RU2002112475A - METHOD FOR PRODUCING ARYLALKYL ETHERS - Google Patents

METHOD FOR PRODUCING ARYLALKYL ETHERS

Info

Publication number
RU2002112475A
RU2002112475A RU2002112475/04A RU2002112475A RU2002112475A RU 2002112475 A RU2002112475 A RU 2002112475A RU 2002112475/04 A RU2002112475/04 A RU 2002112475/04A RU 2002112475 A RU2002112475 A RU 2002112475A RU 2002112475 A RU2002112475 A RU 2002112475A
Authority
RU
Russia
Prior art keywords
alcohol
catalyst
hydroxyaromatic compound
above items
hydroxyaromatic
Prior art date
Application number
RU2002112475/04A
Other languages
Russian (ru)
Other versions
RU2245869C2 (en
Inventor
Ефим БИЛЛЕР
Эдгар ФУРМАНН
Детлеф ХАГЕНА
Хайнц Гюнтер ЙАННЕК
Йорг ТАЛБИРСКИ
Лутц ВАЛЬТЕР
Original Assignee
Хаарман Унд Раймер Гмбх
РЮТГЕРС ФауФТ АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19949319A external-priority patent/DE19949319A1/en
Application filed by Хаарман Унд Раймер Гмбх, РЮТГЕРС ФауФТ АГ filed Critical Хаарман Унд Раймер Гмбх
Publication of RU2002112475A publication Critical patent/RU2002112475A/en
Application granted granted Critical
Publication of RU2245869C2 publication Critical patent/RU2245869C2/en

Links

Claims (6)

1. Способ получения арилалкиловых эфиров, в котором гидроксиароматическое соединение подвергают взаимодействию со спиртом в присутствии катализатора, отличающийся тем, что гомогенную смесь, содержащую гидроксиароматическое соединение, спирт и катализатор, подают в реактор при нормальном давлении, взаимодействие осуществляют при температуре от примерно 250°С до примерно 370°С, и концентрацию продукта в реакционной смеси устанавливают таким образом, что катализатор во время дистилляционной переработки не выпадает в осадок.1. The method of producing arylalkyl ethers, in which the hydroxyaromatic compound is reacted with alcohol in the presence of a catalyst, characterized in that the homogeneous mixture containing the hydroxyaromatic compound, alcohol and catalyst is fed into the reactor at normal pressure, the reaction is carried out at a temperature of from about 250 ° C. to about 370 ° C, and the concentration of the product in the reaction mixture is set so that the catalyst does not precipitate during distillation processing. 2. Способ по п.1, отличающийся тем, что молярное соотношение гидроксиароматического соединения к спирту устанавливают около 0,5:1, преимущественно около 1:1.2. The method according to claim 1, characterized in that the molar ratio of hydroxyaromatic compounds to alcohol is set to about 0.5: 1, preferably about 1: 1. 3. Способ по п.1 или 2, отличающийся тем, что процесс осуществляют непрерывно.3. The method according to claim 1 or 2, characterized in that the process is carried out continuously. 4. Способ по вышеназванным пунктам, отличающийся тем, что соотношение катализатора к гидроксиароматическому соединению устанавливают меньше или равно 1:30.4. The method according to the above items, characterized in that the ratio of catalyst to hydroxyaromatic compound is set to less than or equal to 1:30. 5. Способ по одному из вышеназванных пунктов, отличающийся тем, что гидроксиароматическое соединение выбирают из группы, состоящей из фенола, п-крезола, 2-нафтола, резорцина, пироцкатехина и гидрохинона.5. The method according to one of the above items, characterized in that the hydroxyaromatic compound is selected from the group consisting of phenol, p-cresol, 2-naphthol, resorcinol, pyrocatechol and hydroquinone. 6. Способ по одному из вышеназванных пунктов, отличающийся тем, что спирт выбирают из метанола, этанола, изопропанола, бутанола, трет-бутанола, пропанола, пентанола и/или бензилового спирта.6. The method according to one of the above items, characterized in that the alcohol is selected from methanol, ethanol, isopropanol, butanol, tert-butanol, propanol, pentanol and / or benzyl alcohol.
RU2002112475/04A 1999-10-13 2000-10-04 Arylalkyl ether manufacturing method RU2245869C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19949319A DE19949319A1 (en) 1999-10-13 1999-10-13 Process for the preparation of aryl alkyl ethers
DE19949319.7 1999-10-13

Publications (2)

Publication Number Publication Date
RU2002112475A true RU2002112475A (en) 2003-12-10
RU2245869C2 RU2245869C2 (en) 2005-02-10

