RU2001117583A - Macro granule with secretory cells, method for its preparation and method for treating diseases caused by dysfunction of secretory cells - Google Patents
Macro granule with secretory cells, method for its preparation and method for treating diseases caused by dysfunction of secretory cellsInfo
- Publication number
- RU2001117583A RU2001117583A RU2001117583/13A RU2001117583A RU2001117583A RU 2001117583 A RU2001117583 A RU 2001117583A RU 2001117583/13 A RU2001117583/13 A RU 2001117583/13A RU 2001117583 A RU2001117583 A RU 2001117583A RU 2001117583 A RU2001117583 A RU 2001117583A
- Authority
- RU
- Russia
- Prior art keywords
- pancreatic islets
- secretory cells
- agarose
- isolated
- macrobead
- Prior art date
Links
- 210000002955 secretory cell Anatomy 0.000 title claims 13
- 201000010099 disease Diseases 0.000 title claims 2
- 230000004064 dysfunction Effects 0.000 title 1
- 239000004515 macrogranule Substances 0.000 title 1
- 210000004153 Islets of Langerhans Anatomy 0.000 claims 23
- 229920000936 Agarose Polymers 0.000 claims 11
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 241000282898 Sus scrofa Species 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 206010012601 Diabetes mellitus Diseases 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 230000001419 dependent Effects 0.000 claims 2
- 210000000683 Abdominal Cavity Anatomy 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
Claims (20)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18126994A | 1994-01-13 | 1994-01-13 | |
US08/181,269 | 1994-01-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96115926/13A Division RU2177503C2 (en) | 1994-01-13 | 1995-01-12 | Macrogranule with secretory cells, method of its preparing and method of treatment of patients with diseases caused by secretory cell function disorder |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2001117583A true RU2001117583A (en) | 2003-07-10 |
RU2208636C2 RU2208636C2 (en) | 2003-07-20 |
Family
ID=22663563
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96115926/13A RU2177503C2 (en) | 1994-01-13 | 1995-01-12 | Macrogranule with secretory cells, method of its preparing and method of treatment of patients with diseases caused by secretory cell function disorder |
RU2001117583/13A RU2208636C2 (en) | 1994-01-13 | 1995-01-12 | Macrogranule with secretory cells, method for its preparing and method of treatment of diseases caused by disturbance of secretory cells function |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96115926/13A RU2177503C2 (en) | 1994-01-13 | 1995-01-12 | Macrogranule with secretory cells, method of its preparing and method of treatment of patients with diseases caused by secretory cell function disorder |
Country Status (19)
Country | Link |
---|---|
US (3) | US5643569A (en) |
EP (3) | EP1666585B1 (en) |
JP (4) | JP3948742B2 (en) |
KR (1) | KR100474803B1 (en) |
CN (1) | CN1087779C (en) |
AT (3) | ATE320482T1 (en) |
AU (1) | AU681240C (en) |
CA (1) | CA2181156C (en) |
DE (3) | DE69535842D1 (en) |
DK (2) | DK1418228T3 (en) |
ES (3) | ES2227544T3 (en) |
FI (1) | FI118853B (en) |
HK (1) | HK1084693A1 (en) |
IL (1) | IL112330A (en) |
NO (2) | NO323228B1 (en) |
NZ (3) | NZ278809A (en) |
PT (3) | PT1418228E (en) |
RU (2) | RU2177503C2 (en) |
WO (1) | WO1995019430A1 (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830492A (en) * | 1992-02-24 | 1998-11-03 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5834005A (en) * | 1992-02-24 | 1998-11-10 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US5824331A (en) * | 1992-02-24 | 1998-10-20 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
USRE39542E1 (en) * | 1994-01-13 | 2007-04-03 | The Rogosin Institute | Preparation of agarose coated, solid agarose-collagen beads containing secretory cells |
CA2181156C (en) * | 1994-01-13 | 2001-10-16 | Kanti Jain | Macroencapsulated secretory cells |
