RU2001126559A - Glucokinase Activators - Google Patents
Glucokinase ActivatorsInfo
- Publication number
- RU2001126559A RU2001126559A RU2001126559/04A RU2001126559A RU2001126559A RU 2001126559 A RU2001126559 A RU 2001126559A RU 2001126559/04 A RU2001126559/04 A RU 2001126559/04A RU 2001126559 A RU2001126559 A RU 2001126559A RU 2001126559 A RU2001126559 A RU 2001126559A
- Authority
- RU
- Russia
- Prior art keywords
- cyclopentyl
- ylpropionamide
- dichlorophenyl
- thiazol
- methanesulfonylphenyl
- Prior art date
Links
- 102000019622 EC 2.7.1.2 Human genes 0.000 title 1
- 108010021582 EC 2.7.1.2 Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- -1 amino, hydroxy amino Chemical group 0.000 claims 49
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 35
- 125000004432 carbon atoms Chemical group C* 0.000 claims 17
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 15
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 9
- 238000006243 chemical reaction Methods 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000005842 heteroatoms Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229910052757 nitrogen Chemical group 0.000 claims 4
- 206010012601 Diabetes mellitus Diseases 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 claims 3
- XRIWIBQSPXUIBD-CYBMUJFWSA-N (2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C([C@@H](C(=O)NC(=O)NC)C=1C=C(Cl)C(=CC=1)S(C)(=O)=O)C1CCCC1 XRIWIBQSPXUIBD-CYBMUJFWSA-N 0.000 claims 2
- UCJASZOKKRTZRQ-CYBMUJFWSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-(ethylcarbamoyl)propanamide Chemical compound C([C@@H](C(=O)NC(=O)NCC)C=1C=C(Cl)C(Cl)=CC=1)C1CCCC1 UCJASZOKKRTZRQ-CYBMUJFWSA-N 0.000 claims 2
- IPFOWEUMNGCEDZ-GFCCVEGCSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-(methylcarbamoyl)propanamide Chemical compound C([C@@H](C(=O)NC(=O)NC)C=1C=C(Cl)C(Cl)=CC=1)C1CCCC1 IPFOWEUMNGCEDZ-GFCCVEGCSA-N 0.000 claims 2
- DCAJZFIGUVVDIW-CQSZACIVSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-(prop-2-enylcarbamoyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC(=O)NCC=C)CC1CCCC1 DCAJZFIGUVVDIW-CQSZACIVSA-N 0.000 claims 2
- SSSWIDJKGVZUQR-UHFFFAOYSA-N 2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(S(C)(=O)=O)C(Br)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 SSSWIDJKGVZUQR-UHFFFAOYSA-N 0.000 claims 2
- PXCGDHFIGOGNFA-UHFFFAOYSA-N 2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 PXCGDHFIGOGNFA-UHFFFAOYSA-N 0.000 claims 2
- XRIWIBQSPXUIBD-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(S(C)(=O)=O)C(Cl)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 XRIWIBQSPXUIBD-UHFFFAOYSA-N 0.000 claims 2
- FROPKILFCBRCRO-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 FROPKILFCBRCRO-UHFFFAOYSA-N 0.000 claims 2
- GIZMCHGSQSJKSH-UHFFFAOYSA-N 2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 GIZMCHGSQSJKSH-UHFFFAOYSA-N 0.000 claims 2
- DFEUXSGSGRXESP-UHFFFAOYSA-N 2-(4-chloro-3-nitrophenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC(C(CC2CCCC2)C(=O)NC=2N=CC=CC=2)=C1 DFEUXSGSGRXESP-UHFFFAOYSA-N 0.000 claims 2
- RADNDPLMPBIZAN-UHFFFAOYSA-N 2-(4-cyanophenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1CCCC1CC(C=1C=CC(=CC=1)C#N)C(=O)NC1=CC=CC=N1 RADNDPLMPBIZAN-UHFFFAOYSA-N 0.000 claims 2
- IPFOWEUMNGCEDZ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 IPFOWEUMNGCEDZ-UHFFFAOYSA-N 0.000 claims 2
