RU2001102262A - NITROESTERS AND NITRATE SALTS OF SPECIFIC MEDICINES - Google Patents

NITROESTERS AND NITRATE SALTS OF SPECIFIC MEDICINES

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Publication number
RU2001102262A
RU2001102262A RU2001102262/04A RU2001102262A RU2001102262A RU 2001102262 A RU2001102262 A RU 2001102262A RU 2001102262/04 A RU2001102262/04 A RU 2001102262/04A RU 2001102262 A RU2001102262 A RU 2001102262A RU 2001102262 A RU2001102262 A RU 2001102262A
Authority
RU
Russia
Prior art keywords
formula
salts
integer
compounds
nitrate salts
Prior art date
Application number
RU2001102262/04A
Other languages
Russian (ru)
Other versions
RU2254330C2 (en
Inventor
Солдато Пьеро Дел
Original Assignee
Никокс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1998MI001743A external-priority patent/IT1303671B1/en
Application filed by Никокс С.А. filed Critical Никокс С.А.
Publication of RU2001102262A publication Critical patent/RU2001102262A/en
Application granted granted Critical
Publication of RU2254330C2 publication Critical patent/RU2254330C2/en

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Claims (1)

1. Нитратные соли соединений, выбранных из следующих:
сальбутамол, имеющий формулу (I)
Figure 00000001

цетиризин, имеющий формулу (II)
Figure 00000002

лоратадин, имеющий формулу (III)
Figure 00000003

терфенадин, имеющий формулу (IV)
Figure 00000004

эмедастин, имеющий формулу (V)
Figure 00000005

кетотифен, имеющий формулу (VI)
Figure 00000006

недокромил, имеющий формулу (VII)
Figure 00000007

амброксол, имеющий формулу (VIII)
Figure 00000008

декстрометорфан, имеющий формулу (X)
Figure 00000009

декстрорфан, имеющий формулу (XI)
Figure 00000010

изониазид, имеющий формулу (XIII)
Figure 00000011

эритромицин, имеющий формулу (XIV)
Figure 00000012

пиразинамид, имеющий формулу (XVI)
Figure 00000013

2. Нитратные соли по п. 1, где соединениями являются сальбутамол, цетиризин, эмедастин, амброксол.1. Nitrate salts of compounds selected from the following:
salbutamol having the formula (I)
Figure 00000001

cetirizine having the formula (II)
Figure 00000002

loratadine having the formula (III)
Figure 00000003

terfenadine having the formula (IV)
Figure 00000004

emedastine having the formula (V)
Figure 00000005

ketotifen having the formula (VI)
Figure 00000006

nedocromil having the formula (VII)
Figure 00000007

ambroxol having the formula (VIII)
Figure 00000008

dextromethorphan having the formula (X)
Figure 00000009

dextrorphan having the formula (XI)
Figure 00000010

isoniazid having the formula (XIII)
Figure 00000011

erythromycin having the formula (XIV)
Figure 00000012

pyrazinamide having the formula (XVI)
Figure 00000013

2. The nitrate salts of claim 1, wherein the compounds are salbutamol, cetirizine, emedastine, ambroxol. 3. Нитратные соли по пп. 1 и 2, где соединения содержат одну или более -ONO2 групп, ковалентно связанных с молекулой посредством одного из следующих бивалентных связывающих мостиков:
YO, где Y означает C1-C20 алкилен, линейный или разветвленный, когда это возможно, предпочтительно состоящий из 2-5 атомов углерода, или необязательно замещенный циклоалкилен из 5-7 атомов углерода;
Y1, выбранный из
Figure 00000014

где n3 означает целое число от 0 до 3;
Figure 00000015

Figure 00000016

Figure 00000017

где nf' означает целое число от 1 до 6, предпочтительно от 2 до 4;
Figure 00000018

где R1f= H, СН3 и nf означает целое число от 1 до 6, предпочтительно от 2 до 4.3. Nitrate salts according to paragraphs. 1 and 2, where the compounds contain one or more —ONO 2 groups covalently linked to the molecule via one of the following bivalent linking bridges:
YO, where Y is C 1 -C 20 alkylene, linear or branched when possible, preferably consisting of 2-5 carbon atoms, or optionally substituted cycloalkylene of 5-7 carbon atoms;
Y 1 selected from
Figure 00000014

