RU2000117710A - METHOD FOR OBTAINING SIBERIA-UNIVERSAL NATIVE PROTECTIVE ANTIGEN - Google Patents

METHOD FOR OBTAINING SIBERIA-UNIVERSAL NATIVE PROTECTIVE ANTIGEN

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Publication number
RU2000117710A
RU2000117710A RU2000117710/13A RU2000117710A RU2000117710A RU 2000117710 A RU2000117710 A RU 2000117710A RU 2000117710/13 A RU2000117710/13 A RU 2000117710/13A RU 2000117710 A RU2000117710 A RU 2000117710A RU 2000117710 A RU2000117710 A RU 2000117710A
Authority
RU
Russia
Prior art keywords
protective antigen
siberia
universal
obtaining
native protective
Prior art date
Application number
RU2000117710/13A
Other languages
Russian (ru)
Other versions
RU2223114C2 (en
Inventor
Юрий Николаевич Орлов
Николай Васильевич Садовой
Елена Борисовна Махортова
Надежда Владимировна Федорова
Сергей Васильевич Мельников
Михаил Константинович Кузьмич
Михаил Иванович Дербин
Original Assignee
Центр военно-технических проблем биологической защиты Научно-исследовательского института микробиологии Министерства обороны Российской Федерации
Filing date
Publication date
Application filed by Центр военно-технических проблем биологической защиты Научно-исследовательского института микробиологии Министерства обороны Российской Федерации filed Critical Центр военно-технических проблем биологической защиты Научно-исследовательского института микробиологии Министерства обороны Российской Федерации
Priority to RU2000117710/13A priority Critical patent/RU2223114C2/en
Priority claimed from RU2000117710/13A external-priority patent/RU2223114C2/en
Publication of RU2000117710A publication Critical patent/RU2000117710A/en
Application granted granted Critical
Publication of RU2223114C2 publication Critical patent/RU2223114C2/en

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Claims (2)

1. Способ получения сибиреязвенного нативного протективного антигена при глубинном анаэробном культивировании В anthracis на питательной среде, содержащей бикарбонат натрия, отличающийся тем, что для получения нативного протективного антигена культуральную жидкость в ферментере в течение всего процесса культивирования непрерывно аэрируют воздухом или любым инертным газом.1. The method of producing anthrax native protective antigen in deep anaerobic cultivation In anthracis on a nutrient medium containing sodium bicarbonate, characterized in that to obtain a native protective antigen, the culture fluid in the fermenter is continuously aerated with air or any inert gas during the entire cultivation process. 2. Способ по п. 1, отличающийся тем, что аэрацию культуральной жидкости осуществляют с удельным расходом газа 0,05-0,40 л/(л. мин). 2. The method according to p. 1, characterized in that the aeration of the culture fluid is carried out with a specific gas flow rate of 0.05-0.40 l / (l. Min).
RU2000117710/13A 2000-07-04 2000-07-04 Method for obtaining anthracic native protective antigen RU2223114C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2000117710/13A RU2223114C2 (en) 2000-07-04 2000-07-04 Method for obtaining anthracic native protective antigen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2000117710/13A RU2223114C2 (en) 2000-07-04 2000-07-04 Method for obtaining anthracic native protective antigen

Publications (2)

Publication Number Publication Date
RU2000117710A true RU2000117710A (en) 2002-08-27
RU2223114C2 RU2223114C2 (en) 2004-02-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2000117710/13A RU2223114C2 (en) 2000-07-04 2000-07-04 Method for obtaining anthracic native protective antigen

Country Status (1)

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RU (1) RU2223114C2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2492241C1 (en) * 2012-07-10 2013-09-10 Федеральное казенное учреждение здравоохранения "Российский научно-исследовательский противочумный институт "Микроб" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека ("РосНИПЧИ "Микроб") METHOD OF PRODUCTION OF PROTECTIVE ANTIGEN AND PROTEIN OF S-LAYER EA1OF ASPOROGENOUS RECOMBINANT STRAIN IN anthracis 55 ΔTPA-1Spo-
RU2599035C1 (en) * 2015-07-13 2016-10-10 федеральное государственное бюджетное научное учреждение "Федеральный центр токсикологической, радиационной и биологической безопасности" (ФГБНУ "ФЦТРБ-ВНИВИ") Method of obtaining erythrocyte antigen of anthrax antigen, method of obtaining control positive serum for kit of detection of antibodies in the blood serum of animals vaccinated against anthrax, in the reaction of indirect hemagglutination and kit for detection of antibodies

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