RU2000111506A - PROLONGED TABLETS FOR THE TREATMENT OF PARKINSON'S DISEASE - Google Patents

PROLONGED TABLETS FOR THE TREATMENT OF PARKINSON'S DISEASE

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Publication number
RU2000111506A
RU2000111506A RU2000111506/14A RU2000111506A RU2000111506A RU 2000111506 A RU2000111506 A RU 2000111506A RU 2000111506/14 A RU2000111506/14 A RU 2000111506/14A RU 2000111506 A RU2000111506 A RU 2000111506A RU 2000111506 A RU2000111506 A RU 2000111506A
Authority
RU
Russia
Prior art keywords
pharmaceutical composition
composition according
cps
usp
parkinson
Prior art date
Application number
RU2000111506/14A
Other languages
Russian (ru)
Other versions
RU2205007C2 (en
Inventor
Тцу-чи Роберт ДЗУ
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of RU2000111506A publication Critical patent/RU2000111506A/en
Application granted granted Critical
Publication of RU2205007C2 publication Critical patent/RU2205007C2/en

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Claims (1)

1. Фармацевтическая композиция, представляющая собой таблетку с пролонгированным выделением для перорального введения, которая содержит
(a)(R)-5,6-дигидро-5-(метиламино)-4Н-имидазо [4,5-ij)] -хинолин-2(1Н)-он (Z)-2-бутендиоат (1: 1) 0,3%-16%
(b) крахмал 60%-69%
(c) гидроксипропилметилцеллюлозу 30%-40%
2. Фармацевтическая композиция по п. 1, которая включает
(a) (R)-5,6-дигидро-5-(метиламино)-4Н-имидазо [4,5-ij)] -хинолин-2(1Н)-он(Z)-2-бутендиоат (1: 1) 0,44%-10%
(b) преклейстеризованный или кукурузный крахмал 60%-67%
(c) гидроксипропилметилцеллюлозу 30%-40%
3. Фармацевтическая композиция по п. 1, в которой (R)-5,6-дигидро-5-(метиламино)-4Н-имидазо[4,5-ij] ] -хинолин-2(1Н)-он (Z)-2-бутендиоат (1: 1) присутствует в количестве от около 0,3% (1 мг) до около 16% (56 мг)/таблетку.1. The pharmaceutical composition, which is a tablet with a prolonged release for oral administration, which contains
(a) (R) -5,6-dihydro-5- (methylamino) -4H-imidazo [4,5-ij)] -quinoline-2 (1H) -one (Z) -2-butenedioate (1: 1 ) 0.3% -16%
(b) starch 60% -69%
(c) hydroxypropyl methyl cellulose 30% -40%
2. The pharmaceutical composition according to claim 1, which includes
(a) (R) -5,6-dihydro-5- (methylamino) -4H-imidazo [4,5-ij)] -quinoline-2 (1H) -one (Z) -2-butenedioate (1: 1 ) 0.44% -10%
(b) pre-pasteurized or corn starch 60% -67%
(c) hydroxypropyl methyl cellulose 30% -40%
3. The pharmaceutical composition according to claim 1, in which (R) -5,6-dihydro-5- (methylamino) -4H-imidazo [4,5-ij]] -quinoline-2 (1H) -one (Z) -2-butenedioate (1: 1) is present in an amount of about 0.3% (1 mg) to about 16% (56 mg) / tablet. 4. Фармацевтическая композиция по п. 1, в которой (R)-5,6-дигидро-5-(метиламино)-4Н-имидазо[4,5-ij] ] -хинолин-2(1Н)-он (Z)-2-бутендиоат (1: 1) присутствует в количестве около 0,44% (1,5 мг), 0,88% (3,1 мг), 1,76% (6,2 мг), 3,52% (12,3 мг) и 5,33% (19 мг)/таблетку. 4. The pharmaceutical composition according to claim 1, in which (R) -5,6-dihydro-5- (methylamino) -4H-imidazo [4,5-ij]] -quinoline-2 (1H) -one (Z) -2-butenedioate (1: 1) is present in an amount of about 0.44% (1.5 mg), 0.88% (3.1 mg), 1.76% (6.2 mg), 3.52% (12.3 mg) and 5.33% (19 mg) / tablet. 5. Фармацевтическая композиция по п. 1, в которой крахмал является преклейстеризованным или кукурузным крахмалом. 5. The pharmaceutical composition according to claim 1, in which the starch is pre-pasteurized or corn starch. 6. Фармацевтическая композиция по п. 1, в которой крахмал представляет собой смесь преклейстеризованного и кукурузного крахмала. 6. The pharmaceutical composition according to claim 1, in which the starch is a mixture of pre-pasteurized and corn starch. 7. Фармацевтическая композиция по п. 1, в которой гидроксипропилметилцеллюлозу выбирают из группы, включающей:
гидроксипропилметилцеллюлозу 2208 USP 100 сПз,
гидроксипропилметилцеллюлозу 2208 USP 4000 сПз,
гидроксипропилметилцеллюлозу 2208 USP 15000 сПз,
гидроксипропилметилцеллюлозу 2208 USP 100000 сПз,
гидроксипропилметилцеллюлозу 2910 USP 4000 сПз,
гидроксипропилметилцеллюлозу 2910 USP 10000 сПз
или их смеси.7. The pharmaceutical composition according to claim 1, in which hydroxypropylmethyl cellulose is selected from the group including:
hydroxypropyl methylcellulose 2208 USP 100 cps,
hydroxypropyl methylcellulose 2208 USP 4000 cps,
hydroxypropyl methylcellulose 2208 USP 15,000 cps,
