RU1801011C - Method of endoprosthesis contrasting - Google Patents

Abstract

Scope: the invention relates to the field of medicine, namely X-ray diagnostics. The purpose is to improve the quality of the implantable prosthesis. Summary of the invention: the porous carbon material is ground, mixed with a 38% solution of verographin or triombrast, followed by compression. Positive effect: obtaining a high-quality image of the endoprosthesis on the radiograph, which allows you to monitor the condition of the implant during and after surgery. 3 ill.

Description

The invention relates to medicine, to methods of medical examination with a diagnostic purpose, namely to x-ray diagnostics, can be used when using carbon implants in traumatological and orthopedic practice.

In order to eliminate negative phenomena over the past 5-6 years, the development and application of polymer fixatives such as ceramics, carbon and others in the trauma and orthopedic practice has begun.

Experimental and clinical studies of domestic authors have shown that carbon materials have biocompatibility and stability, satisfactory static and dynamic properties, as well as great promise for endoprosthetics of bones and substrates. It is also emphasized that carbon implants do not have radiopacity. This property of carbon implants is also confirmed by our experimental studies. Transplanted carbon implants in various shapes and sizes do not radiologically differentiate due to their natural non-radiopacity.

The purpose of the invention is to obtain an X-ray contrast carbon implant with a better image on the radiograph, which will allow monitoring the state of the implant after surgery and in dynamics.

To achieve this goal, a method has been developed for the manufacture of a contrasted carbon implant by grinding a porous carbon material, such as synthetically into a powder form and mixing with a contrast agent. Verografin and triombrast used in the form of contrast agents, tested in the form of 76%

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diluted with physiological saline (0.9% sodium chloride solution) in a ratio of (1: 1) -38% verographin and triombrast.

Upon receipt of the contrasted carbon implant, the following ratios of the mixture components were selected:

1.7 g of carbon material + 5.85 g of a 76% triombrust solution,

2.7 carbon material + 5.85 g of a 38% triombrust solution

3.7 g of carbon material + 5.85 g of a 76% solution of verographin,

4.7 g of carbon material + 5.85 g of a 38% solution of verographin.

After mixing the components, the mixture was naturally dried (at room temperature) for 5-6 hours. Then, using a special apparatus for the manufacture of medical tablets, compressed contrasted carbon tablets of 0.35 g in diameter of 9 mm and a thickness of 4 mm were made.

The radiographs of these tablets showed an excellent contrasting image of them, even after repeated x-ray examinations after several months.

The method is illustrated in Figs. 1-3.

Figure 1: 1-image of a contrasted carbon material in a ratio of 7 g of carbon + 5.85 g of a 76% solution of triombrast in the form of 3 116 pressed tablets of 0.35 g; figure 2-image of the contrasted carbon material in the ratio of 4.6 g of carbon + 1.9 g of 76% triombrost solution, where the contrast and density of the tablets are slightly less pronounced than with the ratio of ingredients 7: 5.85; in Fig. 3, the non-contrastable carbon material does not differentiate at all.

Figure 2 clearly differentiates the image of contrasted carbon tablets against the background of bony and soft tissues of a rabbit forearm.

The invention is also illustrated by the following experimental data.

The studies were carried out using carbon implants on 15 chinchilla rabbits weighing 2.5-3 kg. Under general anesthesia with an electric drill, a bone canal with a diameter of 3 mm was created in the intertrochanteric region

the femur and an X-ray contrast carbon implant was inserted into this canal. The morphological picture of bone tissue was studied on 14,30,60,90,120 and 180 days after

operations. Slices 5-7 μm thick were taken from the central regions of the regenerate, stained with hematoxylin-eosin and according to Van Gieson. On histological preparations, the structural components of bone regeneration were evaluated at the stages of bone defect repair. In histological preparations, the study focused on the state of the vessels and the inflammatory process around the implanted carbon tissue and on reparative osteogenesis. Microphotographs of histological sections were performed on an MKU-1 setup. When examining a bone block 14 days after surgery, it was found that

the boundary between the carbons and the bone tissue, carbon particles were detached during implant insertion and there is a bone tissue regenerate consisting of immature beams with particles in it. On the 21st day after the operation, the growth of chondroid tissue with the formation of bone plates is observed. Dusty remnants of a carbon implant in osteoid tissue, among which thin randomly located primitive bone plates and small areas of chondrogenesis are visible. On the whole day, growth of chondroid, fibrous and bone tissue was noted with inclusion

small grains of carbon without an inflammatory reaction. Visible are small sections of grains and the remnants of a carbon implant (FIG. 3). 3 months after surgery on histological preparations, formation is visible

osteoids of newly formed bone tissue. Tender bone plates are separated by a bone marrow substance with well-defined hematopoiesis.

Thus, the proposed method

Claims (1)

allows you to get a better image on the x-ray. SUMMARY OF THE INVENTION A method for contrasting endoprostheses using iodocontrast preparations, characterized in that, in order to increase the contrast of endoprostheses from a carbon porous material, it is crushed, mixed with a 38% solution of verographin or triombrust then molded. fte.2 h "Re-3