- WSKVJPKZDWCVRQ-UHFFFAOYSA-N 3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)-N-pyridin-2-ylpropanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 WSKVJPKZDWCVRQ-UHFFFAOYSA-N 0.000 claims 2
- QKJNBEILGRYUIT-UHFFFAOYSA-N 3-cyclopentyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]-N-pyridin-2-ylpropanamide Chemical compound C1=C(C(F)(F)F)C(F)=CC(C(CC2CCCC2)C(=O)NC=2N=CC=CC=2)=C1 QKJNBEILGRYUIT-UHFFFAOYSA-N 0.000 claims 2
- IPBKPKRBRSQJKK-UHFFFAOYSA-N 3-cyclopentyl-N-(1,3-thiazol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanamide Chemical compound FC(F)(F)C1=CC=CC(C(CC2CCCC2)C(=O)NC=2SC=CN=2)=C1 IPBKPKRBRSQJKK-UHFFFAOYSA-N 0.000 claims 2
- BDHNKBDGERTMEG-UHFFFAOYSA-N 3-cyclopentyl-N-(1,3-thiazol-2-yl)-2-[4-(trifluoromethoxy)phenyl]propanamide Chemical compound C1=CC(OC(F)(F)F)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCC1 BDHNKBDGERTMEG-UHFFFAOYSA-N 0.000 claims 2
- XQRKLUWRUXNULG-UHFFFAOYSA-N 3-cyclopentyl-N-(1,3-thiazol-2-yl)-2-[4-(trifluoromethylsulfonyl)phenyl]propanamide Chemical compound C1=CC(S(=O)(=O)C(F)(F)F)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCC1 XQRKLUWRUXNULG-UHFFFAOYSA-N 0.000 claims 2
- OFKYROVDFKBXPL-UHFFFAOYSA-N 3-cyclopentyl-N-(methylcarbamoyl)-2-(4-methylsulfonylphenyl)propanamide Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 OFKYROVDFKBXPL-UHFFFAOYSA-N 0.000 claims 2
- KWZYRUJAPMMFKW-UHFFFAOYSA-N 3-cyclopentyl-N-pyridin-2-yl-2-[4-(trifluoromethylsulfonyl)phenyl]propanamide Chemical compound C1=CC(S(=O)(=O)C(F)(F)F)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 KWZYRUJAPMMFKW-UHFFFAOYSA-N 0.000 claims 2
- DTISLNHPGONUBO-UHFFFAOYSA-N N-(5-bromopyridin-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC(Br)=CC=1)CC1CCCC1 DTISLNHPGONUBO-UHFFFAOYSA-N 0.000 claims 2
- QLNJFJADRCOGBJ-UHFFFAOYSA-N Propanamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- PHRGVWXIAKHPMO-MRXNPFEDSA-N methyl 6-[[(2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)[C@@H](C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 PHRGVWXIAKHPMO-MRXNPFEDSA-N 0.000 claims 2
- SBDSHCDZEWFJNQ-UHFFFAOYSA-N methyl 6-[[3-cyclopentyl-2-[4-(trifluoromethylsulfonyl)phenyl]propanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)C(C=1C=CC(=CC=1)S(=O)(=O)C(F)(F)F)CC1CCCC1 SBDSHCDZEWFJNQ-UHFFFAOYSA-N 0.000 claims 2
- 150000002829 nitrogen Chemical group 0.000 claims 2
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 2
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 2
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229940080818 propionamide Drugs 0.000 claims 2
- 125000004434 sulfur atoms Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- SJGXOVGSEZKIHH-SBXXRYSUSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-(2-hydroxypropylcarbamoyl)propanamide Chemical compound C([C@@H](C(=O)NC(=O)NCC(O)C)C=1C=C(Cl)C(Cl)=CC=1)C1CCCC1 SJGXOVGSEZKIHH-SBXXRYSUSA-N 0.000 claims 1
- MUYNGBLZFJKXRQ-CQSZACIVSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-(3-hydroxypropylcarbamoyl)propanamide Chemical compound C([C@@H](C(=O)NC(=O)NCCCO)C=1C=C(Cl)C(Cl)=CC=1)C1CCCC1 MUYNGBLZFJKXRQ-CQSZACIVSA-N 0.000 claims 1
- PCZQBEJLQOCRQI-OAHLLOKOSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-[5-(trifluoromethyl)pyridin-2-yl]propanamide Chemical compound N1=CC(C(F)(F)F)=CC=C1NC(=O)[C@@H](C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 PCZQBEJLQOCRQI-OAHLLOKOSA-N 0.000 claims 1