hydroxypropyl methylcellulose 2208 USP 100,000 cps,
hydroxypropyl methylcellulose 2910 USP 4000 cps,
hydroxypropyl methylcellulose 2910 USP 10,000 cps
or mixtures thereof. 8. Фармацевтическая композиция по п. 7, в которой гидроксипропилметилцеллюлоза представляет собой гидроксипропилметилцеллюлозу 2208 USP 4000 спз или гидроксипропилметилцеллюлозу 2910 USP 4000 сПз. 8. The pharmaceutical composition of claim 7, wherein the hydroxypropyl methyl cellulose is hydroxypropyl methyl cellulose 2208 USP 4000 cps or hydroxypropyl methyl cellulose 2910 USP 4000 cps. 9. Фармацевтическая композиция по п. 1, которая дополнительно содержит стеарат магния. 9. The pharmaceutical composition according to claim 1, which further comprises magnesium stearate. 10. Фармацевтическая композиция по п. 9, в которой стеарат магния присутствует в количестве от около 0,2 до около 2,0%. 10. The pharmaceutical composition according to claim 9, in which magnesium stearate is present in an amount of from about 0.2 to about 2.0%. 11. Фармацевтическая композиция по п. 1, которая дополнительно содержит коллоидную двуокись кремния. 11. The pharmaceutical composition according to claim 1, which further comprises colloidal silicon dioxide. 12. Фармацевтическая композиция по п. 11, в которой коллоидная двуокись кремния присутствует в количестве от около 0,2 до около 1,0%. 12. The pharmaceutical composition according to claim 11, in which colloidal silicon dioxide is present in an amount of from about 0.2 to about 1.0%. 13. Фармацевтическая композиция по п. 1, где общий вес таблетки составляет около 350 мг. 13. The pharmaceutical composition according to claim 1, wherein the total weight of the tablet is about 350 mg. 14. Способ лечения человека, страдающего болезнью Паркинсона, который включает пероральное введение эффективного против болезни Паркинсона количества (R)-5,6-дигидро-5-(метиламино)-4Н-имидазо[4,5-ij] ] -хинолин-2(1Н)-она (Z)-2-бутендиоат (1: 1). 14. A method of treating a person suffering from Parkinson’s disease, which comprises oral administration of an effective amount of (R) -5,6-dihydro-5- (methylamino) -4H-imidazo [4,5-ij]] -quinoline-2 against Parkinson's disease (1H) -one (Z) -2-butenedioate (1: 1). 15. Способ лечения человека, страдающего болезнью Паркинсона по п. 14, в котором (R)-5,6-дигидро-5-(метиламино)-4Н-имидазо[4,5-ij] ] -хинолин-2(1Н)-он (Z)-2-бутендиоат (1: 1) вводят дважды в день. 15. A method of treating a person suffering from Parkinson's disease according to claim 14, in which (R) -5,6-dihydro-5- (methylamino) -4H-imidazo [4,5-ij]] -quinoline-2 (1H) -one (Z) -2-butenedioate (1: 1) is administered twice daily. 16. Способ лечения человека, страдающего болезнью Паркинсона по п. 14, в котором эффективное количество составляет от около 2 мг до около 112 мг/день. 16. A method of treating a person suffering from Parkinson's disease according to claim 14, wherein the effective amount is from about 2 mg to about 112 mg / day. 17. Способ лечения человека, страдающего болезнью Паркинсона по п. 16, в котором эффективное количество составляет от около 3 мг до около 70 мг/день. 17. A method of treating a person suffering from Parkinson's disease according to claim 16, wherein the effective amount is from about 3 mg to about 70 mg / day.
RU2000111506/14A 1997-09-30 1998-09-03 Sustained-release tablets for parkinson's disease treatment RU2205007C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6082797P 1997-09-30 1997-09-30
US60/060,827 1997-09-30

Publications (2)

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RU2000111506A true RU2000111506A (en) 2002-05-10
RU2205007C2 RU2205007C2 (en) 2003-05-27

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Country Status (23)

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US (2) US6197339B1 (en)
EP (1) EP1017391B1 (en)
JP (1) JP2001517701A (en)
KR (1) KR100516095B1 (en)
CN (1) CN1195518C (en)
AT (1) ATE297208T1 (en)
AU (1) AU742941B2 (en)
BR (1) BR9812687A (en)
CA (1) CA2301869A1 (en)
DE (1) DE69830503T2 (en)
DK (1) DK1017391T3 (en)
ES (1) ES2242296T3 (en)
FI (1) FI20000720A (en)
HK (1) HK1030163A1 (en)
HU (1) HUP0004586A2 (en)
NO (1) NO320303B1 (en)
NZ (1) NZ504221A (en)
PL (1) PL191125B1 (en)
PT (1) PT1017391E (en)
RU (1) RU2205007C2 (en)
SI (1) SI1017391T1 (en)
SK (1) SK3612000A3 (en)
WO (1) WO1999016442A2 (en)

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