RU2001101708A - METHOD FOR EVALUATING THE RELATIONSHIP OF THE ENDOCRINE AND GENOTOXIC EFFECT OF ESTROGENS - Google Patents

METHOD FOR EVALUATING THE RELATIONSHIP OF THE ENDOCRINE AND GENOTOXIC EFFECT OF ESTROGENS

Info

Publication number
RU2001101708A
RU2001101708A RU2001101708/14A RU2001101708A RU2001101708A RU 2001101708 A RU2001101708 A RU 2001101708A RU 2001101708/14 A RU2001101708/14 A RU 2001101708/14A RU 2001101708 A RU2001101708 A RU 2001101708A RU 2001101708 A RU2001101708 A RU 2001101708A
Authority
RU
Russia
Prior art keywords
estrogens
endocrine
evaluating
relationship
genotoxic effect
Prior art date
Application number
RU2001101708/14A
Other languages
Russian (ru)
Other versions
RU2223503C2 (en
Inventor
Лев Михайлович Берштейн
Татьяна Евгеньевна Порошина
Евгения Владимировна Цырлина
Original Assignee
НИИ онкологии им. профессора Н.Н.Петрова
Filing date
Publication date
Application filed by НИИ онкологии им. профессора Н.Н.Петрова filed Critical НИИ онкологии им. профессора Н.Н.Петрова
Priority to RU2001101708/15A priority Critical patent/RU2223503C2/en
Priority claimed from RU2001101708/15A external-priority patent/RU2223503C2/en
Publication of RU2001101708A publication Critical patent/RU2001101708A/en
Application granted granted Critical
Publication of RU2223503C2 publication Critical patent/RU2223503C2/en

Links

Claims (1)

Способ оценки соотношения эндокринного и генотоксического эффекта эстрогенов, отличающийся тем, что изучают отношение (К) числа "комет" (в %) в ткани матки крыс к ее весу (в мг) или содержанию в ней рецепторов прогестерона (в фМ/мг белка) и, сопоставляя величину К у крыс, которым вводился только эстрадиол, с ее величиной у животных, получавших эстроген в сочетании с каким-либо агентом, определяют степень усиления под влиянием последнего ДНК - повреждающей способности эстрогенов по отношению к их гормональному действию.A method for assessing the ratio of the endocrine and genotoxic effects of estrogens, characterized in that they study the ratio (K) of the number of comets (in%) in rat uterine tissue to its weight (in mg) or its progesterone receptor content (in fM / mg protein) and by comparing the K value in rats administered only estradiol with its value in animals treated with estrogen in combination with any agent, the degree of amplification under the influence of the last DNA, the damaging ability of estrogens with respect to their hormonal action, is determined.
RU2001101708/15A 2001-01-17 2001-01-17 Method for detecting dna-damaging capacity of estrogens RU2223503C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2001101708/15A RU2223503C2 (en) 2001-01-17 2001-01-17 Method for detecting dna-damaging capacity of estrogens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2001101708/15A RU2223503C2 (en) 2001-01-17 2001-01-17 Method for detecting dna-damaging capacity of estrogens

Publications (2)

Publication Number Publication Date
RU2001101708A true RU2001101708A (en) 2002-11-27
RU2223503C2 RU2223503C2 (en) 2004-02-10

Family

ID=32171923

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001101708/15A RU2223503C2 (en) 2001-01-17 2001-01-17 Method for detecting dna-damaging capacity of estrogens

Country Status (1)

Country Link
RU (1) RU2223503C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2527345C1 (en) * 2013-04-05 2014-08-27 ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ ОБРАЗОВАТЕЛЬНОЕ УЧРЕЖДЕНИЕ ВЫСШЕГО ПРОФЕССИОНАЛЬНОГО ОБРАЗОВАНИЯ "НИЖЕГОРОДСКАЯ ГОСУДАРСТВЕННАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РФ (ГБОУ ВПО "НижГМА" МИНЗДРАВА РОССИИ) Method for induced dna damage in individual non-dividing nucleated cells

Similar Documents

Publication Publication Date Title
Levin et al. A scientific basis for the therapeutic effects of Pygeum africanum and Serenoa repens
Ansbacher The pharmacokinetics and efficacy of different estrogens are not equivalent
Zoth et al. Physical activity and estrogen treatment reduce visceral body fat and serum levels of leptin in an additive manner in a diet induced animal model of obesity
BOOTH Sexual behaviour of neonatally castrated rats injected during infancy with oestrogen and dihydrotestosterone
Schürmann et al. Estradiol and drospirenone for climacteric symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled study of the safety and efficacy of three dose regimens
Tchernitchin et al. Imprinting: perinatal exposures cause the development of diseases during the adult age
Pollock et al. Triclosan elevates estradiol levels in serum and tissues of cycling and peri-implantation female mice
Barnes et al. Characterization and manipulation of reproductive cycles in the jaguar (Panthera onca)
Yoshida et al. At what price, glory? Severe cholestasis and acute renal failure in an athlete abusing stanozolol.
Reel et al. Antiovulatory and postcoital antifertility activity of the antiprogestin CDB-2914 when administered as single, multiple, or continuous doses to rats
Husmann et al. Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens
Caufriez Hormonal replacement therapy (HRT) in postmenopause: a reappraisal
Carter et al. Biogenic amines, reproductive hormones and female sexual behavior: a review
CN101621995A (en) Mineralcorticoid receptor antagonists for the treatment of endometriosis
RU2001101708A (en) METHOD FOR EVALUATING THE RELATIONSHIP OF THE ENDOCRINE AND GENOTOXIC EFFECT OF ESTROGENS
Bergqvist et al. Histochemical demonstration of estrogen and progesterone binding in endometriotic tissue and in uterine endometrium: A comparative study.
De Waard et al. Hormonal aspects in the causation of human breast cancer: epidemiological hypotheses reviewed, with special reference to nutritional status and first pregnancy
Tafesse et al. In vivo and in vitro anti-fertility and anti-implantation properties of Leonotis ocymifolia in rats
Superina et al. Characterization of seasonal reproduction patterns in female pichis Zaedyus pichiy (Xenarthra: Dasypodidae) estimated by fecal sex steroid metabolites and ovarian histology
Teede Hormone replacement therapy, cardiovascular and cerebrovascular disease
Das et al. Antifertility efficacy of Drynaria quercifolia (L.) J. Smith on female Wister albino rats
Pallares et al. Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring
Toole et al. Evaluation of irritation and sensitisation of two 50 μg/day oestrogen patches
EA007854B1 (en) Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
Baulieu Contraception by the progesterone antagonist RU 486: a novel approach to human fertility control