RU2001134298A - The use of cortisol antagonists in the treatment of heart failure - Google Patents
The use of cortisol antagonists in the treatment of heart failureInfo
- Publication number
- RU2001134298A RU2001134298A RU2001134298/14A RU2001134298A RU2001134298A RU 2001134298 A RU2001134298 A RU 2001134298A RU 2001134298/14 A RU2001134298/14 A RU 2001134298/14A RU 2001134298 A RU2001134298 A RU 2001134298A RU 2001134298 A RU2001134298 A RU 2001134298A
- Authority
- RU
- Russia
- Prior art keywords
- heart
- cortisol
- heart failure
- use according
- treatment
- Prior art date
Links
- JYGXADMDTFJGBT-VWUMJDOOSA-N Cortisol Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 title claims 11
- 229960000890 hydrocortisone Drugs 0.000 title claims 11
- 206010007554 Cardiac failure Diseases 0.000 title claims 8
- 206010019280 Heart failure Diseases 0.000 title claims 8
- 230000003042 antagnostic Effects 0.000 title claims 8
- 239000005557 antagonist Substances 0.000 title claims 8
- 239000003814 drug Substances 0.000 claims 6
- 208000000059 Dyspnea Diseases 0.000 claims 4
- 206010013975 Dyspnoeas Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 208000005333 Pulmonary Edema Diseases 0.000 claims 3
- 206010037423 Pulmonary oedema Diseases 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 230000002194 synthesizing Effects 0.000 claims 3
- 206010019842 Hepatomegaly Diseases 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N Ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 2
- 210000003141 Lower Extremity Anatomy 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 230000003247 decreasing Effects 0.000 claims 2
- 229960004125 ketoconazole Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 210000004165 Myocardium Anatomy 0.000 claims 1
- 230000003205 diastolic Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
Claims (12)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9915625.9A GB9915625D0 (en) | 1999-07-02 | 1999-07-02 | Method |
GB9915625.9 | 1999-07-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2001134298A true RU2001134298A (en) | 2003-08-27 |
RU2245712C2 RU2245712C2 (en) | 2005-02-10 |
Family
ID=10856599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2001134298/14A RU2245712C2 (en) | 1999-07-02 | 2000-07-03 | Method for applying cortisol antagonists at treating heart failure |
Country Status (16)
Country | Link |
---|---|
US (1) | US6881739B1 (en) |
EP (1) | EP1196152A1 (en) |
JP (1) | JP4039482B2 (en) |
KR (1) | KR100623166B1 (en) |
AU (1) | AU780152B2 (en) |
CA (1) | CA2375751A1 (en) |
CZ (1) | CZ300888B6 (en) |
GB (1) | GB9915625D0 (en) |
HU (1) | HUP0202339A3 (en) |
MX (1) | MXPA01013465A (en) |
NO (1) | NO324395B1 (en) |
NZ (1) | NZ516239A (en) |
PL (1) | PL202859B1 (en) |
RU (1) | RU2245712C2 (en) |
SK (1) | SK285845B6 (en) |
WO (1) | WO2001001971A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642236B1 (en) * | 1998-12-14 | 2003-11-04 | Cortendo Ab | Methods for prophylactic treatment of cardiovascular disease with inhibitor of cortisol synthesis |
SE0001899D0 (en) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
GB0118300D0 (en) * | 2001-07-26 | 2001-09-19 | Cortendo Ab | Formulations |
RS44304A (en) | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
DE50213170D1 (en) * | 2002-09-04 | 2009-02-12 | Fraunhofer Ges Forschung | Use of a means for the treatment of cardiac hypertrophy |
KR101387910B1 (en) * | 2005-01-10 | 2014-04-25 | 콜텐도 인베스트 아베 | Methods and compositions for treating diabetes, metabolic syndrome and other conditions |
BRPI0719835A2 (en) | 2006-10-02 | 2014-05-06 | Cortendo Invest Ab | KETOCONAZOLE ENANTIOMER IN HUMANS |
WO2013103687A2 (en) * | 2012-01-03 | 2013-07-11 | Rhode Island Hospital | Treatment of heart failure and sudden cardiac death |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US460314A (en) * | 1891-09-29 | George a | ||
US4603141A (en) * | 1984-11-30 | 1986-07-29 | Giles Thomas D | Oral clonidine treatment of congestive heart failure |
US5175144A (en) * | 1988-11-29 | 1992-12-29 | The Johns Hopkins University | Method of retarding the progression of chronic renal failure |
GB9014221D0 (en) | 1990-06-26 | 1990-08-15 | Janssen Pharmaceutica Nv | Method of treating alopecia |
JP3918119B2 (en) | 1993-01-21 | 2007-05-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Topical ketoconazole composition |
US5565478A (en) * | 1994-03-14 | 1996-10-15 | The United States Of America As Represented By The Department Of Health & Human Services | Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs |
US5756469A (en) * | 1996-07-26 | 1998-05-26 | Beale; Paxton K. | Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal |
KR100840957B1 (en) * | 1997-10-06 | 2008-06-24 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | Methods for Treating Psychosis Associated with Glucocorticoid Related Dysfunction |
SE9803272D0 (en) | 1998-09-25 | 1998-09-25 | Kerstin Uvnaes Moberg | A drug for cell regeneration |
AU1036999A (en) * | 1998-10-27 | 2000-05-15 | Roumen Antonov | Use of antifungal agents for treating scleroses |
-
1999
- 1999-07-02 GB GBGB9915625.9A patent/GB9915625D0/en not_active Ceased
-
2000
- 2000-07-03 HU HU0202339A patent/HUP0202339A3/en unknown
- 2000-07-03 WO PCT/GB2000/002551 patent/WO2001001971A1/en active Application Filing
- 2000-07-03 US US10/019,613 patent/US6881739B1/en not_active Expired - Fee Related
- 2000-07-03 RU RU2001134298/14A patent/RU2245712C2/en not_active IP Right Cessation
- 2000-07-03 PL PL352479A patent/PL202859B1/en not_active IP Right Cessation
- 2000-07-03 SK SK1933-2001A patent/SK285845B6/en not_active IP Right Cessation
- 2000-07-03 NZ NZ516239A patent/NZ516239A/en unknown
- 2000-07-03 KR KR1020017016790A patent/KR100623166B1/en not_active IP Right Cessation
- 2000-07-03 EP EP00942253A patent/EP1196152A1/en not_active Withdrawn
- 2000-07-03 CA CA002375751A patent/CA2375751A1/en not_active Abandoned
- 2000-07-03 CZ CZ20014684A patent/CZ300888B6/en not_active IP Right Cessation
- 2000-07-03 AU AU56956/00A patent/AU780152B2/en not_active Ceased
- 2000-07-03 JP JP2001507465A patent/JP4039482B2/en not_active Expired - Fee Related
- 2000-07-03 MX MXPA01013465A patent/MXPA01013465A/en active IP Right Grant
-
2002
- 2002-01-02 NO NO20020008A patent/NO324395B1/en not_active IP Right Cessation
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