RU2000112547A - COMPOSITIONS AND METHODS OF SYSTEM DELIVERY OF ORAL VACCINES AND THERAPEUTIC AGENTS - Google Patents
COMPOSITIONS AND METHODS OF SYSTEM DELIVERY OF ORAL VACCINES AND THERAPEUTIC AGENTSInfo
- Publication number
- RU2000112547A RU2000112547A RU2000112547/14A RU2000112547A RU2000112547A RU 2000112547 A RU2000112547 A RU 2000112547A RU 2000112547/14 A RU2000112547/14 A RU 2000112547/14A RU 2000112547 A RU2000112547 A RU 2000112547A RU 2000112547 A RU2000112547 A RU 2000112547A
- Authority
- RU
- Russia
- Prior art keywords
- botulinum toxin
- compositions
- methods
- therapeutic agents
- modified
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 3
- 229960005486 vaccines Drugs 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title 1
- 108010043024 Botulinum Toxins Proteins 0.000 claims 7
- 229940053031 botulinum toxin Drugs 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000003508 Botulism Diseases 0.000 claims 1
- 210000000936 Intestines Anatomy 0.000 claims 1
- 230000003000 nontoxic Effects 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/954,302 | 1997-10-20 | ||
US08/954,302 US6051239A (en) | 1997-10-20 | 1997-10-20 | Compositions and methods for systemic delivery of oral vaccines and therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2000112547A true RU2000112547A (en) | 2002-05-20 |
RU2227042C2 RU2227042C2 (en) | 2004-04-20 |
Family
ID=25495232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2000112547/15A RU2227042C2 (en) | 1997-10-20 | 1998-10-16 | Compositions amd methods for systemic delivery of oral vaccines and therapeutic agents |
Country Status (16)
Country | Link |
---|---|
US (1) | US6051239A (en) |
EP (1) | EP1024827B1 (en) |
JP (1) | JP2001522783A (en) |
KR (1) | KR100594787B1 (en) |
CN (1) | CN1246038C (en) |
AT (1) | ATE355076T1 (en) |
AU (1) | AU756475B2 (en) |
BR (1) | BR9815255A (en) |
CA (1) | CA2306995A1 (en) |
DE (1) | DE69837209T2 (en) |
EE (1) | EE200000536A (en) |
HU (1) | HUP0101017A3 (en) |
IL (1) | IL135743A (en) |
NZ (1) | NZ504549A (en) |
RU (1) | RU2227042C2 (en) |
WO (1) | WO1999020306A1 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7227010B2 (en) | 1993-09-21 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Army | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
US6967088B1 (en) * | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
US7780967B2 (en) * | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
US8632785B2 (en) * | 2000-02-08 | 2014-01-21 | Allergan, Inc. | Clostridial toxin pharmaceutical composition containing a gelatin fragment |
US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
DK1253932T3 (en) * | 2000-02-08 | 2005-06-27 | Allergan Inc | Botulinum toxin drugs |
US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
AU2888702A (en) * | 2000-11-06 | 2002-05-15 | Us Army Med Res Mat Command | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
US7273722B2 (en) * | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
JP4707254B2 (en) * | 2001-04-24 | 2011-06-22 | クミアイ化学工業株式会社 | Granular composition and method for producing the same |
US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
AU2003237346A1 (en) * | 2002-05-31 | 2003-12-19 | Thomas Jefferson University | Compositions and methods for transepithelial molecular transport |
US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
WO2004044161A2 (en) | 2002-11-06 | 2004-05-27 | Fraunhofer Usa | Expression of foreign sequences in plants using trans-activation system |
US7692063B2 (en) * | 2002-11-12 | 2010-04-06 | Ibio, Inc. | Production of foreign nucleic acids and polypeptides in sprout systems |
US7683238B2 (en) * | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
NZ540425A (en) * | 2002-12-20 | 2009-03-31 | Botulinum Toxin Res Ass Inc | Pharmaceutical botulinum toxin compositions |
WO2004070016A2 (en) | 2003-02-03 | 2004-08-19 | Fraunhofer Usa Inc. | System for expression of genes in plants |