- RFZWICAONXFLJJ-OAHLLOKOSA-N (2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)-N-pyridin-2-ylpropanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1N=CC=CC=1)CC1CCCC1 RFZWICAONXFLJJ-OAHLLOKOSA-N 0.000 claims 1
- NEQSWPCDHDQINX-MRXNPFEDSA-N (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(1,3-thiazol-2-yl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1SC=CN=1)CC1CCCC1 NEQSWPCDHDQINX-MRXNPFEDSA-N 0.000 claims 1
- DTISLNHPGONUBO-MRXNPFEDSA-N (2R)-N-(5-bromopyridin-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1N=CC(Br)=CC=1)CC1CCCC1 DTISLNHPGONUBO-MRXNPFEDSA-N 0.000 claims 1
- WTUVOAWMRJPIFM-OAHLLOKOSA-N (2R)-N-(5-bromopyridin-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1N=CC(Br)=CC=1)CC1CCCC1 WTUVOAWMRJPIFM-OAHLLOKOSA-N 0.000 claims 1
- GBNDXXAFSGHQMN-OAHLLOKOSA-N (2R)-N-(5-chloropyridin-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound N1=CC(Cl)=CC=C1NC(=O)[C@@H](C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 GBNDXXAFSGHQMN-OAHLLOKOSA-N 0.000 claims 1
- RXUBUMUJUSDVOE-SECBINFHSA-N (2R)-N-carbamoyl-2-(3,4-dichlorophenyl)-4-methylpentanamide Chemical compound NC(=O)NC(=O)[C@H](CC(C)C)C1=CC=C(Cl)C(Cl)=C1 RXUBUMUJUSDVOE-SECBINFHSA-N 0.000 claims 1
- PTJPIOVAKOVOMS-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-4-methyl-N-(methylcarbamoyl)pentanamide Chemical compound CNC(=O)NC(=O)C(CC(C)C)C1=CC=C(Cl)C(Cl)=C1 PTJPIOVAKOVOMS-UHFFFAOYSA-N 0.000 claims 1
- PMLLJKWFFRYTRA-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-N-(methylcarbamoyl)hexanamide Chemical compound CNC(=O)NC(=O)C(CCCC)C1=CC=C(Cl)C(Cl)=C1 PMLLJKWFFRYTRA-UHFFFAOYSA-N 0.000 claims 1
- VZHKONVMVRJXCH-UHFFFAOYSA-N 2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentyl-N-(1,3-thiazol-2-yl)propanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCC1 VZHKONVMVRJXCH-UHFFFAOYSA-N 0.000 claims 1
- HDJJNAJYYNXSOO-UHFFFAOYSA-N 2-(3-bromo-4-methylsulfonylphenyl)-N-(5-bromopyridin-2-yl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC(Br)=CC=1)CC1CCCC1 HDJJNAJYYNXSOO-UHFFFAOYSA-N 0.000 claims 1
- CERXYDAYZZMUJI-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-(1,3-thiazol-2-yl)propanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCC1 CERXYDAYZZMUJI-UHFFFAOYSA-N 0.000 claims 1
- SDIIWCJMPBUTIX-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-(ethylcarbamoyl)propanamide Chemical compound C=1C=C(S(C)(=O)=O)C(Cl)=CC=1C(C(=O)NC(=O)NCC)CC1CCCC1 SDIIWCJMPBUTIX-UHFFFAOYSA-N 0.000 claims 1
- GYJIAJFUQMLXKQ-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-[5-(trifluoromethyl)pyridin-2-yl]propanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC(=CC=1)C(F)(F)F)CC1CCCC1 GYJIAJFUQMLXKQ-UHFFFAOYSA-N 0.000 claims 1
- JAANTBRTGAOPLN-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-N-(5-chloropyridin-2-yl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC(Cl)=CC=1)CC1CCCC1 JAANTBRTGAOPLN-UHFFFAOYSA-N 0.000 claims 1
- RVQHSJOQTPWKBX-UHFFFAOYSA-N 2-(3-chlorophenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=CC(Cl)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 RVQHSJOQTPWKBX-UHFFFAOYSA-N 0.000 claims 1
- VFQFGUMXWDQORE-UHFFFAOYSA-N 2-(3-chlorophenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound ClC1=CC=CC(C(CC2CCCC2)C(=O)NC=2N=CC=CC=2)=C1 VFQFGUMXWDQORE-UHFFFAOYSA-N 0.000 claims 1
