RU2003118500A - MEANS FOR INHIBITING REPRODUCTION OF COATED VIRUSES, METHOD FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING VIRAL INFECTIONS - Google Patents

MEANS FOR INHIBITING REPRODUCTION OF COATED VIRUSES, METHOD FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING VIRAL INFECTIONS

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Publication number
RU2003118500A
RU2003118500A RU2003118500/15A RU2003118500A RU2003118500A RU 2003118500 A RU2003118500 A RU 2003118500A RU 2003118500/15 A RU2003118500/15 A RU 2003118500/15A RU 2003118500 A RU2003118500 A RU 2003118500A RU 2003118500 A RU2003118500 A RU 2003118500A
Authority
RU
Russia
Prior art keywords
inhibiting
reproduction
pharmaceutical composition
enveloped viruses
fullerene
Prior art date
Application number
RU2003118500/15A
Other languages
Russian (ru)
Other versions
RU2236852C1 (en
Original Assignee
Закрытое акционерное общество "Деско" (ЗАО "Деско")
Filing date
Publication date
Application filed by Закрытое акционерное общество "Деско" (ЗАО "Деско") filed Critical Закрытое акционерное общество "Деско" (ЗАО "Деско")
Priority claimed from RU2003118500/15A external-priority patent/RU2236852C1/en
Priority to RU2003118500/15A priority Critical patent/RU2236852C1/en
Priority to JP2006517009A priority patent/JP2007522082A/en
Priority to CA002530004A priority patent/CA2530004A1/en
Priority to UAA200600635A priority patent/UA82528C2/en
Priority to AU2004249090A priority patent/AU2004249090A1/en
Priority to GEAP20049178A priority patent/GEP20084377B/en
Priority to KR1020057024813A priority patent/KR20060017887A/en
Priority to EP04748919A priority patent/EP1645279A4/en
Priority to BRPI0411679-8A priority patent/BRPI0411679A/en
Priority to AP2006003495A priority patent/AP2006003495A0/en
Priority to CNA2004800171673A priority patent/CN1819834A/en
Priority to US10/559,681 priority patent/US20060122276A1/en
Priority to PCT/RU2004/000208 priority patent/WO2004112804A1/en
Priority to EA200600010A priority patent/EA010483B1/en
Publication of RU2236852C1 publication Critical patent/RU2236852C1/en
Application granted granted Critical
Publication of RU2003118500A publication Critical patent/RU2003118500A/en
Priority to IL172634A priority patent/IL172634A0/en

Links

Claims (5)

1. Средство для ингибирования репродукции оболочечных вирусов, характеризующееся тем, что оно представляет собой водорастворимое соединение фуллеренполикарбоновых анионов общей формулы1. Means for inhibiting the reproduction of enveloped viruses, characterized in that it is a water-soluble compound of fullerene polycarboxylic anions of the General formula C60Hn[NH(CH2)mC(O)O-]n,C 60 H n [NH (CH 2 ) m C (O) O - ] n , где С60 - фуллереновое ядро,where C 60 is the fullerene core, NH(CH2)mC(O)O- - аминокарбоновый анионNH (CH 2 ) m C (O) O - - aminocarboxylic anion m равно целому числу от 1 до 5, предпочтительно 3 и 5, наиболее предпочтительно 5,m is an integer from 1 to 5, preferably 3 and 5, most preferably 5, n равно целому числу от 2 до 12, предпочтительно от 4 до 6, наиболее предпочтительно 6.n is an integer from 2 to 12, preferably from 4 to 6, most preferably 6. 2. Способ получения средства для ингибирования репродукции оболочечных вирусов, характеризующийся тем, что в раствор фуллерена в о-дихлорбензоле вносят аминокислоту в виде калиевой или натриевой соли, далее добавляют солюбилизатор выбранный из группы полиалкиленоксидов: полиэтиленгликоли мол массы от 150 до 400 и выше, а также диметиловые эфиры полиэтиленгликолей, при этом соотношение фуллерена и кислоты увеличено более чем в 50 раз, а синтез проводят при температуре 60-80°С.2. A method of obtaining a tool for inhibiting the reproduction of enveloped viruses, characterized in that an amino acid in the form of potassium or sodium salt is added to the solution of fullerene in o-dichlorobenzene, then a solubilizer selected from the group of polyalkylene oxides is added: polyethylene glycols of a mass of 150 to 400 and higher, and also dimethyl ethers of polyethylene glycols, while the ratio of fullerene and acid is increased by more than 50 times, and the synthesis is carried out at a temperature of 60-80 ° C. 3. Фармацевтическая композиция для ингибирования репродукции оболочечных вирусов, характеризующаяся тем, что она содержит средство по п.1 в эффективном количестве и фармацевтически приемлемые наполнители.3. A pharmaceutical composition for inhibiting the reproduction of enveloped viruses, characterized in that it contains the agent according to claim 1 in an effective amount and pharmaceutically acceptable excipients. 4. Фармацевтическая композиция для ингибирования репродукции оболочечных вирусов по п.3, характеризующаяся тем, что она выполнена в форме таблеток, капсул, раствора для инъекций, суппозиториев, мази, крема, спрея, геля.4. The pharmaceutical composition for inhibiting the reproduction of enveloped viruses according to claim 3, characterized in that it is made in the form of tablets, capsules, injection, suppositories, ointments, cream, spray, gel. 5. Способ ингибирования репродукции оболочечных вирусов, характеризующийся тем, что используют фармацевтическую композицию по п.п.3 и 4 для подавления вирусов при лечении заболеваний ВИЧ и СПИД, герпес-инфекций, вирусного гепатита С.5. A method of inhibiting the reproduction of enveloped viruses, characterized in that they use the pharmaceutical composition according to claims 3 and 4 to suppress viruses in the treatment of HIV and AIDS, herpes infections, hepatitis C.
RU2003118500/15A 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections RU2236852C1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
RU2003118500/15A RU2236852C1 (en) 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections
BRPI0411679-8A BRPI0411679A (en) 2003-06-23 2004-05-31 membrane virus inhibiting agent, method for producing virus, pharmaceutical composition and method for inhibiting viral infection
CNA2004800171673A CN1819834A (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
UAA200600635A UA82528C2 (en) 2003-06-23 2004-05-31 Agent for inhibition of membrane-enveloped viruses propagation based on fullerene water-soluble compound and process for the preparation thereof
AU2004249090A AU2004249090A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
GEAP20049178A GEP20084377B (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
KR1020057024813A KR20060017887A (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
EP04748919A EP1645279A4 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
JP2006517009A JP2007522082A (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus production, method for its production, pharmaceutical composition and method for inhibiting viral infection
AP2006003495A AP2006003495A0 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections.
CA002530004A CA2530004A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
US10/559,681 US20060122276A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
PCT/RU2004/000208 WO2004112804A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
EA200600010A EA010483B1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus production, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
IL172634A IL172634A0 (en) 2003-06-23 2005-12-15 Agent for inhibiting membrane virus reproduction, method for the production thereof pharmaceutical composition and method for inhibiting viral infections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2003118500/15A RU2236852C1 (en) 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections

Publications (2)

Publication Number Publication Date
RU2236852C1 RU2236852C1 (en) 2004-09-27
RU2003118500A true RU2003118500A (en) 2004-12-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003118500/15A RU2236852C1 (en) 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections

Country Status (15)

Country Link
US (1) US20060122276A1 (en)
EP (1) EP1645279A4 (en)
JP (1) JP2007522082A (en)
KR (1) KR20060017887A (en)
CN (1) CN1819834A (en)
AP (1) AP2006003495A0 (en)
AU (1) AU2004249090A1 (en)
BR (1) BRPI0411679A (en)
CA (1) CA2530004A1 (en)
EA (1) EA010483B1 (en)
GE (1) GEP20084377B (en)
IL (1) IL172634A0 (en)
RU (1) RU2236852C1 (en)
UA (1) UA82528C2 (en)
WO (1) WO2004112804A1 (en)

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JP2006160664A (en) * 2004-12-07 2006-06-22 Vitamin C60 Bioresearch Kk Free radical disease-preventing and treating composition
RU2462473C2 (en) * 2007-06-19 2012-09-27 Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) Polyfunctional fullerene c60 amino acid derivatives
CA2687557A1 (en) * 2007-06-19 2008-12-31 Institute Of Problems Of Chemical Physics Ras (Ipcp Ras) Polyfunctional fullerene c60 amino acid derivatives
AP3010A (en) * 2007-10-29 2014-10-31 Cipla Ltd Novel antiretroviral combination
RU2458914C1 (en) * 2011-02-01 2012-08-20 Лев Давидович Раснецов Homo- and hetero-polyamino acid fullerene c60 derivatives, method for preparing them and based pharmaceutical compositions
RU2458046C1 (en) * 2011-02-01 2012-08-10 Лев Давидович Раснецов Hydrated n-fullerene-amino acid derivatives, method for preparing them and based pharmaceutical compositions
RU2477273C2 (en) 2011-03-30 2013-03-10 Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) Sulphur-containing fullerene derivatives and method for production thereof
RU2501785C2 (en) * 2011-08-30 2013-12-20 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук Using pentaaminofullerenes as antimicrobial agents and antimicrobial composition based thereon
CN103347848B (en) * 2012-02-06 2016-09-21 列夫·达维多维奇·拉斯涅特索夫 Hydration N-fullerene aminoacid, its preparation method and the pharmaceutical composition based on it
CN103347849B (en) * 2012-02-06 2016-05-11 列夫·达维多维奇·拉斯涅特索夫 Fullerene С60Homogeneous polyamino acid and assorted amino acids derivative, its preparation method and the pharmaceutical composition based on this derivative
RU2533232C2 (en) * 2012-07-20 2014-11-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вирусологии им. Д.И. Ивановского" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "НИИ вирусологии им. Д.И. Ивановского" Минздравсоцразвития России Using polycarboxylic fullerene deriative as microbiocidal antiviral agent
CN103705388A (en) * 2013-12-19 2014-04-09 深圳市通产丽星股份有限公司 Fullerene capsule and application thereof
CN111135188A (en) * 2018-11-06 2020-05-12 海南森溪海科技有限公司 Application of fullerene and/or water-soluble derivative thereof in medicine for preventing and treating female genital tract diseases

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TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
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