RU2001117583A - Macro granule with secretory cells, method for its preparation and method for treating diseases caused by dysfunction of secretory cells - Google Patents

Macro granule with secretory cells, method for its preparation and method for treating diseases caused by dysfunction of secretory cells

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Publication number
RU2001117583A
RU2001117583A RU2001117583/13A RU2001117583A RU2001117583A RU 2001117583 A RU2001117583 A RU 2001117583A RU 2001117583/13 A RU2001117583/13 A RU 2001117583/13A RU 2001117583 A RU2001117583 A RU 2001117583A RU 2001117583 A RU2001117583 A RU 2001117583A
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RU
Russia
Prior art keywords
pancreatic islets
secretory cells
agarose
isolated
macrobead
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RU2001117583/13A
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Russian (ru)
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RU2208636C2 (en
Inventor
Кэнти ДЖЭЙН
Алберт Л. РУБИН
Бэрри Смит
Original Assignee
Дзе Рогозин Институт
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Publication of RU2001117583A publication Critical patent/RU2001117583A/en
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Publication of RU2208636C2 publication Critical patent/RU2208636C2/en

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Claims (20)

1. Способ получения макрогранулы из агарозы с секреторными клетками и покрытием из агарозы, отличающийся тем, что выделенные секреторные клетки суспендируют на агарозу, формируют макрогранулу, которую затем инкубируют в увлажненном воздухе и покрывают агарозой.1. A method of producing macrogranules from agarose with secretory cells and a coating of agarose, characterized in that the isolated secretory cells are suspended on agarose, form a macrobead, which is then incubated in humidified air and coated with agarose. 2. Способ по п.1, отличающийся тем, что макрогранулу, полученную из агарозы с секреторными клетками покрывают агарозой путем вращения ее в 5%-ном растворе агарозы, затем окунают в минеральное масло, после чего промывают.2. The method according to claim 1, characterized in that the macrobead obtained from agarose with secretory cells is coated with agarose by rotating it in a 5% agarose solution, then dipped in mineral oil, and then washed. 3. Способ по п.1, отличающийся тем, что выделенные секреторные клетки представляют собой панкреатические островки.3. The method according to claim 1, characterized in that the isolated secretory cells are pancreatic islets. 4. Способ по п.3, отличающийся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма человека.4. The method according to claim 3, characterized in that the pancreatic islets are pancreatic islets isolated from the human body. 5. Способ по п.3, отличающийся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма быка.5. The method according to claim 3, characterized in that the pancreatic islets are pancreatic islets isolated from the body of the bull. 6. Способ по п.3, отличающийся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма свиньи.6. The method according to claim 3, characterized in that the pancreatic islets are pancreatic islets isolated from the body of the pig. 7. Способ по п.3, отличающийся тем, что указанная макрогранула содержит от около 50000 до около 700000 панкреатических островков.7. The method according to claim 3, characterized in that said macrobead contains from about 50,000 to about 700,000 pancreatic islets. 8. Макрогранула, отличающаяся тем, что она выполнена из агарозы с секреторными клетками и имеет покрытие из агарозы.8. A macrobead, characterized in that it is made of agarose with secretory cells and has an agarose coating. 9. Макрогранула по п.8, отличающаяся тем, что выделенные секреторные клетки представляют собой панкреатические островки.9. The macrobead according to claim 8, characterized in that the isolated secretory cells are pancreatic islets. 10. Макрогранула по п.9, отличающаяся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма человека.10. The macrobead according to claim 9, characterized in that the pancreatic islets are pancreatic islets isolated from the human body. 11. Макрогранула по п.9, отличающаяся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма быка.11. The macrobead according to claim 9, characterized in that the pancreatic islets are pancreatic islets isolated from the body of a bull. 12. Макрогранула по п.9, отличающаяся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма свиньи.12. The macrobead according to claim 9, characterized in that the pancreatic islets are pancreatic islets isolated from the body of the pig. 13. Способ лечения заболеваний, вызванных нарушением функционирования секреторных клеток, предпочтительно инсулинозависимого диабета, отличающийся тем, что пациенту имплантируют терапевтически эффективное количество секреторных клеток, содержащихся в макрогранулах, из агарозы с секреторными клетками и покрытием из агарозы, в соответствии с пп.8-12.13. A method of treating diseases caused by malfunctioning of secretory cells, preferably insulin-dependent diabetes, characterized in that a therapeutically effective amount of secretory cells contained in macrobeads is implanted from agarose with secretory cells and an agarose coating in accordance with claims 8-12 . 14. Способ по п.13, отличающийся тем, что для лечения инсулинозависимого диабета указанные секреторные клетки являются панкреатическими островками.14. The method according to p. 13, characterized in that for the treatment of insulin-dependent diabetes, these secretory cells are pancreatic islets. 15. Способ по п.14, отличающийся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма человека.15. The method according to 14, characterized in that the pancreatic islets are pancreatic islets isolated from the human body. 16. Способ по п.14, отличающийся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма быка.16. The method according to 14, characterized in that the pancreatic islets are pancreatic islets isolated from the body of the bull. 17. Способ по п.14, отличающийся тем, что панкреатические островки являются панкреатическими островками, выделенными из организма свиньи.17. The method according to 14, characterized in that the pancreatic islets are pancreatic islets isolated from the body of the pig. 18. Способ по п.14, отличающийся тем, что макрогранулы с секреторными клетками трансплантируют в брюшную полость пациента.18. The method according to 14, characterized in that the macrobeads with secretory cells are transplanted into the abdominal cavity of the patient. 19. Способ по п.18, отличающийся тем, что макрогранулы трансплантируют пациенту в количестве примерно 5-10 штук.19. The method according to p. 18, characterized in that the macrobeads are transplanted to the patient in an amount of about 5-10 pieces. 20. Способ по п.18, отличающийся тем, что каждая макрогранула содержит примерно от 50000 до 700000 панкреатических островков.20. The method according to p, characterized in that each macrobead contains from about 50,000 to 700,000 pancreatic islets.
RU2001117583/13A 1994-01-13 1995-01-12 Macrogranule with secretory cells, method for its preparing and method of treatment of diseases caused by disturbance of secretory cells function RU2208636C2 (en)

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US18126994A 1994-01-13 1994-01-13
US08/181,269 1994-01-13

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EP (3) EP1666585B1 (en)
JP (4) JP3948742B2 (en)
KR (1) KR100474803B1 (en)
CN (1) CN1087779C (en)
AT (3) ATE320482T1 (en)
AU (1) AU681240C (en)
CA (1) CA2181156C (en)
DE (3) DE69535842D1 (en)
DK (2) DK1418228T3 (en)
ES (3) ES2227544T3 (en)
FI (1) FI118853B (en)
HK (1) HK1084693A1 (en)
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NO (2) NO323228B1 (en)
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