- NSKZVLLRTKHYAG-UHFFFAOYSA-N 2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentyl-N-(1,3-thiazol-2-yl)propanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCC1 NSKZVLLRTKHYAG-UHFFFAOYSA-N 0.000 claims 1
- KHGOSOVBWBOPNK-UHFFFAOYSA-N 2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(S(C)(=O)=O)C(C#N)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 KHGOSOVBWBOPNK-UHFFFAOYSA-N 0.000 claims 1
- YLPIXGLFJNZLNK-UHFFFAOYSA-N 2-(4-aminophenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=CC(N)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 YLPIXGLFJNZLNK-UHFFFAOYSA-N 0.000 claims 1
- HEPMRJAEEJWANC-UHFFFAOYSA-N 2-(4-bromophenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(Br)C=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 HEPMRJAEEJWANC-UHFFFAOYSA-N 0.000 claims 1
- NDKMKDBCWIGFKC-UHFFFAOYSA-N 2-(4-butylsulfonylphenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C1=CC(S(=O)(=O)CCCC)=CC=C1C(C(=O)NC(=O)NC)CC1CCCC1 NDKMKDBCWIGFKC-UHFFFAOYSA-N 0.000 claims 1
- LZPNSCJMZCTWAT-UHFFFAOYSA-N 2-(4-chloro-3-nitrophenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 LZPNSCJMZCTWAT-UHFFFAOYSA-N 0.000 claims 1
- BZEHFFYIAOOMOU-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 BZEHFFYIAOOMOU-UHFFFAOYSA-N 0.000 claims 1
- PISHDDFWVOQURY-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopentyl-N-[5-(hydroxymethyl)-1,3-thiazol-2-yl]propanamide Chemical compound S1C(CO)=CN=C1NC(=O)C(C=1C=CC(Cl)=CC=1)CC1CCCC1 PISHDDFWVOQURY-UHFFFAOYSA-N 0.000 claims 1
- SAXQLMMJQPHEHD-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopentyl-N-[5-(hydroxymethyl)pyridin-2-yl]propanamide Chemical compound N1=CC(CO)=CC=C1NC(=O)C(C=1C=CC(Cl)=CC=1)CC1CCCC1 SAXQLMMJQPHEHD-UHFFFAOYSA-N 0.000 claims 1
- LYVQHKLYOQUHDM-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=CC(Cl)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 LYVQHKLYOQUHDM-UHFFFAOYSA-N 0.000 claims 1
- CJJJMCHPRVFQJF-UHFFFAOYSA-N 2-(4-cyanophenyl)-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(C#N)C=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 CJJJMCHPRVFQJF-UHFFFAOYSA-N 0.000 claims 1
- HBAZTQMNTUKXSB-UHFFFAOYSA-N 2-[2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazol-4-yl]acetic acid Chemical compound OC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C(Cl)=CC=2)=N1 HBAZTQMNTUKXSB-UHFFFAOYSA-N 0.000 claims 1
- NBDVUGUUDMQIJV-UHFFFAOYSA-N 2-[3,4-bis(methylsulfonyl)phenyl]-3-cyclopentyl-N-(methylcarbamoyl)propanamide Chemical compound C=1C=C(S(C)(=O)=O)C(S(C)(=O)=O)=CC=1C(C(=O)NC(=O)NC)CC1CCCC1 NBDVUGUUDMQIJV-UHFFFAOYSA-N 0.000 claims 1
- MPXVZCLTGVVPGY-UHFFFAOYSA-N 2-[3,4-bis(methylsulfonyl)phenyl]-3-cyclopentyl-N-pyridin-2-ylpropanamide Chemical compound C1=C(S(C)(=O)=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=CC=CC=1)CC1CCCC1 MPXVZCLTGVVPGY-UHFFFAOYSA-N 0.000 claims 1
- FDQRYJSBXWMVHG-UHFFFAOYSA-N 2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C(Cl)=CC=2)=N1 FDQRYJSBXWMVHG-UHFFFAOYSA-N 0.000 claims 1
- RKKJCQFKGLTEBD-UHFFFAOYSA-N 2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazole-5-carboxylic acid Chemical compound S1C(C(=O)O)=CN=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 RKKJCQFKGLTEBD-UHFFFAOYSA-N 0.000 claims 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- ITQTTZVARXURQS-UHFFFAOYSA-N 3-Methylpyridine Chemical compound CC1=CC=CN=C1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 claims 1
