RU2002129518A - METHOD FOR PRODUCING DIPEPTIDES - Google Patents

METHOD FOR PRODUCING DIPEPTIDES

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Publication number
RU2002129518A
RU2002129518A RU2002129518/04A RU2002129518A RU2002129518A RU 2002129518 A RU2002129518 A RU 2002129518A RU 2002129518/04 A RU2002129518/04 A RU 2002129518/04A RU 2002129518 A RU2002129518 A RU 2002129518A RU 2002129518 A RU2002129518 A RU 2002129518A
Authority
RU
Russia
Prior art keywords
phenylalanine
amino acid
triethylamine
acetyl
producing dipeptides
Prior art date
Application number
RU2002129518/04A
Other languages
Russian (ru)
Other versions
RU2233289C2 (en
Inventor
Виктор Павлович Краснов
Елизавета Александровна Жданова
Наталья Зоировна Солиева
Ираида Михайловна Букрина
Лилия Ширмухаметовна Садретдинова
Михаил Исаакович Кодесс
Людмила Ивановна Смирнова
Original Assignee
Институт органического синтеза УрО РАН
Filing date
Publication date
Application filed by Институт органического синтеза УрО РАН filed Critical Институт органического синтеза УрО РАН
Priority to RU2002129518/04A priority Critical patent/RU2233289C2/en
Priority claimed from RU2002129518/04A external-priority patent/RU2233289C2/en
Publication of RU2002129518A publication Critical patent/RU2002129518A/en
Application granted granted Critical
Publication of RU2233289C2 publication Critical patent/RU2233289C2/en

Links

Claims (1)

Способ получения дипептидов, взаимодействием N-защищенной аминокислоты с этерифицированным производным аминокислоты в органическом растворителе в присутствии конденсирующего агента и триэтиламина, отличающийся тем, что в качестве N-защищенной аминокислоты используют N-ацетил-L-фенилаланин или N-ацетил-4[ди-(2-хлорэтил)амино]-DL-фенилаланин, в качестве этерифицированного производного аминокислоты - метиловый, или этиловый, или бензиловый, или трет-бутиловый эфир L-аланина, или L-фенилаланина, или L- и DL-валина, а в качестве конденсирующего агента - изобутилхлоркарбонат, при этом триэтиламин присутствует с 20%-ным избытком по отношению к стехиометрии.A method of producing dipeptides by reacting an N-protected amino acid with an esterified amino acid derivative in an organic solvent in the presence of a condensing agent and triethylamine, characterized in that N-acetyl-L-phenylalanine or N-acetyl-4 [di- (2-Chloroethyl) amino] -DL-phenylalanine, as an esterified derivative of an amino acid - methyl, or ethyl, or benzyl, or tert-butyl ether of L-alanine, or L-phenylalanine, or L- and DL-valine, and in as a condensing agent ta is isobutylchlorocarbonate, while triethylamine is present with a 20% excess with respect to stoichiometry.
RU2002129518/04A 2002-11-04 2002-11-04 Method for preparing dipeptides RU2233289C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2002129518/04A RU2233289C2 (en) 2002-11-04 2002-11-04 Method for preparing dipeptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002129518/04A RU2233289C2 (en) 2002-11-04 2002-11-04 Method for preparing dipeptides

Publications (2)

Publication Number Publication Date
RU2002129518A true RU2002129518A (en) 2004-07-10
RU2233289C2 RU2233289C2 (en) 2004-07-27

Family

ID=33413172

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002129518/04A RU2233289C2 (en) 2002-11-04 2002-11-04 Method for preparing dipeptides

Country Status (1)

Country Link
RU (1) RU2233289C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2309144C2 (en) 2005-03-25 2007-10-27 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Phenyl-containing n-acylamine derivatives, method for production thereof, pharmaceutical composition and uses thereof as anti-inflammatory and analgesic agents

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