RU2002129298A - APPLICATION OF GALANTAMINE FOR THE TREATMENT OF PSYCHONEUROLOGICAL BEHAVIOR ASSOCIATED WITH ALZHEIMER'S DISEASE - Google Patents

APPLICATION OF GALANTAMINE FOR THE TREATMENT OF PSYCHONEUROLOGICAL BEHAVIOR ASSOCIATED WITH ALZHEIMER'S DISEASE Download PDF

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Publication number
RU2002129298A
RU2002129298A RU2002129298/14A RU2002129298A RU2002129298A RU 2002129298 A RU2002129298 A RU 2002129298A RU 2002129298/14 A RU2002129298/14 A RU 2002129298/14A RU 2002129298 A RU2002129298 A RU 2002129298A RU 2002129298 A RU2002129298 A RU 2002129298A
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Russia
Prior art keywords
dose
day
galantamine
administered
use according
Prior art date
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RU2002129298/14A
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Russian (ru)
Inventor
Вим Луи Жюльен ПАРИС (US)
Вим Луи Жюльен ПАРИС
Майкл ПОНТЕКОРВО (US)
Майкл ПОНТЕКОРВО
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Янссен Фармацевтика Н.В. (Be)
Янссен Фармацевтика Н.В.
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Application filed by Янссен Фармацевтика Н.В. (Be), Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В. (Be)
Publication of RU2002129298A publication Critical patent/RU2002129298A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (11)

1. Применение эффективного количества галантамина или его фармацевтически приемлемой соли для изготовления лекарственного средства для лечения психоневрологического поведения, связанного с болезнью Альцгеймера.1. The use of an effective amount of galantamine or its pharmaceutically acceptable salt for the manufacture of a medicament for the treatment of neuropsychiatric behavior associated with Alzheimer's disease. 2. Применение по п.1, где галантамин вводят в количестве примерно от 1 до примерно 100 мг в день.2. The use according to claim 1, where galantamine is administered in an amount of from about 1 to about 100 mg per day. 3. Применение по п.2, где галантамин вводят в количестве примерно от 5 до примерно 50 мг в день.3. The use according to claim 2, where galantamine is administered in an amount of from about 5 to about 50 mg per day. 4. Применение по п.3, где галантамин вводят в количестве примерно от 16 до примерно 32 мг в день.4. The use according to claim 3, where galantamine is administered in an amount of from about 16 to about 32 mg per day. 5. Применение по п.4, где галантамин вводят в дозе примерно 24 мг/день, причем указанной дозы достигают посредством медленного введения дозы примерно 8 мг/день в течение примерно 1 недели, затем примерно 16 мг/день в течение примерно 1 недели с последующим ежедневным приемом 24 мг/день.5. The use according to claim 4, where galantamine is administered at a dose of about 24 mg / day, and the specified dose is achieved by slowly introducing a dose of about 8 mg / day for about 1 week, then about 16 mg / day for about 1 week subsequent daily intake of 24 mg / day. 6. Применение по п.4, где галантамин вводят в дозе примерно 32 мг/день, причем указанной дозы достигают посредством медленного введения дозы примерно 8 мг/день в течение примерно 1 недели, затем дозы примерно 16 мг/день в течение примерно 1 недели, затем дозы 24 мг/день в течение 1 недели с последующим ежедневным приемом 32 мг/день.6. The use according to claim 4, where galantamine is administered at a dose of about 32 mg / day, and the specified dose is achieved by slowly introducing a dose of about 8 mg / day for about 1 week, then a dose of about 16 mg / day for about 1 week , then a dose of 24 mg / day for 1 week, followed by a daily intake of 32 mg / day. 7. Применение по п.4, где галантамин вводят в дозе примерно от 16 до примерно 24 мг, причем указанной дозы достигают посредством медленного введения в течение периода от примерно 2 до примерно 10 недель при начальной дозе примерно 8 мг, увеличивая дозу до конечного значения дозы примерно 16-24 мг.7. The use according to claim 4, where galantamine is administered in a dose of from about 16 to about 24 mg, and the specified dose is achieved by slow administration for a period of from about 2 to about 10 weeks with an initial dose of about 8 mg, increasing the dose to the final value doses of approximately 16-24 mg. 8. Применение по п.7, где галантамин вводят в дозе около 24 мг/день, причем указанной дозы достигают посредством медленного введения дозы примерно 8 мг/день в течение примерно 2-4 недель, затем дозы примерно 16 мг/день в течение примерно 2-4 недель с последующим ежедневным приемом дозы 24 мг/день.8. The use according to claim 7, where galantamine is administered at a dose of about 24 mg / day, and the specified dose is achieved by slowly introducing a dose of about 8 mg / day for about 2-4 weeks, then a dose of about 16 mg / day for about 2-4 weeks, followed by a daily dose of 24 mg / day. 9. Применение по п.7, где галантамин вводят в дозе около 24 мг/день, причем указанной дозы достигают посредством медленного введения примерно 8 мг/день в течение примерно 4 недель, затем примерно 16 мг/день в течение примерно 4 недель с последующим ежедневным приемом дозы 24 мг/день.9. The use according to claim 7, where galantamine is administered at a dose of about 24 mg / day, and the specified dose is achieved by slow administration of about 8 mg / day for about 4 weeks, then about 16 mg / day for about 4 weeks, followed by daily dose of 24 mg / day. 10. Применение по п.4, где галантамин вводят в дозе примерно 16 мг/день, причем указанной дозы достигают посредством медленного введения дозы примерно 8 мг/день в течение примерно 2-4 недель с последующим ежедневным приемом дозы 16 мг/день.10. The use according to claim 4, where galantamine is administered at a dose of about 16 mg / day, and the specified dose is achieved by slow administration of a dose of about 8 mg / day for about 2-4 weeks, followed by a daily dose of 16 mg / day. 11. Применение по п.9, где галантамин вводят в дозе примерно 16 мг/день, причем указанной дозы достигают посредством медленного введения дозы примерно 8 мг/день в течение примерно 4 недель с последующим ежедневным приемом дозы 16 мг/день.11. The use according to claim 9, where galantamine is administered at a dose of about 16 mg / day, and the specified dose is achieved by slowly administering a dose of about 8 mg / day for about 4 weeks, followed by a daily dose of 16 mg / day.
RU2002129298/14A 2000-04-03 2001-03-28 APPLICATION OF GALANTAMINE FOR THE TREATMENT OF PSYCHONEUROLOGICAL BEHAVIOR ASSOCIATED WITH ALZHEIMER'S DISEASE RU2002129298A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19425900P 2000-04-03 2000-04-03
US60/194,259 2000-04-03

