RU2000109293A - Monoclonal antibody obtained using integrin-associated protein, its fragment Fab, Fab 'or F (ab') 2, hybridoma producing a monoclonal antibody (variant), antileukemic agent - Google Patents
Monoclonal antibody obtained using integrin-associated protein, its fragment Fab, Fab 'or F (ab') 2, hybridoma producing a monoclonal antibody (variant), antileukemic agentInfo
- Publication number
- RU2000109293A RU2000109293A RU2000109293/13A RU2000109293A RU2000109293A RU 2000109293 A RU2000109293 A RU 2000109293A RU 2000109293/13 A RU2000109293/13 A RU 2000109293/13A RU 2000109293 A RU2000109293 A RU 2000109293A RU 2000109293 A RU2000109293 A RU 2000109293A
- Authority
- RU
- Russia
- Prior art keywords
- monoclonal antibody
- fab
- associated protein
- integrin
- fragment
- Prior art date
Links
- 102000005614 monoclonal antibodies Human genes 0.000 title claims 7
- 108010045030 monoclonal antibodies Proteins 0.000 title claims 7
- 102100013078 CD47 Human genes 0.000 title claims 6
- 101700033237 CD47 Proteins 0.000 title claims 6
- 239000000063 antileukemic agent Substances 0.000 title claims 4
- 210000004408 Hybridomas Anatomy 0.000 title claims 2
- 230000035693 Fab Effects 0.000 title 2
- 206010059512 Apoptosis Diseases 0.000 claims 3
- 210000000601 Blood Cells Anatomy 0.000 claims 3
- 230000006907 apoptotic process Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26485397 | 1997-09-11 | ||
JP9/264853 | 1997-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2000109293A true RU2000109293A (en) | 2003-06-20 |
RU2212413C2 RU2212413C2 (en) | 2003-09-20 |
Family
ID=17409137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2000109293/13A RU2212413C2 (en) | 1997-09-11 | 1998-09-11 | Monoclonal antibody prepared using integrin-associated protein, its fragment fab, fab' or f(ab')2, hybridoma producing monoclonal antibody (variant), antileukemic agent |
Country Status (14)
Country | Link |
---|---|
US (1) | US20030157100A1 (en) |
EP (1) | EP1035132B1 (en) |
KR (2) | KR20040106585A (en) |
CN (1) | CN1198845C (en) |
AT (1) | ATE395362T1 (en) |
AU (1) | AU740225B2 (en) |
CA (1) | CA2303072A1 (en) |
DE (1) | DE69839492D1 (en) |
HU (1) | HUP0003513A3 (en) |
NO (1) | NO20001238L (en) |
PL (1) | PL339265A1 (en) |
RU (1) | RU2212413C2 (en) |
SK (1) | SK3232000A3 (en) |
WO (1) | WO1999012973A1 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA50708C2 (en) * | 1993-09-03 | 2002-11-15 | Чугай Сейяку Кабусікі Кайся | Monoclonal antibody that is able to recognize an antigen that induces apoptosis in the myelocytic cell, the fragment f(ab)2 of the monoclonal antibody, the hybridoma ferm bp-4382 |
US7531643B2 (en) * | 1997-09-11 | 2009-05-12 | Chugai Seiyaku Kabushiki Kaisha | Monoclonal antibody inducing apoptosis |
US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
AU2940900A (en) * | 1999-03-10 | 2000-09-28 | Chugai Seiyaku Kabushiki Kaisha | Single-stranded fv inducing apoptosis |
TWI242043B (en) * | 2000-03-10 | 2005-10-21 | Chugai Pharmaceutical Co Ltd | Polypeptide inducing apoptosis |
WO2001079494A1 (en) * | 2000-04-17 | 2001-10-25 | Chugai Seiyaku Kabushiki Kaisha | Agonist antibodies |
US20040058393A1 (en) * | 2000-04-17 | 2004-03-25 | Naoshi Fukishima | Agonist antibodies |
KR100870123B1 (en) | 2000-10-20 | 2008-11-25 | 츄가이 세이야꾸 가부시키가이샤 | Degraded agonist antibody |
AU2002210918B2 (en) | 2000-10-20 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | Degraded agonist antibody |
RU2287534C2 (en) | 2000-10-20 | 2006-11-20 | Тугаи Сейяку Кабусики Кайся | Degraded antibody as tpo agonist |
EP1327680B1 (en) * | 2000-10-20 | 2008-04-02 | Chugai Seiyaku Kabushiki Kaisha | Modified tpo agonist antibody |
EP2075256A2 (en) | 2002-01-14 | 2009-07-01 | William Herman | Multispecific binding molecules |
AU2003271175A1 (en) | 2002-10-11 | 2004-05-04 | Masahiro Abe | Cell death-inducing agent |
JP2004279086A (en) | 2003-03-13 | 2004-10-07 | Konica Minolta Holdings Inc | Radiation image conversion panel and method for manufacturing it |
US20070003556A1 (en) * | 2003-03-31 | 2007-01-04 | Masayuki Tsuchiya | Modified antibodies against cd22 and utilization thereof |
US8613922B2 (en) | 2003-04-24 | 2013-12-24 | The University Of North Carolina At Chapel Hill | Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP) |
KR20060121150A (en) * | 2003-11-11 | 2006-11-28 | 추가이 세이야쿠 가부시키가이샤 | Humanized anti-cd47 antibody |
TW200530266A (en) * | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Method of reinforcing antibody activity |
TW200530269A (en) | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
JPWO2005056602A1 (en) * | 2003-12-12 | 2008-03-06 | 中外製薬株式会社 | Screening method for modified antibodies having agonist activity |
