RU2003114752A - TREATMENT OF GASTROINTESTINAL STOMAL TUMORS - Google Patents
TREATMENT OF GASTROINTESTINAL STOMAL TUMORSInfo
- Publication number
- RU2003114752A RU2003114752A RU2003114752/15A RU2003114752A RU2003114752A RU 2003114752 A RU2003114752 A RU 2003114752A RU 2003114752/15 A RU2003114752/15 A RU 2003114752/15A RU 2003114752 A RU2003114752 A RU 2003114752A RU 2003114752 A RU2003114752 A RU 2003114752A
- Authority
- RU
- Russia
- Prior art keywords
- methylpiperazin
- ylamino
- benzamide
- ylmethyl
- pyridin
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 230000002496 gastric Effects 0.000 title 1
- -1 4-methylpiperazin-1-ylmethyl Chemical group 0.000 claims 10
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 5
- UZSCFVMBGQQWQY-UHFFFAOYSA-N COS(=O)=O Chemical compound COS(=O)=O UZSCFVMBGQQWQY-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001058 adult Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24381000P | 2000-10-27 | 2000-10-27 | |
US60/243,810 | 2000-10-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2003114752A true RU2003114752A (en) | 2004-09-10 |
RU2301066C2 RU2301066C2 (en) | 2007-06-20 |
Family
ID=22920224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2003114752/15A RU2301066C2 (en) | 2000-10-27 | 2001-10-26 | Method for treating gastrointestinal stromal tumor cases |
Country Status (26)
Country | Link |
---|---|
US (1) | US6958335B2 (en) |
EP (1) | EP1332137B1 (en) |
JP (1) | JP4386635B2 (en) |
KR (1) | KR100885129B1 (en) |
CN (1) | CN1276754C (en) |
AT (1) | ATE321556T1 (en) |
AU (2) | AU2002218262B2 (en) |
BR (1) | BRPI0114870B8 (en) |
CA (1) | CA2424470C (en) |
CY (1) | CY1105055T1 (en) |
CZ (1) | CZ303944B6 (en) |
DE (1) | DE60118430T2 (en) |
DK (1) | DK1332137T3 (en) |
ES (1) | ES2260317T3 (en) |
HK (1) | HK1058193A1 (en) |
HU (1) | HU229106B1 (en) |
IL (2) | IL155029A0 (en) |
MX (1) | MXPA03003703A (en) |
NO (1) | NO324948B1 (en) |
NZ (1) | NZ525254A (en) |
PL (1) | PL209733B1 (en) |
PT (1) | PT1332137E (en) |
RU (1) | RU2301066C2 (en) |
SK (1) | SK287335B6 (en) |
WO (1) | WO2002034727A2 (en) |
ZA (1) | ZA200302155B (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4477303B2 (en) * | 2001-05-16 | 2010-06-09 | ノバルティス アーゲー | N- {5- [4- (4-Methyl-piperazino-methyl) -benzoylamide] -2-methylphenyl} -4- (3-pyridyl) -2-pyrimidin-amine and a combination comprising a chemotherapeutic agent Agent |
PT1401416E (en) * | 2001-06-29 | 2007-02-28 | Ab Science | Use of c-kit inhibitors for treating inflammatory bowel diseases (ibd) |
WO2003002108A2 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory diseases |
EP1401413B1 (en) * | 2001-06-29 | 2006-11-22 | AB Science | Use of tyrosine kinase inhibitions for treating allergic diseases |
CA2452366A1 (en) * | 2001-06-29 | 2003-01-16 | Ab Science | Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis |
CA2452368A1 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
US20040242612A1 (en) * | 2001-09-20 | 2004-12-02 | Alain Moussy | Use of tyrosine kinase inhibitors for promoting hair growth |
US20040242601A1 (en) * | 2001-09-20 | 2004-12-02 | Alain Moussy | Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis |
ES2269994T3 (en) * | 2002-02-27 | 2007-04-01 | Ab Science | USE OF INHIBITORS OF THE TYROSINE KINASE, FOR THE TREATMENT OF CNS DISORDERS. |
FR2844452A1 (en) * | 2002-09-18 | 2004-03-19 | Inst Gustave Roussy Igr | Modulating dendritic cell activity, e.g. for treatment of viral infections, NK-sensitive tumors or autoimmune diseases, using inhibitors or specific tyrosine kinases, e.g. c-abl, bcr/abl and c-kit |
US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
AU2004273605B2 (en) * | 2003-09-19 | 2008-07-31 | Novartis Ag | Treatment of gastrointestinal stromal tumors with imatinib and midostaurin |
US20100210596A1 (en) * | 2006-02-01 | 2010-08-19 | Bluestone Jeffrey A | Use of aminopyrimidine compounds in the treatment of immune disorders |
US20080221132A1 (en) * | 2006-09-11 | 2008-09-11 | Xiong Cai | Multi-Functional Small Molecules as Anti-Proliferative Agents |
AU2007296743B2 (en) * | 2006-09-11 | 2012-02-16 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
US20090082361A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched imatinib |