US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
EP0815212A1 (en) * | 1995-03-03 | 1998-01-07 | Metabolex, Inc. | Novel encapsulation process by a gelling polymer |
US5965125A (en) * | 1995-10-25 | 1999-10-12 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
US6419920B1 (en) | 1995-10-25 | 2002-07-16 | Trans Karyotic Therapies, Inc. | Hybrid matrix implants and explants |
EP0822857A1 (en) * | 1996-02-23 | 1998-02-11 | Circe Biomedical, Inc. | Novel artificial pancreas |
US5888497A (en) * | 1996-04-03 | 1999-03-30 | The Rogosin Institute | Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation |
DE69738170T2 (en) * | 1996-04-03 | 2008-01-24 | The Rogosin Institute | Conditioned medium and diffusible biological material obtained by incubating trapped cells |
US7297331B2 (en) | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
US6303151B1 (en) * | 1996-04-03 | 2001-10-16 | The Rogosin Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
KR100477296B1 (en) * | 1996-04-03 | 2005-05-16 | 더 로고신 인스티튜트 | Implantable Agarose-Collagen Beads Containing Cells Which Produce a Diffusible Biological Product, and Uses Thereof |
US6224912B1 (en) * | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
WO1998011206A2 (en) | 1996-09-13 | 1998-03-19 | Transkaryotic Therapies, Inc. | THERAPY FOR α-GALACTOSIDASE A DEFICIENCY |
US6368858B1 (en) | 1997-07-22 | 2002-04-09 | The General Hospital Corporation | Modulation of multicellular aggregates by pressure from growth in a matrix |
US5922339A (en) * | 1998-01-27 | 1999-07-13 | Usala; Anton-Lewis | Compositions and methods for biocompatible implants |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US6365385B1 (en) * | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US6391576B1 (en) * | 1999-10-13 | 2002-05-21 | Japan Bioindustry Association | Method for isolating a microbe |
US6279656B1 (en) | 1999-11-03 | 2001-08-28 | Santrol, Inc. | Downhole chemical delivery system for oil and gas wells |
WO2001091774A2 (en) | 2000-05-31 | 2001-12-06 | Encelle, Inc. | Method of treating chronic ulcers |
US20040191246A1 (en) * | 2003-02-26 | 2004-09-30 | Connelly Patrick R. | Process for in vivo treatment of specific biological targets in bodily fluid |
AU2003294541A1 (en) * | 2002-12-24 | 2004-07-22 | An-Go-Gen Inc. | Encapsulated cell for therapy |
US20050053586A1 (en) | 2003-09-04 | 2005-03-10 | Bryan Conn | Entrapped stem cells and uses thereof |
US20060121077A1 (en) * | 2004-11-11 | 2006-06-08 | Lawrence Gazda | Method for treating patients with implants of islets which have been kept in long term, in vitro culture |
AU2006295114B2 (en) * | 2005-09-26 | 2010-01-28 | The Rogosin Institute, Inc. | Secretory cell-containing macrobeads comprising Seakem Gold agarose, and uses thereof |
US20070116680A1 (en) * | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
ES2386123T3 (en) | 2006-06-16 | 2012-08-09 | Fmc Biopolymer As | Cellular device with an alginate-coated collagen matrix, process for its formation and uses |
EP2126048B1 (en) * | 2007-01-24 | 2012-06-20 | Koninklijke Philips Electronics N.V. | Process for treating cultured cells |
KR20100049084A (en) | 2007-08-23 | 2010-05-11 | 인트렉손 코포레이션 | Methods and compositions for diagnosing disease |
KR101666228B1 (en) * | 2007-09-28 | 2016-10-13 | 인트렉손 코포레이션 | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
DE102010040687A1 (en) | 2010-09-14 | 2012-03-15 | Hamilton Bonaduz Ag | Process for producing active agent beads |
WO2012127224A1 (en) | 2011-03-21 | 2012-09-27 | University Of Reading | Transport of cells in hydrogels |
DE102011050024A1 (en) | 2011-04-29 | 2012-10-31 | Hamilton Bonaduz Ag | Analytical device for a non-contact analysis of the formation of a transparent body and method for carrying out the non-contact analysis |
JP5986226B2 (en) | 2012-01-31 | 2016-09-06 | ザ ロゴシン インスティチュート, インク.The Rogosin Institute, Inc | Improved method for macrobead manufacturing |
