RU1796179C - Compound for remineralization of dental enamel - Google Patents

Abstract

Usage: in medicine, in particular in dentistry. The purpose of the invention is to increase the adhesion of the gel to the teeth and to provide a prolonged release of protium against carious agents. The essence of the proposal lies in the fact that the polyelectrolyte complex is taken in a certain composition and quantitative limits. The advantage of the proposal is in improving the functional results.

Description

The invention relates to medicine, in particular to therapeutic dentistry and can be used for the prevention and treatment of dental caries.

The development of anti-caries prophylactic agents is an urgent task in connection with the high prevalence of dental caries.

Of the therapeutic agents for mineralizing teeth in the form of powders, varnishes, gels, and mouthwashes, gels are more promising. These include carboxymethyl cellulose gels containing anti-caries fluoride, calcium and phosphorus compounds.

The closest solution is a composition (gel) for mineralization of teeth based on a polyelectrolyte complex of polyethyleneimine and polyacrylic acid, taken in the ratio of 1: 1.5 anti-caries compounds, sodium lignosulfonate as a crosslinking agent and water. As anticariogenic compounds, zinc chloride, calcium chloride, strontium chloride, sodium phosphate disubstituted, potassium phosphate monosubstituted, sodium glycerophosphate, sodium monofluorophosphate are used.

However, this agent has insufficient adhesion to the teeth at the time of application and accordingly requires technical skill to reduce the number of clinical procedures.

The aim of the invention is to increase the adhesion of the gel to the teeth and to provide a prolonged release of anticaries agents.

The indicated goal is achieved by that. that in the dental composition to prevent demineralization and remineralization of tooth enamel, containing as its base a polyelectrolyte complex and compounds of calcium, zinc, phosphorus and water, a distinctive feature is that the polyelectrolyte complex contains copolymer M, M-dimethyl-Y. M diallylammonium chloride with M, M-dimethyl-M, diallylammonium dihydrogen phosphate. cellulose sulfate and polyacrylic acid, and, as Calcium and Zinc Compounds, their citrate salts in the following ratio of components, May. %:

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ABOUT

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The copolymer M, hL-dimethyl-M, M-diallylammonium chloride with M, M-dimethyl-M, M-diallyldihydrophosphate composition 3/97, respectively / CPL / 25-30 Cellulose sulfate / SC / 3.5-4, 0 Polyacrylic acid / PAA / 30-40 Zinc citrate / L Zn / 1-3 Calcium citrate / LSa / 3-4 Water Else It has been found that when the copolymer and polyacrylic acid are mixed, a gel is formed that is well distributed on the teeth. Further, as it is wetted with water or saliva, a polyelectrolyte complex is formed, which contributes to the further strengthening of the gel coating on the teeth.

Quantitative molar ratios of polyacids and polybases are selected from the condition of the most complete interaction of these components during complex formation, equal to 1: 1. When deviating from the selected limit, the quantitative ratio between the components of the complex with polyacid and polybase / below CPL is 25 wt.%, PAA is 30 wt.%, SC is 3.5 wt.% And above CPL is 30 wt.%, PAA is May 40 . %, SC - May 4. % / amount of complex formed decreases, resulting in a decrease in gel adhesion to teeth (see table).

Dimethyldiallylammonium chloride copolymer with dimethyldiallylammonium dihydrogen phosphate and a method for its preparation.

Example 1. A dental gel preparation is prepared by adding calcium citrate and zinc to other copolymer and polyacrylic acid solutions. Next, the prepared mixtures of polybases and polyacids are thoroughly mixed to obtain a fibrous mass and applied to the previously cleaned tooth surface.

Viability / working time / 8 min. The components are taken in the following proportions, wt.% :. A copolymer of composition 3/97 25 Polyacrylic acid 30 Cellulose sulfate 3.5 Calcium citrate 3 Zinc citrate 1 Water 37.5 Example 2 Same as Example 1 except that the components are taken in the following proportions:.

Composition copolymer 3/97 30 Polyacrylic acid40 Cellulose sulfate 4 Calcium citrate 4 Zinc citrate 3

Water 29 PRI me R 3. Similar to example 1 except that the components are taken in the following proportions: Copolymer composition 3/97 27.5 Polyacrylic acid. 35 Cellulose sulfate 3.75 Calcium citrate 3.5 Zinc citrate 2 Water 28.25

PRI me R 4. Similar to example 1 except that the components are taken in the following proportions :.

A copolymer of the composition .50 / 5030 Polyacrylic acid 40 Cellulose sulfate 4. Calcium citrate 4 Zinc citrate 3 Water 29 EXAMPLE 5. It is similar to Example 1 except that 30 wt.% Polyacrylic acid and 3.5 wt.% Cellulose sulfate are taken from 30 wt.% Of the copolymer. Pot life 6-7 minutes. Example 6. Similar to example 1 except that 25 wt.% Of the copolymer take 40 wt.% Polyacrylic acid and 4 wt.% Cellulose sulfate. Pot life 8 min. Example 7. Similar to example 3 except that 30 wt.% Polyacrylic acid and 4 wt.% Cellulose sulfate are taken from 27.5 wt.% Of the copolymer / composition of the copolymer in the last three examples 3/97 /. Pot life of 8 minutes.

The use of a gel-based agent provides a longer duration of action of anticaries agents due to adhesion of the coating to the teeth, which makes it possible to reduce the number of clinical procedures.

Numerous kinetic measurements have shown that the rate of release of major anti-caries. agents / calcium, ion phosphate / from the gel agent are constant for 5-8 hours, which allows maintaining the necessary therapeutically effective concentrations that prevent demineralization of tooth enamel and contribute to their faster remineralization.

Patient B., aged 20, was admitted July 14, 87 to the Central Scientific Research Institute for Hygiene with a diagnosis of caries 31. Tzubov. In the stage of white spot. A 31.31-tooth patient was given a gel containing CPF — 25%, polyacrylic acid 30%, cellulose sulfate 3.5%, calcium citrate 3%, zinc citrate 1%, water 37.5% for 6 hours;

After 4 applications, the white spot disappeared.

Claims (1)

SUMMARY OF THE INVENTION Composition for remineralizing tooth enamel containing, as a base, a polyelectrolyte complex, cellulose sulfate and polyacrylic acid, and, as an anti-variotic compound, cal-Qi, zinc, phosphorus compounds, characterized in order to increase gel adhesion to teeth and providing a prolonged release of anticariogenic agents, the polyelectrolyte complex contains a copolymer of M, M-dimethyl-M, M-diallylammonium chloride with M, M-dimethyl-M, M-diallylammonium hydrophosphate, and as compounds calcium and zinc - their citrate salts in the following ratio of components, wt%: Copolymer of N.N-dimethyl-M.M-diallylammonium chloride with N.N-dimethyl- N.N-diallylammonium dihydrogen phosphate 25-30 Polyacrylic acid 30-40 Cellulose sulfate 3.5-4.5 Calcium citrate 3-4 Zinc citric acid 01-3 Water Rest