RU2003102888A - 3,4-DIHYDROISOCHINOLINE DERIVATIVES AND A PHARMACEUTICAL AGENT, INCLUDING IT AS AN ACTIVE INGREDIENT - Google Patents

Claims (14)

1. The derivative of 3,4-dihydroisoquinoline of the formula (I)

where R ¹ and R ² are each independently 1) hydrogen or 2) C1-8 alkyl or R ¹ and R ² taken together with the carbon atom to which they are attached form Cyc1, provided that R ¹ and R ² do not represent hydrogen at the same time, Z represents 1) -CR ³ R ⁴ or 2) -O-, R ³ and R ⁴ are each independently 1) hydrogen 2) C1-8 alkyl, 3) C1-8 alkoxy or 4) hydroxy or R ³ and R ⁴ taken together with the carbon atom to which they are attached form Cyc1 or —C (O) -, R ⁵ and R ⁶ are each independently 1) hydrogen or 2) C1-8 alkyl or R ⁵ and R ⁶ taken together with the carbon atom to which they are attached form Cyc1, Cyc1 represented by R ¹ and R ² , R ³ and R ⁴ and R ⁵ and R ⁶ are each independently 1) C3-10-cycloalkyl or 2) a 3-10 membered monocyclic hetero ring comprising 1-2 heteroatoms selected from oxygen, nitrogen or sulfur, Cyc1 may be substituted with R ¹⁰ , R ¹⁰ represents 1) C1-8-alkyl, 2) C1-8-alkoxy, 3) hydroxy, 4) -COOR ¹¹ , 5) keto, 6) -SO ₂ R ¹² or 7) -COR ¹³ , R ¹¹ represents hydrogen or C1-8 alkyl, R ¹² and R ¹³ are 1) C1-8 alkyl or 2) phenyl which may be substituted with C1-8 alkyl, R ⁷ and R ⁸ are each independently 1) hydrogen 2) C1-8 alkyl, 3) C1-8 alkoxy, 4) hydroxy, 5) cyano 6) halogen 7) -COOR ¹⁴ , 8) -CONR ¹⁵ R ¹⁶ , 9) Cyc2, 10) C2-8 alkenyl, 11) C2-8-alkynyl, 12) -NR ⁵¹ R ⁵² , 13) nitro 14) formed 15) C2-8-acyl, 16) hydroxy, C1-8 alkoxy, Cyc2, —NR ⁵¹ R ⁵² or C1-8 alkyl substituted with —NR ⁵³ —Cyc2, 17) -NR ⁵⁴ COR ⁵⁵ , 18) -NR ⁵⁶ SO ₂ R ⁵⁷ , 19) -SO ₂ NR ⁵⁸ R ⁵⁹ , 20) C2-8 alkenyl substituted with COOR ¹⁴ , 21) -CH = N-OH, 22) - (C1-8 alkylene) -NR ⁶⁰ - (C1-8 alkylene) -R ⁶¹ or 23) C1-8-alkylthio, R ¹⁴ represents hydrogen or C1-8 alkyl, R ¹⁵ and R ¹⁶ are each independently hydrogen or C1-8 alkyl, R ⁵¹ and R ⁵² , R ⁵⁸ and R ⁵⁹ are each independently hydrogen or C1-8 alkyl, R ⁵³ , R ⁵⁴ , R ⁵⁶ and R ⁶⁰ are each independently hydrogen or C1-8 alkyl, R ⁵⁵ represents hydrogen, C1-8 alkyl or C1-8 alkoxy, R ⁵⁷ represents C1-8 alkyl, R ⁶¹ is —NR ⁶² R ⁶³ or hydroxy, R ⁶² and R ⁶³ are each independently hydrogen or C1-8 alkyl

, hereinafter referred to as ″ ring ″, represents Cyc2, but the atom that is attached to the carbonyl is carbon. Cyc2 represented by R ⁷ , R ⁸ and “ring” mean each independently, 1) a C3-15-mono-, -bi- or -tricyclic (fused or spiro) carb ring or 2) a 3-15-membered mono-, -bi- or -tricyclic (fused or spiro) hetero ring comprising 1-4 heteroatoms selected from oxygen, nitrogen or sulfur, Cyc2 may be substituted with 1-5 R ¹⁷ , R ¹⁷ represents 1) C1-8-alkyl, 2) C2-8-alkenyl, 3) C2-8-alkynyl, 4) C1-8-alkoxy, 5) C1-8-alkylthio, 6) hydroxy, 7) halogen 8) nitro, 9) keto, 10) carboxy, 11) formyl, 12) cyano, 13) -NR ¹⁸ R ¹⁹ , 14) phenyl, phenoxy or phenylthio, which may be substituted with 1-5 R ²⁰ , 15) C1 -C8-alkyl, C2-8-alkenyl, C1-8-alkoxy or C1-8-alkylthio, which may be substituted with 1-5 R ²¹ , 16) -OCOR ²² , 17) -CON ²³ R ²⁴ , 18) - SO ₂ N ²⁵ R ²⁶ , 19) -COOR ²⁷ , 20) -COCOOR ²⁸ , 21) -COR ²⁹ , 22) -COCOR ³⁰ , 23) -NR ³¹ COR ³² , 24) -SO ₂ R ³³ , 25) - NR ³⁴ SO ₂ R ³⁵ or 26) -SOR ⁶⁴ , R ¹⁸ and R ¹⁹ , R ³¹ and R ³⁴ are each independently hydrogen or C1-8 alkyl, R ²⁰ and R ²¹ are C1-8 alkyl, C1-8 alkoxy, hydroxy, halogen, nitro or —COOR ³⁶ , R ²² and R ⁶⁴ are each independently C1-8 alkyl, R ²³ and R ²⁴ , R ²⁵ and R ²⁶ are each independently hydrogen, C1-8 alkyl or phenyl, R ²⁷ , R ²⁸ , R ²⁹ , R ³⁰ , R ³² , R ³³ and R ³⁵ represent 1) C1-8 alkyl, 2) C2-8 alkenyl, 3) C1-8 alkyl substituted with 1-5 R ³⁷ , 4) diphenylmethyl, 5) triphenylmethyl, 6) Cyc3, 7) C1-8-alkyl or C2-8-alkenyl substituted with Cyc3, 8) C1-8-alkyl substituted with -O-Cyc3, -S-Cyc3 or -SO ₂ -Cyc3, R ³⁶ represents hydrogen or C1-8 alkyl, R ³⁷ represents C1-8 alkoxy, C1-8 alkylthio, benzyloxy, halogen, nitro or —COOR ³⁸ , R ³⁸ represents hydrogen, C1-8 alkyl or C2-8 alkenyl, Cyc3 presents 1) a C3-15-mono-, -bi- or -tricyclic (fused or spiro) carb ring or 2) a 3-15-membered mono-, -bi- or -tricyclic (fused or spiro) hetero ring comprising 1-4 heteroatoms selected from oxygen, nitrogen or sulfur, Cyc3 may be substituted with 1-5 R ³⁹ , R ³⁹ is 1) C1-8-alkyl, 2) C2-8-alkenyl, 3) C2-8-alkynyl, 4) C1-8-alkoxy, 5) C1-8-alkylthio, 6) hydroxy, 7) halogen 8) nitro, 9) keto, 10) cyano, 11) benzyl, 12) benzyloxy, 13) C1-C8-alkyl, C1-8-alkoxy or C1-8-alkylthio, substituted with 1-5 R ⁴⁰ , 14) phenyl, phenoxy, phenylthio, phenylsulfonyl or benzoyl, which may be substituted with 1-5 R ⁴¹ , 15) -OCOR ⁴² , 16) -SO ₂ R ⁴³ , 17) -NR ⁴⁴ COR ⁴⁵ , 18) -SO ₂ NR ⁴⁶ R ⁴⁷ , 19) -COOR ⁴⁸ or 20) -NR ⁴⁹ R ⁵⁰ , R ⁴⁰ is halogen, R ⁴¹ represents C1-C8 alkyl, C1-8 alkoxy, halogen or nitro, R ⁴² , R ⁴³ and R ⁴⁵ are C1-8 alkyl, R ⁴⁴ and R ⁴⁸ represent hydrogen or C1-C8 alkyl, R ⁴⁶ and R ⁴⁷ , R ⁴⁹ and R ⁵⁰ are each independently hydrogen or —C 1-8 alkyl, Cyc4 presents 1) a C5-7 monocyclic carb ring or 2) 5-7-membered monocyclic hetero ring, including 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen or sulfur

(called dashed line a below) and

(referred to as dashed line b below) represent 1) a bond or 2) a double bond. R ⁹ 1) is absent or 2) represents hydrogen, provided that 1) when the dashed line a represents a bond, the dashed line b represents a double bond and R ^{9 is} absent, 2) when the dashed line a represents a double bond, the dashed line b represents a bond, and R ⁹ represents hydrogen and R ^{6 is} absent, and 3) excluded 2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one), or its non-toxic salt. 2. The compound according to claim 1, where Cyc4 is a C5-7 monocyclic carb ring. 3. The compound according to claim 1, where Cyc4 is a 5-7-membered monocyclic hetero ring comprising 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur. 4. The compound of claim 2, wherein Z is —CR ³ R ⁴ - and the “ring” is a C3-15 membered mono-, bi- or tricyclic (fused or spiro) carbocyclic ring. 5. The compound according to claim 2, where Z is —CR ³ R ⁴ - and the ″ ring ″ is a 3-15 membered mono-, bi- or tricyclic (fused or spiro) hetero ring comprising 1-4 heteroatoms selected from a group consisting of oxygen, nitrogen and sulfur. 