RU2002105375A - APPLICATION OF GABAB RECEPTOR AGONISTS AND THEIR PHARMACEUTICALLY ACCEPTABLE DERIVATIVES FOR SUPPORTING THERAPY OF NICOTINE-DEPENDENT PATIENTS - Google Patents

APPLICATION OF GABAB RECEPTOR AGONISTS AND THEIR PHARMACEUTICALLY ACCEPTABLE DERIVATIVES FOR SUPPORTING THERAPY OF NICOTINE-DEPENDENT PATIENTS

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Publication number
RU2002105375A
RU2002105375A RU2002105375/14A RU2002105375A RU2002105375A RU 2002105375 A RU2002105375 A RU 2002105375A RU 2002105375/14 A RU2002105375/14 A RU 2002105375/14A RU 2002105375 A RU2002105375 A RU 2002105375A RU 2002105375 A RU2002105375 A RU 2002105375A
Authority
RU
Russia
Prior art keywords
use according
gaba
transdermal
nicotine
baclofen
Prior art date
Application number
RU2002105375/14A
Other languages
Russian (ru)
Other versions
RU2262352C2 (en
Inventor
Джиан Луиджи ДЖЕССА
Джианкарло КОЛОМБО
Лука ПАНИ
Вальтер ФРАТТА
Original Assignee
Л.Мольтени Энд К.Дей Фрателли Алитти Сочиета' Ди Эсерчицио С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1999MI001715A external-priority patent/IT1313585B1/en
Application filed by Л.Мольтени Энд К.Дей Фрателли Алитти Сочиета' Ди Эсерчицио С.П.А. filed Critical Л.Мольтени Энд К.Дей Фрателли Алитти Сочиета' Ди Эсерчицио С.П.А.
Publication of RU2002105375A publication Critical patent/RU2002105375A/en
Application granted granted Critical
Publication of RU2262352C2 publication Critical patent/RU2262352C2/en

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Claims (9)

1. Применение агонистов GABAB рецепторов, или их фармацевтически используемых производных, для получения фармацевтических композиций, предназначенных для уменьшения тяги к курению у никотин-зависимых пациентов при лечении никотиновой зависимости.1. The use of GABA B receptor agonists, or their pharmaceutically used derivatives, for the manufacture of pharmaceutical compositions intended to reduce smoking cravings in nicotine-dependent patients in the treatment of nicotine addiction. 2. Применение по п.1, отличающееся тем, что в качестве агонистов GABAB рецепторов используют β-(4-хлорфенил)GABA (Baclofen), 3-аминопропил(метил)фосфиновую кислоту, 3-аминопропилфосфиновую кислоту, γ-амино-β-4-(4-хлорфенил)нитропропан или их фармацевтически применимые производные, выбранные из группы, состоящей из их солей, сложных эфиров, простых эфиров, комплексов и их соответствующих изомеров.2. The use according to claim 1, characterized in that β- (4-chlorophenyl) GABA (Baclofen), 3-aminopropyl (methyl) phosphinic acid, 3-aminopropylphosphinic acid, γ-amino-β are used as agonists of GABA B receptors -4- (4-chlorophenyl) nitropropane or their pharmaceutically applicable derivatives selected from the group consisting of their salts, esters, ethers, complexes and their corresponding isomers. 3. Применение по п.2, отличающееся тем, что агонист GABAB рецепторов представляет собой Baclofen.3. The use according to claim 2, characterized in that the GABA B receptor agonist is Baclofen. 4. Применение по п.3, отличающееся тем, что агонист GABAB рецепторов представляет собой изомер R(-) Baclofen в виде свободного основания или его фармацевтически применимые производные, выбранные из группы, состоящей из их солей, сложных эфиров, простых эфиров и комплексов.4. The use according to claim 3, characterized in that the GABA B receptor agonist is an isomer of R (-) Baclofen in the form of a free base or its pharmaceutically applicable derivatives selected from the group consisting of their salts, esters, ethers and complexes . 5. Применение по п.1, отличающееся тем, что фармацевтическая композиция имеет форму, подходящую для перорального, парентерального, трансдермального введения или введения типа депо.5. The use according to claim 1, characterized in that the pharmaceutical composition is in a form suitable for oral, parenteral, transdermal administration or administration of a depot type. 6. Применение по п.5, отличающееся тем, что в качестве подходящих форм используют капсулы, таблетки, трансдермальные повязки, сублингвальные гели, внутримышечные препараты типа депо.6. The use according to claim 5, characterized in that capsules, tablets, transdermal dressings, sublingual gels, intramuscular preparations of the depot type are used as suitable forms. 7. Применение по п.6, отличающееся тем, что таблетки представляют собой таблетки пролонгированного действия и их получают с использованием замкнутых или матричных систем.7. The use according to claim 6, characterized in that the tablets are sustained release tablets and are prepared using closed or matrix systems. 8. Применение по п.5, отличающееся тем, что трансдермальные композиции представляют собой системы трансдермальной доставки лекарственного средства и трансдермальные терапевтические системы.8. The use according to claim 5, characterized in that the transdermal compositions are transdermal drug delivery systems and transdermal therapeutic systems. 9. Применение по п.8, отличающееся тем, что указанные средства представляют собой липкие приспособления, резервуарные приспособления, монолитные приспособления.9. The use of claim 8, characterized in that the said means are sticky devices, reservoir devices, monolithic devices.
RU2002105375/15A 1999-07-30 2000-06-30 Applying agonists of gamma-aminobutyric acid receptors of b-type and their pharmaceutically acceptable derivatives in treatment of nicotine dependence RU2262352C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001715A IT1313585B1 (en) 1999-07-30 1999-07-30 USE OF GABAB RECEPTOR AGONISTS FOR THE MAINTENANCE THERAPY OF NICOTINE ABSTINENCE IN NICOTINO-EMPLOYEES.
ITM199A001715 1999-07-30

