RU2000116260A - LTB ADJUVANT VACCINES - Google Patents
LTB ADJUVANT VACCINESInfo
- Publication number
- RU2000116260A RU2000116260A RU2000116260/14A RU2000116260A RU2000116260A RU 2000116260 A RU2000116260 A RU 2000116260A RU 2000116260/14 A RU2000116260/14 A RU 2000116260/14A RU 2000116260 A RU2000116260 A RU 2000116260A RU 2000116260 A RU2000116260 A RU 2000116260A
- Authority
- RU
- Russia
- Prior art keywords
- immunogen
- subunits
- ltb
- mucous membranes
- holotoxin
- Prior art date
Links
- 229960005486 vaccines Drugs 0.000 title claims 8
- 230000000240 adjuvant Effects 0.000 title claims 6
- 239000002671 adjuvant Substances 0.000 title claims 6
- 230000002163 immunogen Effects 0.000 claims 12
- 210000004400 Mucous Membrane Anatomy 0.000 claims 7
- 101700032127 ETX1 Proteins 0.000 claims 5
- 101700029730 ETX2 Proteins 0.000 claims 5
- 231100000655 Enterotoxin Toxicity 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 5
- 101710023118 btfP Proteins 0.000 claims 5
- 239000000147 enterotoxin Substances 0.000 claims 5
- 230000002588 toxic Effects 0.000 claims 5
- 231100000331 toxic Toxicity 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- 102000018358 Immunoglobulins Human genes 0.000 claims 2
- 108060003951 Immunoglobulins Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 208000006572 Human Influenza Diseases 0.000 claims 1
- 206010022000 Influenza Diseases 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 230000001580 bacterial Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 230000002538 fungal Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000016379 mucosal immune response Effects 0.000 claims 1
- 230000003612 virological Effects 0.000 claims 1
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97203671A EP0919243A1 (en) | 1997-11-25 | 1997-11-25 | Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant |
EP97203671.9 | 1997-11-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2000116260A true RU2000116260A (en) | 2002-06-27 |
RU2211050C2 RU2211050C2 (en) | 2003-08-27 |
Family
ID=8228966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2000116260/14A RU2211050C2 (en) | 1997-11-25 | 1998-11-24 | Vaccines with ltb adjuvant |
Country Status (25)
Country | Link |
---|---|
US (1) | US6793928B1 (en) |
EP (2) | EP0919243A1 (en) |
JP (1) | JP4235359B2 (en) |
KR (1) | KR100575019B1 (en) |
CN (1) | CN1227032C (en) |
AT (1) | ATE238809T1 (en) |
AU (1) | AU747061C (en) |
BR (1) | BR9815413A (en) |
CA (1) | CA2311492C (en) |
CZ (1) | CZ299770B6 (en) |
DE (1) | DE69814177T2 (en) |
DK (1) | DK1071456T3 (en) |
ES (1) | ES2198089T3 (en) |
HK (1) | HK1031102A1 (en) |
HU (1) | HU226214B1 (en) |
IL (2) | IL135905A0 (en) |
NO (1) | NO324690B1 (en) |
NZ (1) | NZ504396A (en) |
PL (1) | PL190925B1 (en) |
PT (1) | PT1071456E (en) |
RU (1) | RU2211050C2 (en) |
SK (1) | SK284572B6 (en) |
TR (1) | TR200001485T2 (en) |
UA (1) | UA72199C2 (en) |
WO (1) | WO1999026654A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2473691C2 (en) * | 2006-10-12 | 2013-01-27 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П.Анджелетти Спа | Fused protein of telomerase reverse transcriptase, nucleotides coding them, and using them |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
MXPA00010934A (en) * | 1998-05-08 | 2003-07-14 | Univ Bristol | Vaccine. |
AU2003261492B2 (en) * | 1998-05-08 | 2006-09-07 | Trident Pharmaceuticals, Inc. | Vaccine |
KR20010043441A (en) | 1998-05-08 | 2001-05-25 | 더 유니버시티 오브 브리스톨 | Immunomodulators for vaccines |
WO2001035993A2 (en) * | 1999-10-18 | 2001-05-25 | Chiron Corporation | Compositions and methods for stimulating an immune response against infectious agents |
IL158140A0 (en) * | 2003-09-25 | 2004-03-28 | Hadasit Med Res Service | Multiepitope polypeptides for cancer immunotherapy |
EP1708744A4 (en) * | 2003-12-09 | 2009-07-15 | Intercell Usa Inc | Gm1 binding deficient exotoxins for use as immunoadjuvants |
EP1930025B1 (en) | 2005-08-05 | 2013-05-01 | The University of Tokushima | ANTIGEN-AND-DRUG VEHICLE WHICH ENABLES THE CHANGEOVER FROM THE SELECTIVE PRODUCTION OF IgA ANTIBODY TO THE PRODUCTION OF BOTH OF IgA AND IgG ANTIBODIES, AND TRANSNASAL/TRANSMUCOSAL VACCINE USING THE VEHICLE |
