RU2000129658A - METHOD FOR THERAPEUTIC INFERTILITY TREATMENT - Google Patents

METHOD FOR THERAPEUTIC INFERTILITY TREATMENT

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Publication number
RU2000129658A
RU2000129658A RU2000129658/14A RU2000129658A RU2000129658A RU 2000129658 A RU2000129658 A RU 2000129658A RU 2000129658/14 A RU2000129658/14 A RU 2000129658/14A RU 2000129658 A RU2000129658 A RU 2000129658A RU 2000129658 A RU2000129658 A RU 2000129658A
Authority
RU
Russia
Prior art keywords
lhrh
carried out
stimulation
recombinant
antagonist
Prior art date
Application number
RU2000129658/14A
Other languages
Russian (ru)
Other versions
RU2221588C2 (en
Inventor
Томас РЕЙССМАНН
Хильда РИХТМЮЛЛЕР-ВИНЦЕН
Юрген Энгель
Original Assignee
Аста Медика Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аста Медика Акциенгезельшафт filed Critical Аста Медика Акциенгезельшафт
Publication of RU2000129658A publication Critical patent/RU2000129658A/en
Application granted granted Critical
Publication of RU2221588C2 publication Critical patent/RU2221588C2/en

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Claims (6)

1. Способ терапевтического лечения бесплодия путем внутриматочного оплодотворения, отличающийся тем, что осуществляют доза-зависимую супрессию эндогенных гонадотропинов, в особенности LH, с помощью антагониста LHRH для поддержания физиологических уровней эстрогена, проводят экзогенную стимуляцию роста фолликула яичника, индуцируют овуляцию с помощью HCG, нативного LHRH, агонистов LHRH или рекомбинантного LH, а внутриматочное оплодотворение осуществляют путем инъекции спермы.1. A method for the therapeutic treatment of infertility by intrauterine fertilization, characterized in that dose-dependent suppression of endogenous gonadotropins, in particular LH, is carried out using an LHRH antagonist to maintain physiological levels of estrogen, exogenously stimulate the growth of the ovarian follicle, induce ovulation using HCG, native LHRH, LHRH agonists, or recombinant LH, and intrauterine fertilization is performed by sperm injection. 2. Способ по п. 1, отличающийся тем, что в качестве антагониста LHRH используют цетрореликс. 2. The method according to p. 1, characterized in that cetrorelix is used as an LHRH antagonist. 3. Способ по п. 1, отличающийся тем, что в качестве антагониста LHRH используют антареликс. 3. The method according to p. 1, characterized in that as an antagonist of LHRH use antarelix. 4. Способ по п. 1, отличающийся тем, что стимуляцию осуществляют путем введения выделенного из мочи или рекомбинантного FSH или HMG в сочетании с рекомбинантным LH или без него. 4. The method according to p. 1, characterized in that the stimulation is carried out by introducing isolated from urine or recombinant FSH or HMG in combination with or without recombinant LH. 5. Способ по п. 1, отличающийся тем, что стимуляцию яичников проводят с использованием антиэстрогенов, например, таких как кломифен. 5. The method according to p. 1, characterized in that the stimulation of the ovaries is carried out using antiestrogens, for example, such as clomiphene. 6. Способ по п. 1, отличающийся тем, что стимуляцию яичников проводят с использованием комбинации антиэстрогенов, например, таких как кломифен, с гонадотропинами. 6. The method according to p. 1, characterized in that the stimulation of the ovaries is carried out using a combination of antiestrogens, such as clomiphene, with gonadotropins.
RU2000129658/14A 1998-04-23 1999-03-29 Method for therapeutic treatment of sterility RU2221588C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8274398P 1998-04-23 1998-04-23
US60/082,743 1998-04-23

Publications (2)

Publication Number Publication Date
RU2000129658A true RU2000129658A (en) 2002-10-10
RU2221588C2 RU2221588C2 (en) 2004-01-20