Publications (1)

Publication Number Publication Date
RU2002129298A true RU2002129298A (en) 2004-03-27

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RU2002129298/14A RU2002129298A (en) 2000-04-03 2001-03-28 APPLICATION OF GALANTAMINE FOR THE TREATMENT OF PSYCHONEUROLOGICAL BEHAVIOR ASSOCIATED WITH ALZHEIMER'S DISEASE

Country Status (20)

Country Link
EP (1) EP1272192A2 (en)
JP (1) JP2003528913A (en)
KR (1) KR20020086911A (en)
CN (1) CN1430514A (en)
AU (2) AU2001265844B2 (en)
BG (1) BG107093A (en)
BR (1) BR0109770A (en)
CA (1) CA2310926C (en)
CZ (1) CZ20023543A3 (en)
EE (1) EE200200554A (en)
HR (1) HRP20020778A2 (en)
HU (1) HUP0300566A3 (en)
IL (1) IL152061A0 (en)
MX (1) MXPA02009777A (en)
NO (1) NO20024746L (en)
PL (1) PL361272A1 (en)
RU (1) RU2002129298A (en)
SK (1) SK15422002A3 (en)
WO (1) WO2001074339A2 (en)
ZA (1) ZA200207935B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617361B2 (en) * 1999-11-05 2003-09-09 Be Able, Llc Behavior chemotherapy
RU2357734C2 (en) 2003-07-25 2009-06-10 Ф.Хоффманн-Ля Рош Аг COMBINATION OF mGluR2 RECEPTOR ANTAGONIST AND AChE ENZYME INHIBITOR FOR ACUTE ANDN/OR CHRONIC NEURALGIC DISEASES
DE10338544B4 (en) * 2003-08-19 2017-08-31 Janssen Pharmaceutica N.V. Buccal formulations of galanthamine and their applications
AU2009229372C1 (en) 2008-03-27 2017-02-02 Chase Pharmaceuticals Corporation Use and composition for treating dementia
WO2013160728A1 (en) 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Dual targeting compounds for the treatment of alzheimer's disease
BG66818B1 (en) * 2013-03-07 2019-01-31 Berbee Beheer B. V. Composition of hippeastrum papilio extract for the production of medicines and nutritional supplements
EP3297632A4 (en) * 2015-05-18 2019-01-16 Synaptec Development LLC GALANTAMINE CLEARANCE OF AMYLOIDß
CN117957003A (en) * 2021-09-09 2024-04-30 上海日馨医药科技股份有限公司 Methods of treating neurodegenerative diseases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663318A (en) * 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
DE19509663A1 (en) * 1995-03-17 1996-09-19 Lohmann Therapie Syst Lts Process for the isolation of galanthamine
GB9600080D0 (en) * 1996-01-04 1996-03-06 Chiroscience Ltd Resolution process
JP5558648B2 (en) 1998-11-23 2014-07-23 デイビス、ボニー Administration formulation for acetylcholinesterase inhibitors
PT1140105E (en) * 1998-12-24 2004-03-31 Janssen Pharmaceutica Nv GALANTAMINE COMPOSITION OF CONTROLLED LIBERTACAO
CA2310950C (en) * 2000-04-03 2005-11-08 Janssen Pharmaceutica N.V. An efficacious dosage regiment of galantamine that reduces side effects
CA2310990A1 (en) * 2000-04-03 2000-10-09 Michael Pontecorvo A use of galantamine for the treatment of alzheimer's disease; targeting the underlying cause of the disease

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Publication number Publication date
CZ20023543A3 (en) 2003-03-12
WO2001074339A2 (en) 2001-10-11
HUP0300566A2 (en) 2003-06-28
HUP0300566A3 (en) 2004-10-28
KR20020086911A (en) 2002-11-20
HRP20020778A2 (en) 2004-04-30
IL152061A0 (en) 2003-05-29
NO20024746D0 (en) 2002-10-02
BG107093A (en) 2003-06-30
WO2001074339A3 (en) 2002-09-12
BR0109770A (en) 2003-02-04
JP2003528913A (en) 2003-09-30
AU6584401A (en) 2001-10-15
CA2310926A1 (en) 2000-10-04
CN1430514A (en) 2003-07-16
PL361272A1 (en) 2004-10-04
CA2310926C (en) 2002-10-15
NO20024746L (en) 2002-11-28
AU2001265844B2 (en) 2005-04-14
MXPA02009777A (en) 2003-03-27
ZA200207935B (en) 2004-01-30
EE200200554A (en) 2004-04-15
SK15422002A3 (en) 2003-04-01
EP1272192A2 (en) 2003-01-08

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20060405