5-dichlorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (144) 8-dipropylamino-2-methyl-3- (2,4-dichlorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (145) 8-dipropylamino-2-methyl-3- (4-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (146) 8-dipropylamino-2-methyl-3- (3-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (147) 8-dipropylamino-2-methyl-3- (2-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (148) 8- (N-propyl-N- (benz [d] 1,3-dioxolan-5-yl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7- dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (149) 8- (N-propyl-N- (benz [d] 1,3-dioxolan-5-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7- dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (150) 8- (3-pentylamino) -2-methyl-3- (2-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (151) 8- (3-pentylamino) -2-methyl-3- (3-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (152) 8- (3-pentylamino) -2-methyl-3- (4-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (153) 8- (3-pentylamino) -2-methyl-3- (2-methylthio-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (154) 8- (N-benzyl-N-cyclopropylmethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (155) 8- (N-benzyl-N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (156) 8- (N-butyl-N- (2-butynyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (157) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-fluorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (158) 8- (3-pentylamino) -2-methyl-3- (2,5-dichlorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (159) 8- (3-pentylamino) -2-methyl-3- (2,4-dimethoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (160) 8- (3-pentylamino) -2-methyl-3- (2-fluoro-4-methylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (161) 8- (N-butyl-N- (2-butynyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (162) 8- (3-methyl-2-butylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (163) 8- (1-cyclohexylethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (164) 8- (2-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (165) 8- (2-heptylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (166) 8- (1-methoxy-2-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (167) 8- (2-octylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (168) 8- (1,2,3,4-tetrahydronaphthalen-1-yl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (169) 8 - ((1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3.1.1] -3-heptyl) amino) -2-methyl-3- (2-methyl-4- methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (170) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (171) 8- (3-pentylamino) -2-methyl-3- (2,5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (172) 8- (3-pentylamino) -2-methyl-3- (2-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (173) 8- (N-ethyl-N- (4-hydroxybutyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (174) 8- (3-pentylamino) -2-methyl-3- (2-methoxy-5-isopropyl-phenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (175) 8- (3-pentylamino) -2-methyl-3- (2-methoxy-5-fluorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (176) 8- (N-butyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (177) 8- (3-pentylamino) -2-methyl-3- (2-methoxy-5-chlorophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (178) 8- (N-cyclopropylmethyl-N- (4-trifluoromethylphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (179) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-cyanophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (180) 8- (N-propyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-chloro-5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (181) 8- (N-ethyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-chloro-5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (182) 8- (3-pentylamino) -2-methyl-3- (4-methylthiophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (183) 8- (3-pentylamino) -2-methyl-3- (4-dimethylaminophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (184) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-methylthiophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (185) 8- (N- (2-methoxyethyl) -N- (2-butynyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [ d] pyrazolo [1,5-a] pyrimidine; (186) 8- (N-propyl-N- (5-methylfuran-2-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [ d] pyrazolo [1,5-a] pyrimidine; (187) 8- (N-benzyl-N-cyclopropylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (188) 8- (N-cyclopropylmethyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (189) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-bromophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (190) 8- (3-pentylamino) -2-methyl-3- (2,5-dichloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (191) 