Publications (2)

Publication Number Publication Date
RU2002105375A true RU2002105375A (en) 2003-11-10
RU2262352C2 RU2262352C2 (en) 2005-10-20

Family

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Application Number Title Priority Date Filing Date
RU2002105375/15A RU2262352C2 (en) 1999-07-30 2000-06-30 Applying agonists of gamma-aminobutyric acid receptors of b-type and their pharmaceutically acceptable derivatives in treatment of nicotine dependence

Country Status (16)

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EP (1) EP1202727B1 (en)
CN (1) CN1176650C (en)
AT (1) ATE285763T1 (en)
AU (1) AU6153400A (en)
CA (1) CA2379752C (en)
DE (1) DE60017147T2 (en)
DK (1) DK1202727T3 (en)
ES (1) ES2235913T3 (en)
HK (1) HK1046849B (en)
IL (2) IL147876A0 (en)
IT (1) IT1313585B1 (en)
PL (1) PL196334B1 (en)
PT (1) PT1202727E (en)
RU (1) RU2262352C2 (en)
SI (1) SI1202727T1 (en)
WO (1) WO2001008675A1 (en)

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EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
US7494985B2 (en) 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7566738B2 (en) 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7585996B2 (en) 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
JP4498407B2 (en) 2006-12-22 2010-07-07 キヤノン株式会社 Process cartridge, electrophotographic image forming apparatus, and electrophotographic photosensitive drum unit
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
TWI380812B (en) 2008-01-25 2013-01-01 Xenoport Inc Crystalline form of a (3s)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
US8299291B2 (en) 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
AU2010221270B2 (en) 2009-03-03 2014-02-27 Xenoport, Inc. Sustained release oral dosage forms of an R-baclofen prodrug
JP2012524065A (en) 2009-04-17 2012-10-11 ゼノポート，インコーポレーテッド Γ-aminobutyric acid derivatives as GABAB receptor ligands
WO2011081558A1 (en) * 2009-08-21 2011-07-07 Komissarov Jury Vladimirovich Smoking device for giving up tobacco smoking
WO2013023155A1 (en) 2011-08-11 2013-02-14 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use
JP2021521103A (en) * 2018-04-06 2021-08-26 オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Use of gaboxadol in the treatment of substance use disorders

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