CN101584696A (en) * | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | Composition containing quinazoline derivatives, preparation method and use |
WO2010120386A1 (en) | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
BR112013022552B1 (en) | 2011-03-04 | 2021-11-23 | Newgen Therapeutics, Inc | QUINAZOLINE COMPOUNDS REPLACED WITH ALCINE, THEIR USE, PHARMACEUTICAL COMPOSITION, AND KIT |
CN102918029B (en) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-phenylamino-6-butenamide-7-alkyloxy quinazoline derivatives, preparative method and use thereof |
AU2013223749A1 (en) | 2012-02-21 | 2014-09-11 | Sun Pharmaceutical Industries Limited | Stable dosage forms of imatinib mesylate |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
US20140235631A1 (en) | 2012-07-27 | 2014-08-21 | Antonius Martinus Gustave Bunt | Efflux inhibitor compositions and methods of treatment using the same |
CA3172586A1 (en) | 2013-07-31 | 2015-02-05 | Avalyn Pharma Inc. | Aerosol imatininb compounds and uses thereof |
US11285152B2 (en) | 2017-07-20 | 2022-03-29 | Kashiv Biosciences, Llc | Stable oral pharmaceutical composition of imatinib |
CA3089566A1 (en) | 2018-01-31 | 2019-08-08 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
CN114615982A (en) | 2019-08-12 | 2022-06-10 | 德西费拉制药有限责任公司 | Ripoctinib for treating gastrointestinal stromal tumor |
CN115243681A (en) | 2019-12-30 | 2022-10-25 | 德西费拉制药有限责任公司 | Compositions of 1- (4-bromo-5- (1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -2-fluorophenyl) -3-phenylurea |
LT4084778T (en) | 2019-12-30 | 2024-01-25 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
KR102535840B1 (en) | 2020-07-31 | 2023-05-23 | (주)파로스아이바이오 | Use of 2,3,5-Substituted Thiophene Compound for Prevention, Improvement or Treatment of Gastrointestinal Stromal Tumor |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW225528B (en) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
CO4940418A1 (en) * | 1997-07-18 | 2000-07-24 | Novartis Ag | MODIFICATION OF A CRYSTAL OF A DERIVATIVE OF N-PHENYL-2-PIRIMIDINAMINE, PROCESSES FOR ITS MANUFACTURE AND USE |
EP1117397A1 (en) * | 1998-08-31 | 2001-07-25 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
-
2001
- 2001-10-26 CA CA002424470A patent/CA2424470C/en not_active Expired - Lifetime
- 2001-10-26 JP JP2002537718A patent/JP4386635B2/en not_active Expired - Lifetime
- 2001-10-26 US US10/415,015 patent/US6958335B2/en not_active Expired - Lifetime
- 2001-10-26 AU AU2002218262A patent/AU2002218262B2/en not_active Expired
- 2001-10-26 CN CNB018178952A patent/CN1276754C/en not_active Ceased
- 2001-10-26 PT PT01988712T patent/PT1332137E/en unknown
- 2001-10-26 DE DE60118430T patent/DE60118430T2/en not_active Expired - Lifetime
- 2001-10-26 HU HU0301512A patent/HU229106B1/en unknown
- 2001-10-26 EP EP01988712A patent/EP1332137B1/en not_active Expired - Lifetime
- 2001-10-26 AU AU1826202A patent/AU1826202A/en active Pending
- 2001-10-26 CZ CZ20031152A patent/CZ303944B6/en not_active IP Right Cessation
- 2001-10-26 IL IL15502901A patent/IL155029A0/en unknown
- 2001-10-26 AT AT01988712T patent/ATE321556T1/en active
- 2001-10-26 NZ NZ525254A patent/NZ525254A/en not_active IP Right Cessation
- 2001-10-26 KR KR1020037003903A patent/KR100885129B1/en active IP Right Review Request
- 2001-10-26 SK SK518-2003A patent/SK287335B6/en not_active IP Right Cessation
- 2001-10-26 ES ES01988712T patent/ES2260317T3/en not_active Expired - Lifetime
- 2001-10-26 WO PCT/EP2001/012442 patent/WO2002034727A2/en active IP Right Grant
- 2001-10-26 MX MXPA03003703A patent/MXPA03003703A/en active IP Right Grant
- 2001-10-26 PL PL362148A patent/PL209733B1/en unknown
- 2001-10-26 BR BRPI0114870-2 patent/BRPI0114870B8/en active IP Right Grant
- 2001-10-26 DK DK01988712T patent/DK1332137T3/en active
- 2001-10-26 RU RU2003114752/15A patent/RU2301066C2/en not_active IP Right Cessation
-
2003
- 2003-03-18 ZA ZA200302155A patent/ZA200302155B/en unknown
- 2003-03-20 IL IL155029A patent/IL155029A/en active IP Right Grant
- 2003-04-24 NO NO20031833A patent/NO324948B1/en not_active IP Right Cessation
- 2003-12-29 HK HK03109439A patent/HK1058193A1/en not_active IP Right Cessation
-
2006
- 2006-06-21 CY CY20061100839T patent/CY1105055T1/en unknown
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