RU1801489C - Method for treatment pigment gelbert hepatitis at children - Google Patents

Abstract

The invention relates to medicine and can be used to treat Gilbert hepatitis in children. The aim of the invention is to extend the duration of remission. This is achieved by administering benzobamil and peppermint in therapeutic doses in combination with a biomed in a dose of 0.2 ml for children up to 5 years old and a dose of 0.1 ml for children over 5 years old for 15 days. The invention allows to extend the remission time by 2.6 times in comparison with the known method. 1 tab.

Description

The invention relates to medicine and relates to methods for treating liver disease in children.

An object of the invention is to increase the effectiveness of treatment conduction by lengthening the duration of remission.

Benzrbamil belongs to the group of drugs inducing microsomal liver enzymes involved in the biotransformation of bilirubin and bile acids; In this case, the conjugate of bilirubin is accelerated in sick children with Gilbert syndrome. It has been experimentally established that benzobamyl stimulates the reactions of the 1st phase of biotransformation, as a result of which the final products of bilirubin conversion become more hydrophilic in comparison with the initial products. This contributes to a significant acceleration of the second phase of biotransformation, the products of which are conjugates with glucuronic acid, which are rapidly excreted from the body. As a result, in patients with Gilbert's syndrome, children normalize serum bilirubin levels and detoxify bile acids. It is established that benzobamyl is less toxic than phenobarbital and therefore its use in children is preferable.

Bio-neighbor is an aqueous extract of grass with a large ocelot, approved for clinical use (instruction of the Ministry of Health of the USSR of 06/08/1986). The drug has a pronounced biostimulating effect, enhances the regeneration processes, has an anti-inflammatory and tonic effect. The bioseed is approved for use in children of various ages.

As a result of experimental and clinical studies, it was shown that the bioseed is able to stimulate metabolic processes, in particular protein biosynthesis in the liver and with

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administration with benzobamyl potentiates its effect on the monooxygenated system and prevents the development of undesirable side effects.

This list has choleretic, antispasmodic and sedative effects. When prescribing to children with Gilbert's syndrome, infusion of peppermint leaf has a positive effect in the presence of biliary dyskinesia, improves bile secretion, and relieves the spastic state of the biliary tract. In addition, peppermint leaf infusion has a good anti-inflammatory effect, as well as a healing effect, which contributes to the elimination of the concomitant pathology of the gastrointestinal tract (duodenitis, cholecystitis), which are found in most patients with Gilbert's syndrome in children.

The combination of peppermint and bioseed leads to the elimination of astheno-vegetative symptoms.

The proposed method is based on the results of experimental and clinical studies, which made it possible to develop a pharmacological correction scheme for all the main parts of the pathological process in case of pigmented hepatosis (Gilbert’s syndrome), while the mutual potentiation of the effect of the bioseed, peppermint and benzobmils, which ensures the achievement of the purpose of the invention, is improved the effectiveness of the treatment by extending the remission period.

. The method is as follows

When a patient is diagnosed with Gilbert's pigmented hepatosis in the acute phase, with clinical symptoms (icteric sclera, increased levels of free bilirubin, as-vegetative disorders, dyspeptic disorders), benzobamil is prescribed at 0.05 g (1/2 tablet) 3 times a day D for 10 days, injections of a bioseed. intramuscularly, 0.2 ml for children under 5 years of age and 1.0 ml for children over 5 years of age per day, for 15 days, infusion of peppermint leaf, 1 tablespoon 3 times a day 15 minutes before meals for 15 days in the form of heat (5.0-200.0).

When developing the proposed method, the results of clinical observations of 28 children with a diagnosis of pigmented hepatosis Gilbert aged 3 to 15 years were analyzed, of which 14 received treatment according to the proposed method and 14 according to the existing one (prototype). Both groups of children were comparable in age, gender, and clinical symptoms of hepatosis. The diagnosis is confirmed in all cases.

by ultrasound, and in some cases by puncture biopsy of the liver.