8-dibutylamino-2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (192) 8-bis (2-methoxyethyl) amino-2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (193) 8- (N-ethyl-N- (cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (194) 8- (N-cyclopropylmethyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (195) 8- (N-cyclopropylmethyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (196) 8- (N-butyl-N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (197) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-ethoxycarbonylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (198) 8- (N-propyl-N- (2-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (199) 8- (N-propyl-N- (5-methylthiophen-2-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [ d] pyrazolo [1,5-a] pyrimidine; (200) 8- (N-propyl-N- (thiophen-3-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (201) 8- (N-ethyl-N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (202) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-carbamoylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (203) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4- (N-methylcarbamoyl) phenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (204) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4- (N, N-dimethylcarbamoylphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (205) 8- (N-ethyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (206) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4,6-dimethoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (207) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-aminophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (208) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-methylaminophenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (209) 8- (3-pentylamino) -2-methyl-3- (2-formyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (210) 8- (3-pentylamino) -2-methyl-3- (2-cyano-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (211) 8- (3-pentylamino) -2-methyl-3- (2-ethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (212) 8- (4-heptylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (213) 8- (N, N-dipropylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (214) 8- (3-pentylamino) -2-methyl-3- (2-methoxycarbonyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (215) 8- (N-cyclopropyl-N- (2-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (216) 8- (N-cyclopropylmethyl-N- (2-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (217) 8- (N-cyclopropylmethyl-N-propylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (218) 8- (N-propyl-N- (4-methylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (219) 8- (N-benzyl-N-cyclopropylmethylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (220) 8- (N-cyclopropylmethyl-N- (4-methylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (221) 8- (N-propyl-N- (4-fluorophenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (222) 8-dicyclopropylmethylamino-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (223) 8- (N-cyclopropyl-N- (4-methylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (224) 8- (N-cyclopropylmethyl-N- (4-trifluoromethylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (225) 8- (3-pentylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (226) 8- (N-cyclopropylmethyl-N- (4-fluorophenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5- a] pyrimidine; (227) 8- (3-pentylamino) -2-methyl-3- (2- (1-methyl-1-hydroxyethyl) -4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1 5-a] pyrimidine; (228) 8- (N-propyl-N- (4-trifluoromethyloxyphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (229) 8- (3-hexylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (230) 8- (3-pentylamino) -2-methyl-3- (2-methoxy-4-methylpyridin-5-yl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (231) 8- (N-butyl-N-cyclopropylmethylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (232) 8- (N-propyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (233) 8- (N-propyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (234) 8- (N-cyclopropylmethyl-N-methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (235) 8- (N-ethyl-N-n-butylamino) -2-hydroxymethyl-3- (2-methyl-4-hydroxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (236) 8- (N-ethyl-N-n-butylamino) -2-hydroxymethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (237) 8- (N-propyl-N- (2-methoxyiminoethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (238) 8- (N-ethyl-N-n-butylamino) -2-hydroxyiminomethyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (239) 8 - [(2S) -1-hydroxyiminobutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (240) 8 - [(1S) -1-cyanopropylamino] -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (241) 