RU175245U1 - Separation device for determining biochemical parameters and markers of diseases in blood plasma - Google Patents

Abstract

The utility model relates to medical diagnostics. The separation device for determining biochemical parameters and markers of diseases in the blood plasma contains a housing with a bowl in which the diagnosticum is located, at least two diametrically located control cuts are made along the edges of the bowl, and on top of the body of the device is covered with a separation membrane with a recess. The bowl and the recess of the separation membrane can be made in the form of a hemisphere. The technical result is an acceleration of the process and increased accuracy in determining biochemical parameters or markers of the disease in blood plasma.

Description

Separation device for determining biochemical parameters and markers of diseases in blood plasma

The technical field to which the utility model relates.

The utility model relates to medical diagnostics, namely, devices for blood separation, separation of uniform elements from plasma and determination of biochemical parameters and markers of diseases in blood plasma.

State of the art

There are a lot of known membrane separation devices used in blood treatment procedures, including for plasma separation (RF patents for inventions: No. 2601449, publ. 10.11.2016; No. 2578418, publ. 03/27/2016; No. 2597140, publ. 10.09 .2016; No. 2215544, publ. 10.11.2003; No. 2514545, publ. 04/27/2014; No. 2595704, publ. 08/27/2016).

A known membrane apparatus for the separation and purification of blood (RF patent for the invention No. 2046646, IPC class B01D 63/14, А61М 1/34, publ. 10/27/1995), containing a housing with cameras for supplying and removing blood and located in it means for separation and plasma purification, made in the form of a multi-chamber membrane module containing two groups of alternating, blood chambers and plasma chambers cross-directed along the fluid streams formed by a set of flat semipermeable membranes and sealing means (SG) and open from the sides of the inlet and outlet of the media, sep radio-drainage elements (SDE), placed in the chambers, while the SG is made in the form of strips of material containing thermoplastic, located along the direction of movement of the media and permanently connected to the sorbent with the formation in the places of contact with them supporting elements in the form of columns, and SDE in plasma chambers are made of microporous material containing a sorbent. As membranes, track membranes can be used, and the strips are made of polymer hot melt glue.

A common disadvantage of the known devices is their structural complexity, due to the large number of parts, elements and components.

A device for separating blood plasma is also known (RF patent for the invention No. 2523681, IPC class A61M 1/34, publ. 05/20/2016), selected as a prototype, which has a supply device for collecting blood, a membrane for separating its components from blood as the analyzed liquid, the channel into which the analyzed liquid enters and through which it moves under the action of capillary forces, and a feeding device for filling the channel with the analyzed liquid at its inlet or inlet section. The membrane is made convex in shape, with the apex of its convex part protruding into the feeding device in the filling direction and in its central part adjoining the bottom of the feeding device, or the distance between the apex of the convex part of the membrane and the bottom of the feeding device is from 10 to 25 μm, as a result leaving side of the membrane, the analyzed liquid directly wets the bottom of the feed device.

The disadvantage of this device is the structural complexity of the device, as well as the relatively low speed of the plasma separation process.

Utility Model Disclosure

The claimed utility model is based on the task of improving the device for separating blood constituents, such as plasma, as an analyte, through a semipermeable membrane, while optimizing the filling of the device cup with the analyte fluid and ensuring the creation of capillary contact between the separation element and the cup, as well as effectively improving the ability to conduct diagnostics and, accordingly, research.

The technical result achieved in the process of implementing the utility model accelerates the process and improves the accuracy of determining biochemical parameters or markers of the disease in blood plasma.

The specified technical result is achieved in that the separation device for determining biochemical parameters and disease markers in the blood plasma contains a housing with a bowl in which the diagnosticum is located, at least two diametrically located control recesses are made along the edges of the bowl, and on top of the device case is covered with a separation membrane with a recess .

The bowl and the recess of the separation membrane can be made in the form of a hemisphere.

In FIG. 1 shows a separation device for determining biochemical parameters and markers of diseases in blood plasma, general view.

In FIG. 2 is the same, sectional side view.

The following notation is used in the figures: 1 - a separation membrane with a recess, 2 - a device case, 3 - a bowl, 4 - control notches, 5 - a drop of blood, 6 - diagnosticum, 7 - formed blood elements.

Utility Model Implementation

The separation device for determining biochemical parameters and markers of diseases in the blood plasma contains a housing 2 with a bowl 3, in which the diagnosticum 6 is located, at least two diametrically located control recesses 4 are made along the edges of the bowl 3, and on top of the housing 2 of the device is covered with a separation membrane 1 with a recess .

The bowl 3 in the housing of the device 2 is a recess, usually in the form of a hemisphere.

The separation membrane 1 is a semipermeable membrane and is designed to separate the formed elements of blood from plasma. The membrane 1 also has a recess in the form of a hemisphere.

The control recesses 4 allow you to control the filling of the bowl 3.

As a diagnosticum 6, a reagent is used to determine the necessary biochemical indicator or marker of a specific disease in blood plasma.

The separation device operates as follows.

A drop of blood is placed in the recess of the separation membrane 1. Blood is separated, and the plasma separated from the formed elements of the blood enters the bowl 3 with diagnosticum 6. The color change of diagnosticum 6 (reagent) makes it possible to determine the necessary biochemical indicator or marker of a specific disease. The process of filling the bowl 3 is controlled visually using the control recesses 4.

After the process of determining the biochemical indicator or marker of the disease is completed, a separation membrane 1 is removed from the surface of the device casing 2, on which blood cells are deposited.

The proposed device can significantly accelerate the process of determining biochemical parameters or disease markers in plasma in the absence of the need for additional manipulation, such as centrifugation of blood. This process occurs in the bowl of the separation device housing, after which the semipermeable membrane is removed with the formed blood elements deposited on it.

The advantages of the developed device are:

1. The determination of indicators in blood plasma occurs at the patient's bedside.

2. No need for complex instruments (centrifuge), as well as trained laboratory personnel and laboratories.

3. The speed of obtaining the result.

4. Minimally invasive.

5. The use of a minimum blood volume to determine which is very important for small infants.

6. The process of separation of blood into plasma and formed elements occurs immediately, without the centrifugation process, in one separation device.

7. Due to the lack of centrifugation process and the need for transportation, there is no process of oxidation and decomposition of blood and reagents, thereby increasing the accuracy of measurement.

8. In connection with the separation of blood through a semipermeable membrane in the bowl of the separation device, there is no possibility of the formation of air cavities, as well as the passage of blood cells and fibrin inclusions, which can negatively affect the result of determining indicators or markers in the plasma by creating additional color deviations.

The novelty of the developed separation device are:

1. The presence in the device of a semipermeable membrane for blood separation, since the determination of indicators or markers occurs directly in the plasma. Thus, the determination process is accelerated, and there is no need for separation and centrifugation of blood on a mechanical apparatus.

2. The absence of mechanical and electronic components in the separation device eliminates the possibility of technical error and malfunction.

A comparative analysis of the claimed utility model showed that the totality of the features of the claimed separation device is unknown from the prior art and, therefore, meets the patentability condition “Novelty”.

The above information confirms the possibility of using the claimed utility model for determining biochemical parameters and disease markers in blood plasma, and therefore meets the patentability condition “Industrial Applicability”.

Claims (2)

1. A separation device for determining biochemical parameters and markers of diseases in blood plasma, comprising a housing with a bowl in which the diagnosticum is located, at least two diametrically located control recesses are made along the edges of the bowl, the device housing being covered with a separation membrane with a recess on top. 2. The separation device according to claim 1, characterized in that the bowl and the recess of the separation membrane are made in the form of a hemisphere.

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