RU1782613C - Method for treating the rossolimo-melkersson-rosenthal syndrome - Google Patents

Description

1

(21) 4835052/14 (22) 05.06.90 (46) 12/23/92. Bull. Number 47

(71) Moscow Medical Dental Institute. N.A.Semashko

(72) V.A. Karlov and I.K. Tebloev. A.K. Seleznev, R.S. Megdtov, S.A. Kozlov and I.Yu. Kurbatov (56) Copyright certificate of the USSR

N 1055516, A 61 K 31/00. 1982.

(54) METHOD FOR TREATING ROS-SOLIMO-MELKERSON-ROSENTHAL SYNDROME

(57) Usage: in medicine, in particular in neurology, dentistry, dermatology. Summary of the invention: in the application of electrophoresis of a 2% solution of xidifon once a day, 8-10 times per course. Moreover, the electrodes are located symmetrically in one plane 1 cm above the corners of the mouth in the area of the edema. The ease of use of this method allows it to be used both in the hospital and on an outpatient basis. The use of one drug eliminates the negative effect of polypharmacy.

The invention relates to medicine and may find application in neurology, dermatology, dentistry.

A known method of treating Rossolimo-Melkerson-Rosenthal syndrome using antibiotics, prednisolone according to the scheme with five four-day cycles, diazolin 0.1 g or suprastin 0.025 g per day, bellataminal 1t x 3 times a day, compliment 0.15 x 3 times per day or 1 ml / w /, ascorutin 1t x 3 times a day, a solution of calcium gluconate 10% - 10.0 w / w every other day No. 10, 25 mg / 0.5 ml prodigiosan. “1 / m / on the first day, and then after four days, 50 mg / 1 ml / v / m, i75 mg per treatment course, with vitamins Bi, Be, phonophoresis with hydrocortisone, complex LFKL massage and acupuncture. (Rassolimo-Melkerson-Rosenthal Syndrome Methodological Recommendations, M. 1982, p. 11).

However, this method of treatment requires long-term use, a large number of medications, including glucocorticoids, which have a strong side effect, which with prolonged

use often leads to side reactions.

The closest solution to the prototype is a method for treating Rossolimo-Melkerson-Rosenthal syndrome using drugs: intramuscular injection of 1000-2500 units. heparin - 2 times a day, alternate topical application every day of electrophoresis of nicotinic acid and lidase, oral administration of phytin, glutamic acid, glycerin, dirididomol and topical application of heparin ointment and venoruton gel on the face every other day (A.S. N 1055516 , USSR, A 61 K 31/00. 1982).

The disadvantages of this method of treatment are the use of a large number of drugs, which, with the duration and repeatability of treatment courses, leads to the effect of polyprogram and, moreover,. the use of this method is not possible on an outpatient basis.

The aim of the proposed method of treatment is. elimination of polySP effect

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progmazias and outpatient applications.

The goal is achieved by using a 2% solution of xidiphon (potassium sodium salt of hydroxyethylidene diphosphonic acid). Another difference of this method is that xidophone is administered by electrophoresis once a day, the number of daily procedures is 8-10. The third difference of this method is that electrophoresis electrodes are located symmetrically in the same plane 1 cm above the corners of the mouth in the area of the edema.

The amount of the drug administered per day and the course were selected empirically.

Thus, the maximum effect is obtained with the number of procedures per day and per course indicated in the proposed method, as evidenced by the act of clinical trials, a decrease in these numbers leads to a decrease in the clinical effect, and an increase does not give its further dynamics / table. 1/.

The location of the electrodes during electrophoresis is symmetrical in one plane, 1 cm above the corners of the mouth, in the edema area was selected during the development of the method.

Changing the location of the electrodes reduces the efficiency and appropriateness of the method, i.e., the most pronounced clinical effect is obtained in the proposed method, as evidenced by the act of clinical trials.

The treatment method is as follows: the patient is placed electrodes on gauze pads moistened with a 2% solution of xidifon in one plane 1 cm higher than the corners of the mouth (per edema area), the procedure is carried out in a frequency mode of 50 Hz and a pulse duration of 1 ms for 10-15 min daily. On a course of 8-10 procedures.

Clinical example.

