RU2003118718A - DIHYDRONAFTALINE DERIVATIVES AND MEDICINAL PRODUCT INCLUDING THE INDICATED DERIVATIVES AS AN ACTIVE INGREDIENT - Google Patents

Claims (19)

1. The dihydronaphthalene derivative represented by the formula (I)

where X represents (1) a bond or (2) C1-4 alkylene, Y represents (1) –O— or (2) –S–, Z represents C1-4 alkylene, A represents (1) –O— or (2) –S–, R ¹ represents (1) COOR ⁵ , (2) CONH ₂ , (3) CONHOH, (4) CH ₂ OH, (5) CHO, (6) 1H-tetrazol-5-yl or (7) 3,5 dioxoisoisoxolin-4-yl, R ⁵ represents (1) hydrogen or (2) C1-8 alkyl, R ² and R ³ each independently represents (1) hydrogen, (2) C1-8 alkyl, (3) C1-8 alkoxy or (4) C1-8 alkoxy substituted with phenyl, R ⁴ represents (1) hydrogen or (2) C1-8 alkyl, D represents D ¹ , D ² or D ³ , D ¹ represents

cycle 1 is a partially or completely optionally saturated C3-10 mono- or bicarbocyclic aryl, D ² represents

cycle 2 is a partially or completely optionally saturated 3-10 membered mono- or bigherocyclic aryl containing 1-4 heteroatoms selected from oxygen, nitrogen or sulfur atoms, D ³ represents C1-8 alkyl, R ⁶ is (1) hydrogen, (2) C1-8 alkyl, (3) nitro, (4) NR ⁷ R ⁸ , (5) halogen, (6) C1-8 alkoxy, (7) C1-8 alkylthio , (8) CF ₃ , (9) CF ₃ O, (10) partially or completely optionally saturated C3-10 mono- or bicarbocyclic aryl, or (11) partially or completely optionally saturated 3-10-membered mono- or bigherocyclic aryl, containing 1-4-heteroatoms selected from oxygen, nitrogen or sulfur atoms, R ⁷ and R ⁸ each independently represent (1) a hydrogen atom or (2) C1-alkyl, m = 1-3 or its non-toxic salt. 2. The dihydronaphthalene derivative of claim 1, wherein D is D ¹ and R ¹ is COOR ⁵ , or a non-toxic salt thereof. 3. The dihydronaphthalene derivative of claim 1, wherein D is D ¹ and R ¹ is NH ₂ , CONHOH, CH ₂ OH, CHO, 1H-tetrazol-5-yl or 3,5-dioxoisoisoxolin-4-yl, or its non-toxic salt. 4. The dihydronaphthalene derivative of claim 1, wherein D is D ² and R ¹ is COOR ⁵ , or a non-toxic salt thereof. 5. The dihydronaphthalene derivative of claim 1, wherein D is D ² and R ¹ is CONH ₂ , CONHOH, CH ₂ OH, CHO, 1H-tetrazol-5-yl or 3,5-dioxoisoisoxolin-4-yl, or its non-toxic salt. 6. The dihydronaphthalene derivative of claim 1, wherein D is D ³ and R ¹ is COOR ⁵ , or a non-toxic salt thereof. 7. The dihydronaphthalene derivative of claim 1, wherein D is D ³ and R ¹ is CONH ₂ , CONHOH, CH ₂ OH, CHO, 1H-tetrazol-5-yl or 3,5-dioxoisoisoxolin-4-yl, or its non-toxic salt. 8. The derivative of dihydronaphthalene according to claim 2, which is a 1) 3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 2) 3- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 3) 3- (5- (2- (2- (4-tert-butylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 4) 3- (5- (2- (2- (4-dimethylaminophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 5) 3- (5- (2- (2- (4-trifluoromethylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 6) 3- (5- (2- (2- (4-trifluoromethyloxyphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 7) 3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 8) 3- (5- (2- (2- (4-chlorophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 9) 3- (5- (2- (2- (4-methylthiophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 10) 3- (5- (2- (2- (4-isopropylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 11) 3- (5- (2- (2- (4-propylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 12) 2- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid ethyl ester, 13) 2- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid ethyl ester, 14) 2- (5- (2- (2- (4-cyclohexylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid ethyl ester, 15) 5- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid methyl ester, 16) 5- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid methyl ester, 17) 5- (5- (2- (2- (4-dimethylaminophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid methyl ester, 18) 2,2-dimethyl-3- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 19) 2,2-dimethyl-5- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid methyl ester, 20) 2-benzyloxy-3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 21) 3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 22) 3- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 23) 3- (5- (2- (2- (4-tert-butylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 24) 3- (5- (2- (2- (4-dimethylaminophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 25) 3- (5- (2- (2- (4-trifluoromethylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 26) 3- (5- (2- (2- (4-trifluoromethyloxyphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 27) 3- (5- (2- (2- (4-chlorophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 28) 3- (5- (2- (2- (4-methylthiophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 29) 3- (5- (2- (2- (4-isopropylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 30) 