8- (N-ethyl-N-n-butylamino) -2-cyano-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (242) 1-cyano-2-methyl-8- (3-pentylamino) -3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,2-a ] pyrimidine; (243) 1-cyano-2-methyl-8-dipropylamino-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,2-a] pyrimidine; (244) 2,3-dimethyl-4-amino-1- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [e] pyrrolo [2,3-b] pyridine; (245) 2,3-dimethyl-4-ethylcarbonylamino-1- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [e] pyrrolo [2,3-b] pyridine; (246) 2,3-dimethyl-4-propylamino-1- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [e] pyrrolo [2,3-b] pyridine; (247) 2,3-dimethyl-4- (N-ethylcarbonyl-N-propylamino) -1- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [e] pyrrolo [2,3 -b] pyridine; (248) 2,3-dimethyl-4-dipropylamino-1- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [e] pyrrolo [2,3-b] pyridine; (249) 8- (4-heptylamino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (250) 8-dipropylamino-3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (251) 8- (N-cyclopropylmethyl-N-propylamino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (252) 8- (N-benzyl-N-cyclopropylmethylamino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (253) 8- (N-cyclopropylmethyl-N- (4-methylphenylmethyl) amino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1, 5-a] pyrimidine; (254) 8- (N-propyl-N- (4-fluorophenylmethyl) amino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1, 5-a] pyrimidine; (255) 8-dicyclopropylmethylamino-3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (256) 8- (N-butyl-N-cyclopropylmethylamino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (257) 8- (N-cyclopropylmethyl-N- (4-fluorophenyl) methylamino) -3- (2,6-dimethyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1, 5-a] pyrimidine; and (258) 2,3-dimethyl-4- (N-ethyl-N-pentylamino) -1- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [e] pyrrolo [2,3 -b] pyridine; their pharmaceutically acceptable salt or hydrate. 18. The compound according to claim 1, which is selected from the group including: (1) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrothieno [3,4-d] pyrazolo [1,5-a] pyrimidine; (2) 9- (3-pentylamino) -6-methyl-5- (2-methyl-4-methoxyphenyl) -2,3-dihydrothieno [3,2-d] pyrazolo [1,5-a] pyrimidine; (3) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (4) 9- (3-pentylamino) -6-methyl-5- (2-methyl-4-methoxyphenyl) -2,3-dihydrofuro [3,2-d] pyrazolo [1,5-a] pyrimidine; (5) 9- (3-pentylamino) -6-methyl-5- (2-methyl-4-methoxyphenyl) -2,3-dihydropyrrolo [3,2-d] pyrazolo [1,5-a] pyrimidine; (6) 8-isopropylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (7) 8 - [(2S) -1,1-dimethoxybutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (8) 8- [1,3-dimethoxypropan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1, 5-a] pyrimidine; (9) 8-bis (2-methoxyethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (10) (5RS) -8- (3-pentylamino) -2,5-dimethyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5 -a] pyrimidine; (11) 8- (3-pentylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydropyrrolo [3,4-d] pyrazolo [1,5-a] pyrimidine; (12) 8- (N-propyl-N- (2-hydroxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (14) 8- (N-methyl-N-cyclopropylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (15) 8 - [(2R) -1-methoxybutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (16) 8 - [(2R) -1-methoxybutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -2,3-dihydrofuro [3,2-d] pyrazolo [ 1,5-a] pyrimidine; (17) 8- (N-cyclopropylmethyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (18) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-ethoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (19) 8- (N-cyclopropyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (20) 8- (N-cyclopropylmethyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (21) 8- (N-propyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (22) 8- (N-cyclopropylmethyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (23) 8- (N, N-dipropylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (24) 8- (N, N-dibutylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (25) 8- (N-propyl-N- (4-methylphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (26) 8- (N-butyl-N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (27) 8- (4-heptylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (28) 8- (N-butyl-N-ethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (29) 8-dicyclopropylmethylamino-2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (30) 8- (N-cyclopropylmethyl-N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (31) 8- (N- (2-butynyl) -N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1 