RU2002111900A - Recombinant alpha-2 human interferon preparation for injection in dry lyophilized form - Google Patents
Recombinant alpha-2 human interferon preparation for injection in dry lyophilized formInfo
- Publication number
- RU2002111900A RU2002111900A RU2002111900/15A RU2002111900A RU2002111900A RU 2002111900 A RU2002111900 A RU 2002111900A RU 2002111900/15 A RU2002111900/15 A RU 2002111900/15A RU 2002111900 A RU2002111900 A RU 2002111900A RU 2002111900 A RU2002111900 A RU 2002111900A
- Authority
- RU
- Russia
- Prior art keywords
- polyvinylpyrrolidone
- plasma
- drug according
- hemodesis
- polyglucin
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 3
- 102000014150 Interferons Human genes 0.000 title claims 2
- 108010050904 Interferons Proteins 0.000 title claims 2
- 238000002347 injection Methods 0.000 title claims 2
- 239000007924 injection Substances 0.000 title claims 2
- 229940079322 interferon Drugs 0.000 title claims 2
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drugs Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinylpyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 101000130640 IFNA2 Proteins 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 102000035427 human IFNA2 protein Human genes 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 238000007664 blowing Methods 0.000 claims 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 1
- 230000003139 buffering Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 230000000087 stabilizing Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002111900/15A RU2236866C2 (en) | 2002-05-06 | 2002-05-06 | Preparation based upon human recombinant alpha-2-interferon for injections in dry lyophilized form |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002111900/15A RU2236866C2 (en) | 2002-05-06 | 2002-05-06 | Preparation based upon human recombinant alpha-2-interferon for injections in dry lyophilized form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002111900A true RU2002111900A (en) | 2003-12-27 |
| RU2236866C2 RU2236866C2 (en) | 2004-09-27 |
Family
ID=33432794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002111900/15A RU2236866C2 (en) | 2002-05-06 | 2002-05-06 | Preparation based upon human recombinant alpha-2-interferon for injections in dry lyophilized form |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2236866C2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2564951C1 (en) * | 2014-08-28 | 2015-10-10 | Закрытое акционерное общество "Вектор-Медика" (ЗАО "Вектор-Медика") | Composition of aqueous solution of recombinant human interferon alpha-2 for rectal administration |
| RU2690677C1 (en) * | 2018-06-27 | 2019-06-05 | Георгий Георгиевич Чумбуридзе | Stabilized composition possessing antiviral, anticancer, immunomodulatory, actoprotective, antimutagenic and antioxidant activity |
-
2002
- 2002-05-06 RU RU2002111900/15A patent/RU2236866C2/en active IP Right Revival
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