Family

ID=7925469

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002112475/04A RU2245869C2 (en) 1999-10-13 2000-10-04 Arylalkyl ether manufacturing method

Country Status (15)

Country Link
US (1) US6624334B1 (en)
EP (1) EP1224157B1 (en)
JP (1) JP2003511430A (en)
KR (1) KR100716077B1 (en)
CN (1) CN1263719C (en)
AT (1) ATE285391T1 (en)
AU (1) AU7661600A (en)
CA (1) CA2388218A1 (en)
DE (2) DE19949319A1 (en)
IL (2) IL148761A0 (en)
MX (1) MXPA02003739A (en)
PL (1) PL200685B1 (en)
RU (1) RU2245869C2 (en)
WO (1) WO2001027060A1 (en)
ZA (1) ZA200202146B (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CN1902177A (en) 2003-09-22 2007-01-24 万有制药株式会社 Novel piperidine derivative
US7396895B2 (en) * 2003-11-25 2008-07-08 Xerox Corporation Branched polyarylene ethers and processes for the preparation thereof
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US8394765B2 (en) * 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
DE602005013811D1 (en) * 2004-11-01 2009-05-20 Amylin Pharmaceuticals Inc TREATMENT OF FAT AND HEALTHY DISEASES
US20090286723A1 (en) 2005-02-11 2009-11-19 Amylin Pharmaceuticals, Inc. Hybrid Polypeptides with Selectable Properties
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
ES2574014T3 (en) 2005-05-30 2016-06-14 Msd K.K. Novel Piperidine Derivative
AU2006277253A1 (en) 2005-08-10 2007-02-15 Msd K.K. Pyridone compound
BRPI0614649A2 (en) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc hybrid polypeptides with selectable properties
CA2619770A1 (en) 2005-08-24 2007-03-01 Banyu Pharmaceutical Co., Ltd. Phenylpyridone derivative
CA2621470A1 (en) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. Bicyclic aromatic substituted pyridone derivative
US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
RU2008119687A (en) 2005-10-21 2009-11-27 Новартис АГ (CH) COMBINATIONS OF ORGANIC COMPOUNDS
CA2627139A1 (en) 2005-10-27 2007-05-03 Banyu Pharmaceutical Co., Ltd. Novel benzoxathiin derivative
WO2007055418A1 (en) 2005-11-10 2007-05-18 Banyu Pharmaceutical Co., Ltd. Aza-substituted spiro derivative
EP2946778A1 (en) 2006-09-22 2015-11-25 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
EP2072519A4 (en) 2006-09-28 2009-10-21 Banyu Pharma Co Ltd Diaryl ketimine derivative
DK2118279T3 (en) 2007-01-16 2018-02-26 Ipintl Llc HIS UNKNOWN COMPOSITION FOR TREATMENT OF METABOLIC SYNDROME
JP5319518B2 (en) 2007-04-02 2013-10-16 Msd株式会社 Indoledione derivative
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2010005345A (en) * 2007-11-14 2010-08-31 Amylin Pharmaceuticals Inc Methods for treating obesity and obesity related diseases and disorders.
WO2009110510A1 (en) 2008-03-06 2009-09-11 萬有製薬株式会社 Alkylaminopyridine derivative
EP2272841A1 (en) 2008-03-28 2011-01-12 Banyu Pharmaceutical Co., Ltd. Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor
CA2666036C (en) 2008-05-16 2017-09-12 Chien-Hung Chen Novel compositions and methods for treating hyperproliferative diseases
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2727914A1 (en) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diaryl ketoxime derivative technical field
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
AU2009277736A1 (en) 2008-07-30 2010-02-04 Banyu Pharmaceutical Co., Ltd. (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2677869B1 (en) 2011-02-25 2017-11-08 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
RU2015106909A (en) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. ANTI-DIABETIC TRICYCLIC COMPOUNDS
CA2898482A1 (en) 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists in combination with other drugs
BR112015030326A2 (en) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc ULTRAPURE GUANYLATE CYCLASE C AGONISTS, METHOD OF MANUFACTURING AND USING THEM
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
RU2021109549A (en) 2014-08-29 2021-05-13 Тес Фарма С.Р.Л. Α-AMINO-β-CARBOXYMUCONATE INHIBITORS of ε-SEMIALDEHYDE-DECARBOXYLASE
BR112019007543A2 (en) 2016-10-14 2019-07-02 Tes Pharma S R L alpha-amino-beta-carboximuconic acid inhibitors semialdehyde decarboxylase
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
CN108002988B (en) * 2017-11-24 2020-12-15 西安近代化学研究所 Preparation method of 1, 2-di (2- (2, 6-dimethoxyphenoxy) ethoxy) ethane
WO2019119363A1 (en) * 2017-12-21 2019-06-27 中国科学院大连化学物理研究所 Method for producing mixed ether from mixed phenol and methol by gas phase etherification
CN108569957B (en) * 2018-05-04 2021-08-10 南京师范大学 Device and method for extracting 2-naphthyl methyl ether from 2-naphthol, methanol, 2-naphthyl methyl ether and p-toluenesulfonic acid and recovering components
AR117122A1 (en) 2018-11-20 2021-07-14 Tes Pharma S R L A-AMINO-b-CARBOXIMUCONIC ACID INHIBITORS SEMIALDEHYDE DECARBOXYLASE
CN109879728B (en) * 2019-02-01 2022-04-19 宝鸡文理学院 Method for synthesizing anisole by catalyzing phenol and methanol
CN109809970B (en) * 2019-02-01 2022-05-06 宝鸡文理学院 Method for producing anisole by catalyzing phenol and methanol
CN109879727B (en) * 2019-02-01 2022-04-19 宝鸡文理学院 Method for synthesizing anisole from phenol and methanol
CN109879730B (en) * 2019-02-01 2022-04-19 宝鸡文理学院 Method for producing anisole from phenol and methanol
CN116082125A (en) * 2023-03-17 2023-05-09 山东兴文工业技术研究院有限公司 Method for preparing beta-anisole by dynamic tubular reactor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911022A (en) * 1973-06-04 1975-10-07 Eastman Kodak Co Etherification of phenolic compounds
US4487975A (en) * 1980-03-31 1984-12-11 Rhone-Poulenc Industries Etherification of phenols
FR2513633A1 (en) * 1981-09-29 1983-04-01 Rhone Poulenc Spec Chim PHENOLS ETHERIFICATION PROCESS
FR2488883A1 (en) * 1980-08-25 1982-02-26 Rhone Poulenc Ind PHENOLS ETHERIFICATION PROCESS