5-a] pyrimidine; (32) 8- (N-butyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (33) 8- (N-propyl-N- (4-trifluoromethyloxyphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (34) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (35) 8- (N-cyclopropylmethylamino-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (36) 8- (N-benzyl-N- (2-dimethylaminoethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (37) 8- (N- (2-butynyl) -N-ethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1 5-a] pyrimidine; (38) 8- (N- (2-butynyl) -N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1 5-a] pyrimidine; (39) 8- (N-cyclopropyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (40) 8- (N-propyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5 -a] pyrimidine; (41) 8- (N-cyclopropyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (42) 8- (N-propyl-N- (3-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (43) 8- (N-propyl-N- (benz [d] 1,3-dioxolan-5-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7- dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (44) 8- (N-benzyl-N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (45) 8- (N-butyl-N- (2-butynyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (46) 8-dicyclopropylmethylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (47) 8- (N-butyl-N-ethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (48) 8- (N-butyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (49) 8- (N, N-dipropylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (50) 8-bis (2-methoxyethyl) amino-2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (51) 8- (N-butyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (52) 8- (N-butyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (53) 8- (N-ethyl-N- (2-butyryl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (54) 8- (N-propyl-N- (2-butyryl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (55) 8- (N-propyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (56) 8- (N-propyl-N- (benz [d] 1,3-dioxolan-5-yl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7- dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (57) 8- (N-benzyl-N-cyclopropylmethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (58) 8- (N-cyclopropylmethyl-N- (4-trifluoromethylphenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (59) 8- (N-cyclopropylmethyl-N- (4-trifluoromethylphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (60) 8- (N-propyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (61) 8- (N-cyclopropyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (62) 8- (N-cyclopropyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (63) 8- (N-cyclopropylmethyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (64) 8- (N-propyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (65) 8- (N-propyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (66) 8- (N-ethyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (67) 8- (N-ethyl-N- (4-methylthiophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (68) 8- (N-butyl-N- (2-methoxyethyl) amino) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (69) 8- (N-cyclopropylmethyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (70) 8- (N-propyl-N- (5-methylfuran-2-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4- d] pyrazolo [1,5-a] pyrimidine; (71) 8- (N-propyl-N- (5-methylfuran-2-yl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4- d] pyrazolo [1,5-a] pyrimidine; (72) 8- (N-cyclopropylmethyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (73) 8- (N-propyl-N- (4-trifluoromethyloxyphenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (74) 8- (N-propyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (75) 8- (N-cyclopropylmethyl-N- (2-butynyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (76) 8- (N- (2-methoxyethyl) -N- (2-butynyl) amino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4- d] pyrazolo [1,5-a] pyrimidine; (77) 8- (N- (2-methoxyethyl) -N- (2-butynyl) amino-2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d ] pyrazolo [1,5-a] pyrimidine; (78) 8- (N-benzyl-N-cyclopropylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (79) 8- (N-benzyl-N-cyclopropylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (80) 8- (N-cyclopropylmethyl-N- (2-methoxyethyl) amino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (81) 8- (3-pentylamino) -2-methyl-3- (2,5-dichloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (82) 8- (N-cyclopropyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (83) 8- (N-cyclopropyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (84) 8-dibutylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (85) 8- (N-ethyl-N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (86) 