KR101327630B1 (en) * | 2012-03-05 | 2013-11-13 | 울산대학교 산학협력단 | Method for manufacturing a carrier of transplanting pancreatic islet cells using atelocollagen, and artificial pancreas manufactured by the same method |
UY38389A (en) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | IMPLANTABLE DEVICES FOR CELLULAR THERAPY AND RELATED METHODS |
WO2024081310A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4409331A (en) * | 1979-03-28 | 1983-10-11 | Damon Corporation | Preparation of substances with encapsulated cells |
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
SE441009B (en) * | 1982-03-08 | 1985-09-02 | Kjell Nilsson | WAY TO IMMOBILIZE LIVING BIOMATERIAL IN PEARLY POLYMERS |
US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
CA1196862A (en) * | 1983-06-01 | 1985-11-19 | Anthony M.F. Sun | Microencapsulation of living tissue and cells |
US4663286A (en) * | 1984-02-13 | 1987-05-05 | Damon Biotech, Inc. | Encapsulation of materials |
US4997443A (en) * | 1985-08-26 | 1991-03-05 | Hana Biologics, Inc. | Transplantable artificial tissue and process |
US4902295A (en) * | 1985-08-26 | 1990-02-20 | Hana Biologics, Inc. | Transplantable artificial tissue |
SE8604684L (en) * | 1986-11-03 | 1988-05-04 | Excorim Kommanditbolag | SET TO COAT SOLID PARTICLES WITH A HYDROPHIL GEL AND THROUGH SEAT COATED PARTICLES |
US5053332A (en) * | 1989-07-24 | 1991-10-01 | Cook Richard B | Agarose beads, preferably incorporating biological materials |
US5227298A (en) * | 1990-08-17 | 1993-07-13 | The Trustees Of Columbia University In The City Of New York | Method for microencapuslation of cells or tissue |
FR2686250A1 (en) * | 1992-01-16 | 1993-07-23 | Coletica | INJECTABLE COMPOSITIONS CONTAINING SUSPENSION OF COLLAGEN - BASED MICROCAPSULES, THEIR BIOMEDICAL USE AND PHARMACEUTICAL COMPOSITIONS. |
CA2135769A1 (en) * | 1992-05-29 | 1993-12-09 | Kent C. Cochrum | Coated transplant and method for making same |
WO1994012161A1 (en) * | 1992-11-24 | 1994-06-09 | Clover Consolidated, Limited | Cytoprotective, biocompatible, retrievable macrocapsules |
CA2181156C (en) * | 1994-01-13 | 2001-10-16 | Kanti Jain | Macroencapsulated secretory cells |
US5888497A (en) * | 1996-04-03 | 1999-03-30 | The Rogosin Institute | Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation |
US6224912B1 (en) * | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
-
1995
- 1995-01-12 CA CA002181156A patent/CA2181156C/en not_active Expired - Lifetime
- 1995-01-12 ES ES95906814T patent/ES2227544T3/en not_active Expired - Lifetime
- 1995-01-12 DE DE69535842T patent/DE69535842D1/en not_active Expired - Lifetime
- 1995-01-12 PT PT03028476T patent/PT1418228E/en unknown
- 1995-01-12 AT AT03028476T patent/ATE320482T1/en active
- 1995-01-12 CN CN95191589A patent/CN1087779C/en not_active Expired - Lifetime
- 1995-01-12 KR KR10-2002-7006924A patent/KR100474803B1/en not_active IP Right Cessation
- 1995-01-12 PT PT95906814T patent/PT742818E/en unknown
- 1995-01-12 RU RU96115926/13A patent/RU2177503C2/en active
- 1995-01-12 NZ NZ278809A patent/NZ278809A/en not_active IP Right Cessation
- 1995-01-12 ES ES06004970T patent/ES2309849T3/en not_active Expired - Lifetime
- 1995-01-12 EP EP06004970A patent/EP1666585B1/en not_active Expired - Lifetime
- 1995-01-12 PT PT06004970T patent/PT1666585E/en unknown
- 1995-01-12 DE DE69534865T patent/DE69534865T2/en not_active Expired - Lifetime
- 1995-01-12 DK DK03028476T patent/DK1418228T3/en active
- 1995-01-12 DK DK06004970T patent/DK1666585T3/en active
- 1995-01-12 JP JP51910195A patent/JP3948742B2/en not_active Expired - Lifetime
- 1995-01-12 WO PCT/US1995/000400 patent/WO1995019430A1/en active IP Right Grant
- 1995-01-12 AT AT06004970T patent/ATE408005T1/en active
- 1995-01-12 EP EP95906814A patent/EP0742818B1/en not_active Expired - Lifetime
- 1995-01-12 ES ES03028476T patent/ES2260568T3/en not_active Expired - Lifetime
- 1995-01-12 AU AU15267/95A patent/AU681240C/en not_active Expired