Similar Documents

Publication Publication Date Title
RU2002112475A (en) METHOD FOR PRODUCING ARYLALKYL ETHERS
TW474913B (en) Production of organic carboxylic acid esters
CA1264330A (en) Process for the production of deuterated methyl acrylate or deuterated methyl methacrylate
Nelson et al. Intermolecular allylic C− H etherification of internal olefins
Stacchiola et al. Elucidation of the reaction mechanism for the palladium‐catalyzed synthesis of vinyl acetate
JPS5955351A (en) Catalyst for alkoxylating reaction and alkoxylation method using same
RU99101909A (en) METHOD FOR SYNTHESIS OF COMPLEX ETHERS
ES486823A1 (en) Process for the simultaneous manufacture of pure MTBE and a substantially isobutene-free mixture of C4-hydrocarbons
EP0902023A3 (en) Process for preparing condensation product of hydroxy-substituted aromatic compounds and glyoxylic reactants
Jalowiecki-Duhamel et al. Oxidation of isobutane on a heteropolycompound hydrogen reservoir
JPS58185533A (en) Manufacture of alkanol alkoxylate
Maeta et al. Two-and four-carbon homologation of aldehyde by AgClO4-catalyzed addition of alkoxyalkenylzirconocene chloride
JPH0629221B2 (en) Method for catalytic production of alkoxylated ester
TWI267505B (en) Method for the catalytic conversion of alkylene carbonate with Mg, Al mixed (hydr)oxide catalyst and its use therefore
CA1270857A (en) Process for preparing improved poly(tetramethylene ether) glycol by alcoholysis
US4450306A (en) Selective catalytic alkylation of phenols to alkyl aryl ethers
CA1316945C (en) Process for the condensation of alcohols
EP0239993A2 (en) A process of reduction of aldehydes and ketones
CN100513373C (en) Production process of 3-alkoxy-1-propanols, and 3-alkoxy-1-propanols obtained by the production process
EP0194328B1 (en) Manufacture of phenyl esters and phenol
KR20010050081A (en) Production process for hydroxyalkyl ester
AU2001266429A1 (en) Process for regenerating pd catalysts
DE50309862D1 (en) Process for the preparation of alkenes
US4451343A (en) Photo-initiators for decarboxylation reactions
RU1768579C (en) Method of cyclooctenecarboxylic acid synthesis