As the table suggests. Method for the treatment of pigmented hepatosis

0 Gilbert in children has significant advantages over the existing one, which is confirmed by the results of statistical processing.

A comparison of a number of factors of immune and metabolism suggests that the immuno-biochemical parameters of the proposed method tend to normalize, while in the treatment according to the existing method they remain altered.

The average duration of remission after the proposed method of treatment is 2.6 times greater than when using the existing method.

5 Thus, the clinical observations made suggest that the proposed method for the treatment of Gilbert's pigmented hepatosis has significant advantages over the existing one and implements the goal of the study - to increase the effectiveness of the treatment in children by extending the remission period.

PRI me R 1. Taking into account the family history and clinical and laboratory data in a child N., 14 years old, the diagnosis of pigment hepatosis Gilbert in the acute phase is established. He was prescribed treatment with benzobamil at 0.05 g 3 times a day, biomed in 0.2 ml intramuscularly and infusion of peppermint leaf 1 tablespoon 3 times a day 15 minutes before meals (5.0-200.0).

The duration of treatment with benzobamil was 10 days, peppermint infusion and biosed were prescribed for 15

5 days...

Under the influence of the treatment, the condition of the child has significantly improved. On the 10th day of treatment, the serum bilirubin level decreased from 45.6 mmol / L to 16.8

0 mmol / L, no bound fraction was present. The appetite normalized on the 5th day of treatment, the severity in the right hypochondrium disappeared on the 6th day of the treatment. The manifestations of astheno-vegetative syndrome are also

5 disappeared on the 6th day. On the 10th day of treatment, the liver was located at the edge of the costal arch (before the treatment it protruded 2-3 cm from under the edge of the costal arch), there was no sensitivity at the Kera point. After 10 days of treatment, the yellowness of the sclera disappeared.

The child was discharged home in satisfactory condition. No exacerbations were observed during the year after discharge during the follow-up period.

Example 2. In a child K., 14 years old, on the basis of the family history and the results of clinical and laboratory studies, the diagnosis was made: Gilbert's pigmented hepatosis. Prescribed treatment: benzene with 0.05 g 3 times a day for 10 days, biomed in 1.0 ml intramuscularly for 15 days, infusion of peppermint leaf (5.0-200.0) in 1 tablespoon 3 times a day in the form of heat 15 minutes before meals: for 15 days.

Under the influence of the treatment, the condition of the sick child has improved significantly. On the 10th day of therapy, the serum bilirubin level decreased from 22.4 mmol / L to 20.3 mmol / L, on the 15th day - to 16.8 mmol / L, there was no associated fraction. On the 5th day of treatment, the severity in the right hypochondrium disappeared, on the 10th day, the yellowness of the sclera. Astheno-vegetative disorders disappeared on the 6th day of treatment according to the proposed method.

With repeated duodenal sounding in portion C, single leukocytes (before treatment, 10-20 leukocytes). The child was discharged home in satisfactory condition. An exacerbation of the disease was noted 6 months after discharge from the hospital and was associated with a past respiratory viral infection. Assigned

treatment as proposed

in a way that gave a good result.

Thus, the proposed method

It has an advantage over the existing one, expressed in increasing the effectiveness of the therapy by extending the time of remission, which indicates the achievement of the goal of the study.

Moreover, when using the proposed method, there were no undesirable side effects when prescribing drugs, while in the group of children treated by the existing method, 4 people reported adverse reactions in the form of dizziness, nausea, and vomiting. In the treatment according to the proposed method, widely available domestic preparations are used, which makes

it is possible to use the method in hospitals, outpatient facilities of the country.

Claims (1)

SUMMARY OF THE INVENTION A method for treating Gilbert's pigmented hepatosis in children, comprising administering barbiturates and herbal choleretic drugs, and also with the fact that, in order to extend the duration of remission, benzobamyl and peppermint infusion are administered in therapeutic doses in combination with a bioseed at a dose of 0.2 ml for children under 5 years of age and at a dose of 0.1 ml for children over 5 years of age for 15 days.