RU2001133784A - Method for non-invasive diagnosis of Helicobacter pylori infection - Google Patents

Claims (2)

1. A method for non-invasive diagnosis of Helicobacter pylori infection in the human gastrointestinal tract, based on the detection of the presence of Helicobacter pylori bacteria in the human gastrointestinal tract by urease activity by determining the amount of ¹³ C isotope in carbon dioxide of exhaled air before and after taking a test preparation containing ¹³ C-urea, which reveals the presence or absence of Helicobacter pylori infection, characterized in that the quality of the test drug is taken on an empty stomach, per os, an aqueous solution of a mixture of ¹³ C-urea in quantity at least 20 mg in terms of 99% enrichment of ¹³ C-isotope and food citric acid containing ¹³ C-isotope is less than in carbon dioxide produced by the human body in the process of consuming ordinary food, with a quantitative ratio of ¹³ C-urea and citric acid not less than 1: 100, and Helicobacter pylori infection is detected by the degree of excess of the amount of ¹³ C-isotope in exhaled carbon dioxide after taking the test drug in comparison with the carbon isotopic composition of test citric acid. 2. The method according to claim 1, characterized in that after receiving a per os aqueous solution of a mixture of ¹³ C-urea and citric acid, the patient takes out exhaled air for an hour, determines the yield of the ¹³ C-isotope with exhaled carbon dioxide in the observation time and uses the obtained dependence for calculating the degree of infection with bacteria Helicobacter pylori of the human gastrointestinal tract.