RU2000122833A - METHOD FOR PRODUCING TRANSGENIC ANIMAL - Google Patents

METHOD FOR PRODUCING TRANSGENIC ANIMAL

Info

Publication number
RU2000122833A
RU2000122833A RU2000122833/13A RU2000122833A RU2000122833A RU 2000122833 A RU2000122833 A RU 2000122833A RU 2000122833/13 A RU2000122833/13 A RU 2000122833/13A RU 2000122833 A RU2000122833 A RU 2000122833A RU 2000122833 A RU2000122833 A RU 2000122833A
Authority
RU
Russia
Prior art keywords
transgenic animal
dna
animal
producing transgenic
complement
Prior art date
Application number
RU2000122833/13A
Other languages
Russian (ru)
Other versions
RU2252533C2 (en
Inventor
Дэвид Джеймс Грехем УАЙТ
Алан Фредерик ВИЛЛЬЯМС
Original Assignee
Аймутран Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898922987A external-priority patent/GB8922987D0/en
Application filed by Аймутран Лимитед filed Critical Аймутран Лимитед
Publication of RU2000122833A publication Critical patent/RU2000122833A/en
Application granted granted Critical
Publication of RU2252533C2 publication Critical patent/RU2252533C2/en

Links

Claims (2)

1. Способ получения трансгенного животного, причем указанный способ включает в себя введение ДНК в генетический материал животного, отличающийся тем, что ДНК кодирует по крайней мере один гомологичный фактор рестрикции комплемента дискордантного вида и одну или несколько последовательностей, которые позволяют кодирующей ДНК экспрессироваться по крайней мере в некоторых клетках трансгенного животного, причем указанные клетки можно изъять из трансгенного животного и трансплантировать в указанный дискордантный вид без гиперострого отторжения благодаря присутствию по крайней мере одного гомологичного фактора рестрикции комплемента, предотвращающего полную активацию комплемента.1. A method for producing a transgenic animal, said method comprising introducing DNA into the animal’s genetic material, characterized in that the DNA encodes at least one homologous restriction factor of complement of the discordant species and one or more sequences that allow the coding DNA to be expressed at least in some cells of a transgenic animal, and these cells can be removed from the transgenic animal and transplanted into the indicated discordant species without hyper-acute orzheniya by the presence of at least one homologous complement restriction factor of preventing a complete complement activation. 2. Способ по п. 1, отличающийся тем, что в указанном способе для введения указанной ДНК в генетический материал животного применяется микроинъекция или сперма. 2. The method according to p. 1, characterized in that in the specified method for introducing the specified DNA into the genetic material of an animal, microinjection or semen is used.
RU2000122833/13A 1989-10-12 1990-10-12 Method for obtaining transgenic animal RU2252533C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898922987A GB8922987D0 (en) 1989-10-12 1989-10-12 Modified biological material
GB8922987.6 1989-10-12
GB9017198.4 1990-08-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU5052198 Division 1992-04-10

Publications (2)

Publication Number Publication Date
RU2000122833A true RU2000122833A (en) 2002-12-27
RU2252533C2 RU2252533C2 (en) 2005-05-27

Family

ID=10664457

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2000122833/13A RU2252533C2 (en) 1989-10-12 1990-10-12 Method for obtaining transgenic animal
SU5052198 RU2195956C2 (en) 1989-10-12 1990-10-12 Method for transplantation of animal cell, tissue or organ for a recipient and preparation for its implementation

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU5052198 RU2195956C2 (en) 1989-10-12 1990-10-12 Method for transplantation of animal cell, tissue or organ for a recipient and preparation for its implementation

Country Status (6)

Country Link
BR (1) BR1100034A (en)
GB (1) GB8922987D0 (en)
PL (1) PL287301A1 (en)
RU (2) RU2252533C2 (en)
SG (1) SG48827A1 (en)
ZA (1) ZA908191B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015117054A (en) * 2008-05-06 2015-10-20 Дженентек, Инк. CRIg OPTIONS WITH MATURE AFFINITY

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