- 1995-01-12 AT AT95906814T patent/ATE275194T1/en active
- 1995-01-12 NZ NZ509363A patent/NZ509363A/en not_active IP Right Cessation
- 1995-01-12 EP EP03028476A patent/EP1418228B1/en not_active Expired - Lifetime
- 1995-01-12 RU RU2001117583/13A patent/RU2208636C2/en active
- 1995-01-12 NZ NZ329619A patent/NZ329619A/en not_active IP Right Cessation
- 1995-01-12 DE DE69533437T patent/DE69533437T2/en not_active Expired - Lifetime
- 1995-01-13 IL IL11233095A patent/IL112330A/en not_active IP Right Cessation
- 1995-06-07 US US08/483,728 patent/US5643569A/en not_active Ceased
-
1996
- 1996-07-12 FI FI962841A patent/FI118853B/en not_active IP Right Cessation
- 1996-07-15 NO NO19962955A patent/NO323228B1/en not_active IP Right Cessation
-
1999
- 1999-06-30 US US09/345,196 patent/USRE38027E1/en not_active Expired - Lifetime
-
2004
- 2004-11-01 US US10/979,527 patent/USRE40555E1/en not_active Expired - Lifetime
-
2005
- 2005-02-03 JP JP2005027914A patent/JP3989492B2/en not_active Expired - Lifetime
- 2005-03-16 NO NO20051359A patent/NO324570B1/en not_active IP Right Cessation
-
2006
- 2006-06-15 HK HK06106884A patent/HK1084693A1/en not_active IP Right Cessation
- 2006-09-25 JP JP2006258762A patent/JP2006345875A/en active Pending
- 2006-10-17 JP JP2006282280A patent/JP4435134B2/en not_active Expired - Lifetime
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2001117583A (en) | Macro granule with secretory cells, method for its preparation and method for treating diseases caused by dysfunction of secretory cells | |
RU96115926A (en) | MACROINCAPSULATED SECRETARY CELLS | |
BR8204925A (en) | PROCESS FOR FIXING A NATURAL TISSUE HEART VALVE FOR IMPLANTATION PROCESS TO IMPROVE THE FLOW CHARACTERISTICS OF A HEART VALVE PROCESS FOR THE PREPARATION OF HEART AID VALVE AND HEART VALVE | |
DE68918285D1 (en) | METHOD FOR TREATING TRANSPLANTS BEFORE TRANSPLANTS. | |
NO168083C (en) | Tissue prosthesis of a porous tissue prosthesis body as well as a method of preparation thereof | |
ES2180653T3 (en) | TREATMENT OF BIOLOGICAL MATERIAL BEFORE IMPLEMENTATION. | |
FR2562891B1 (en) | NOVEL 1-ALKYL DERIVATIVES OF 3-ARYLOXY-4- (2-CARBALKOXY) -PHENYL-AZET-2-ONES AND THEIR APPLICATION AS PLANT GROWTH SUBSTANCES | |
ID16296A (en) | SUBSTANCE AND PROCESSES THAT CAN PROVIDE BIOLOGICAL BENEFITS OF ALL WHO ARE CONNECTED TO NATURAL WATER AND PARK WATER | |
NO20000087D0 (en) | Treatment of inflammatory diseases of the intestine and bladder | |
Jawahar et al. | Rapid proliferation of multiple shoots in Solanum trilobatum L | |
DE69007065D1 (en) | Use of diadenosine 5 ', 5' '' - p1, p4-tetraphosphate for the manufacture of a medicament for the treatment of heart diseases. | |
DE59510704D1 (en) | Packing material and method for producing the same | |
FR2519269B1 (en) | CHAMBER FOR EXPERIMENTAL TREATMENT OF ANIMALS AND PLANTS | |
NO147232C (en) | PROCEDURE FOR AA IMPROVING THE BIOLOGICAL LANGUAGE OF POLYAMIDE IMPLANT PROCESSES | |
SU1651890A1 (en) | Method for treatment of heart valve bioprothesis | |
RU95101233A (en) | METHOD FOR TREATING NEUROSENSOR Hearing Aid | |
ATE59556T1 (en) | PROCESS FOR THE PREPARATION OF A NUTRITIONAL CENTER SPECIFIC APPETITE CONTROLLING INGREDIENT AND THE ACTIVE ACTIVE OBTAINABLE BY THIS PROCESS. | |
SU993950A1 (en) | Method of antibacterial treatment of heart artificial valve | |
RU2002115241A (en) | A method for preventing the development of pannus of an artificial heart valve | |
RU1789096C (en) | Method for presowing hard seed treatment | |
RU97115829A (en) | METHOD FOR TREATING PERFORMANCE OF COLLUS IN CHILDREN | |
RU2093175C1 (en) | Method for curing paraproctitis | |
BE848037A (en) | NEW DERIVATIVES OF IMIDAZOLIDINE-DIONE, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS PLANT GROWTH SUBSTANCES | |
SU1490688A1 (en) | Method of simulating synesuppurative granulational process | |
RU95120488A (en) | METHOD OF SURGICAL TREATMENT OF MYOPIA |