RU2001124828A

RU2001124828A - MATERIAL FOR SURFACING SURFACES ON THE BASIS OF METHYLIDENMALONATE

Info

Publication number: RU2001124828A
Application number: RU2001124828/14A
Authority: RU
Inventors: Николь БРЮ-МАНЬЕ; Паскаль БРЕТОН; Клод РОК-КАРМ; Изабель БЕЛЬЯР
Original assignee: Вирсоль
Priority date: 1999-02-09
Filing date: 2000-02-09
Publication date: 2003-06-27

Claims

1. Material for suturing wounds, characterized in that it consists of a biocompatible bioadhesive mixture containing at least 50 wt.% And, preferably, at least 80 wt.% Composition based on methylidene malonate, consisting of 40 to 100 wt. % and preferably 50 to 100% of one or more methylidene malonates of the formula (I)

in which A and B independently denote group (a) or (b):

in which R ₁ and R ₂ independently represent an alkyl group, linear or branched, containing from 1 to 6 carbon atoms, and n is an integer from 1 to 5, wherein at least one of A and B represents group (b);

and / or one or more methylidene malonate oligomer (s), the molecular weight of which (s) is less than or equal to 6000 and which (s) consists of the repeating units of the formula (II):

in which A and B have the meanings indicated above; from 0 to 60 wt.%, preferably from 0 to 50 wt.% of one or more methylidene malonate polymer (s), the molecular weight of which (s) is more than 6000 and which (s) consists of repeating units of the formula (II).

2. The material according to claim 1, characterized in that in the above formulas (I) and (II) A denotes a group (a) in which R ₁ denotes an alkyl group having 1 to 6 carbon atoms, preferably an ethyl group, B denotes a group (b) in which R ₂ denotes an alkyl group having from 1 to 6 carbon atoms, preferably an ethyl group, and n denotes a number equal to 1.

3. The material according to claim 2, characterized in that in the above formulas (I) and (II) A denotes a group (a) in which R ₁ denotes an ethyl group, and B denotes a group (b) in which R ₂ denotes ethyl group and n denotes an integer equal to 1.

4. The material according to one of claims 1 to 3, characterized in that the said composition based on methylidene malonate contains from 50 to 90 wt.% One or more oligomers of methylidene malonate, the molecular weight of which is less than or equal to 6000, preferably less than or equal to 3000, and which consist of repeating units of formula (II), from 10 to 50 wt.% one or more methylidene malonate polymers, the molecular weight of which is more than 6000, and that said material has a glass transition temperature below or equal to 0 ° C, preferably from -10 to -35 ° C.

5. The material according to claim 4, characterized in that the named composition based on methylidene malonate contains 55 - 65 wt.% One or more oligomer (s) methylidene malonate, the molecular weight of which is less than or equal to 3000, and which consists of repeating units of the formula (II ), from 35 to 45 wt.% one or more polymers of methylidene malonate, the molecular weight of which is more than 6000, preferably more than 9000.

6. The material according to claim 5, characterized in that the said composition based on methylidene malonate contains from 55 to 65 wt.% One or more oligomer (s) based on methylidene malonate, the molecular weight of which is from 300 to 1000, and which consists of repeating units of the formula (II), from 35 to 45 wt.% one or more polymers of methylidene malonate, the molecular weight of which is from 12000 to 25000.

7. The material according to one of claims 4 to 6, characterized in that it contains at least 90% and, preferably, at least 95 wt.% Of the composition based on methylidene malonate according to one of paragraphs 4-6.

8. The material according to one of claims 4 to 6, characterized in that it contains up to 50 wt.%, Preferably up to 20 wt.% Of one or more component (s) other than the specified composition based on methylidene malonate selected from polycyanoacrylates, predominantly polyalkyl cyanoacrylates; alkyl polymethacrylates; biocompatible polyurethanes; polyoxyalkylene; polyamino acids; polylactates; polylactate co-glycolates; polyvinyl alcohols.

9. The material of claim 8, characterized in that at least a portion of the mentioned component (s) is presented (s) in the form of monomer units connected to methylidene malonate units of the indicated formula (II) in copolymers and, in particular, in the form of constitutive monomer units of polyacrylates, polysaccharides, polyoxyalkylenes, polylactates and copolymers of polylactate with glycolates.

10. New material, characterized in that it consists of at least 90% and, preferably, at least 95 wt.% Of the composition, based on methylidene malonate, containing from 50 to 90 wt.% One or more oligomers (s ) methylidene malonate, the molecular weight of which (s) is less than or equal to 6000, preferably less than or equal to 3000, and which (s) consists of repeating units of the formula (II), from 10 to 50 wt.% of one or more polymers of methylidene malonate, the molecular weight of which is more than 6000, and the fact that the specified material has a temperature of less than or equal to 0 ° C, preferably from -10 to -35 ° C.

11. The material of claim 10, characterized in that the said composition based on methylidene malonate contains from 55 to 65 wt.% One or more oligomer (s) methylidene malonate, the molecular weight of which is less than or equal to 3000, and which (s) consists of ) from the repeating units of formula (II), from 35 to 45 wt.% one or more polymers of methylidene malonate, the molecular weight of which is more than 6000, preferably more than 9000.

12. The material according to claim 11, characterized in that the named composition based on methylidene malonate contains from 55 to 65 wt.% One or more oligomer (s) methylidene malonate, the molecular weight of which (s) is from 300 to 1000, and which (s ) consists of repeating units of the formula (II), from 35 to 45% by weight of one or more methylidene malonate polymers, the molecular weight of which is from 12,000 to 25,000.