RU1801382C - Method for medicinal agent injection into lymphatic system - Google Patents

Abstract

The invention relates to medicine and can be used in intensive care in adults and children. The aim of the proposed invention is to reduce side effects, eliminate complications, simplify the procedure for administering drugs to the lymphatic system and reduce the time of manipulation. The essence of the invention lies in the fact that the drug is administered intradermally, while it is proved that the administered drug accumulates and is retained in the lymphatic system for a period of more than 24 hours.

Description

The invention relates to medicine and can be used in intensive care in adults and children.

The aim of our invention is to reduce side effects, eliminate complications and reduce the time of manipulation.

The goal is achieved. that the drug is administered intradermally. In this case, the drug accumulates in the lymphatic system, its therapeutic effect is maintained and increased.

From the literature on the structure and anatomy of the lymphatic system, it is known that lymphatic capillaries are maximally represented in the thickness of the skin. Therefore, it can be considered that the drug administered intradermally will be maximally concentrated in the lymphatic system. It is checked by us in

animal experiments (white rats).

Experiment Ne 1. A 0.5% solution of methylene blue in a 0.5% solution of novocaine in a volume of 1 ml was injected intradermally to laboratory animals. After 2 hours, the animals are slaughtered. In the lymphatic. In the pelvic, abdominal, and paro-aortic nodes, methylene blue inclusions were detected. Another group of animals was sacrificed after 24 hours; Lymphatic nodes of the pelvis, abdominal cavity, paro-aortic intensively stained with methylene blue.

Experience No. 2. In laboratory animals under local anesthesia with a 0.5% solution of novocaine 1 ml, a femoral vein was isolated, 1 ml of 0.5% methylene blue in a 0.5% solution of novocaine was introduced into it. After 2 hours, part of the animals were killed, with a microscopic examination of the central

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No lymph, no pelvic lymph nodes, no methylene blue abdominal cavity, no dye was detected after 24 hours of slaughter of the remaining animals.

Test No. 3. Laboratory animals in the middle third of the right thigh were injected intramuscularly with 1 ml of 0.5% methylene blue in a 0.5% solution of novocaine. The thigh was pressed proximal to the injection site for 3 hours using a hollow rubber sleeve connected to a blood pressure monitor (40 mmHg). After 2 hours, five animals were slaughtered. Microscopic examination of the lymph nodes of the pelvis and abdominal cavity revealed rare inclusions of methylene blue. Some animals were killed after 24 hours. Microscopic examination of the central lymph did not reveal any dye. In the lymph nodes of the pelvis, abdominal cavity, isolated inclusions of methylene blue are noted.

Thus, it was found that when the drug was injected intradermally, it enters the lymphatic system and remains there for at least 24 hours. When administered intramuscularly and by creating a compression proximal to the injection site, the amount of indicator in the lymphatic system is much smaller and after 24 hours it is practically there not defined. With the intravenous administration of the drug in the lymphatic system was not found.

 Therefore, the literature data on the structure of the skin and our experimental studies confirm the possibility of endolymphatic administration of drugs, for example, antibiotics, by their intradermal administration.

Our proposed method is carried out as follows.

A drug, in this case an antibiotic, at a concentration of 1-3% (daily dose) in a 0.5% solution of novocaine is administered intradermally along the anterolateral surface of the chest to the right and left from 2-3 to 9-10 ribs with diseases of the organs of the chest, the injection site is selected taking into account lymphocycle circulation, or into the anteroposterior surface of the thighs with diseases of the abdominal cavity and pelvis, or damage to the lower extremities. Injections are made so that they form a continuous path, the volume of the drug for each injection is 1-2 ml, the total volume of the injected solution is 0.5-1.5 ml / kg of the patient’s body weight, the number of injections depending on the patient’s weight and body from 4-5 to 12-15 on each side of the chest or in each thigh. Visual monitoring of intradermal drug delivery is the formation of a lemon peel. The skin after injection is covered with a bactericidal film of Lifusol. The drug is administered in a daily dosage, once a day, from three to five days. The time spent on manipulation is 15-20 minutes.

