RU2001132334A - METHOD FOR IDENTIFICATION OF AN INDIVIDUAL IN WHICH THERE IS A RISK OF IRREVERSIBLE NEUROLOGICAL DAMAGES, INCLUDING STEPS OF QUANTITATIVE DETERMINATION OF THE PEPSINOGEN I12 (PG) CONCENTRATION - Google Patents

METHOD FOR IDENTIFICATION OF AN INDIVIDUAL IN WHICH THERE IS A RISK OF IRREVERSIBLE NEUROLOGICAL DAMAGES, INCLUDING STEPS OF QUANTITATIVE DETERMINATION OF THE PEPSINOGEN I12 (PG) CONCENTRATION

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Publication number
RU2001132334A
RU2001132334A RU2001132334/14A RU2001132334A RU2001132334A RU 2001132334 A RU2001132334 A RU 2001132334A RU 2001132334/14 A RU2001132334/14 A RU 2001132334/14A RU 2001132334 A RU2001132334 A RU 2001132334A RU 2001132334 A RU2001132334 A RU 2001132334A
Authority
RU
Russia
Prior art keywords
concentration
analyte
individual
vitamin
pgi
Prior art date
Application number
RU2001132334/14A
Other languages
Russian (ru)
Other versions
RU2224258C2 (en
Inventor
Пентти Сиппонен
Матти Хяркенен
Осмо Суованиеми
Эрик ФОРСБЛОМ
Original Assignee
Биохит Ойй
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI990991A external-priority patent/FI990991A/en
Application filed by Биохит Ойй filed Critical Биохит Ойй
Publication of RU2001132334A publication Critical patent/RU2001132334A/en
Application granted granted Critical
Publication of RU2224258C2 publication Critical patent/RU2224258C2/en

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Claims (5)

1. Способ идентификации индивидуума, у которого существует риск развития необратимого неврологического повреждения и пернициозной анемии, причем способ включает в себя этапы количественного определения концентрации анализируемого пепсиногена I (PGI) в образце сыворотки указанного индивидуума, выбора специфической для способа величины отсечки для указанного анализируемого вещества, сравнения концентрации анализируемого вещества, определяемой таким образом, со специфической для способа величиной отсечки для анализируемого вещества и определения концентрации витамина В12 или концентрации анализируемого вещества, коррелирующей с указанной концентрацией витамина В12, в образце сыворотки указанного индивидуума и сравнения ее со специфической для способа эталонной величиной для определяемого таким образом содержания анализируемого вещества.1. A method for identifying an individual at risk of developing irreversible neurological damage and pernicious anemia, the method comprising the steps of quantitatively determining the concentration of the analyzed pepsinogen I (PGI) in a serum sample of said individual, selecting a cut-off specific value for the specified analyte, comparing the concentration of the analyte, determined in this way, with the method-specific cutoff value for the analyte and determining the concentration of vitamin B12 or the concentration of the analyte correlating with the specified concentration of vitamin B12 in the serum sample of the indicated individual and comparing it with the method-specific reference value for the analyte content thus determined. 2. Способ по п.1, включающий в себя определение концентрации PGI в сыворотке и отбор для дальнейшего определения концентрации витамина В12 или анализируемого вещества, которое коррелирует с ней, индивидуума, у которого концентрация PGI в сыворотке ниже величины отсечки для PGI.2. The method according to claim 1, comprising determining the concentration of PGI in serum and selecting to further determine the concentration of vitamin B12 or an analyte that correlates with it, an individual whose concentration of PGI in serum is lower than the cutoff value for PGI. 3. Способ по п.1, при котором определяется концентрация витамина В12 в образце.3. The method according to claim 1, wherein the concentration of vitamin B12 in the sample is determined. 4. Способ по п.1, при котором определяется концентрация метилмалоната. или гомоцистеина в образце.4. The method according to claim 1, wherein the concentration of methyl malonate is determined. or homocysteine in the sample. 5. Набор для осуществления способа по п.1, включающий в себя средство для определения концентрации PGI в образце сыворотки, средство для определения концентрации витамина В12 или концентрации анализируемого вещества, коррелирующей с концентрацией указанного витамина В12, в образце сыворотки.5. The kit for implementing the method according to claim 1, comprising a means for determining the concentration of PGI in a serum sample, a means for determining a concentration of vitamin B12 or a concentration of an analyte that correlates with a concentration of said vitamin B12 in a serum sample.
RU2001132334/15A 1999-04-30 2000-04-28 Method for identifying person with the risk of non reversible neurological lesions including stages for quantitative detection of pepsinogen i (pg i) and vitamin b 12 concentrations RU2224258C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI990991 1999-04-30
FI990991A FI990991A (en) 1999-04-30 1999-04-30 Procedure for identifying an individual at risk of irreversible neurological damage

Publications (2)

Publication Number Publication Date
RU2001132334A true RU2001132334A (en) 2003-08-27
RU2224258C2 RU2224258C2 (en) 2004-02-20

Family

ID=8554566

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001132334/15A RU2224258C2 (en) 1999-04-30 2000-04-28 Method for identifying person with the risk of non reversible neurological lesions including stages for quantitative detection of pepsinogen i (pg i) and vitamin b 12 concentrations

Country Status (12)

Country Link
EP (1) EP1173764B1 (en)
JP (1) JP2002543430A (en)
CN (1) CN1353816A (en)
AT (1) ATE319088T1 (en)
AU (1) AU4299700A (en)
DE (1) DE60026285T2 (en)
DK (1) DK1173764T3 (en)
ES (1) ES2258453T3 (en)
FI (1) FI990991A (en)
PT (1) PT1173764E (en)
RU (1) RU2224258C2 (en)
WO (1) WO2000067029A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20010019A (en) * 2001-01-05 2002-07-06 Biohit Oyj Procedure for the diagnosis of atrophic gastritis
FI20065542A0 (en) * 2006-09-01 2006-09-01 Biohit Oyj Method and Sampling Kit for Assessment of Abdominal Mucosal Condition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97304C (en) * 1994-11-16 1996-11-25 Locus Genex Oy A method for screening for the risk of gastric cancer

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