3- (5- (2- (2- (4-propylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 31) 2- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid, 32) 2- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid, 33) 5- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid, 34) 5- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid, 35) 5- (5- (2- (2- (4-dimethylaminophenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid, 36) 2,2-dimethyl-3- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid, 37) 2,2-dimethyl-5- (5- (2- (2-phenyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid, 38) 2-benzyloxy-3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 39) 2-ethoxy-3- (5- (2- (2- (4-cyclohexylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 40) 2-ethoxy-3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, or its non-toxic salt. 9. The derivative of dihydronaphthalene according to claim 3, which is 1) 2- (5- (2- (2- (4-cyclohexylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) ethanol, 2) 2- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) ethanol, 3) 3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanol, 4) 2- (5- (2- (2- (4-cyclohexylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetaldehyde, 5) 2- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetaldehyde, 6) 2-ethoxy-3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanamide, 7) N-hydroxy-3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanamide, 8) N-hydroxy-2- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetamide, 9) 3- (5- (2- (2- (4-methylphenyl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanamide, 10) 5- (2- (5- (2- (5-methyl-2- (4-methylphenyl) oxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) ethyl) -1H-tetrazole or 11) 4 - ((5- (2- (5-methyl-2- (4-methylphenyl) oxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) methyl) isoxazolidin-3,5- dion or its non-toxic salt. 10. The derivative of dihydronaphthalene according to claim 4, which is a 1) 3- (5- (2- (2- (6-dimethylaminopyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 2) 3- (5- (2- (2- (1,3-dioxaindan-5-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester , 3) 3- (5- (2- (2- (6- (Morpholin-4-yl) pyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalene-1 methyl ester -yl) propanoic acid, 4) 3- (5- (2- (2- (2,2-difluoro-1,3-dioxaindan-5-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalene ethyl ester 1-yl) propanoic acid, 5) 3- (5- (2- (2- (6-diethylaminopyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 6) 3- (5- (2- (2-piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 7) 3- (5- (2- (2- (4-methylpiperazin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 8) 3- (5- (2- (2- (morpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 9) 3- (5- (2- (2- (thiomorpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 10) 3- (5- (2- (2- (6-methylpyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 11) 3- (5- (2- (2- (1,5-dimethylpyrazol-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester , 12) 3- (5- (2- (2- (4-methylpiperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 13) 3- (5- (2- (2- (5-methylpyrazin-2-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 14) 3- (5- (2- (2- (1,2,3,6-tetrahydropyridin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalene-1- ethyl ester il) propanoic acid, 15) 2- (5- (2- (2- (4-methylpiperazin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid ethyl ester, 16) 2- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid ethyl ester, 17) 5- (5- (2- (2- (1,3-dioxaindan-5-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid methyl ester , 18) 2,2-dimethyl-3- (5- (2- (2- (6-dimethylaminopyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalene-1- methyl ester il) propanoic acid, 19) 2,2-dimethyl-3- (5- (2- (2- (6- (pyridin-1-yl) pyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3 methyl ester , 4-dihydronaphthalen-1-yl) propanoic acid, 20) 2,2-dimethyl-3- (5- (2- (2- (6- (morpholin-4-yl) pyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3 methyl ester , 4-dihydronaphthalen-1-yl) propanoic acid, 21) 2,2-dimethyl-3- (5- (2- (2- (6-methylpyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalene-1- methyl ester il) propanoic acid, 22) 2,2-dimethyl-3- (5- (2- (2- (morpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl methyl ester) propanoic acid 23) 2,2-dimethyl-3- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl methyl ester) propanoic acid 24) 2,2-dimethyl-3- (5- (2- (2- (thiomorpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl methyl ester) propanoic acid 25) 3- (5- (2- (2- (6-dimethylaminopyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 26) 3- (5- (2- (2- (1,3-dioxaindan-5-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 27) 3- (5- (2- (2- (6- (morpholin-4-yl) pyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl ) propanoic acid, 28) 