8- (N-ethyl-N-cyclopropylmethylamino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (87) 8- (N-cyclopropylmethyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (88) 8- (N-cyclopropylmethyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (89) 8- (N-propyl-N- (thiophen-3-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (90) 8- (N-propyl-N- (5-methylthiophen-2-yl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4- d] pyrazolo [1,5-a] pyrimidine; (91) 8- (N-butyl-N-cyclopropylmethylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (92) 8- (N-butyl-N-cyclopropylmethylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (93) 8- (N-propyl-N- (thiophen-3-yl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (94) 8- (N-propyl-N- (5-methylthiophen-2-yl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4- d] pyrazolo [1,5-a] pyrimidine; (95) 8- (N-propyl-N- (2-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (96) 8- (N-propyl-N- (2-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (97) 8- (N-ethyl-N-propylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (98) 8- (N-ethyl-N-propylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (99) 8- (3-pentylamino) -2-methyl-3- (2,6-dimethyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (100) 8- (N-ethyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (101) 8- (N-ethyl-N- (4-fluorophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (102) 8- (3-pentylamino) -2-methyl-3- (2-chloro-4,6-dimethoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine ; (103) 8- (4-heptylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (104) 8- (N, N-dipropylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (105) 8- (N-cyclopropylmethyl-N-propylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (106) 8- (N-benzyl-N-cyclopropylmethylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (107) 8- (N-cyclopropylmethyl-N- (4-methylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (108) 8- (N-propyl-N- (2-butynyl) amino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (109) 8- (N-butyl-N-cyclopropylmethylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (110) 8- (3-pentylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (111) 8- (N-cyclopropylmethyl-N- (4-fluorophenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (112) 8- (4-heptylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (113) 8- (N-propyl-N- (4-methylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (114) 8- (N-propyl-N- (4-fluorophenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (115) 8-dicyclopropylmethylamino-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; (116) 8- (N-cyclopropylmethyl-N- (4-trifluoromethylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (117) 8- (N-cyclopropyl-N- (4-methylphenyl) methylamino) -3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5- a] pyrimidine; (118) 8- (N-propyl-N- (4-cyanophenyl) methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; (119) 8- (N-cyclopropylmethyl-N-methylamino) -2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (120) 8- (N-cyclopropylmethyl-N-methylamino) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a ] pyrimidine; (121) 8- (N-propyl-N- (2-methoxyiminoethyl) amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1 5-a] pyrimidine; (122) 8 - [(2S) -1-methoxyiminobutan-2-yl] amino-2-methyl-3- (2-methyl-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [ 1,5-a] pyrimidine; and (123) 9- (3-pentylamino) -6-methyl-5- (2-methyl-4-methoxyphenyl) furo [3,2-d] pyrazolo [1,5-a] pyrimidine; their pharmaceutically acceptable salt or hydrate. 19. The compound according to claim 1, which is selected from the group including: (1) 8-hydroxy-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (2) 2-methyl-3- (2-methyl-4-methoxyphenyl) -8 - [(2S, 4R) -4-methoxy-2-methoxymethylpyrrolidin-1-yl] -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (3) 8- (1,2,5,6-tetrahydropyridyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (4) 8- (1,2,3,4-tetrahydroisoquinolin-2-yl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (5) 8 - ((3S) -3-methoxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro -5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (6) 8- (4-phenylpiperazin-1-yl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a ] pyrimidine; (7) 8- (4- (2-chlorophenyl) piperazin-1-yl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [ 1,5-a] pyrimidine; (8) 8- (3-ethoxycarbonyl-1,2,5,6-tetrahydropyridyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (9) 8- (3- (3-methyl-1,2,4-oxadiazol-5-yl) -1,2,5,6-tetrahydropyridyl) -2-methyl-3- (2-methyl-4- methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (10) 8- (4- (4-chlorophenyl) -1,2,5,6-tetrahydropyridyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (11) 