where n 3 means an integer from 0 to 3;
Figure 00000015

Figure 00000016

Figure 00000017

where nf 'is an integer from 1 to 6, preferably from 2 to 4;
Figure 00000018

where R 1f = H, CH 3 and nf is an integer from 1 to 6, preferably from 2 to 4. 4. Нитратные соли по пп. 1-3, содержащие один или более изомеров указанных соединений. 4. Nitrate salts according to paragraphs. 1-3, containing one or more isomers of these compounds. 5. Нитратные соли по пп. 1-4, где соли вышеупомянутых соединений содержат, по крайней мере, один моль нитратных ионов/моль соединения. 5. Nitrate salts according to paragraphs. 1-4, where the salts of the above compounds contain at least one mol of nitrate ions / mol of compound. 6. Фармацевтические композиции нитратных солей по пп. 1-5. 6. The pharmaceutical composition of nitrate salts according to paragraphs. 1-5. 7. Нитратные соли и фармацевтические композиции по пп. 1-6 для использования в качестве лекарственных средств. 7. Nitrate salts and pharmaceutical compositions according to claims. 1-6 for use as medicines. 8. Использование солей и композиций по п. 7 и следующих соединений:
метронидазол, имеющий формулу (XII)
Figure 00000019

ацикловир, имеющий формулу (XV)
Figure 00000020

для получения лекарственных средств для лечения патологий респираторной системы.8. The use of salts and compositions according to claim 7 and the following compounds:
metronidazole having the formula (XII)
Figure 00000019

acyclovir having the formula (XV)
Figure 00000020

to obtain drugs for the treatment of pathologies of the respiratory system. 9. Использование солей и композиций по п. 7 для получения лекарственных средств для использования в качестве токолитических средств. 9. The use of salts and compositions according to claim 7 for the manufacture of medicines for use as tocolytic agents. 10. Использование солей и композиций по п. 7 для получения лекарственных средств для использования в качестве противоаллергических средств предпочтительно для глазных применений. 10. The use of salts and compositions of claim 7 for the manufacture of medicaments for use as antiallergic agents, preferably for ophthalmic uses. 11. Соединения по п. 1, имеющие формулы (I), (II), (III), (VII), (VIII), (XI), содержащие одну или более -ONO2 групп, ковалентно связанных с молекулой посредством одного из следующих бивалентных связывающих мостиков:
YO, где Y означает C1-C20 алкилен, линейный или разветвленный, когда это возможно, предпочтительно состоящий из 2-5 атомов углерода, или необязательно замещенный циклоалкилен из 5-7 атомов углерода;
Y1, выбранный из:
Figure 00000021

где n3 означает целое число от 0 до 3;
Figure 00000022

Figure 00000023

Figure 00000024

где nf' означает целое число от 0 до 6, предпочтительно от 2 до 4;
Figure 00000025

где R1f= H, СН3 и nf означает целое число от 1 до 6, предпочтительно от 2 до 4.11. The compounds of claim 1, having formulas (I), (II), (III), (VII), (VIII), (XI), containing one or more —ONO 2 groups covalently linked to the molecule by one of the following bivalent linking bridges:
YO, where Y is C 1 -C 20 alkylene, linear or branched when possible, preferably consisting of 2-5 carbon atoms, or optionally substituted cycloalkylene of 5-7 carbon atoms;
Y 1 selected from:
Figure 00000021

where n 3 means an integer from 0 to 3;
Figure 00000022

Figure 00000023

Figure 00000024

where nf 'is an integer from 0 to 6, preferably from 2 to 4;
Figure 00000025

where R 1f = H, CH 3 and nf is an integer from 1 to 6, preferably from 2 to 4.
RU2001102262/04A 1998-07-28 1999-07-20 Acid-additive nitrate salts of compounds and pharmaceutical composition RU2254330C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI001743A IT1303671B1 (en) 1998-07-28 1998-07-28 SALTS OF NITRIC ACID WITH ACTIVE DRUGS IN THE TREATMENT OF DISEASES OF THE RESPIRATORY SYSTEM
ITMI98A001743 1998-07-28

Publications (2)

Publication Number Publication Date
RU2001102262A true RU2001102262A (en) 2003-01-20
RU2254330C2 RU2254330C2 (en) 2005-06-20

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Country Status (18)

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US (3) US6410791B1 (en)
EP (1) EP1098870B1 (en)
JP (1) JP4455760B2 (en)
KR (1) KR100687806B1 (en)
CN (1) CN1264828C (en)
AT (1) ATE307796T1 (en)
AU (2) AU770313C (en)
BR (1) BR9912375A (en)
CA (1) CA2338854C (en)
DE (1) DE69927977T2 (en)
DK (1) DK1098870T3 (en)
ES (1) ES2252958T3 (en)
HU (1) HUP0102706A3 (en)
IL (1) IL140685A0 (en)
IT (1) IT1303671B1 (en)
RU (1) RU2254330C2 (en)
WO (1) WO2000006531A2 (en)
ZA (1) ZA200100457B (en)

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