36 patients (12 adults and 24 children of different ages) were treated with this method against the background of complex therapy.

PRI me R 1. Sick P., 29 years old, body weight 64 kg Diagnosis: obstetric sepsis, bilateral drainage pneumonia, posthypoxic encephalopathy. She entered the intensive care unit and intensive care unit from the hospital. Intensive therapy was continued, including intravenous and intramuscular administration of antibiotics, but without a noticeable clinical effect. In the intensive care unit and

of intensive care for the antibacterial treatment of sepsis and pneumonia in the intensive care complex, intradermal administration of gentamicin 6 mg / kg of body weight in a 0.5% solution of novocaine along the midline on both sides (22 ml on each side, in 14 injection x). Manipuli qi was carried out daily for 5 days. On the third day after the start of daily intradermal

injection, the patient's body temperature returned to normal, and the indicators of the internal environment of the body improved significantly. Radiologically and clinically, the stand was positive dynamics. At 9

day the patient was transferred to the specialized department, the condition is satisfactory during the transfer.

Example 2. Patient M., 2 years old, body weight 14 kg, was in very serious condition in the intensive care unit and intensive care of children with a diagnosis of influenza (toxic form), neurotoxicosis, bilateral pneumonia with ob- structural syndrome, myocarditis. On the

amikacin was administered intradermally at a dose of 12 mg / kg body weight on a 0.5% solution of novocaine (10 ml each side, in 8

injections x) daily for 4 days. On the first day the patient underwent mechanical ventilation in connection with severe respiratory failure. Against the background of intradermal injections of the antibiotic, positive dynamics were noted (decrease in body temperature, intoxication), the general condition and the radiological picture of the lungs improved. On the fifth day, the child was transferred to the pediatric ward in satisfactory condition -

Research institutes.

Example 3. Patient E., age 3 days, body weight 3 kg I was in the intensive care unit of newborns in a serious condition due to intrauterine infection, bilateral bronchopneumonia, post-hypoxic encephalopathy. Amikacin was administered intradermally along the front axial line at the left and left at a dose of 12 mg / kg body weight 0.5% novocaine (6 ml on each side, in 6 injections), daily for 4 days. On day 3, body temperature returned to normal, and the amount of purulent sputum decreased significantly. On the 8th day, the child's condition is satisfactory, transferred to the somatic department, from where he was discharged home after three days.

When using the method of our proposed method, no complications were detected in patients of different ages and with various pathologies.

When using intradermal antibiotics, the number of days spent by the patient in the intensive care unit decreased compared with the control group. The control group consisted of patients with a similar pathology who did not receive antibiotics during the course of complex therapy.

The average bed day in patients to whom the proposed method was applied was: adults 10 ± 2 bed days, children

from one year to ten years 6 ± 1 bed-day, newborns 9 ± 2 bed-day. The average bed day in patients of the control group was: adults 19 ± 4 bed days, children from one to ten years of age 14 ± 5 bed days, newborns 22 ± 6 bed days.

On the background of intradermal administration of antibiotics in patients, the body temperature returned to normal on the third or fourth day, the parameters of homeostasis and the radiological picture of the lungs improved significantly. In the course of complex therapy, but without intradermal administration of antibiotics, body temperature returned to normal on the fifth to seventh day, homeostasis improved on the fourth to sixth day, and positive dynamics in the X-ray picture of the lungs was observed only on the eighth to tenth day.

Thus, intradermal administration of drugs, e.g. antibiotics, can be used as a method of endolymphatic therapy (indirect administration to the lymphatic system).

The method is simple, safe and has a pronounced therapeutic effect. No complications associated with its use were found.

Claims (1)

SUMMARY OF THE INVENTION A method of administering a drug to the lymphatic system by injecting the drug into body tissues, characterized in that, in order to reduce complications by eliminating microcirculation disturbance, the injection is carried out intradermally.