Patient B., 36 years old, was admitted to the 1Gneological Department with complaints of severe swelling of the right cheek and upper lip on the right. From the anamnesis it is known that in 1968, after the first right-sided neuropathy of the facial nerve that developed with a good restoration of facial muscles, the swelling of the right cheek and upper lip on the right was corrected. It was treated with vascular preparations with a satisfactory effect. After this, a facial neuropathy occurred 4 more times. After the fourth relapse, it was treated with vascular, antihistamines, glucocorticoid drugs, as well as antibiotics and gamma globulin, since swelling of the right cheek and upper lip on the right again with a subsequent sweep.

by a similar recid effect of this therapy was reduced. The present admission to the clinic is associated with the lack of effect from previous therapy.

Upon receipt, the condition is satisfactory. HELL - 110/70 mm RT. Art. Pulse 78 beats. in 1 min. For organs without features.

In neurological status: the pupils are uniform, there is no instagma. Hidden paresis

gaze to the right. The face is asymmetrical. Easy deviation of the language to the right. Taste and hearing are not disturbed. There are no paresis in the extremities; muscle tone in them is not changed. Tendon and periosteal reflexes are lively and symmetrical. There are no coordinating violations and sensory.

The tongue is folded. Prior to treatment, pronounced edema of the right cheek and upper lip on the right. On the right cheek in the edema area

hyperemia. Dense tissue is palpated on the upper lip on the right side of the edema, the area of which is less than the area of the edema.

Fluorogafi of the chest without features.

Gynecologist - without features.

Urine and blood tests, ECG-without features.

With capilloscopy, prior to treatment, intravascular aggregation of blood cells, sinuosity of the venules, slowing of capillary blood flow, perivascular edema were detected.

Thermography - before treatment of temperature asymmetry with increased thermal

flow to the right.

Diagnosed with Rossolimo-Melkerson-Rosenthal syndrome on the right, in the acute stage.

The patient underwent 10 procedures daily electrophoresis with xidifon for 15 minutes. The active electrode was placed on the edema side 1 cm above the angle of the mouth, and the passive one was symmetrical.

After the treatment in the patient

the asymmetry of the face significantly decreased due to the removal of edema, while hyperemia decreased at the same time. The seal has been preserved.

With capillaryoscopy after treatment

intravascular aggregation, lirivascular edema practically disappeared, and capillary blood flow was restored. The thermogram after treatment showed a decrease in thermal asymmetry due to a decrease in the heat flux to the right.

By this method 13 patients were carried out during the exacerbation period / group 1 /. A control group of 10 people was treated according to the prototype method / group 2 /. The severity control group corresponded to group 1.

To objectify the results of treatment, the following were used: capilloscopy on SchL-2B. Telegraphy on the AGA-780, photo shooting. At the same time, the content of macro- and microelements in the gauze pad under the active electrode was investigated.

During capilloscopic examination of the edematous part of the lip before treatment, patients with both groups showed significant tortuosity of the venules, slowing of capillary blood flow, the phenomenon of intravascular aggregation, perivascular edema. After treatment of patients 1 and 12 of groups 1 and 6, the control disappeared, the phenomenon of intravascular aggregation accelerated, blood flow in the capillaries accelerated, perivascular edema disappeared. In one patient of group 1 and 3 control these phenomena were less pronounced and in one patient of group 2 the picture of capilloscopy remained the same against a background of slight clinical improvement. The tortuosity of venules was preserved in all patients of both groups.

On the telegrams of the face after treatment, the heat flux from the edema zone significantly decreased and the thermo-asymmetry decreased, except for three patients of the control group.

To explain the effect of the action of Oyl Xydiphone, it was taken as the basis for its ability to influence the level of macro- and microelements. To do this, along with an analysis of the clinical effect in order to

After the procedure was completed, the macro- and micronutrients in the gauze pad under the active electrode were quantified by the ion circulation between the electrode and the tissue. As a control, 10 patients of the control group underwent an electrophoresis procedure with the replacement of xidiphon with distilled water, the remaining parameters of the procedure were preserved. The data obtained showed that the use of electrophoresis with xidiphone compared with distilled water contributed to an increase in the yield of trace elements and their accumulation in a gauze pad under the active electrode. The data are given in table. 2.

Micronutrients are average values.

The high magnesium content in the gauze and its ability to bind water molecules led to the conclusion that this is the basis for the treatment of Rossolimo-Melkerson-Rosenthal syndrome with xidiphone.

Claims (1)

The claims A method of treating Rossolimo-Melkerson-Rosenthal syndrome, comprising administering drugs, characterized in that, in order to simplify the method by eliminating polyprograms, electrophoresis of a 2% xidiphon solution is performed on the edema region, while the electrodes are placed symmetrically in one plane on course of 8-10 procedures. Table method - adsorption spectrophotometry p - number of patients table 2