6. The compound of claim 2, wherein Z is —O— and the “ring” is a C3-15 mono, bi or tricyclic (fused or spiro) carbocyclic ring. 7. The compound according to claim 2, where Z represents —O— and the ring is a C3-15 membered mono-, bi- or tricyclic (fused or spiro) ring comprising 1-4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur. 8. The compound according to claim 4, which is a (1) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (2) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methoxycarbonylphenyl) ethan-1-one, (3) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclopentylethan-1-one, (4) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methylphenyl) ethan-1-one, (5) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-methylphenyl) ethan-1-one, (6) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methylphenyl) ethan-1-one, (7) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-chlorophenyl) ethan-1-one, (8) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-chlorophenyl) ethan-1-one, (9) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclobutylethan-1-one, (10) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (11) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-chlorophenyl) ethan-1-one, (12) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (13) (Z) -2- (3,3,5-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (14) (Z) -2- (3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one. (15) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalen-2-yl) ethan-1-one, (16) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methoxyphenyl) ethan-1-one, (17) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-methoxyphenyl) ethan-1-one, (18) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-fluorophenyl) ethan-1-one, (19) (Z) -2- (3,3,7-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (20) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalen-1-yl) ethan-1-one, (21) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (22) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-fluorophenyl) ethan-1-one, (23) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-fluorophenyl) ethan-1-one, (24) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -2-methyl-1-phenylethan-1-one, (25) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-cyclohexane] -1-ylidene) -1-phenylethan-1-one, (26) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-cyclopentane] -1-ylidene -) - 1-phenylethan-1-one, (27) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-cycloheptane] -1-ylidene) -1-phenylethan-1-one, (28) (Z) -2- (3,3-diethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (29) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-methoxycarbonylphenyl) ethan-1-one, (30) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-cyclobutane] -1-ylidene) -1-phenylethan-1-one, (31) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinoline-3,4'-3,4,5,6-tetrahydropyran] -1-ylidene) -1-phenylethan-1 -he, (32) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-1’-methylpiperidine] -1-ylidene) -1-phenylethan-1-one, (33) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-trifluoromethylphenyl) ethan-1-one, (34) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-trifluoromethylphenyl) ethan-1-one, (35) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-trifluoromethylphenyl) ethan-1-one, (36) (Z) -2- (3,3,6,8-tetramethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (37) (Z) -2- (8-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (38) (Z) -2- (6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (39) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,4'-piperidine] -1-ylidene) -1-phenylethan-1-one, (40) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2,6-dimethylphenyl) ethan-1-one, (41) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinoline-3,1’-4’-ethoxycarbonylcyclohexane] -1-ylidene) -1-phenylethan-1-one, (42) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclododecyl ethan-1-one, (43) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-tert-butylphenyl) ethan-1-one, (44) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-4’-oxocyclohexane] -1-ylidene) -1-phenylethan-1-one, (45) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-isopropylphenyl) ethan-1-one, (46) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclooctylethan-1-one, (47) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-methylcyclohexyl) ethan-1-one, (48) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-ethylphenyl) ethan-1-one, (49) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-butylphenyl) ethan-1-one, (50) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-phenylcyclohexyl) ethan-1-one, (51) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-propylphenyl) ethan-1-one, (52) 2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -1-phenylbutan-1-one, (53) 2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -1-phenylpentan-1-one (54) (Z) -cis-2- (3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1- (2-methylcyclohexyl) ethan-1-one, (55) (Z) -trans-2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methylcyclohexyl) ethan-1-one, (56) (Z) -trans-2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-methylcyclohexyl) ethan-1-one, (57) (Z) -cis-2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-methylcyclohexyl) ethan-1-one, (58) (Z) -cis-2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methylcyclohexyl) ethan-1-one, (59) (Z) -trans-2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methylcyclohexyl) ethan-1-one, (60) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-trifluoromethoxyphenyl) ethan-1-one, (61) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (62) (Z) -2- (5-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (63) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (64) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (65) (Z) -2- (6-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (66) (Z) -2- (5-flora-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (67) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-pentylbicyclo [2.2.2] octan-1-yl) ethan-1-one, (68) (Z) -trans-2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-tert-butylcyclohexyl) ethan-1-one, (69) (Z) -2- (3,3,4,4-tetramethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (70) (Z) -2- (spiro [3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-4,1'-cyclohexane] -1-ylidene) -1-phenylethan-1-one , (71) (Z) -2- (6,7-dimethoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (72) (Z) -2- (spiro [3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-4,1'-cyclopentane] -1-ylidene) -1-phenylethan-1-one , (73) 2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -1-cyclopentylethan-1-one, (74) 2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -1-cycloheptylethan-1-one, (75) 2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -1-phenylpropan-1-one, (76) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-cyanophenyl) ethan-1-one, (77) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (78) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-trifluoromethoxyphenyl) ethan-1-one, (79) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-cyanophenyl) ethan-1-one, (80) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-trifluoromethoxyphenyl) ethan-1-one, (81) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-carboxyphenyl) ethan-1-one, (82) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-carboxyphenyl) ethan-1-one, (83) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinoline-3,1’-4’-carboxycyclohexane] -1-ylidene) -1-phenylethan-1-one, (84) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-hydroxyphenyl) ethan-1-one, (85) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-hydroxyphenyl) ethan-1-one, (86) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-hydroxyphenyl) ethan-1-one, (87) (Z) -2- (6-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (88) 2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -2-methyl-1-phenylpropan-1-one, (89) 1- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) cyclopentylphenylketone, (90) 1- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) cyclohexylphenylketone, (91) 4- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -3,4,5,6-tetrahydropyran-4-ylphenylketone, (92) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,1’-4’-hydroxycyclohexane] -1-ylidene) -1-phenylethan-1-one, (93) (Z) -2- (spiro [3,4-dihydro- (2H) -isoquinolin-3,4’-1’-acetylpiperidine] -1-ylidene) -1-phenylethan-1-one, (94) (Z) -2- (6-phenyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (95) (Z) -2- (6- (pyridin-3-yl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one , (96) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-hydroxymethylphenyl) ethan-1-one, (97) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-hydroxymethylphenyl) ethan-1-one, (98) (Z) -2- (7-isopropyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (99) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (100) (Z) -2- (7-ethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (101) (Z) -2- (7-tert-butyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (102) (Z) -2- (7-propyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (103) (Z) -2- (7-butyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (104) (Z) -2- (7-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (105) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (106) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (107) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (108) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (109) (Z) -2- (7-tert-butyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (110) (Z) -2- (7-tert-butyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (111) (Z) -2- (7-tert-butyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1- he, (112) (Z) -2- (7-tert-butyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (113) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (114) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (115) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (116) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (117) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (118) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (119) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (120) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (121) (Z) -2- (3,3,7-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (122) (Z) -2- (3,3,7-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (123) (Z) -2- (3,3,7-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (124) (Z) -2- (3,3,7-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (125) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-nitrophenyl) ethan-1-one, (126) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-nitrophenyl) ethan-1-one, (127) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-nitrophenyl) ethan-1-one, (128) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2,5-dimethoxyphenyl) ethan-1-one, (129) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2,4-dimethoxyphenyl) ethan-1-one, (130) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalene-1-yl) ethan-1- he, (131) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (anthracene-9-yl) ethan-1-one, (132) (Z) -2- (3,3,7-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (133) (Z) -2- (7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (134) (Z) -2- (7-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalene-1-yl) ethan-1- he, (135) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (136) (Z) -2- (8-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (137) (Z) -2- (8-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (138) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (139) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (140) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (141) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-bromophenyl) ethan-1-one, (142) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methylthiophenyl) ethan-1-one, (143) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-dimethylaminophenyl) ethan-1-one, (144) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-mesylphenyl) ethan-1-one, (145) (Z) -2- (8-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (146) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2,4-dichlorophenyl) ethan-1-one, (147) (Z) -2- (6-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (148) (Z) -2- (6-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (149) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methylnaphthalen-1-yl) ethan-1-one, (150) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-fluoronaphthalen-1-yl) ethan-1-one, (151) (Z) -2- (7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (152) (Z) -2- (spiro [6-chloro-3,4-dihydro- (2H) -isoquinoline-3,4'-3,4,5,6-tetrahydropyran] -1-ylidene) -1 -phenylethan-1-one, (153) (Z) -2- (spiro [6-chloro-3,4-dihydro- (2H) -isoquinoline-3,4'-3,4,5,6-tetrahydropyran] -1-ylidene) -1 - (4-cyanophenyl) ethan-1-one, (154) (Z) -2- (spiro [6-chloro-3,4-dihydro- (2H) -isoquinoline-3,4'-3,4,5,6-tetrahydropyran] -1-ylidene) -1 - (adamantan-1-yl) ethan-1-one, (155) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (noradamantan-1-yl) ethan-1-one, (156) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (noradamantan-1-yl) ethan-1- he, (157) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-chloro-4-mesylphenyl) ethan-1-one, (158) (Z) -2- (6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (159) (Z) -2- (6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (160) (Z) -2- (7-bromo-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (161) (Z) -2- (5-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (162) (Z) -2- (3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (163) (Z) -2- (3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (164) (Z) -2- (7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (165) (Z) -2- (6-chloro-7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (166) (Z) -2- (6-chloro-7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (167) (Z) -2- (6-chloro-7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (168) (Z) -2- (6-chloro-7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (169) (Z) -2- (7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (170) (Z) -2- (7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (171) (Z) -2- (7-amino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (172) (Z) -2- (7-amino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (173) (Z) -2- (6-chloro-7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (174) (Z) -2- (6-chloro-7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (175) (Z) -2- (6-chloro-7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (176) (Z) -2- (6-chloro-7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (177) (Z) -2- (7-dimethylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (178) (Z) -2- (7-dimethylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (179) (Z) -2- (7-dimethylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (180) (Z) -2- (7-dimethylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (181) (Z) -2- (7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (182) (Z) -2- (7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (183) (Z) -2- (6-methoxy-7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (184) (Z) -2- (6-methoxy-7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (185) (Z) -2- (7-dimethylamino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (186) (Z) -2- (7-dimethylamino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (187) (Z) -2- (7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (188) (Z) -2- (7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (189) (Z) -2- (7-amino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (190) (Z) -2- (7-amino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (191) (Z) -2- (7-bromo-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoinolin-1-ylidene) -1-cyclohexylene-1-one, (192) (Z) -2- (7-bromo-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (193) (Z) -2- (7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (194) (Z) -2- (7-bromo-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (195) (Z) -2- (7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl)) ethan-1 -he, (196) (Z) -2- (7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (197) (Z) -2- (7-Dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (198) (Z) -2- (7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (199) (Z) -2- (7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (200) (Z) -2- (7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (201) (Z) -2- (7-cyano-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (202) (Z) -2- (7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (203) (Z) -2- (7-cyano-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (204) (Z) -2- (7-cyano-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (205) (Z) -2- (7-cyano-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (206) (Z) -2- (7-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (207) (Z) -2- (7-dimethylaminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (208) (Z) -2- (7-bromo-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (209) (Z) -2- (7-dimethylaminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (210) (Z) -2- (7-nitro-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (211) (Z) -2- (6-methoxy-7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (212) (Z) -2- (7-dimethylaminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (213) (Z) -2- (7-nitro-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (214) (Z) -2- (7-nitro-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (215) (Z) -2- (7-nitro-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (216) (Z) -2- (7-methylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (217) (Z) -2- (7-methylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (218) (Z) -2- (7-methylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (219) (Z) -2- (7-bromo-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (220) (Z) -2- (6,7-dicyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (221) (Z) -2- (6,7-dicyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (222) (Z) -2- (7-bromo-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (223) (Z) -2- (6,7-dicyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (224) (Z) -2- (6,7-dicyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (225) (Z) -2- (7-methylamino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (226) (Z) -2- (7-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (227) (Z) -2- (7-bromo-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (228) (Z) -2- (6-chloro-7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (229) (Z) -2- (6-chloro-7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (230) (Z) -2- (6-chloro-7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (231) (Z) -2- (7-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (232) (Z) -2- (7-bromo-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (233) (Z) -2- (7-nitro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinoin-1-ylidene) -1-cycloheptylethan-1-one, (234) (Z) -2- (7-dimethylsulfamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (235) (Z) -2- (7-butoxycarbonyl-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (236) (