8- (3-pentyloxy) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (12) 8- (3-pentyloxy) -2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (13) 8- (4-heptyloxy) -2-methyl-3- (2-chloro-5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (14) 8-isopropyloxy-2-methyl-3- (2-chloro-5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (15) 8- (1,6-heptadien-4-yl) oxy-2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1, 5-a] pyrimidine; (16) 8- (3-pentylthio) -2-methyl-3- (2-chloro-5-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (17) 8- (4-methylphenyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (18) 8- (2,4-Dichlorophenyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (19) 8- (3-trifluoromethylphenyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (20) 8- (4-methoxyphenyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (21) 8- (3,5-dichlorophenyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; (22) 8- (2-methylphenyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (23) 8-bis (ethoxycarbonyl) methyl-2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (24) 8- (1-dimethylamino-1,3-dioxo-2-butyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (25) 8- (2,4-dioxo-3-pentyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (26) 8-bis (ethoxycarbonyl) methyl-2-methyl-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine; (27) 8- (1,3-hydroxy-2-propyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (28) 8- (1,3-dimethoxy-2-propyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5 -a] pyrimidine; (29) 8- (N, N-dimethylcarbamoylmethyl) -2-methyl-3- (2-methyl-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,5-a] pyrimidine ; and (30) 1-cyano-2-methyl-8-hydroxy-3- (2-chloro-4-methoxyphenyl) -6,7-dihydro-5H-cyclopenta [d] pyrazolo [1,2-a] pyrimidine; its pharmaceutically acceptable salt or hydrate. 20. The compound according to claim 1, which is selected from the group including: (1) 6-methyl-5- (2-methyl-4-methoxyphenyl) -9 - [(2S, 4R) -4-methoxy-2-methoxymethylpyrrolidin-1-yl] -2,3-dihydrofuro [3,2 -d] pyrazolo [1,5-a] pyrimidine; (2) 2-methyl-3- (2-methyl-4-methoxyphenyl) -8 - [(2S, 4R) -4-methoxy-2-methoxymethylpyrrolidin-1-yl] -5,7-dihydrofuro [3,4 -d] pyrazolo [1,5-a] pyrimidine; (3) 6-methyl-5- (2-methyl-4-methoxyphenyl) -9 - [(2S, 4R) -4-methoxy-2-methoxymethylpyrrolidin-1-yl] -2,3-dihydropyrrolo [3,2 -d] pyrazolo [1,5-a] pyrimidine; (4) 8- (3-pentyloxy) -2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; and (5) 8-bis (ethoxycarbonyl) methyl-2-methyl-3- (2-chloro-4-methoxyphenyl) -5,7-dihydrofuro [3,4-d] pyrazolo [1,5-a] pyrimidine; its pharmaceutically acceptable salt and hydrate. 21. A pharmaceutical composition that contains a compound of formula (I) described in claim 1, its pharmaceutically an acceptable salt or hydrate as an active ingredient. 22. The pharmaceutical composition for the treatment and / or prevention of diseases caused by excessive secretion of the corticotropin releasing factor, which contains a compound of formula (I):

where each of X and Y independently from each other represents carbon or nitrogen, and both are not simultaneously nitrogen; W represents carbon or nitrogen; U and Z each independently of each other represents CR ² , NR ¹³ , nitrogen, oxygen, sulfur, C = O or C = S; R ² represents (i) hydrogen, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) halogen, (vi) CF ₃ , (vii) cyano, (viii) nitro, (ix) NR ⁹ R ¹⁰ where each of the substituents R ⁹ and R ¹⁰ independently from each other represents: (i) hydrogen, (ii) C1-4 alkyl, (iii) a C3-10 mono- or bi-carbocyclic ring, (iv) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, or (v) C1-4 alkyl substituted with a C3-10 mono- or bi-carbocyclic ring or a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, (x) OR ¹¹ , where R ¹¹ represents: (i) hydrogen, (ii) C1-4 alkyl, (iii) a C5-6 carbocyclic ring, (iv) a 5- or 6-membered heterocyclic ring containing 1 to 2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, or (v) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, (xi) SH, (xii) S (O) _n R ¹² , where n is 0, 1 or 2, R ¹² represents: (i) C1-4 alkyl, (ii) a C5-6 carbocyclic ring, (iii) a 5- or 6-membered heterocyclic ring containing 1 to 2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, or (iv) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, (xiii) COR ¹¹ , (xiv) COOR ¹¹ , (xv) CONR ⁹ R ¹⁰ , (xvi) a C3-10 mono- or bi-carbocyclic ring, (xvii) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, or (xviii) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , C3-10-mono- or bi-carbocyclic ring and 3-10-membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 atoms oxygen and / or 1-2 sulfur atoms, R ¹³ represents (i) hydrogen, (ii) C1-4 alkyl, (iii) C2-4 alkenyl, (iv) C2-4 alkynyl, (v) C3-10 mono- or bi-carbocyclic ring, (vi) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, or (vii) C1-4 alkyl substituted with a C3-10 mono- or bi-carbocyclic ring or a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms,