- NYPYPOZNGOXYSU-UHFFFAOYSA-N 3-bromopyridine Chemical compound BrC1=CC=CN=C1 NYPYPOZNGOXYSU-UHFFFAOYSA-N 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- KHKGLZYUHLKKRG-UHFFFAOYSA-N 3-cycloheptyl-2-(4-methylsulfonylphenyl)-N-(1,3-thiazol-2-yl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCCCC1 KHKGLZYUHLKKRG-UHFFFAOYSA-N 0.000 claims 1
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- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- OGDSCUHHJIEKGP-UHFFFAOYSA-N ethyl 2-[2-[[2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazol-4-yl]-2-oxoacetate Chemical compound CCOC(=O)C(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C(=CC=2)S(C)(=O)=O)=N1 OGDSCUHHJIEKGP-UHFFFAOYSA-N 0.000 claims 1
- LQYMYFLHZNKBIW-UHFFFAOYSA-N ethyl 2-[2-[[2-(3-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C=CC=2)=N1 LQYMYFLHZNKBIW-UHFFFAOYSA-N 0.000 claims 1
- WKRQNTYMPQFEDE-UHFFFAOYSA-N ethyl 2-[2-[[2-(4-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound CCOC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(Cl)=CC=2)=N1 WKRQNTYMPQFEDE-UHFFFAOYSA-N 0.000 claims 1
- ABRUKNWQAFXTLG-UHFFFAOYSA-N ethyl 2-[2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazol-5-yl]-2-oxoacetate Chemical compound S1C(C(=O)C(=O)OCC)=CN=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 ABRUKNWQAFXTLG-UHFFFAOYSA-N 0.000 claims 1
- VDZCZKADNSVOIG-UHFFFAOYSA-N ethyl 2-[2-[[3-cyclopentyl-2-(4-nitrophenyl)propanoyl]amino]-1,3-thiazol-4-yl]-2-oxoacetate Chemical compound CCOC(=O)C(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(=CC=2)[N+]([O-])=O)=N1 VDZCZKADNSVOIG-UHFFFAOYSA-N 0.000 claims 1
- JMLDJWSFGPBJSH-UHFFFAOYSA-N ethyl 2-[2-[[3-cyclopentyl-2-[4-fluoro-3-(trifluoromethyl)phenyl]propanoyl]amino]-1,3-thiazol-4-yl]-2-oxoacetate Chemical compound CCOC(=O)C(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(C(F)=CC=2)C(F)(F)F)=N1 JMLDJWSFGPBJSH-UHFFFAOYSA-N 0.000 claims 1
- CIKLMPYJSYDZEK-UHFFFAOYSA-N ethyl 2-[[2-(3-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C=CC=2)=N1 CIKLMPYJSYDZEK-UHFFFAOYSA-N 0.000 claims 1
- ZPJDBJMHMCOKKX-UHFFFAOYSA-N ethyl 2-[[2-(4-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(Cl)=CC=2)=N1 ZPJDBJMHMCOKKX-UHFFFAOYSA-N 0.000 claims 1
- UJINJBQVRZGYAU-UHFFFAOYSA-N ethyl 2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazole-5-carboxylate Chemical compound S1C(C(=O)OCC)=CN=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 UJINJBQVRZGYAU-UHFFFAOYSA-N 0.000 claims 1
- JUXYBFRKUPRJRJ-UHFFFAOYSA-N ethyl 2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]carbamoylamino]acetate Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C(=O)NC(=O)NCC(=O)OCC)CC1CCCC1 JUXYBFRKUPRJRJ-UHFFFAOYSA-N 0.000 claims 1
- AZDMCWKLNPQMIE-UHFFFAOYSA-N ethyl 2-[[3-cyclopentyl-2-(4-methylsulfonylphenyl)propanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(=CC=2)S(C)(=O)=O)=N1 AZDMCWKLNPQMIE-UHFFFAOYSA-N 0.000 claims 1
- IGLOREVOTWYIQQ-UHFFFAOYSA-N ethyl 2-[[3-cyclopentyl-2-(4-nitrophenyl)propanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound CCOC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(=CC=2)[N+]([O-])=O)=N1 IGLOREVOTWYIQQ-UHFFFAOYSA-N 0.000 claims 1
- XYZQDANSANGSJQ-UHFFFAOYSA-N ethyl 3-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]carbamoylamino]-3-oxopropanoate Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C(=O)NC(=O)NC(=O)CC(=O)OCC)CC1CCCC1 XYZQDANSANGSJQ-UHFFFAOYSA-N 0.000 claims 1