3- (5- (2- (2- (2,2-difluoro-1,3-dioxaindan-5-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalene-1- sludge) propanoic acid, 29) 3- (5- (2- (2- (6-diethylaminopyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 30) 3- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 31) 3- (5- (2- (2- (4-methylpiperazin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 32) 3- (5- (2- (2- (morpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 33) 2- (5- (2- (2- (thiomorpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 34) 3- (5- (2- (2- (6-methylpyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 35) 3- (5- (2- (2- (1,5-dimethylpyrazol-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 36) 3- (5- (2- (2- (4-methylpiperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 37) 3- (5- (2- (2- (5-methylpyrazin-2-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 38) 3- (5- (2- (2- (1,2,3,6-tetrahydropyridin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid 39) 5- (5- (2- (2- (1,3-dioxaindan-5-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) pentanoic acid, 40) 2,2-dimethyl-3- (5- (2- (2- (6-dimethylaminopyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid 41) 2,2-dimethyl-3- (5- (2- (2- (6- (pyridin-1-yl) pyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4 -dihydronaphthalen-1-yl) propanoic acid, 42) 2,2-dimethyl-3- (5- (2- (2- (6- (morpholin-4-yl) pyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4 -dihydronaphthalen-1-yl) propanoic acid, 43) 2,2-dimethyl-3- (5- (2- (2- (6-methylpyridin-3-yl) -5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid 44) 2,2-dimethyl-3- (5- (2- (2- (morpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid , 45) 2,2-dimethyl-3- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid , 46) 2,2-dimethyl-3- (5- (2- (2- (thiomorpholin-4-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid , 47) 2-ethoxy-3- (5- (2- (2- (4-methylpiperazin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid or 48) 2-ethoxy-3- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, or its non-toxic salt. 11. The derivative of dihydronaphthalene according to claim 5, which is a 1) 2- (5- (2- (2- (4-methylpiperazin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) ethanol, 2) 2- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) ethanol, 3) 2- (5- (2- (2- (4-methylpiperazin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetaldehyde or 4) 2- (5- (2- (2- (piperidin-1-yl) -5-methylthiazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetaldehyde, or its non-toxic salt. 12. The dihydronaphthalene derivative of claim 6, which is 1) 3- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid ethyl ester, 2) 2- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetic acid ethyl ester, 3) 2,2-dimethyl-3- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid methyl ester, 4) 3- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, 5) 2,2-dimethyl-3- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid or 6) 2-ethoxy-3- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) propanoic acid, or its non-toxic salt. 13. The dihydronaphthalene derivative of claim 7, which is 1) 2- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) ethanol or 2) 2- (5- (2- (2-isopropyl-5-methyloxazol-4-yl) ethoxy) -3,4-dihydronaphthalen-1-yl) acetaldehyde, or its non-toxic salt. 14. A peroxisome proliferator activated receptor (PPAR) receptor regulator comprising a dihydronaphthalene derivative of the formula (I) described in claim 1, or a non-toxic salt thereof as an active ingredient. 15. The regulator of the receptor activated by the peroxisome proliferator (PPAR) α- and γ-type, including the dihydronaphthalene derivative of the formula (I) described in claim 1, or its non-toxic salt as an active ingredient. 16. An α- and γ-type peroxisome proliferator (PPAR) activated receptor agonist comprising a dihydronaphthalene derivative of the formula (I) described in claim 1, or a non-toxic salt thereof as an active ingredient. 17. A hypoglycemic agent and / or lipid-lowering agent, including a dihydronaphthalene derivative of the formula (I) described in claim 1, or a non-toxic salt thereof as an active ingredient. 18 Means for the prevention and / or treatment of diseases associated with metabolic disorders (diabetes, obesity, X syndrome, hypercholesterolemia, hyperproteinemia, etc.), lipemia, atherosclerosis, hypertension, circulatory diseases, overeating or coronary heart diseases, including a dihydronaphthalene derivative of the formula (I) described in claim 1, or a non-toxic salt thereof as an active ingredient. 19. An agent that increases the content of HDL-cholesterol and reduces the content of LDL-cholesterol and / or VLDL-cholesterol, or an agent for reducing the risk factor for diabetes and / or syndrome X, comprising the dihydronaphthalene derivative of the formula (I) described in claim 1, or its non-toxic salt as an active ingredient.