represents a single or double bond,

represents a C4-6 carbocyclic ring or a 4-6 membered heterocyclic ring containing at least one nitrogen, oxygen and sulfur atom, and these rings are unsubstituted or substituted by 1-3 substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen and CF ₃ , R ¹ represents (i) C1-8 alkyl which is unsubstituted or substituted by 1-5 R ¹⁴ substituents; (ii) C2-8 alkenyl, which is unsubstituted or substituted with 1-5 R ¹⁴ substituents; (iii) C2-8-alkynyl, which is unsubstituted or substituted with 1-5 R ¹⁴ substituents; (iv) NR ⁴ R ⁵ where each of the substituents R ⁴ and R ⁵ independently from each other represents (i) hydrogen, (ii) C1-15 alkyl, which is unsubstituted or substituted with 1-5 substituents R ¹⁷ ; (iii) C2-15 alkenyl, which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (iv) C2-15 alkynyl which is unsubstituted or substituted by 1-5 R ¹⁷ substituents; (v) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 R ¹⁸ substituents; (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (v) OR ⁶ where the substituent R ⁶ represents (i) hydrogen, (ii) C1-10 alkyl, (iii) C2-10 alkenyl, (iv) C2-10 alkynyl, (v) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted with 1-5 R ¹⁸ substituents; (vi) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (vii) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , a C3-10 mono- or bi-carbocyclic ring that is unsubstituted or substituted with 1-5 substituents R ¹⁸ , and a 3-10-membered mono- or bi-heterocyclic a ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (vi) SH, (vii) S (O) _n R ⁷ , where n takes the above values, R ⁷ represents: (i) C1-8 alkyl, (ii) a C3-10 mono- or bi-carbocyclic ring that is unsubstituted or is substituted with 1-5 R ¹⁸ substituents; (iii) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (iv) C1-4 alkyl substituted with a C3-10-mono- or bi-carbocyclic ring which is unsubstituted or substituted by 1-5 substituents R ¹⁸ , or a 3-10-membered mono- or bi-heterocyclic ring containing 1 -4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (viii) COR ⁶ , (ix) COOR ⁶ , (x) CONR ⁴ R ⁵ , (xi) NR ⁸ COR ^6a , where R ^6a represents: (i) hydrogen, (ii) C1-10 alkyl, (iii) C2-10 alkenyl, (iv) C2-10 alkynyl or (v) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ^11a , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ and CONR ⁹ R ¹⁰ , (xii) NR ⁸ COOR ⁶ , where R ⁶ has the above meanings, R ⁸ represents: (i) hydrogen, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl, (v) a C3-10 mono- or bi-carbocyclic ring which is unsubstituted or is substituted with 1-5 R ¹⁸ substituents; (vi) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; or (vii) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , a C3-10 mono- or bi-carbocyclic ring that is unsubstituted or substituted with 1-5 substituents R ¹⁸ , and a 3-10-membered mono- or bi-heterocyclic a ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁸ substituents; (xiii) NR ⁸ CONR ⁴ R ⁵ , (xiv) a C3-15 mono- or bi-carbocyclic ring which is unsubstituted or is substituted with 1-5 R ¹⁵ substituents; or (xv) a 3-15 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁵ substituents, R ^11a represents (i) hydrogen, (ii) C1-4 alkyl or (iii) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, R ¹⁴ represents (a) halogen, (b) CF ₃ , (c) OCF ₃ , (d) cyano, (e) nitro, (f) NR ⁴ R ⁵ , (g) OR ⁶ , (h) = N -OR ⁶ , (j) SH, (k) S (O) _n R ⁷ , (l) COR ⁶ , (m) COOR ⁶ , (n) CONR ⁴ R ⁵ , (o) NR ⁸ COR ⁶ , (p ) NR ⁸ COOR ⁶ , (q) NR ⁸ CONR ⁴ R ⁵ , (r) C3-15-mono- or bi-carbocyclic ring, which is unsubstituted or substituted by 1-5 substituents R ¹⁵ , or (s) 3-15 a membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ¹⁵ substituents; R ¹⁵ represents (a) C1-8 alkyl, (b) C2-8 alkenyl, (c) C2-8 alkynyl, (d) C1-4 alkoxy (C1-4) alkyl, (e) halogen, (f) CF ₃ , (g) OCF ₃ , (h) cyano, (j) nitro, (k) NR ⁴ R ⁵ , (l) OR ⁶ , (m) SH, (n) S (O) _n R ⁷ , (o) COR ⁶ , (p) COOR ⁶ , (q) CONR ⁴ R ⁵ , (r) NR ⁸ COR ⁶ , (s) NR ⁸ COOR ⁶ , (t) NR ⁸ CONR ⁴ R ⁵ , (u) a C3-10 mono- or bi-carbocyclic ring which is unsubstituted or substituted by 1-5 R ²⁰ substituents, (v) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 substituents R ²⁰ , or (w) C1-4 alkyl, substituted by 1-2 substituents, selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁴ R ⁵ , OR ⁶ , = N-OR ⁶ , SH, S (O) _n R ⁷ , COR ⁶ , COOR ⁶ , CONR ⁴ R ⁵ , NR ⁸ COR ⁶ , NR ⁸ COOR ⁶ , NR ⁸ CONR ⁴ R ⁵ , C3-10 mono- or bi-carbocyclic