- GGBZRGGAZMIDNJ-UHFFFAOYSA-N ethyl 3-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]carbamoylamino]propanoate Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C(=O)NC(=O)NCCC(=O)OCC)CC1CCCC1 GGBZRGGAZMIDNJ-UHFFFAOYSA-N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- SGBUNAYVAMGZPQ-UHFFFAOYSA-N methyl 2-[2-[[2-(3-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound COC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C=CC=2)=N1 SGBUNAYVAMGZPQ-UHFFFAOYSA-N 0.000 claims 1
- LHFCDJFDFAKZKF-UHFFFAOYSA-N methyl 2-[2-[[2-(4-aminophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound COC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(N)=CC=2)=N1 LHFCDJFDFAKZKF-UHFFFAOYSA-N 0.000 claims 1
- YJXMHFRYLOMIGS-UHFFFAOYSA-N methyl 2-[2-[[2-(4-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound COC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(Cl)=CC=2)=N1 YJXMHFRYLOMIGS-UHFFFAOYSA-N 0.000 claims 1
- GNHJXSIKSWYCMU-UHFFFAOYSA-N methyl 2-[2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound COC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C(Cl)=CC=2)=N1 GNHJXSIKSWYCMU-UHFFFAOYSA-N 0.000 claims 1
- SXQQYTWMGOXJGZ-UHFFFAOYSA-N methyl 2-[2-[[3-cyclopentyl-2-(4-nitrophenyl)propanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound COC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(=CC=2)[N+]([O-])=O)=N1 SXQQYTWMGOXJGZ-UHFFFAOYSA-N 0.000 claims 1
- IWXBKSPSCQOABP-UHFFFAOYSA-N methyl 2-[2-[[3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanoyl]amino]-1,3-thiazol-4-yl]acetate Chemical compound COC(=O)CC1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(C(=CC=2)S(C)(=O)=O)C(F)(F)F)=N1 IWXBKSPSCQOABP-UHFFFAOYSA-N 0.000 claims 1
- GLJHRZZRWZRDGK-CYBMUJFWSA-N methyl 2-[[(2R)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H](CC2CCCC2)C=2C=C(Cl)C(Cl)=CC=2)=N1 GLJHRZZRWZRDGK-CYBMUJFWSA-N 0.000 claims 1
- HDKBSJPSLJJDQO-UHFFFAOYSA-N methyl 2-[[2-(3-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(Cl)C=CC=2)=N1 HDKBSJPSLJJDQO-UHFFFAOYSA-N 0.000 claims 1
- FEBTXNSXXXLTFE-UHFFFAOYSA-N methyl 2-[[2-(4-aminophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(N)=CC=2)=N1 FEBTXNSXXXLTFE-UHFFFAOYSA-N 0.000 claims 1
- VAWBMWMYWHQDQP-UHFFFAOYSA-N methyl 2-[[2-(4-chlorophenyl)-3-cyclopentylpropanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(Cl)=CC=2)=N1 VAWBMWMYWHQDQP-UHFFFAOYSA-N 0.000 claims 1
- XSJRZLZLXXYZDQ-UHFFFAOYSA-N methyl 2-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]carbamoylamino]acetate Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C(=O)NC(=O)NCC(=O)OC)CC1CCCC1 XSJRZLZLXXYZDQ-UHFFFAOYSA-N 0.000 claims 1
- FOFAZRPPNQUZIP-UHFFFAOYSA-N methyl 2-[[3-cyclopentyl-2-(4-nitrophenyl)propanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=CC(=CC=2)[N+]([O-])=O)=N1 FOFAZRPPNQUZIP-UHFFFAOYSA-N 0.000 claims 1
- KQMACNAZGRMREM-UHFFFAOYSA-N methyl 2-[[3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)C(CC2CCCC2)C=2C=C(C(=CC=2)S(C)(=O)=O)C(F)(F)F)=N1 KQMACNAZGRMREM-UHFFFAOYSA-N 0.000 claims 1
- CJQUPGBTPTYESJ-UHFFFAOYSA-N methyl 3-[[3-cyclopentyl-2-(3,4-dichlorophenyl)propanoyl]carbamoylamino]propanoate Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C(=O)NC(=O)NCCC(=O)OC)CC1CCCC1 CJQUPGBTPTYESJ-UHFFFAOYSA-N 0.000 claims 1
