RU1784920C - Optoelectrical hemocoagulograph - Google Patents

Abstract

Usage: the invention relates to the field of medical technology and can be used for clinical diagnostics in the field and experimental research of the blood coagulation system. Essence: a hollow optical fiber 8 is installed in the cuvette, connected by a pipe 9 to the first 10 and second 11 pumps. The piston of the latter is connected by a crank mechanism 12 to an electric motor 13, and an optical fiber 1 and coaxial coaxial electrodes 15 and 16 connected to the source 17 of the electric volume are located in the bottom of the cuvette. 1 ill.

Description

The invention relates to medical technology and can be used for clinical diagnosis and experimental study of a blood coagulation system.

Known methods for studying blood coagulation when exposed to an electromagnetic field.

The disadvantage of these methods is the low accuracy, since with the same parameters of physical impact (50-170 Oe) the methods give opposite results.

A known method for determining platelet aggregation activity is based on measuring the absorption of optical radiation.

The disadvantage of this method is the inability to determine aggregation activity when exposed to physical factors.

There is also known a device for examining blood properties, comprising a cuvette with a magnetic stirrer, a thermostat, an optical channel consisting of a light source, a filter and a light detector, a recorder and a device for generating pressure.

The disadvantage of this device is its low accuracy, since the contact of the substrate with the magnetic stirrer changes the biological properties of the blood, and the long optical path does not allow the study of the coagulation process of blood, which has high light absorption.

 The aim of the invention is to increase the reliability of measurement results and expand the diagnostic capabilities of the device.

This is achieved by placing a hollow fiber connected to W

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a pipeline with the first - installation, and the second - working, pumps, the piston of the latter is connected by a crank mechanism with an electric motor. a layer, and in the bottom of the cuvette there is an optical fiber and coaxial electrodes coaxial with it, connected to an electric current source.

The drawing shows a block diagram and .JQ design features of an electro-optic hemocoagulograph.

The electro-optical hemocoagulograph consists of a cuvette 1 placed in a thermostat 2, a light source 3, a light filter A, a photodetector 5, an electric amplifier 6 connected to a recorder 7; a hollow fiber 8 is connected to the cuvette and connected to the substrate slots, and the recorder detects oscillations of the output signal with a constant amplitude. If on the liquid substrate the optical properties change (for example, during aggregation, agglutination, deposition of blood cells, etc.), a corresponding change in the magnitude of the electric signal occurs. During gel formation, the viscosity of the substrate and the resistance to movement of the gas cavity increase. Therefore, the amplitude of the signal oscillations decreases and, when a bunch forms, becomes minimal. The magnitude of this amplitude will ultimately be determined by the density and elasticity of the formed bunch, i.e. factors

piping 9 with installation 10 and affect how the gas boundary mixes

we flank 11 pumps, the piston of the latter is connected by a crank mechanism 12 to an electric motor 13; in the bottom of the cell there are optical cavities along the axis of the optical radiation.

When connecting an electric current source 17 to the electrodes 15, 16

KI optical fiber And and coaxial with it coak-25 it is possible to evaluate cell reactivity

sleeping electrodes 15, 16 connected to an electric current source 17.

Electro-optical hemocoagulograph works as follows. thirty

The cuvette 1 is filled with a coagulating substrate (blood, plasma rich and poor in platelets), and a hollow fiber 8 is placed in it. Using the installation pump 10, excess pressure is created in the light-jg water 8 and, therefore, is formed at its end immersed in the substrate gas hootiness. (In this case, the thickness of the substrate is the formation of a blood clot and its mechanical properties when exposed to a standard irritant.

Electro-optical hemocoagulogra has significant differences compared with the known device: biological processes are recorded in media with any optical density (in blood, plasma, rich and poor in platelets), during the measurement, no blood components are subjected to mechanical effects of a magnetic stirrer, aggregation blood cells, the formation of a clot and its mechanical

substrate, and the recorder detects fluctuations in the output signal with a constant amplitude. If optical properties change on a liquid substrate (e.g., during aggregation, agglutination, deposition of blood cells, etc.), a corresponding change in the magnitude of the electrical signal occurs. During gel formation, the viscosity of the substrate and the resistance to movement of the gas cavity increase. Therefore, the amplitude of the oscillations of the signal decreases and, when a clot forms, becomes minimal. The magnitude of this amplitude will ultimately be determined by the density and elasticity of the formed bunch, i.e. factors that

affect how the gas boundary mix

cavities along the axis of the optical radiation.

When connecting an electric current source 17 to the electrodes 15, 16,

blood clot formation and its mechanical properties when exposed to a standard irritant.

The electro-optical hemocoagulograph has significant differences compared with the known device: biological processes are recorded in media with any optical density (in blood, plasma, rich and poor in platelets), during the measurement, the blood components are not subjected to mechanical effects of a magnetic stirrer, aggregation of blood cells, clot formation and its mechanical

The gate through which optical properties pass is determined upon exposure

Some radiation from source 3, the reduced standard physical, is irritated. A photodetector 5 (for example, a l. Photodiode) converts optical radiation into an electric signal, and it goes to an amplifier 6, and then to a recorder 7 о. After turning on the electric motor 13, the piston of the second working one, the pump 11 makes reciprocating movements in the cylinder, and in hollow fiber variable pressure occurs. Under the influence of this pressure, the boundary of the gas cavity oscillates, periodically changes the length of the optical path of the beam in the substrate.

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Claims (1)

The claims An electro-optical hemocoagulograph containing a cuvette, a light source, a light filter, a photodetector, an amplifier placed in a thermostat, as well as a first pump with a pipeline, are necessary for the purpose of increasing the reliability of measurement results and expanding diagnostic capabilities, contains the second pump, and the cuvette has the postal and mechanical properties i 55 a light guide, the connected pipe substrate remains unchanged, with the first and second pumps, the piston of the latter is connected by a crank gear Under the influence of the electric motor, optical radiation deposition depends on a periodically changing thickness The claims An electro-optical hemocoagulograph containing a cuvette, a light source, a light filter, a photodetector, an amplifier placed in a thermostat, as well as a first pump with a pipeline, are necessary for the purpose of increasing the reliability of measurement results and expanding diagnostic capabilities, contains a second pump, and in the cuvette a hollow fiber is installed, connected by a pipeline to the first and second pumps, the piston of the latter is connected by a crank mechanism with an electric motor optical fiber and coaxial with it to an electric current source.