ring, which is unsubstituted or substituted by 1-5 substituents of R ²⁰ , and a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ²⁰ substituents ; R ¹⁷ represents (a) halogen, (b) CF ₃ , (c) OCF ₃ , (d) cyano, (e) nitro, (f) NR ⁹ R ¹⁰ , (g) OR ^11a , (h) = N -OR ¹¹ , (j) SH, (k) S (O) _n R ¹² , (l) COR ¹¹ , (m) COOR ¹¹ , (n) CONR ⁹ R ¹⁰ , (o) NR ⁸ COR ¹¹ , (p ) NR ⁸ COOR ¹¹ , (q) NR ⁸ CONR ⁹ R ¹⁰ , (r) C3-15 mono- or bi-carbocyclic ring which is unsubstituted or substituted by 1-5 substituents R ^18a , or (s) 3-15 a membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, which is unsubstituted or substituted by 1-5 R ^18a substituents; R ¹⁸ is (a) C1-4 alkyl, (b) C2-4 alkenyl, (c) C2-4 alkynyl, (d) halogen, (e) CF ₃ , (f) OCF ₃ , (g ) cyano, (h) nitro, (j) SH, (k) S (O) _n R ¹² , (l) NR ⁹ R ¹⁰ , (m) OR ¹¹ , (n) COR ¹¹ , (o) COOR ¹¹ , (p) CONR ⁹ R ¹⁰ , (q) a C5-6 carbocyclic ring, (r) a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, or (s ) C1-4 alkyl substituted with a C5-6 carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1-2 nitrogen atoms, 1 oxygen atom and / or 1 sulfur atom, R ^18a represents (a) C1-4 alkyl, (b) C2-4 alkenyl, (c) C2-4 alkynyl, (d) halogen, (e) CF ₃ , (f) OCF ₃ , (g ) cyano, (h) nitro, (j) SH, (k) S (O) _n R ¹² , (l) NR ⁹ R ¹⁰ , (m) OR ^11a , (n) COR ¹¹ , (o) COOR ¹¹ or (p) CONR ⁹ R ¹⁰ , R ¹⁹ represents C1-4 alkyl, C1-4 alkoxy, halogen, CF ₃ , OCF ₃ , cyano, nitro, amino, NH (C1-4 alkyl) or N (C1-4 alkyl) ₂ , R ³ represents (i) a C5-10 mono- or bi-carbocyclic ring substituted with 1-5 substituents R ¹⁶ , or (ii) a 5-10-membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms 1-2 oxygen atoms and / or 1-2 sulfur atoms substituted with 1-5 R ¹⁶ substituents, R ¹⁶ represents (a) C1-8 alkyl, (b) C2-8 alkenyl, (c) C2-8 alkynyl, (d) halogen, (e) CF ₃ , (f) OCF ₃ , (g) cyano, (h) nitro, (j) NR ⁹ R ¹⁰ , (k) OR ¹¹ , (l) SH, (m) S (O) _n R ¹² , except phenylthio, (n) COR ¹¹ , (o) COOR ¹¹ , (p) CONR ⁹ R ¹⁰ , (q) NR ⁸ COR ¹¹ , (r) NR ⁸ COOR ¹¹ , (s) NR ⁸ CONR ⁹ R ¹⁰ , (t) a C3-10 mono- or bi-carbocyclic ring, (u) a 3-10 membered mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, (v) C1-4 alkyl substituted with 1-2 substituents selected from halogen, CF ₃ , OCF ₃ , cyano, nitro, NR ⁹ R ¹⁰ , OR ¹¹ , = N-OR ¹¹ , SH, S (O) _n R ¹² , COR ¹¹ , COOR ¹¹ , CONR ⁹ R ¹⁰ , NR ⁸ COR ¹¹ , NR ⁸ COOR ¹¹ , NR ⁸ CONR ⁹ R ¹⁰ , C3-10 mono- or bi-carbocyclic ring, and 3-10 membered a mono- or bi-heterocyclic ring containing 1-4 nitrogen atoms, 1-2 oxygen atoms and / or 1-2 sulfur atoms, provided that (1) when each of X and W is carbon, each of Y and Z is nitrogen, U is CR ⁴ and R ¹ is OR ⁶ , then R ^{3 is} not phenyl substituted with 1 halogen, phenyl substituted with 1 trifluoromethyl and phenyl substituted with trifluoromethyl and nitro, (2) when each of X, Y and Z is carbon and each of U and W is nitrogen, then the substituent R ³ is C5-10-mono or a bi-carbocyclic ring substituted with 1-5 substituents R ¹⁶ ; its pharmaceutically acceptable salt or hydrate. 23. The pharmaceutical composition according to item 22 for the treatment and / or prevention of diseases caused by excessive secretion of the corticotropin releasing factor, namely: depression, a single attack of depression, recurrent depression, postpartum depression, depression caused by maltreatment, anxiety, disorders associated with fear (e.g., panic, specific phobia, fear of ruin, social phobia, compulsive compulsive disorder), emotional disturbance, bipolar disorder, post-traumatic stress spring, peptic ulcer, diarrhea, constipation, irritable bowel syndrome, inflammatory bowel disease (ulcerative colitis, Crohn's disease) caused by stress disorders of the gastrointestinal tract, nervous vomiting, eating disorder (for example, loss of appetite, bulimia due to nervous system) , stress-related obesity, sleep disturbance, muscle fiber pain caused by sleep disturbance caused by stress suppression of the immune system caused by stress headache caused by stress fever caused by stress om pain, postoperative stress, rheumatoid arthritis, osteoarthritis, osteoporosis, psoriasis, thyroid dysfunction, uveitis, asthma induced by inappropriate antidiarrheal hormone disorders, pain, inflammation, allergic disease, head wounds, spinal cord injuries, ischemic neuronal damage, toxic neuronal damage, toxic toxic , Cushing's disease (Cushing), apoplexy stroke, spasm, muscle spasm, epilepsy, ischemia, Parkinson's disease, Huntington's disease, urinary incontinence, Alz disease gamers, senile dementia of the Alzheimer's type, multi-infarct dementia, amyotrophic lateral sclerosis, hypoglycemia, cardiovascular or heart-related diseases (hypertension, tachycardia, congestive heart failure), addiction to excessive use of drugs or alcohol dependence syndrome.