- NBKBSEBPJKFBRP-UHFFFAOYSA-N methyl 4-[3-cyclopentyl-1-oxo-1-(1,3-thiazol-2-ylamino)propan-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C(C(=O)NC=1SC=CN=1)CC1CCCC1 NBKBSEBPJKFBRP-UHFFFAOYSA-N 0.000 claims 1
- ZOMRXTAHSVSQEN-UHFFFAOYSA-N methyl 6-[[2-(3-chlorophenyl)-3-cyclopentylpropanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)C(C=1C=C(Cl)C=CC=1)CC1CCCC1 ZOMRXTAHSVSQEN-UHFFFAOYSA-N 0.000 claims 1
- WTYBLBICEQHSSK-UHFFFAOYSA-N methyl 6-[[2-(4-aminophenyl)-3-cyclopentylpropanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)C(C=1C=CC(N)=CC=1)CC1CCCC1 WTYBLBICEQHSSK-UHFFFAOYSA-N 0.000 claims 1
- IWEYOBVWSOOLQG-UHFFFAOYSA-N methyl 6-[[2-(4-chlorophenyl)-3-cyclopentylpropanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)C(C=1C=CC(Cl)=CC=1)CC1CCCC1 IWEYOBVWSOOLQG-UHFFFAOYSA-N 0.000 claims 1
- WEJXSOOSQGAQRE-UHFFFAOYSA-N methyl 6-[[3-cyclopentyl-2-(4-methylsulfonylphenyl)propanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)C(C=1C=CC(=CC=1)S(C)(=O)=O)CC1CCCC1 WEJXSOOSQGAQRE-UHFFFAOYSA-N 0.000 claims 1
- VHUOHAQHXXPVRP-UHFFFAOYSA-N methyl 6-[[3-cyclopentyl-2-(4-nitrophenyl)propanoyl]amino]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1NC(=O)C(C=1C=CC(=CC=1)[N+]([O-])=O)CC1CCCC1 VHUOHAQHXXPVRP-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 238000005897 peptide coupling reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000565 sulfonamide group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- FFBUZJNZRSJCCQ-UHFFFAOYSA-N CCC(C(O)=O)c1cc(I)c(C)cc1 Chemical compound CCC(C(O)=O)c1cc(I)c(C)cc1 FFBUZJNZRSJCCQ-UHFFFAOYSA-N 0.000 description 1
Claims (23)
Applications Claiming Priority (5)
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US12670799P | 1999-03-29 | 1999-03-29 | |
US16594899P | 1999-11-17 | 1999-11-17 | |
US60/165,948 | 1999-11-17 | ||
US60/126,707 | 1999-11-17 | ||
US60/165,944 | 1999-11-17 |
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RU2001126559A true RU2001126559A (en) | 2003-06-27 |
RU2242469C2 RU2242469C2 (en) | 2004-12-20 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2001126559/04A RU2242469C2 (en) | 1999-03-29 | 2000-03-20 | Glucokinase activating agents |
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US (1) | US6528543B1 (en) |
RU (1) | RU2242469C2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2386622C9 (en) * | 2004-01-06 | 2021-04-21 | Ново Нордиск А/С | Heteroaromatic derivatives of urea and use thereof as glucokinase activators |
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SE0102764D0 (en) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
CN101805358A (en) * | 2002-10-03 | 2010-08-18 | 诺瓦提斯公司 | As glucokinase activating agents, can be used for treating (thiazol-2-yl) acid amides or the sulphonamide of the replacement of type II diabetes |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
US7132425B2 (en) | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
AU2005214137B2 (en) * | 2004-02-18 | 2008-05-29 | Astrazeneca Ab | Compounds |
AU2005214132B9 (en) * | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
BRPI0509573A (en) * | 2004-04-02 | 2007-09-25 | Novartis Ag | sulfonamide thiazolpyridine derivatives as useful glucokinase activators for the treatment of type 2 diabetes |
CN101098876A (en) * | 2004-04-02 | 2008-01-02 | 诺瓦提斯公司 | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
CA2581619A1 (en) | 2004-10-16 | 2006-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