Family

ID=22173160

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2000129658/14A RU2221588C2 (en) 1998-04-23 1999-03-29 Method for therapeutic treatment of sterility

Country Status (24)

Country Link
US (1) US6319192B1 (en)
EP (1) EP1082129B1 (en)
JP (1) JP2002512975A (en)
KR (1) KR100632722B1 (en)
AT (1) ATE252910T1 (en)
AU (1) AU752415B2 (en)
BR (1) BR9909802A (en)
CA (1) CA2330131C (en)
CZ (1) CZ301912B6 (en)
DE (1) DE69912422T2 (en)
DK (1) DK1082129T3 (en)
ES (1) ES2207941T3 (en)
HU (1) HU228736B1 (en)
IL (1) IL139027A0 (en)
NO (1) NO326406B1 (en)
NZ (1) NZ507405A (en)
PL (1) PL195989B1 (en)
PT (1) PT1082129E (en)
RU (1) RU2221588C2 (en)
SI (1) SI1082129T1 (en)
SK (1) SK285192B6 (en)
TR (1) TR200003063T2 (en)
UA (1) UA66850C2 (en)
WO (1) WO1999055357A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
EP0788799A3 (en) * 1996-02-07 1998-10-21 ASTA Medica Aktiengesellschaft LHRH-Antagonists in the treatment of fertility disorders
US8173592B1 (en) * 1999-03-31 2012-05-08 Zentaris Ivf Gmbh Method for a programmed controlled ovarian stimulation protocol
US6623422B2 (en) * 2001-01-12 2003-09-23 Napoli, Llc Method and apparatus for assisted embryo implantation
US20060183973A1 (en) * 2001-01-12 2006-08-17 Kamrava Michael M Endoscopic devices and method of use
US8465412B2 (en) * 2001-01-12 2013-06-18 Michael Levy Uterine devices and method of use
US6758806B2 (en) 2001-01-12 2004-07-06 Napoli, Llc Endoscopic devices and method of use
EP1351612B1 (en) * 2001-01-12 2007-10-03 Napoli, LLC Intra-uterine microcatheter
PT1463493E (en) * 2001-12-14 2008-01-04 Serono Lab Methods of inducing ovulation-using a non-polypeptide camp level modulator
US7033314B2 (en) * 2002-01-11 2006-04-25 Fidelitycorp Limited Endoscopic devices and method of use
US20030186892A1 (en) * 2002-03-28 2003-10-02 Rajneesh Taneja Enhancement of endogenous gonadotropin production
US6695766B2 (en) 2002-04-26 2004-02-24 Olympia Womens Health Magnetic embryo transfer
EP1364658A1 (en) * 2002-05-24 2003-11-26 Applied Research Systems ARS Holding N.V. Use of varying ratios of gonadotrophins in controlled ovarian hyperstimulation
UA81251C2 (en) * 2002-06-07 2007-12-25 Ares Trading Sa Method of controlled ovarian hyperstimulation and pharmaceutical kit for use in such method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130137A (en) * 1989-08-09 1992-07-14 The General Hospital Corporation Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders
DE4305225A1 (en) * 1993-02-19 1994-08-25 Asta Medica Ag New manufacturing process for Cetrorelix lyophilisate
DE19604231A1 (en) * 1996-01-29 1997-07-31 Schering Ag Combined pharmaceutical preparation and its use for the treatment of gynecological disorders
EP0788799A3 (en) * 1996-02-07 1998-10-21 ASTA Medica Aktiengesellschaft LHRH-Antagonists in the treatment of fertility disorders
US5824548A (en) * 1996-05-29 1998-10-20 Wisconsin Alumni Research Foundation Method of increasing survival of cultured primate embryos in medium containing exogenous gonadotrophin releasor hormone
DE19712718C2 (en) * 1997-03-26 1999-09-23 Asta Medica Ag Immobilized and activity-stabilized complexes of LHRH antagonists and process for their preparation
US5961444A (en) * 1997-10-17 1999-10-05 Medworks Corporation In vitro fertilization procedure using direct vision

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