RU2000119753A - SYNTHETIC POLYSACCHARIDES, METHOD FOR PRODUCING THERE AND THEIR PHARMACEUTICAL COMPOSITIONS - Google Patents

Claims (11)

1. Synthetic polysaccharide in acid form and its pharmaceutically acceptable salts. the anionic form of which corresponds to one of the formulas (I) - (V) below (see graphic part).  2. The polysaccharide according to claim 1 in the form of sodium or potassium salt. 3. The polysaccharide according to any one of paragraphs. 1 and 2 of the formula: methyl-O- (2,3,4,6-tetra-O-sulfo-α-D-glucopyranosyl) - (1 -> 4) -O- (2,3,6-tri- O-sulfo-α-D-glucopyranosyl) - (1 -> 4) -O- (2,3,6-tri-O-sulfo-β-D-glucopyranosyl) - (1 -> 4) -O - (2,3-di-O-methyl-6-O-sulfo-α-D-glucopyranosyl) - (1 -> 4) -O- (2,3,6-tri-O-methylβ-D- glucopyranosyl) - (1 -> 4) - [O- (2,3,6-tri-O-methyl-α-D-glucopyranosyl) - (1 -> 4) -O- (2,3,6 -tri-O-methyl-β-D-glucopyranosyl) - (1 -> 4)] ₃ -O- (2,3-di-O-methyl-6-O-sulfo-α-D-glucopyranosyl) - (1 -> 4) -O- (2,3-di-O-methyl-β-D-glucopyranosyluronic acid) - (1 -> 4) -O- (2,3,6-tri-O- sulfo-α-D-glucopyranosyl) - (1 -> 4) -O- (2,3-di-O-methyl-α-L-idopyranosyluronic acid) - (1 -> 4) -3-O- methyl 2,6-di-O-sulfo-α-D-glucopyranoside on rievaya salt.  4. Pharmaceutical compositions containing, as an active principle, the polysaccharide according to any one of claims. 1-3 in the form of a salt with a pharmaceutically acceptable base or in acid form, in combination or as a mixture with an inert, non-toxic, pharmaceutically acceptable excipient.  5. The pharmaceutical composition according to claim 4 in the form of dosage units. in which the active principle is mixed with at least one pharmaceutical excipient.  6. The composition according to p. 5, where each dosage unit contains 0.1 to 100 mg of active principle.  7. The composition according to p. 6, where each dosage unit contains 0.5 to 50 mg of active principle.  8. The use of the polysaccharide in paragraphs. 1-3, for the preparation of a medicine that is useful in pathologies associated with coagulation dysfunction.  9. The use of the polysaccharide in paragraphs. 1-3 for the preparation of a medicine that is useful in the treatment and prevention of disorders of the cardiovascular and cerebrovascular systems, thromboembolic disorders associated with arteriosclerosis and diabetes, or thromboembolic disorders associated with retrombosis after thrombolysis, heart attack, dementia of ischemic origin, with peripheral arterial diseases, with hemodialysis or with auricular fibrillation, or, alternatively, when using vascular prostheses of coronary artery bypass grafting.  10. The use according to claim 9, characterized in that the prepared drugs are used in the prevention or treatment of thromboembolic diseases.  11. The use of claim 10, wherein that the prepared drugs are used in the prevention or treatment of unstable angina, strokes, restenosis after angioplasty, endarterectomy or the installation of endovascular prostheses.

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