US20110059941A1 (en) * | 2005-05-24 | 2011-03-10 | Peter William Rodney Caulkett | 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
NZ575513A (en) * | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
EP2027113A1 (en) * | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
JP2009500442A (en) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | 2-Heterocyclyloxybenzoylaminoheterocyclyl compounds as modulators of glucokinase for treating type 2 diabetes |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
JP2007063225A (en) * | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | Imidazopyridine compound |
GT200600429A (en) * | 2005-09-30 | 2007-04-30 | ORGANIC COMPOUNDS | |
GT200600428A (en) * | 2005-09-30 | 2007-05-21 | ORGANIC COMPOUNDS | |
JP2009514835A (en) * | 2005-11-03 | 2009-04-09 | プロシディオン・リミテッド | Tricyclo-substituted amide |
EP1948614A2 (en) * | 2005-11-18 | 2008-07-30 | Takeda San Diego, Inc. | Glucokinase activators |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
WO2007104034A2 (en) | 2006-03-08 | 2007-09-13 | Takeda San Diego, Inc. | Glucokinase activators |
US8008332B2 (en) | 2006-05-31 | 2011-08-30 | Takeda San Diego, Inc. | Substituted indazoles as glucokinase activators |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
SA07280576B1 (en) * | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators |
JP5419706B2 (en) | 2006-12-20 | 2014-02-19 | タケダ カリフォルニア インコーポレイテッド | Glucokinase activator |
UY30822A1 (en) * | 2006-12-21 | 2008-07-31 | Astrazeneca Ab | NEW CRYSTAL FORM OF 3 - {[5-AZETIDIN-1-YLCABONYL) PYRAZIN-2-YL] OXY} -5- [1-METHYLETHYLOXY] -N-1H-PYRAZOL-3-YLBENZAMIDA, COMPOSITIONS CONTAINING AND PREPARATION, PROCESSING AND PREPARATION APPLICATIONS |
TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
EP2116533B1 (en) * | 2007-03-07 | 2013-07-10 | Kyorin Pharmaceutical Co., Ltd. | Glucokinase activator |
US8173645B2 (en) * | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
US7741327B2 (en) * | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
HUE025224T2 (en) | 2008-04-28 | 2016-02-29 | Kyorin Seiyaku Kk | Cyclopentylacrylamide derivative |
CA2732165A1 (en) | 2008-08-04 | 2010-02-11 | Astrazeneca Ab | Therapeutic agents 414 |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
WO2010116176A1 (en) * | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
US20110021570A1 (en) * | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
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DE249241C (en) | 1910-05-01 | 1912-07-13 | ||
US3431301A (en) | 1966-03-24 | 1969-03-04 | Hoffmann La Roche | Process for producing methylhydrazine derivatives |
US3776917A (en) | 1972-06-05 | 1973-12-04 | Schering Corp | 2-amino-6-phenalkyl-aminopyridines and derivatives thereof |
JPS5659755A (en) | 1979-10-05 | 1981-05-23 | Invest Tecnica Aplicada | Acylurea compound* its manufacture and coagulation inhibitor containing it as main component |
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2000
- 2000-03-20 RU RU2001126559/04A patent/RU2242469C2/en not_active IP Right Cessation
- 2000-03-21 US US09/532,506 patent/US6528543B1/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2386622C9 (en) * | 2004-01-06 | 2021-04-21 | Ново Нордиск А/С | Heteroaromatic derivatives of urea and use thereof as glucokinase activators |
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