RU2003112078A - METHOD FOR PRODUCING SUBSTITUTED PYRIDO [1,2-A] [1,3] BENZIMIDAZOLE - Google Patents

METHOD FOR PRODUCING SUBSTITUTED PYRIDO [1,2-A] [1,3] BENZIMIDAZOLE

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Publication number
RU2003112078A
RU2003112078A RU2003112078/04A RU2003112078A RU2003112078A RU 2003112078 A RU2003112078 A RU 2003112078A RU 2003112078/04 A RU2003112078/04 A RU 2003112078/04A RU 2003112078 A RU2003112078 A RU 2003112078A RU 2003112078 A RU2003112078 A RU 2003112078A
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RU
Russia
Prior art keywords
nitro
pyridinium
phenyl
benzimidazole
substituted pyrido
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RU2003112078/04A
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Russian (ru)
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RU2241710C1 (en
Inventor
Роман Сергеевич Бегунов
Наталья Юрьевна Демидова
Галина Васильевна Криницына
Игорь Геннадьевич Абрамов
Алексей Владимирович Смирнов
Леван Сергоевич Каландадзе
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Ярославский государственный технический университет
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Priority to RU2003112078/04A priority Critical patent/RU2241710C1/en
Priority claimed from RU2003112078/04A external-priority patent/RU2241710C1/en
Publication of RU2003112078A publication Critical patent/RU2003112078A/en
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Способ получения замещенных пиридо[1,2-α ][1,3|бензимидазолов общей формулыThe method of obtaining substituted pyrido [1,2-α] [1,3 | benzimidazoles of the General formula
Figure 00000001
Figure 00000001
 где 1 R=NO2, R1=H, 2 R=CF3, R1=Н, 3 R=CN, R1=H, 4 R=R1=CN,where 1 R = NO 2 , R1 = H, 2 R = CF 3 , R1 = H, 3 R = CN, R1 = H, 4 R = R1 = CN, включающий взаимодействие пиридина с 2-нитро-4-R-5-R1-галогенбензолом, и восстановление образующейся соли N-(2-нитро-4-R-5-R1-фенил)пиридиния общей формулыcomprising the interaction of pyridine with 2-nitro-4-R-5-R1-halogenbenzene, and the restoration of the resulting salt of N- (2-nitro-4-R-5-R1-phenyl) pyridinium of the General formula
Figure 00000002
Figure 00000002
 где Х=Cl, Br; 1 R=NO2, R1=Н, 2 R=CF3, R1=Н, 3 R=CN, R1=H, 4 R=R1=CN,where X = Cl, Br; 1 R = NO 2 , R1 = H, 2 R = CF 3 , R1 = H, 3 R = CN, R1 = H, 4 R = R1 = CN, хлоридом олова (II) в кислом водно-этанольном растворе с одновременной циклизацией, отличающийся тем, что нуклеофильное замещение проводят при температуре 20° С и мольном соотношении 2-нитро-4-R-5-R1-галогенбензол:пиридин 1:7, в течение 1 ч, восстановление спиртового раствора соли N-(2-нитро-4-R-5-R1-фенил)пиридиния проводят раствором SnCl2· 2H2O в 3%-ной соляной кислоте и мольном соотношении соль N-(2-нитро-4-R-5-R1-фенил)пиридиния:SnCl2· 2H2O 1:3 при температуре 20° С в течение 0,12 ч.tin (II) chloride in an acidic water-ethanol solution with simultaneous cyclization, characterized in that the nucleophilic substitution is carried out at a temperature of 20 ° C and a molar ratio of 2-nitro-4-R-5-R1-halogenbenzene: pyridine 1: 7, in for 1 h, the restoration of an alcoholic solution of the salt of N- (2-nitro-4-R-5-R1-phenyl) pyridinium is carried out with a solution of SnCl 2 · 2H 2 O in 3% hydrochloric acid and a molar ratio of salt of N- (2- nitro-4-R-5-R1-phenyl) pyridinium: SnCl 2 · 2H 2 O 1: 3 at a temperature of 20 ° C for 0.12 hours
RU2003112078/04A 2003-04-24 2003-04-24 Method for preparing substituted pyrido[1,2-a][1,3]-benzimidazoles RU2241710C1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2455356C1 (en) * 2011-04-13 2012-07-10 Государственное образовательное учреждение высшего профессионального образования "Ярославский государственный университет им. П.Г. Демидова" Dna intercalators for cytogenetic studies of genomes of plants with small chromosomes
RU2645917C1 (en) * 2017-04-12 2018-03-01 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" METHOD OF SYNTHESIS OF PYRIDO [1,2-a]IMIDAZO[4,5-f]BENZIMIDAZOLE AND ITS DERIVATIVES

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