RU2001132333A - The method of obtaining derivatives of steroid glycosides RUSCUS ACULEATUS - Google Patents

The method of obtaining derivatives of steroid glycosides RUSCUS ACULEATUS

Info

Publication number
RU2001132333A
RU2001132333A RU2001132333/13A RU2001132333A RU2001132333A RU 2001132333 A RU2001132333 A RU 2001132333A RU 2001132333/13 A RU2001132333/13 A RU 2001132333/13A RU 2001132333 A RU2001132333 A RU 2001132333A RU 2001132333 A RU2001132333 A RU 2001132333A
Authority
RU
Russia
Prior art keywords
range
steroid glycosides
ruscus aculeatus
glycosides
obtaining derivatives
Prior art date
Application number
RU2001132333/13A
Other languages
Russian (ru)
Other versions
RU2249043C2 (en
Inventor
Вальтер АККУАТИ
Чезаре ПОНДЗОНЕ
Original Assignee
Индена С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1999MI001223A external-priority patent/ITMI991223A1/en
Application filed by Индена С.П.А. filed Critical Индена С.П.А.
Publication of RU2001132333A publication Critical patent/RU2001132333A/en
Application granted granted Critical
Publication of RU2249043C2 publication Critical patent/RU2249043C2/en

Links

Claims (8)

1. Способ получения десглюкодесрамнорусцина, включающий гидролиз стероидных гликозидов Ruscus aculeatus (рускосапонинов) в результате ферментации субстрата, содержащего указанные гликозиды с помощью грибка вида Aspergillus niger.1. A method of producing desglucodesramnoruzcin, including the hydrolysis of steroid glycosides Ruscus aculeatus (ruscosaponins) by fermentation of a substrate containing these glycosides using a fungus of the species Aspergillus niger. 2. Способ по п.1, в котором указанный субстрат представляет собой бульон культуры.2. The method according to claim 1, wherein said substrate is a culture broth. 3. Способ по п.2, в котором указанную ферментацию проводят при температуре 25-30°С, в условия перемешивания и барботажа воздуха для достижения величины pO2 равной 50% или более.3. The method according to claim 2, in which the specified fermentation is carried out at a temperature of 25-30 ° C, under conditions of mixing and bubbling of air to achieve a pO 2 value of 50% or more. 4. Способ по п.3, в котором температура составляет 27°С.4. The method according to claim 3, in which the temperature is 27 ° C. 5. Способ по п.3, в котором исходная концентрация указанных стероидных гликозидов имеет значение в интервале 5-15% мас./об.5. The method according to claim 3, in which the initial concentration of these steroid glycosides is in the range of 5-15% wt./about. 6. Способ по п.5, в котором указанный интервал концентраций составляет 8-10% мас./об.6. The method according to claim 5, in which the specified range of concentrations is 8-10% wt./about. 7. Способ по любому из пп.2-6, в котором рН культурного бульона имеет значение в интервале 4-6.7. The method according to any one of claims 2 to 6, in which the pH of the culture broth has a value in the range of 4-6. 8. Способ по п.1, в котором рН культурального бульона имеет значение в интервале 4,5-5,5.8. The method according to claim 1, in which the pH of the culture broth has a value in the range of 4.5-5.5.
RU2001132333/13A 1999-06-01 2000-05-26 Method for preparing derivatives of steroid glycosides from ruscus aculeatus RU2249043C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI99A001223 1999-06-01
IT1999MI001223A ITMI991223A1 (en) 1999-06-01 1999-06-01 PROCESS FOR THE PREPARATION OF STEROID GLYCOSIDES DERIVATIVES OF RUSCUS ACULEATUS

Publications (2)

Publication Number Publication Date
RU2001132333A true RU2001132333A (en) 2003-09-10
RU2249043C2 RU2249043C2 (en) 2005-03-27

Family

ID=11383097

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001132333/13A RU2249043C2 (en) 1999-06-01 2000-05-26 Method for preparing derivatives of steroid glycosides from ruscus aculeatus

Country Status (21)

Country Link
US (1) US6528280B1 (en)
EP (1) EP1181384B1 (en)
JP (1) JP4699661B2 (en)
KR (1) KR100670413B1 (en)
CN (1) CN1261587C (en)
AT (1) ATE290603T1 (en)
AU (1) AU773234B2 (en)
CA (1) CA2375087C (en)
CZ (1) CZ301224B6 (en)
DE (1) DE60018560T2 (en)
ES (1) ES2237436T3 (en)
HK (1) HK1046432B (en)
HU (1) HUP0201380A3 (en)
IL (1) IL146827A0 (en)
IT (1) ITMI991223A1 (en)
NO (1) NO326848B1 (en)
PL (1) PL200908B1 (en)
PT (1) PT1181384E (en)
RU (1) RU2249043C2 (en)
SK (1) SK286195B6 (en)
WO (1) WO2000073489A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009138994A1 (en) * 2008-05-14 2009-11-19 Biocon Limited A fermentation process for the production of secondary metabolites
CN102504007B (en) * 2011-12-15 2013-09-25 成都普思生物科技有限公司 Method for separation and purification of ruscogenin monomer
CN103588852B (en) * 2013-11-26 2016-03-30 陕西嘉禾生物科技股份有限公司 The method of extraction and isolation ruscogenin from ruscus aculeatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2104911A1 (en) 1970-09-03 1972-04-28 Investigations Sci Pharm Heterosides from ruscus aculeatus l - useful as antiinflammatories vasconstructors and fibrinolytics
GB1380253A (en) * 1971-01-21 1975-01-08 Inverni Della Beffa Spa Prosapogenins
JPS59192075A (en) * 1983-04-12 1984-10-31 Dainippon Ink & Chem Inc Improvement of bitterness of aloe extract

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