CA2548929A1 (en) * | 2003-12-12 | 2005-06-23 | Chugai Seiyaku Kabushiki Kaisha | Cell death inducing agent |
US9493569B2 (en) | 2005-03-31 | 2016-11-15 | Chugai Seiyaku Kabushiki Kaisha | Structural isomers of sc(Fv)2 |
EP1927367A4 (en) * | 2005-05-18 | 2009-08-12 | Univ Tokushima | Novel pharmaceutical using anti-hla antibody |
CN101237890A (en) | 2005-06-10 | 2008-08-06 | 中外制药株式会社 | Stabilizer for protein preparation comprising meglumine and use thereof |
CN101262885B (en) | 2005-06-10 | 2015-04-01 | 中外制药株式会社 | Pharmaceutical compositions containing sc(Fv)2 |
WO2007033221A2 (en) * | 2005-09-13 | 2007-03-22 | The General Hospital Corporation | Methods and compositions for inhibition of immune responses |
WO2008007755A1 (en) * | 2006-07-13 | 2008-01-17 | Chugai Seiyaku Kabushiki Kaisha | Cell death inducer |
CL2008000719A1 (en) * | 2007-03-12 | 2008-09-05 | Univ Tokushima Chugai Seiyaku | THERAPEUTIC AGENT FOR CANCER RESISTANT TO CHEMOTHERAPEUTIC AGENTS THAT UNDERSTAND AN ANTIBODY THAT RECOGNIZES IT CLASS I AS ACTIVE INGREDIENT; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH ANTIBODY; AND METHOD TO TREAT CANCER RESISTANT TO |
SI4160212T1 (en) | 2008-01-15 | 2024-06-28 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
PT3056515T (en) * | 2008-01-15 | 2019-07-19 | Univ Leland Stanford Junior | Methods for manipulating phagocytosis mediated by cd47 |
US8951527B2 (en) | 2008-08-07 | 2015-02-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Radioprotectants targeting thrombospondin-1 and CD47 |
BR112014019331A2 (en) * | 2012-02-06 | 2022-07-12 | Inhibrx Inc | cd47 antibodies and methods of use of these |
SG11201504469XA (en) | 2012-12-12 | 2015-07-30 | Vasculox Inc | Therapeutic cd47 antibodies |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
JP6885606B2 (en) | 2015-09-18 | 2021-06-16 | アーチ オンコロジー, インコーポレイテッドArch Oncology, Inc. | Therapeutic CD47 antibody |
EP3484448A4 (en) | 2016-07-13 | 2020-04-01 | President and Fellows of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
WO2018075960A1 (en) | 2016-10-21 | 2018-04-26 | Tioma Therapeutics, Inc. | Therapeutic cd47 antibodies |
AR113862A1 (en) | 2017-12-01 | 2020-06-17 | Seattle Genetics Inc | ANTI-CD47 ANTIBODIES AND THEIR USES TO TREAT CANCER |
CN110066336B (en) * | 2019-05-12 | 2021-11-09 | 杭州科兴生物科技有限公司 | anti-CD 47 monoclonal antibody, fragment and medical application thereof |
IL312302A (en) | 2021-10-28 | 2024-06-01 | Lyell Immunopharma Inc | Methods of generating cells |
WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2150262C (en) * | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
UA50708C2 (en) * | 1993-09-03 | 2002-11-15 | Чугай Сейяку Кабусікі Кайся | Monoclonal antibody that is able to recognize an antigen that induces apoptosis in the myelocytic cell, the fragment f(ab)2 of the monoclonal antibody, the hybridoma ferm bp-4382 |
US6719972B1 (en) * | 1994-06-03 | 2004-04-13 | Repligen Corporation | Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies |
US5885574A (en) * | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
WO1997032601A1 (en) * | 1996-03-06 | 1997-09-12 | Chugai Seiyaku Kabushiki Kaisha | Method of screening apoptosis inducing substances |
US7531643B2 (en) * | 1997-09-11 | 2009-05-12 | Chugai Seiyaku Kabushiki Kaisha | Monoclonal antibody inducing apoptosis |
US7696325B2 (en) * | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
-
1998
- 1998-09-11 KR KR10-2004-7019086A patent/KR20040106585A/en active IP Right Grant
- 1998-09-11 PL PL98339265A patent/PL339265A1/en unknown
- 1998-09-11 CN CNB988103435A patent/CN1198845C/en not_active Expired - Fee Related
- 1998-09-11 WO PCT/JP1998/004118 patent/WO1999012973A1/en active IP Right Grant
- 1998-09-11 CA CA002303072A patent/CA2303072A1/en not_active Abandoned
- 1998-09-11 AU AU90028/98A patent/AU740225B2/en not_active Ceased
- 1998-09-11 EP EP98941848A patent/EP1035132B1/en not_active Expired - Lifetime
- 1998-09-11 AT AT98941848T patent/ATE395362T1/en not_active IP Right Cessation
- 1998-09-11 RU RU2000109293/13A patent/RU2212413C2/en not_active IP Right Cessation
- 1998-09-11 HU HU0003513A patent/HUP0003513A3/en unknown
- 1998-09-11 DE DE69839492T patent/DE69839492D1/en not_active Expired - Lifetime
- 1998-09-11 KR KR1020007002548A patent/KR20010023866A/en not_active Application Discontinuation
-
2000
- 2000-03-07 SK SK323-2000A patent/SK3232000A3/en unknown
- 2000-03-09 NO NO20001238A patent/NO20001238L/en unknown
-
2003
- 2003-03-10 US US10/383,512 patent/US20030157100A1/en not_active Abandoned
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