Z) -2- (7-butoxycarbonyl-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (237) (Z) -2- (7-methylsulfamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (238) (Z) -2- (6-chloro-7-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (239) (Z) -2- (7-methoxy-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (240) (Z) -2- (7-methoxy-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (241) (Z) -2- (7-methoxy-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (242) (Z) -2- (6-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (243) (Z) -2- (6-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (244) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (245) (Z) -2- (6-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (246) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (247) (Z) -2- (8-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (248) (Z) -2- (6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (249) (Z) -2- (8-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (250) (Z) -2- (6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (251) (Z) -2- (3,3,4,4-tetramethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (252) (Z) -2- (3,3,4,4-tetramethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-cyclohexylethan-1-one, (253) (Z) -2- (3,3,4,4-tetramethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (254) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (255) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-chlorophenyl) ethan-1-one, (256) (Z) -2- (6,8-dichloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (257) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-ethoxyphenyl) ethan-1-one, (258) (Z) -2- (3,3-dimethyl-3,4-dihydroisoquinolin-1-yl) -1- (adamantan-1-yl) propan-1-one, (259) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-chloro-2-methoxyphenyl) ethan-1-one, (260) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxy-4-methylthiophenyl) ethan-1-one, (261) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxy-4-mesylphenyl) ethan-1-one, (262) 2- (6-fluoro-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-phenylpropan-1-one, (263) (Z) -2- (6,7-dichloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (264) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-bromo-2-methoxyphenyl) ethan-1-one, (265) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-bromo-2-chlorophenyl) ethan-1-one, (266) (Z) -2- (6-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (267) (Z) -2- (6-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (268) (Z) -2- (6-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (269) (Z) -2- (6-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (270) (Z) -2- (7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (271) (Z) -2- (7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalen-1-yl) ethan-1- he, (272) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-formylphenyl) ethan-1-one, (273) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-formyl-2-methoxyphenyl) ethan-1-one, (274) (Z) -2- (6-chloro-7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (275) (Z) -2- (6-chloro-7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (276) (Z) -2- (6-chloro-7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (277) (Z) -2- (7-formyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (278) (Z) -2- (7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (279) (Z) -2- (7-formyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (280) (Z) -2- (7-formyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (281) (Z) -2- (7-formyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (282) (Z) -2- (7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (283) (Z) -2- (7-formyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (284) (Z) -2- (7-formyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (285) (Z) -2- (7-formyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (286) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-aminophenyl) ethan-1-one, (287) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-aminophenyl) ethan-1-one, (288) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-aminophenyl) ethan-1-one, (289) (Z) -2- (7-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (290) (Z) -2- (7-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (291) (Z) -2- (7-amino-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (292) (Z) -2- (7-amino-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (293) (Z) -2- (7-amino-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (294) (Z) -2- (7-amino-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (295) (Z) -2- (7-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (296) (Z) -2- (7-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (297) (Z) -2- (7-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (298) (Z) -2- (7-amino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (299) (Z) -2- (7-amino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (300) (Z) -2- (7-amino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (301) (Z) -2- (7-amino-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (302) (Z) -2- (6-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (303) (Z) -2- (7-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (304) (Z) -2- (7-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (305) (Z) -2- (6-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (306) (Z) -2- (6-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (307) (Z) -2- (7-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (308) (Z) -2- (7-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (309) (Z) -2- (7-carboxy-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (310) (Z) -2- (7-carboxy-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (311) (Z) -2- (7-carboxy-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (312) (Z) -2- (7-carboxy-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (313) (Z) -2- (7-carboxy-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (314) (Z) -2- (7-carboxy-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (315) (Z) -2- (6-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (316) (Z) -2- (3,3,4,4-tetramethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1- (2-hydroxyphenyl) ethan-1-one, (317) (Z) -2- (7-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalene-1-yl) ethan-1- he, (318) (Z) -2- (7-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (319) (Z) -2- (5-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (320) (Z) -2- (6-chloro-7-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (321) (Z) -2- (7-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (322) (Z) -2- (7-hydroxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (323) (Z) -2- (7-phenyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (324) (Z) -2- (7- (pyridin-3-yl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one , (325) (Z) -2- (6- (morpholin-4-yl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one , (326) (Z) -2- (7- (morpholin-4-yl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one , (327) (Z) -2- (6-chloro-7-propoxycarbonyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (328) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methylsulfinyl phenyl) ethan-1-one, (329) (Z) -2- (6-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (330) (Z) -2- (7- (1-hydroxy-1-methylethyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1 -he, (331) (Z) -2- (7- (1-hydroxy-1-methylethyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1- -he, (332) (Z) -2- (7- (1-hydroxy-1-methylethyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantane- 1-yl) ethan-1-one, (333) (Z) -2- (6-acetyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (334) (Z) -2- (7-hydroxymininomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (335) (Z) -2- (6-hydroxymininomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (336) (Z) -2- (7-hydroxymininomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (337) (Z) -2- (7-hydroxymininomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (338) (Z) -2- (7-hydroxymininomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (339) (Z) -2- (7-hydroxymininomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (340) (Z) -2- (7-hydroxymininomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (341) (Z) -2- (7-hydroxymininomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (342) (Z) -2- (7-hydroxymininomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (343) (Z) -2- (7-hydroxymininomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (344) (Z) -2- (7-hydroxymininomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (345) (Z) -2- (6-aminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (346) (Z) -2- (7-aminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (347) (Z) -2- (7-aminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (348) (Z) -2- (7-aminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (349) (Z) -2- (7-aminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (350) (Z) -2- (7-aminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (351) (Z) -2- (7-aminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (352) (Z) -2- (7-aminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (353) (Z) -2- (7-aminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (354) (Z) -2- (7-aminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (355) (Z) -2- (7-aminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (356) (Z) -2- (7-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (357) (Z) -2- (7-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (358) (Z) -2- (7-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (359) (Z) -2- (7- (morpholin-4-yl) methyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (naphthalene-1 -yl) ethan-1-one, (360) (Z) -2- (7- (morpholin-4-yl) methyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1- he, (361) (Z) -2- (7- (piperidin-1-yl) methyl-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-phenylethan-1- he, (362) (Z) -2- (7- (N-methyl-N- (2-dimethylaminoethyl) aminomethyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) - 1-phenylethan-1-one, (363) (Z) -2- (7- (N- (2-hydroxyethyl) -N-methylaminomethyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1 -phenylethan-1-one, (364) (Z) -2- (7- (N-cyclohexylaminomethyl) -3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (365) (Z) -2- (6- (morpholin-4-yl) methyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1- he, (366) (Z) -2- (6-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (367) (Z) -2- (6-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (368) (Z) -2- (7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (369) (Z) -2- (7-dimethylaminomethyl-6-methoxy-3,3-dimethyl-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (370) (Z) -2- (6-methoxy-7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (371) (Z) -2- (7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (372) (Z) -2- (6-methoxy-7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (373) (Z) -2- (6-chloro-7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (374) (Z) -2- (7-methylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (375) (Z) -2- (7-dimethylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (376) (Z) -2- (6-chloro-7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (377) (Z) -2- (7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (378) (Z) -2- (6-chloro-7-methylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one , (379) (Z) -2- (6-chloro-7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (380) (Z) -2- (7-methylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (381) (Z) -2- (7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (382) (Z) -2- (7-dimethylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (383) (Z) -2- (6-chloro-7-methylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one , (384) (Z) -2- (6-chloro-7-dimethylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (385) (Z) -2- (7-methylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (386) (Z) -2- (7-dimethylaminomethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (387) (Z) -2- (6-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (388) (Z) -2- (7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (389) (Z) -2- (6-chloro-7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (390) (Z) -2- (6-chloro-7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (391) (Z) -2- (6-chloro-7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (392) (Z) -2- (7-hydroxymethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (393) (Z) -2- (7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (394) (Z) -2- (7-hydroxymethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (395) (Z) -2- (7-hydroxymethyl-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (396) (Z) -2- (7-hydroxymethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (397) (Z) -2- (7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (398) (Z) -2- (7-hydroxymethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (399) (Z) -2- (7-hydroxymethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (400) (Z) -2- (7-hydroxymethyl-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (401) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-acetylaminophenyl) ethan-1-one, (402) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-acetylaminophenyl) ethan-1-one, (403) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3-mesylaminophenyl) ethan-1-one, (404) (Z) -2- (7-acetylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (405) (Z) -2- (7-acetylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (406) (Z) -2- (7-mesylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (407) (Z) -2- (7-mesylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (408) (Z) -2- (6-methylcarbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (409) (Z) -2- (6-dimethylcarbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (410) (Z) -2- (6-carbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (411) (Z) -2- (7-carbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (412) (Z) -2- (7-methylcarbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (413) (Z) -2- (7-dimethylcarbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (414) (Z) -2- (7-carbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (415) (Z) -2- (7-methylcarbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (416) (Z) -2- (7-dimethylcarbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (417) (Z) -2- (6-carbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (418) (Z) -2- (6-carbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (419) (Z) -2- (6-carbamoyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (420) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyano-2-methoxyphenyl) ethan-1-one, (421) (Z) -2- (7-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinoin-1-ylidene) -1-phenylethan-1-one, (422) (Z) -2- (7-cyano-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (423) (Z) -2- (7-cyano-3,3,6-trimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (424) (Z) -2- (6-ethynyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (425) (Z) -2- (7-ethynyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (426) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-ethynylphenyl) ethan-1-one, (427) (Z) -2- (6 - ((E) -2-carboxyethenyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1 -he, (428) (Z) -2- (6 - ((E) -2-methoxycarbonylethenyl) -3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1 -he, (429) (Z) -2- (6-methoxycarbonyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (430) (Z) -2- (7-methoxycarbonyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (431) (Z) -2- (7-carboxy-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (432) (Z) -2- (7-carboxy-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (433) (Z) -2- (7-carboxy-6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (434) (Z) -2- (3,3,4,4-tetramethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (435) (Z) -2- (7-formylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (436) (Z) -2- (6-formylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (437) (Z) -2- (7-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (438) (Z) -2- (6-methylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (439) (Z) -2- (7-methylaminomethyl-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (440) (Z) -2- (6-tert-butoxycarbonylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (441) (Z) -2- (6-tert-butoxycarbonylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (442) (Z) -2- (6-tert-butoxycarbonylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (443) (Z) -2- (6-tert-butoxycarbonylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (444) (Z) -2- (6-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (445) (Z) -2- (6-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (446) (Z) -2- (6-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (447) (Z) -2- (6-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (448) (Z) -2- (7-dimethylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (449) (Z) -2- (7-dimethylamino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (450) (Z) -2- (7-dimethylamino-6-methoxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (451) (Z) -2- (3,3-dimethyl-4-hydroxy-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (452) (Z) -2- (3,3-dimethyl-4-oxo-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (453) (Z) -2- (6-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (454) (Z) -2- (6-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one or (455) (Z) -2- (6-cyano-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he. 9. The compound according to claim 5, which is a (1) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (furan-2-yl) ethan-1-one, (2) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (thiophen-2-yl) ethan-1-one, (3) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (quinolin-6-yl) ethan-1-one, (4) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyridin-3-yl) ethan-1-one, (5) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyridin-4-yl) ethan-1-one, (6) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (piperidin-4-yl) ethan-1-one, (7) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (3,5-dimethylisoxazol-4-yl) ethan-1- he, (8) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (5-methyl-2-phenyloxazol-4-yl) ethane- 1-he (9) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-methyl-2-phenylthiazol-5-yl) ethane- 1-he (10) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-acetylpyridin-4-yl) ethan-1-one, (11) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-tert-butoxycarbonylpyridin-4-yl) ethan-1- he, (12) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-mesylpyridin-4-yl) ethan-1-one, (13) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (thiazol-2-yl) ethan-1-one, (14) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyrrol-2-yl) ethan-1-one, (15 (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyrazin-2-yl) ethan-1-one, (16) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (thiophen-3-yl) ethan-1-one, (17) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (5-methylfuran-2-yl) ethan-1-one, (18) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (5-methylthiophen-2-yl) ethan-1-one, (19) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2,5-dimethylfuran-3-yl) ethan-1- he, (20) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (5-cyanothiophen-2-yl) ethan-1-one, (21) (Z) -2- (6-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (tetrahydropyran-4-yl) ethan-1- he, (22) (Z) -2- (7-chloro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (tetrahydropyran-4-yl) ethan-1- he, (23) (Z) -2- (7-fluoro-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (tetrahydropyran-4-yl) ethan-1- he, (24) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2,5-dichlorothiophen-3-yl) ethan-1- he, (25) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (tetrahydropyran-4-yl) ethan-1-one, (26) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (isoquinolin-1-yl) ethan-1-one, (27) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (quinolin-4-yl) ethan-1-one, (28) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (quinolin-8-yl) ethan-1-one, (29) (Z) -2- (6-bromo-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyridin-3-yl) ethan-1- he, (30) (Z) -2- (6-carboxy-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyridin-3-yl) ethan-1- he, (31) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-phenylsulfonylpyridin-4-yl) ethan-1-one, (32) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-ethylsulfonylpyridin-4-yl) ethan-1-one, (33) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-propylsulfonylpyridin-4-yl) ethan-1-one, (34) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-butylsulfonylpyridin-4-yl) ethan-1-one, (35) (Z) -2- (3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (1-octylsulfonylpyridin-4-yl) ethan-1-one or (36) (Z) -2- (6-tert-butoxycarbonylamino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyridin-3-yl) ethane- 1-he (37) (Z) -2- (6-amino-3,3-dimethyl-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (pyridin-3-yl) ethan-1- he. 10. The compound according to claim 6, which is a (1) (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (2) (Z) -2- (7-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (3) (Z) -2- (7-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (4) (Z) -2- (7-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethane- 1-he (5) (Z) -2- (7-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (6) (Z) -2- (3,3,7-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (7) (Z) -2- (7-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (8) (Z) -2- (7-fluoro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (9) (Z) -2- (3,3,7-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1- he, (10) (Z) -2- (7-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethane- 1-he (11) (Z) -2- (7-fluoro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethane- 1-he (12) (Z) -2- (3,3,7-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (13) (Z) -2- (7-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (14) (Z) -2- (7-fluoro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (15) (Z) -2- (3,3,7-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he, (16) (Z) -2- (7-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (17) (Z) -2- (7-fluoro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (18) (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (2-methoxyphenyl) ethan-1-one, (19) (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1-one, (20) (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (21 (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (22) (Z) -2- (3,3,7-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (23) (Z) -2- (7-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (24) (Z) -2- (7-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (25) (Z) -2- (7-fluoro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (26) (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1- he, (27) (Z) -2- (7-fluoro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (28) (Z) -2- (7-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (29) (Z) -2- (7-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (30) (Z) -2- (3,3,7-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he (31) (Z) -2- (6-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (32) (Z) -2- (6-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (33) (Z) -2- (6-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cyclohexylene-1-one, (34) (Z) -2- (6-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-cycloheptylethan-1-one, (35) (Z) -2- (6-chloro-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (36) (Z) -2- (6-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethane- 1-he (37) (Z) -2- (6-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (38) (Z) -2- (6-methoxy-3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethan-1-one, (39) (Z) -2- (3,3,6-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1-phenylethan-1-one, (40) (Z) -2- (3,3,6-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (4-cyanophenyl) ethan-1- he or (41) (Z) -2- (3,3,6-trimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (adamantan-1-yl) ethane- 1-he 11. The compound according to claim 7, which is a (1) (Z) -2- (3,3-dimethyl-4-oxa-3,4-dihydro- (2H) -isoquinolin-1-ylidene) -1- (tetrahydropyran-4-yl) ethan-1- he. 12. The compound according to claim 3, which is a (1) (Z) -2- (6,6-dimethyl-4,5,6,7-tetrahydrothiopheno [3,2-c] pyridin-4-ylidene) -1-phenylethan-1-one, (2) (Z) -2- (6,6-dimethyl-4,5,6,7-tetrahydrothiopheno [3,2-c] pyridin-4-ylidene) -1- (adamantyl-1-yl) ethane- 1-he (3) (Z) -2- (6,6-dimethyl-4,5,6,7-tetrahydrothiopheno [3,2-c] pyridin-4-ylidene) -1- (4-cyanophenyl) ethan-1- he, (4) (Z) -2- (2-chloro-6,6-dimethyl-4,5,6,7-tetrahydrothiopheno [3,2-c] pyridin-4-ylidene) -1-phenylethan-1-one , (5) (Z) -2- (2-chloro-6,6-dimethyl-4,5,6,7-tetrahydrothiopheno [3,2-c] pyridin-4-ylidene) -1- (adamantane-1- il) ethan-1-one or (6) (Z) -2- (2-chloro-6,6-dimethyl-4,5,6,7-tetrahydrothiopheno [3,2-c] pyridin-4-ylidene) -1- (4-cyanophenyl) ethan-1-one. 13. Cannabinoid (CB) 2 receptor agonist, comprising a 3,4-dihydroisoquinoline derivative of formula (I) or a non-toxic salt thereof according to claim 1, as an active ingredient. 14. A pharmaceutical agent for the prevention and / or treatment of asthma, nasal allergy, atopic dermatitis, autoimmune diseases, rheumatoid arthritis, immune dysfunction, postoperative pain, carcinomatous pain, comprising a compound of formula (I) or its non-toxic salt according to claim 1, as active ingredient.