US20040253274A1 (en) * | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
US7172764B2 (en) * | 2003-11-17 | 2007-02-06 | Allergan, Inc. | Rescue agents for treating botulinum toxin intoxications |
US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
EP1769068B1 (en) * | 2004-02-20 | 2014-12-31 | iBio, Inc. | Systems and methods for clonal expression in plants |
US7306807B2 (en) * | 2004-09-13 | 2007-12-11 | Wyeth | Hemorrhagic feline calicivirus, calicivirus vaccine and method for preventing calicivirus infection or disease |
CA2588758C (en) * | 2004-11-22 | 2017-01-03 | New York University | Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof |
KR20110126726A (en) | 2005-10-07 | 2011-11-23 | 화이자 프로덕츠 인코포레이티드 | Vaccines and methods to treat canine influenza |
EP1931379B1 (en) | 2005-10-07 | 2013-05-29 | Health Protection Agency | Proteins with improved solubility and methods for producing and using same |
CA2681183A1 (en) * | 2007-05-30 | 2008-12-11 | Wyeth | Raccoon poxvirus expressing genes of feline antigens |
WO2009042165A2 (en) * | 2007-09-25 | 2009-04-02 | Thomas Jefferson University | Mutant botulinum neurotoxin serotype a polypeptide and uses thereof |
WO2010096134A1 (en) | 2008-12-04 | 2010-08-26 | Botulinum Toxin Research Associates, Inc. | Extended length botulinum toxin formulation for human or mammalian use |
US9393291B2 (en) | 2012-04-12 | 2016-07-19 | Botulinum Toxin Research Associates, Inc. | Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds |
WO2014117148A1 (en) | 2013-01-28 | 2014-07-31 | New York University | Treatment methods using atoxic neurotoxin derivatives |
US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
US9901627B2 (en) | 2014-07-18 | 2018-02-27 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
US11897921B2 (en) | 2014-12-09 | 2024-02-13 | New York University | Propeptide fusion comprising a mutated clostridium botulinum neurotoxin and a VHH domain |
KR20200100755A (en) | 2017-12-20 | 2020-08-26 | 알레간 인코포레이티드 | Botulinum toxin cell binding domain polypeptide and method of use for skin regeneration |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919665A (en) * | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
JP3523879B2 (en) * | 1994-05-31 | 2004-04-26 | アレルガン インコーポレイテッド | Modification of Clostridium toxin for transport proteins |
ATE366312T1 (en) * | 1994-10-24 | 2007-07-15 | Ophidian Pharm Inc | VACCINE AND ANTITOXINS FOR THE TREATMENT AND PREVENTION OF C. DIFFICILE DISEASES |
WO1996040229A1 (en) * | 1995-06-07 | 1996-12-19 | Thomas Jefferson University | Vaccines synthesized by transgenic plants |
-
1997
- 1997-10-20 US US08/954,302 patent/US6051239A/en not_active Expired - Fee Related
-
1998
- 1998-10-16 EP EP98953617A patent/EP1024827B1/en not_active Expired - Lifetime
- 1998-10-16 AU AU10947/99A patent/AU756475B2/en not_active Ceased
- 1998-10-16 HU HU0101017A patent/HUP0101017A3/en unknown
- 1998-10-16 CN CNB988112981A patent/CN1246038C/en not_active Expired - Fee Related
- 1998-10-16 IL IL13574398A patent/IL135743A/en not_active IP Right Cessation
- 1998-10-16 KR KR1020007004197A patent/KR100594787B1/en not_active IP Right Cessation
- 1998-10-16 JP JP2000516701A patent/JP2001522783A/en active Pending
- 1998-10-16 BR BR9815255-6A patent/BR9815255A/en not_active Application Discontinuation
- 1998-10-16 EE EEP200000536A patent/EE200000536A/en unknown
- 1998-10-16 AT AT98953617T patent/ATE355076T1/en not_active IP Right Cessation
- 1998-10-16 DE DE69837209T patent/DE69837209T2/en not_active Expired - Fee Related
- 1998-10-16 CA CA002306995A patent/CA2306995A1/en not_active Abandoned
- 1998-10-16 NZ NZ504549A patent/NZ504549A/en unknown
- 1998-10-16 RU RU2000112547/15A patent/RU2227042C2/en not_active IP Right Cessation
- 1998-10-16 WO PCT/US1998/021897 patent/WO1999020306A1/en active IP Right Grant
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