TWI397419B (en) * | 2006-03-22 | 2013-06-01 | Abbott Biologicals Bv | Intranasal or inhalational administration of virosomes |
US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
EP3058954B1 (en) | 2007-08-27 | 2017-03-01 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
ES2552858T3 (en) | 2007-10-01 | 2015-12-02 | Longhorn Vaccines And Diagnostics, Llc | Collection of biological samples and transport system and methods of use |
EP3494989A1 (en) | 2012-01-26 | 2019-06-12 | Longhorn Vaccines and Diagnostics, LLC | Composite antigenic sequences and vaccines |
KR101705268B1 (en) * | 2012-06-20 | 2017-02-09 | 고쿠리츠다이가쿠호징 도쿄다이가쿠 | Mucosal immunity-stimulating agent, and oral pharmaceutical composition for treating hpv infection |
CN106170551B (en) | 2013-12-16 | 2020-01-07 | 财团法人农业科技研究院 | Plasmid, method and kit for producing thermolabile enterotoxin B subunit |
US9976136B2 (en) | 2015-05-14 | 2018-05-22 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
US20210299247A1 (en) * | 2017-11-01 | 2021-09-30 | Merck Sharp & Dohme Corp. | Stable formulations of cytomegalovirus |
WO2019139891A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
WO2019183209A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
EP3768302A4 (en) | 2018-03-20 | 2021-12-15 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
CN113616783A (en) * | 2020-05-08 | 2021-11-09 | 昱厚生技股份有限公司 | Methods of preventing or treating coronavirus infection using immunomodulators and vaccine compositions comprising the immunomodulators |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH589453A5 (en) | 1974-01-14 | 1977-07-15 | Sandoz Ag | |
JP2849632B2 (en) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | Vaccine preparation |
AU4754490A (en) * | 1988-12-07 | 1990-06-26 | University Of Leicester | Heat-labile toxin b subunit fusion proteins |
US5241053A (en) * | 1990-09-05 | 1993-08-31 | Takeda Chemical Industries, Ltd. | Fused proteins comprising glycoprotein gD of HSV-1 and LTB |
-
1997
- 1997-11-25 EP EP97203671A patent/EP0919243A1/en not_active Withdrawn
-
1998
- 1998-11-24 EP EP98963503A patent/EP1071456B1/en not_active Expired - Lifetime
- 1998-11-24 UA UA2000063620A patent/UA72199C2/en unknown
- 1998-11-24 JP JP2000521855A patent/JP4235359B2/en not_active Expired - Fee Related
- 1998-11-24 HU HU0100058A patent/HU226214B1/en not_active IP Right Cessation
- 1998-11-24 CZ CZ20001895A patent/CZ299770B6/en not_active IP Right Cessation
- 1998-11-24 TR TR2000/01485T patent/TR200001485T2/en unknown
- 1998-11-24 RU RU2000116260/14A patent/RU2211050C2/en not_active IP Right Cessation
- 1998-11-24 BR BR9815413-3A patent/BR9815413A/en not_active IP Right Cessation
- 1998-11-24 PL PL340635A patent/PL190925B1/en unknown
- 1998-11-24 AT AT98963503T patent/ATE238809T1/en active
- 1998-11-24 KR KR1020007005665A patent/KR100575019B1/en not_active IP Right Cessation
- 1998-11-24 CN CNB988115492A patent/CN1227032C/en not_active Expired - Fee Related
- 1998-11-24 SK SK776-2000A patent/SK284572B6/en not_active IP Right Cessation
- 1998-11-24 IL IL13590598A patent/IL135905A0/en active IP Right Grant
- 1998-11-24 CA CA2311492A patent/CA2311492C/en not_active Expired - Fee Related
- 1998-11-24 WO PCT/EP1998/007553 patent/WO1999026654A1/en active IP Right Grant
- 1998-11-24 PT PT98963503T patent/PT1071456E/en unknown
- 1998-11-24 DK DK98963503T patent/DK1071456T3/en active
- 1998-11-24 US US09/555,139 patent/US6793928B1/en not_active Expired - Fee Related
- 1998-11-24 NZ NZ504396A patent/NZ504396A/en not_active IP Right Cessation
- 1998-11-24 ES ES98963503T patent/ES2198089T3/en not_active Expired - Lifetime
- 1998-11-24 DE DE69814177T patent/DE69814177T2/en not_active Expired - Lifetime
- 1998-11-24 AU AU18750/99A patent/AU747061C/en not_active Ceased
-
2000
- 2000-05-01 IL IL135905A patent/IL135905A/en not_active IP Right Cessation
- 2000-05-22 NO NO20002613A patent/NO324690B1/en not_active IP Right Cessation
-
2001
- 2001-03-07 HK HK01101650A patent/HK1031102A1/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2473691C2 (en) * | 2006-10-12 | 2013-01-27 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П.Анджелетти Спа | Fused protein of telomerase reverse transcriptase, nucleotides coding them, and using them |
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